A new study published in Genetic Testing and Molecular Biomarkers found that analyzing cell-free DNA using next-generation sequencing is more accurate than the current standard approach of Sanger sequencing. This method can detect genetic abnormalities responsible for myelodysplastic syndrome (MDS) with greater sensitivity.
SourceMary Ann Liebert, Inc./Genetic Engineering News·JournalGenetic Testing and Molecular Biomarkers·DateAug 2, 2016
Nottingham researchers demonstrate highly selective DNA sequencing method called Read Until, reducing time needed to analyze biological samples. The technique uses real-time nanopore sequencing and enables analysis of specific DNA strands with pre-determined signatures.
SourceUniversity of Nottingham·JournalNature Methods·DateJul 25, 2016
Researchers at Washington State University have developed a technique to visualize DNA damage caused by ultraviolet radiation, shedding light on its impact on skin cancer. The study provides clues on how sunlight triggers mutations and cancer, with implications for future therapies.
SourceWashington State University·JournalProceedings of the National Academy of Sciences·DateJul 25, 2016
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A recent study has shed light on the pathogenesis of DNA breakpoints associated with leukemia, revealing a mechanism that explains up to 90% of DNA damages in the most common type of childhood leukemia. The study identified a new high-risk subtype of leukemia characterized by abnormal expression of enzymes causing DNA damage.
A new diagnostic tool uses short-strand DNA library preparation to analyze cell-free DNA in plasma, enabling transplant recipients to get an idea of how their new organ is responding via a simple blood test. This method can help determine whether the transplanted organ is injured or being rejected.
SourceCornell University·JournalScientific Reports·DateJul 8, 2016
A new platform harnesses DNA as the engine of a microscopic nanomachine, detecting trace amounts of substances such as viruses, bacteria, and metals. The technology uses selectively triggered DNA molecules to create a signal, enabling ultra-sensitive detection and potential clinical testing.
SourceMcMaster University·JournalNature Communications·DateJul 7, 2016
A significant proportion of men with advanced prostate cancer have inherited mutations in DNA repair genes, making them eligible for precision treatments such as PARP inhibitors. Genetic testing could help identify these patients and offer targeted therapies to improve their treatment outcomes.
SourceInstitute of Cancer Research·JournalNew England Journal of Medicine·DateJul 6, 2016
Researchers are using DNA origami to create large, two-dimensional honeycombs and tubes with precise structures. They aim to develop new medicines by exposing the immune system to DNA origami scaffolds holding virus pieces, and explore protein arrangements for sophisticated medicines and electronic devices.
SourceThe Kavli Foundation·JournalJournal of the American Ceramic Society·DateJul 6, 2016
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Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers have discovered a new molecular mechanism that directs cellular DNA repair proteins to lesions in DNA, making it an attractive target for cancer therapy. By understanding how this mechanism works, scientists can design small molecule inhibitors that block the function of TONSL protein and promote cancer cell death.
SourceUniversity of Copenhagen - The Faculty of Health and Medical Sciences·JournalNature·DateJun 22, 2016
Core proteins partially disassemble to facilitate gene activation, according to Rice University researchers. Their detailed models support the idea that DNA unwrapping and core protein unfolding are coupled, with histone tails playing a crucial role in nucleosome stability.
SourceRice University·JournalJournal of the American Chemical Society·DateJun 21, 2016
Researchers developed a new enhanced DNA imaging technique that can probe individual DNA strands at the nanoscale, providing orientation information and rotational dynamics. The technique offers more detailed information than current methods, enabling monitoring of DNA conformation changes and interactions with proteins.
Geneticists at KU Leuven have discovered that tumour protein TP53 can autonomously locate and bind to specific DNA sequences, activating the right genes to repair damaged cells. This finding sheds light on the mechanisms controlling gene expression and holds promise for future cancer therapies.
The IBS team identified baicalein as a suitable antagonist to battle malignant cancerous cells, binding to mismatched DNA and causing cancerous cells to self-destruct. The research found that baicalein significantly shrunk MutSα-deficient tumors in mice models, offering a viable option for patients with DNA MMR deficient tumors.
SourceInstitute for Basic Science·JournalCancer Research·DateJun 14, 2016
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GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
Cells use programmed fork arrest to halt DNA replication at terminator sites, controlling life span and preserving genome stability. The process involves proteins working together to calibrate fork movement, preventing constant machinery operation.
SourceMedical University of South Carolina·JournalProceedings of the National Academy of Sciences·DateJun 14, 2016
Researchers at the University of Pennsylvania School of Medicine propose a new model for viral replication, suggesting that DNA 'scrunching' generates forces to drive DNA into a virus during replication. This understanding could lead to new ways to fight infectious pathogens.
SourceUniversity of Pennsylvania School of Medicine·JournalThe Journal of Physical Chemistry B·DateJun 8, 2016
Sheffield scientists capture never-before-seen snapshots of enzymes trimming branched DNA after cell division. The discovery provides insight into the molecular process of DNA replication and repair, essential for all life forms.
SourceUniversity of Sheffield·JournalNature Structural & Molecular Biology·DateJun 6, 2016
Researchers found that anti-DNA antibodies preferentially bind to damaged double-stranded DNA (dsDNA) over native DNA, contributing to the pathogenesis of autoimmune diseases. This study provides mechanistic insight into the formation and properties of pathogenic anti-DNA antibodies.
SourceKazan Federal University·JournalJournal of Biomolecular Structure and Dynamics·DateJun 3, 2016
A new method for designing geometric forms built from DNA has been developed, allowing for the creation of tiny structures in 2 and 3 dimensions. The technique, known as DNA origami, relies on a top-down strategy and can produce virtually any polyhedral shape.
SourceArizona State University·JournalScience·DateMay 26, 2016
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AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers at Osaka University found that DNA damage response errors can lead to tumor formation when proteins are not removed correctly. Ku protein plays a key role in DNA repair, but its incorrect function can result in genetic information loss and cancer.
SourceOsaka University·JournalPLOS Genetics·DateMay 24, 2016
A study published in Cell Stem Cell found that small amounts of mitochondrial DNA can override the mitochondria in donor cells after nuclear transfer, raising concerns about the therapy's safety and effectiveness. The researchers are now exploring strategies to avoid this carryover and ensure complete mitochondrial DNA replacement.
A study published in Science reveals that a molecule called ppGpp enables bacteria to repair damage to their DNA, including that caused by antibiotics. Adjusting the action of ppGpp may make bacteria more vulnerable to existing antibiotics, potentially yielding future solutions for antibiotic resistance and degenerative diseases.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalScience·DateMay 19, 2016
Four-stranded DNA (G4) structures were formed in yeast and could potentially contribute to cancer development. A motor protein called Pfh1 unfolds these structures, ensuring genome stability during replication. The study provides insights into G4 structures and their role in maintaining genome integrity.
SourceUmea University·JournalNucleic Acids Research·DateMay 16, 2016
Researchers at UC San Diego found that DNA segments become jammed within viruses when sticky, causing the DNA to behave like LEGO pieces. Adding polyamines can cause viral DNA to become jammed and halt packaging.
SourceUniversity of California - San Diego·JournalNature Physics·DateMay 2, 2016
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
Researchers at University of Montreal developed programmable DNA thermometers that can measure temperature at the nanoscale. The smallest thermometer is 5 nm-wide and produces an easily detectable signal as a function of temperature.
SourceUniversity of Montreal·JournalNano Letters·DateApr 27, 2016
A new study reveals how retroviral DNA insertion complexes hunt for suitable spots and insert rapidly, with search times exceeding 2-3 seconds and insertion happening in under half a second at chosen sites. The findings could improve treatments for HIV infection and make gene therapy safer and more efficient.
SourceOhio State University Wexner Medical Center·JournalNature Communications·DateApr 26, 2016
Researchers have developed a complete system to sequence DNA in nanopores electronically at single molecule level with single-base resolution. The system uses a protein nanopore array and polymer-tagged nucleotides to perform single molecule electronic DNA sequencing, enabling real-time and parallel sequencing of multiple DNA molecules.
SourceColumbia University School of Engineering and Applied Science·JournalProceedings of the National Academy of Sciences·DateApr 21, 2016
Research by Georgia Institute of Technology's Harold Kim reveals DNA's movements defy intuition, with entropic forces prevailing over elastic ones. The study improves understanding of how DNA snaps free from proteins and may help predict the lifespans of DNA loops.
SourceGeorgia Institute of Technology·JournalPhysical Review E·DateApr 20, 2016
Researchers found that SLE neutrophils release oxidized mitochondrial DNA, stimulating type I interferon production and contributing to disease pathogenesis. Targeting pathways for oxidized DNA degradation may offer new treatment options for chronic autoimmune disease.
SourceRockefeller University Press·JournalJournal of Experimental Medicine·DateApr 18, 2016
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Researchers created knockout mice that lack a gene involved in DNA repair, shedding light on how cells fix broken DNA. The mice developed kidney and liver dysfunction due to impaired detoxification, highlighting the importance of FAN1 protein.
SourceRockefeller University·JournalGenes & Development·DateApr 12, 2016
Researchers found that DNA molecules interact with each other in a way that depends on the sequence of the DNA and epigenetic factors. The team presented direct evidence for sequence-dependent attractive interactions between double-stranded DNA molecules.
SourceUlsan National Institute of Science and Technology(UNIST)·JournalNature Communications·DateApr 8, 2016
Researchers discovered that DNA molecules interact directly with each other based on their sequence and epigenetic factors, suggesting a new mechanism for DNA organization in the cell. The study found that methyl groups play a key role in regulating these interactions, which could impact gene expression and chromosome organization.
SourceUniversity of Illinois at Urbana-Champaign, News Bureau·JournalNature Communications·DateMar 22, 2016
Researchers are exploring DNA origami to create nanoscale structures for electronics, potentially leading to smaller, faster, and cheaper computer chips. The technique involves forming specific shapes in DNA to create three-dimensional structures that can be used as a scaffold for other materials.
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The CHOP/Rutgers team developed new experimental approaches to detect DNA scrunching during transcription start site selection. They identified the TSS, front and rear positions where RNA polymerase attached to DNA, and found that as the position of the TSS changes, the position of the enzyme's leading edge changes in lock step.
SourceChildren's Hospital of Philadelphia·JournalScience·DateMar 3, 2016
Researchers at McGill University discover that cyanuric acid can coax DNA into forming a triple helix, unlike the familiar double helix. This breakthrough could lead to the creation of new DNA structures with unique properties.
SourceMcGill University·JournalNature Chemistry·DateMar 1, 2016
Scientists have developed a systematic approach to discovering unknown DNA modifications, using a combination of bioanalytical chemistry, comparative genomics, and single-molecule real-time sequencing. This approach has led to the discovery of a new epigenetic mark, dADG, which helps bacteria defend their genomes from viral infection.
SourceMassachusetts Institute of Technology·JournalProceedings of the National Academy of Sciences·DateFeb 29, 2016
A team of scientists found that 5hmC localizes at sites of DNA damage and repair, with TET enzymes playing a critical role in maintaining its reparative function. This discovery raises the possibility that 5hmC helps keep chromatin open for other DNA damage response proteins.
SourceInstitute for Integrated Cell-Material Sciences, Kyoto University·JournalCell Reports·DateFeb 12, 2016
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Kestrel 3000 Pocket Weather Meter measures wind, temperature, and humidity in real time for site assessments, aviation checks, and safety briefings.
Researchers at the John Innes Centre have identified DNA gyrase as a key enzyme in plants that can be targeted for the development of new, more effective herbicides. This discovery holds promise for reducing the risk of antibiotic resistance and ensuring the safety of farmers and gardeners.
SourceJohn Innes Centre·JournalJournal of Biological Chemistry·DateFeb 11, 2016
Researchers discovered a novel mechanism by which adenovirus protein E4orf4 inhibits the DNA damage response, improving viral replication. This finding provides insight into the virus's ability to infect immunocompromised patients and may lead to new cancer therapies.
Researchers used DREEM to visualize how DNA wraps around TRF2, forming T-loops that protect chromosome ends. The new technique provides insights into telomere maintenance and structure-function relationships.
Researchers identified 27 genes in brain stem cells prone to DNA damage, which could promote disease but also benefit brain diversity. The fragility of these genes may lead to mutations or deletions in cancers and neuropsychiatric disorders.
SourceHoward Hughes Medical Institute·JournalCell·DateFeb 11, 2016
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Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers found that APOBEC3 enzymes target the lagging-strand template during DNA copying, causing C-to-T mutations. This discovery sheds light on a major source of mutations driving tumor growth and explains microbial evolution.
SourceWayne State University - Office of the Vice President for Research·JournalProceedings of the National Academy of Sciences·DateFeb 9, 2016
Researchers at Sam Houston State University are developing new sample preparation methods for skeletal and decomposing remains using emerging next generation DNA technology. The goal is to improve the ability to resolve more missing person cases, as conventional methods may fail.
Two studies on yeast reveal that gene expression among tandem DNA repeats varies substantially depending on position within the array. These findings provide key information about DNA architecture in cells, highlighting the central role of chromosome architecture in regulating these sequences.
SourceNew York University·JournalCell Reports·DateJan 28, 2016
A team of Swiss and Russian scientists has deciphered how APOBEC takes advantage of a weakness in DNA replication to induce mutations, primarily affecting early-replicating genes. The study reveals that APOBEC targets single-stranded DNA regions during replication, which are more prone to mutations.
SourceUniversité de Genève·JournalGenome Research·DateJan 22, 2016
Researchers at Rice University have created a new tool to analyze DNA in its native conditions, reducing analysis time from months to hours. The method generates more accurate results and can be used to build a comprehensive database of thermal behaviors of genetic molecules.
SourceRice University·JournalNature Communications·DateJan 19, 2016
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Researchers at UW Medicine developed a method to identify tissues contributing to cell-free DNA by analyzing fragmentation patterns, expanding the scope of liquid biopsies. This approach may aid in diagnosing unknown metastatic cancers and help guide treatment.
SourceUniversity of Washington School of Medicine/UW Medicine·JournalCell·DateJan 14, 2016
Researchers at the University of Notre Dame have developed a novel method for noninvasive genetic sampling using spider webs. This approach enables biomonitoring without direct observation or disturbance of target organisms, with potential applications in conservation research, pest management, and biogeography studies.
SourceUniversity of Notre Dame·JournalPLOS ONE·DateJan 12, 2016
Scientists at the Institute of Molecular Biology have identified two proteins, Neil1 and Neil2, essential for DNA demethylation. These proteins boost the activity of Tdg, a central protein in DNA demethylation, promoting efficient removal of epigenetic marks.
SourceJohannes Gutenberg Universitaet Mainz·JournalNature Structural & Molecular Biology·DateJan 12, 2016
Researchers at UC Davis have demonstrated that DNA can be modulated to act as an electromechanical switch, enabling the design of unique nanodevices. The discovery could lead to new paradigms for computing and improve energy efficiency in electronic devices.
SourceUniversity of California - Davis·JournalNature Communications·DateDec 11, 2015
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Researchers have developed a rolling DNA-based motor that's 1,000 times faster than any other synthetic DNA motor, offering potential for real-world applications in disease diagnostics. The new motor uses a burnt-bridge mechanism to guide its movement, allowing it to travel one centimeter in seven days.
SourceEmory Health Sciences·JournalNature Nanotechnology·DateDec 1, 2015
Researchers found that tardigrades have a massive amount of foreign DNA, with around 17.5% coming from non-tardigrade sources, primarily bacteria. This challenges conventional views on how DNA is inherited and raises new questions about the connection between foreign DNA and extreme environment survival.
SourceUniversity of North Carolina at Chapel Hill·JournalProceedings of the National Academy of Sciences·DateNov 23, 2015
Studies reveal crucial role of histone chaperone protein in maintaining epigenetic landscape and genomic fidelity. Deletion of key protein leads to severe developmental defects, DNA damage, and compromised gene regulation.
SourceBabraham Institute·JournalMolecular Cell·DateNov 6, 2015
The project aims to analyze core replication complexes crucial for repairing damaged DNA and understanding cancer initiation and progression. The study may lead to insights into human health and disease, particularly cancer susceptibility.
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Research by Rockefeller University scientists shows DNA strands increase mobility during repair, which may serve as a 'fail-safe mechanism'. This process is linked to chemotherapy and cancer treatment, and understanding its mechanisms could lead to new therapies.
SourceRockefeller University·JournalCell·DateNov 5, 2015
Researchers at UT Austin developed a nanoscale machine made of DNA that can autonomously walk in any direction, opening doors for cancer detection and therapeutic delivery. The DNA walker, with two legs connected by a torso, moves randomly and avoids re-tracing its steps, demonstrating a new level of complexity.
SourceUniversity of Texas at Austin·JournalNature Nanotechnology·DateNov 2, 2015
Scientists have identified a new class of DNA repair enzyme that can recognize and remove positively charged lesions, including bulky ones. This discovery expands the understanding of DNA damage repair pathways and offers insights into alternative mechanisms for repairing genetic information.
New research reveals the three-dimensional structure of supercoiled DNA, showing it forms multiple shapes, including figure-8s and handcuffs. The study challenges the traditional Watson-Crick double helix structure, suggesting a dynamic nature that helps explain how a meter of DNA can fit in a human cell.
SourceUniversity of Leeds·JournalNature Communications·DateOct 12, 2015
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Researchers at Baylor College of Medicine studied tiny DNA minicircles containing only 336 base pairs to understand biologically active DNA. They found that the coiling caused many different shapes, including sharp bends and figure-8s, and showed how these structures facilitate DNA interactions with proteins and anticancer drugs.
SourceBaylor College of Medicine·JournalNature Communications·DateOct 12, 2015
Researchers at EPFL have created a groundbreaking DNA stain called SiR-Hoechst, which enables the safe imaging of living cells for extended periods. This innovation allows biologists to track biological processes such as cell division in real-time, paving the way for further breakthroughs in bioimaging.
SourceEcole Polytechnique Fédérale de Lausanne·JournalNature Communications·DateOct 1, 2015
A team of scientists created a new single-molecule tool to observe enzymatic proteins at work, providing fast and reliable characterization of their interactions with DNA. This tool offers picometer-resolution nanopore tweezers, enabling detection of minute differences in protein binding and motion.
SourceUniversity of Washington·JournalNature Biotechnology·DateSep 28, 2015