A phase III trial found T-DM1 significantly reduced invasive disease-free survival risk in patients with HER2-positive early-stage breast cancer and residual invasive disease after neoadjuvant chemotherapy and trastuzumab. The treatment also showed promise in reducing recurrence risk across various subgroups of patients.
A program providing individually tailored lifestyle recommendations for patients undergoing colorectal cancer screening helped encourage healthy behavior, according to a study published in Cancer Epidemiology, Biomarkers & Prevention. Participants who received tailored feedback increased their cancer preventive behaviors by 0.11 compar...
A recent study published in Cancer Epidemiology, Biomarkers & Prevention found that many patients diagnosed with adenomas often do not receive subsequent colonoscopies within the recommended time frame. The study analyzed patterns and factors associated with the receipt of colonoscopy within approximately three years of a diagnosis of ...
A new study reveals that states expanding Medicaid from 2011 to 2017 experienced a significant 27% increase in prescriptions for hormonal therapy medications compared to non-expansion states. This rise was attributed to increased access for previously uninsured women who required long-term treatment with these life-saving drugs.
An interactive online LGBT cultural competency training program improved oncologists' knowledge and clinical practices on LGBT patients. The program increased correct answers on LGBT-related knowledge items by 52% and favorable perspectives toward LGBT people by 70%.
A study by V. Wendy Setiawan and colleagues found that cancer mortality rates among Latinos in the US increase with each successive generation born in the country. The highest risk was observed among third-generation U.S.-born Latinos, followed by second- and first-generation immigrants.
A prognostic model using machine learning accurately stratifies African-American breast cancer patients into high- and low-risk populations based on protein expression levels. The model identifies a combination of four proteins associated with increased risk of death, suggesting specific therapeutic regimens for this underserved demogr...
A culturally tailored multilevel strategy increased HPV vaccination rates among low-income, mostly Chinese American adolescent girls and boys. The intervention, which engaged pediatricians, parents, and adolescents through various channels, showed a significant increase in vaccine uptake compared to control groups.
A recent study found that African-American caregivers experience better mental health outcomes than their white peers, likely due to stronger social support networks. The study's authors suggest that adequate preparation for the caregiving role and access to religious communities are key factors in reducing caregiver burden.
Women carrying rare breast cancer variants are more likely to develop interval breast cancers, which are often aggressive and lethal. The study found that these women have a higher risk of death from breast cancer compared to those with common mutations.
A study of female childhood cancer survivors found that genetic profiling can identify high-risk individuals for subsequent breast cancer. Polygenic determinants and rare mutations significantly contribute to breast cancer risk, with a notable age-specific association in younger women.
A new statistical method estimates the short- and long-term risk of recurrence for hormone receptor-positive and HR-negative breast cancers in US women. The study found that while HR-positive breast cancer has a lower risk of progression to metastatic disease soon after diagnosis, the risk persists for several years.
A deep learning approach can identify nuanced mammographic imaging features specific to recalled but benign (false-positive) mammograms, distinguishing them from those identified as malignant or negative. The study achieved an area under the curve (AUC) of 0.76-0.91, indicating high performance in detecting false recalls.
Three leading researchers, Ian Smith, Ann Partridge, and Zena Werb, receive top honors for their groundbreaking work on breast cancer treatment and research. Their contributions have propelled advances in breast cancer science and medicine, saving countless lives from the disease.
A patient-partnered genomics study identified immune checkpoint inhibition as a potential treatment option for patients with angiosarcomas of the head, face, neck, or scalp. The study found that patients with these tumors have high mutational burdens and may respond to immunotherapy.
A new cancer vaccine targeting HER2 has demonstrated clinical benefits in a phase I clinical trial, with six out of eleven evaluable patients experiencing improvements in their condition. The vaccine provided complete or partial responses and stable disease in some cases.
The conference features cutting-edge research studies to answer urgent questions in cancer immunotherapy, aiming to advance progress more rapidly for patients. New approaches to identifying responders and non-responders to immune checkpoint inhibitors are being developed.
A phase I clinical trial found bacterial Clostridium novyi-NT spores to be tolerable and clinically effective in patients with treatment-refractory solid tumor malignancies. The therapy showed early clinical efficacy, with 86% of evaluable patients experiencing stable disease.
Adolescent and young adult (AYA) leukemia patients are significantly more likely to relapse than pediatric ALL patients. Factors such as lower clinical trial enrollment, shorter treatment duration, race, and insurance status contribute to this disparity.
Children who develop B-cell precursor ALL have dysregulated immune function at birth, as indicated by significantly different neonatal concentrations of eight detectable inflammatory markers. These findings suggest that early immune modulation may hold promise for preventing childhood ALL.
A study published in Cancer Immunology Research found that immune checkpoint inhibitors showed high efficacy and low toxicity in treating HIV-associated Kaposi's sarcoma. The treatment resulted in partial or complete remission in over 65% of patients, with limited side effects compared to standard chemotherapy.
Researchers developed a predictive model using liquid biopsies and serial blood samples from patients with advanced colorectal cancer treated with anti-EGFR therapies. The model accurately predicted personalized waiting times for disease progression, outperforming traditional tumor genotyping methods.
Heavy alcohol consumption during adolescence and young adulthood may increase the odds of developing high-grade prostate cancer. Men who drank at least seven drinks per week between ages 15-19 had three times the odds of being diagnosed with clinically significant prostate cancer compared to non-drinkers.
The global age-standardized lung cancer mortality rate among women is expected to rise by 43% from 2015 to 2030, while breast cancer mortality rates are projected to decrease by 9%. Lung cancer mortality rates will be highest in Europe and Oceania, with lower rates in America and Asia.
A study found that a diet discouraging alcohol consumption and promoting healthy eating was associated with reduced overall and breast, prostate, and colorectal cancer risks. Adherence to the WCRF/AICR score had the strongest association with reduced risk.
A microRNA panel developed by researchers identified 19 microRNAs that can categorize indeterminate thyroid nodule samples into malignant and benign. The panel showed high sensitivity, specificity, and accuracy in diagnosing cancer in patients with suspicious thyroid nodules.
A study analyzing NY state cancer death data from 2008-2014 found high mortality rates among U.S.-born blacks and Puerto Ricans, while South American Hispanics had relatively low rates. The researchers also identified significant disparities in liver cancer mortality between these groups.
Checkpoint inhibitors improve median and four-year overall survival rates for melanoma brain metastasis patients by 1.4- and 1.5-fold, respectively, according to a national cohort study published in Cancer Immunology Research.
A study found that educational interventions significantly increased sunscreen use and decreased reported sunburns among operating engineers. The interventions resulted in a 38% decrease in never wearing sunscreen and an 18.6-5.8% reduction in reported sunburns.
A wireless device called Vivio accurately detected heart dysfunction in childhood cancer survivors treated with anthracycline chemotherapy. The device displayed high sensitivity and a low false-negative rate compared to cardiac magnetic resonance (CMR) imaging.
A study found that parents of adolescents believe the potential to prevent certain types of cancer is the most persuasive reason for their children to receive the HPV vaccine. The researchers evaluated 11 reasons healthcare providers typically give for HPV vaccination and ranked them according to their persuasiveness.
A recent study published in Clinical Cancer Research found that older melanoma patients are more likely to respond to anti-PD1 immunotherapy compared to younger patients. Researchers analyzed data from 538 patients with melanoma treated with pembrolizumab and found a 13% decrease in progression rates for each decade of life.
Researchers discovered that tau protein mutations can increase cancer risk by up to 3.72 times, highlighting a new association between neurodegenerative disorders and cancer. The study's findings suggest that clinicians should monitor patients with tau mutations for their cancer risk, in addition to attending to neurodegeneration.
A recent study found that less than 13% of individuals born between 1945 and 1965 have undergone HCV screening. The researchers also noted a significant disparity in HCV screening rates among different ethnic groups, with Hispanics and non-Hispanic Blacks receiving lower rates of screening.
A study found that bacterial composition differs in patients with pancreatic ductal adenocarcinoma, promoting immune suppression and tumor growth. Eliminating certain bacteria slowed cancer progression and increased T-cell infiltration into tumors.
A study found that targeted cancer drugs can cause cognitive and behavioral deficits in young mice, but these effects can be reversed with environmental stimulation and physical exercise. Researchers suggest that pediatric brain cancer patients may experience similar side effects, highlighting the need for remediation efforts.
A study found that nearly all adolescents aged 13-19 in an economically disadvantaged San Francisco population had measurable levels of NNAL, a biomarker for exposure to tobacco smoke. The prevalence of tobacco exposure was highest among African-American adolescents, with 32% identified as active smokers.
Reducing Canada's overweight and obese population by 50% could prevent up to 59,829 cancer cases by 2042. Effective interventions could lower cancer incidence by projecting the impact of population-level changes on cancer rates.
A study found that poor sleep quality in children is associated with higher body mass index (BMI) and waist circumference, indicating a link between sleep patterns and weight gain. The researchers suggest that examining markers of sleep quality may be useful in designing childhood obesity prevention strategies.
Research finds that postmenopausal women with higher body fat levels, even those with a normal BMI, have an increased risk of invasive breast cancer. Dual energy X-ray absorptiometry (DXA) measurements show that whole body fat levels are more accurately assessed than traditional BMI methods.
A large retrospective study found that obese men and those with metabolic syndrome had a higher risk of biochemical recurrence after radical prostatectomy. Patients with obesity had a 32% higher chance of recurrence compared to those with normal weight, while those with metabolic syndrome had over four-fold increased risk.
Researchers identified mutational signatures characteristic of homologous recombination deficiency (HRD) as associated with improved clinical outcomes to platinum-based chemotherapy. High HRDetect scores were significantly linked to radiographic tumor shrinkage and longer overall survival in patients treated with the medication.
A study found that younger women with breast cancer who underwent axillary lymph node dissection were more likely to experience arm swelling and decreased range of motion compared to those who received sentinel lymph node biopsies. The study highlights the importance of de-escalating axillary treatment in young patients.
Differences in gene expression between non-small cell lung cancers from African-Americans and European-Americans suggest racial disparities in NSCLC biology. The study identified distinct patterns of gene expression involved in stem cell biology and invasive behavior in African-American NSCLCs.
A recent study published in Cancer Research found that certain oral microbiota are associated with an increased risk of esophageal cancer. Bacteria such as Tannerella forsythia and Porphyromonas gingivalis were linked to higher risks of esophageal adenocarcinoma and squamous cell carcinoma, respectively.
The study found that urban American-Indian and Alaskan Native individuals had a higher risk of mortality from prostate and breast cancer, with AIANs facing an 87% increased risk for prostate cancer-specific mortality. The community's unique history of social and environmental injustices may be contributing to these disparities.
Research shows adult survivors of childhood cancer were 2.6 times more likely to have hypertension than expected based on age, sex, race, and BMI. The prevalence increased over time, with 70% of survivors having hypertension by age 50.
A study found that thyroid cancer survivors are at increased risk of many aging-related diseases, including diabetes, heart disease, and osteoporosis. Those diagnosed with thyroid cancer before age 40 had the highest risk for some of these diseases.
African-American women with type 2 diabetes are disproportionately affected by ER-negative breast cancers. The study found a statistically significant association between type 2 diabetes and increased risk of ER-negative breast cancer in black women, particularly those with lower BMI.
Researchers detected TMPRSS2-ERG fusions in 45% of analyzed prostate cancers, with those retaining interstitial genes showing lower risk of progression. The study suggests that identifying the formation mechanism of gene fusions could help stratify patients into more well-defined risk groups.