Researchers found that adipocytes can metabolize daunorubicin, making it less toxic to leukemia cells. This discovery highlights the need for new chemotherapy strategies that are resistant to fat cell enzymes.
Researchers found that PARP inhibitor talazoparib caused regression of patient-derived xenografts (PDXs) of triple-negative breast cancers (TNBC) lacking BRCA mutations. The study suggests that PARP inhibitors may be effective in selected patients with other alterations in DNA damage repair genes.
A study found that young non-Hispanic white women who tan indoors are more likely to be dependent on indoor tanning due to beliefs about physical appearance and depressive symptoms. The research, published in Cancer Epidemiology, Biomarkers & Prevention, suggests a need for targeted interventions to address this behavior change.
A study has identified potential biomarkers to predict patients at increased risk of severe neurotoxicity after receiving CD19 CAR T-cell therapy. Patients with early onset of CRS were found to be more susceptible to severe neurotoxicity.
A study found that healthcare professionals' recommendations were the most important factor in driving decisions by women at high risk of breast cancer to take selective estrogen receptor modulators (SERMs) for chemoprevention. The recommendation played a statistically significant role and was associated with attitudes, beliefs, and ex...
Researchers found that patients with high numbers of alterations detected in their DNA collected from blood samples had a higher response rate to treatment, and median survival was longer. The study suggests that counting mutations in the bloodstream could help predict response to checkpoint inhibitor therapy.
A study found that a religiously sensitive educational effort increased Muslim women's perceived likelihood of getting mammograms and their eventual receipt of breast screenings. The intervention, held in mosques, addressed cultural and religious barriers to mammography, reframing modesty as not the ultimate value.
Researchers found significant differences in tumor infiltrating lymphocyte count between African-American and European-American women with triple negative breast cancer. Higher counts of TILs were associated with better survival in early-stage African-American TNBC patients, suggesting a potential prognostic biomarker.
A study found that Mexican-Americans living in the US have more risk factors for liver cancer, including obesity and diabetes, compared to those in Mexico. The study's lead author notes that having multiple risk factors increases the likelihood of developing liver cancer.
A study found that cancer clinical trials lack appropriate representation of ethnic minorities and the elderly, resulting in findings that may not be generalizable to all patients. The study analyzed enrollment data from 2003 to 2016 and showed a decline in African-American and Hispanic representation over time.
A study published in Cancer Research found that serum from women with breast cancer after exercise reduces breast cancer cell viability and tumor growth via activation of the Hippo signaling pathway. The effects were most pronounced on hormone receptor-positive breast cancer cells.
This review indicates that adipose tissue can affect cancer development through various mechanisms, including inflammation, cell metabolism, and immune clearance. The study found that different types of fat have distinct effects on cancer cells, with some types promoting tumor growth and others inhibiting it.
Researchers found that concurrent administration of anti-OX40 and anti-PD1 antibodies attenuated the effect of anti-OX40, resulting in poor treatment outcomes in mice. Sequential treatment with anti-OX40 followed by anti-PD1 improved therapeutic efficacy in some cases.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that the average cost of treating oropharyngeal cancer in Texas for two years is $139,749. The study suggests that HPV vaccination could prevent many cases of the disease and result in significant cost savings.
A study using liquid biopsies found distinct genomic profiles in 99.7% of patients with CUP, harboring potentially targetable alterations. These findings suggest that liquid biopsies can guide treatment response in this patient population.
Researchers developed a genome sequencing method that can detect clinically relevant mutations using just 5 circulating tumor cells. The technique, known as long fragment read (LFR), is more comprehensive than gene panels and can analyze the entire genomic content of small numbers of cells.
A large cohort study found that women with periodontal disease were at increased risk of developing any type of cancer, with the strongest association seen for esophageal cancer. Certain cancers were associated with higher risks in smokers or nonsmokers with periodontal disease.
A new SU2C-Lustgarten Foundation team aims to apply CAR T-cell therapy to pancreatic cancer, a deadly form of cancer with low five-year survival rate. The team will focus on epigenetics and exploring new therapies targeting mesothelin in pancreatic cancer.
Research found that four molecular subtypes of gastric cancer have different prognoses and responses to chemotherapy, with the EBV subtype associated with the best outcome and the GS subtype with no benefit. The study suggests that classifying gastric cancer cases by subtype could provide personalized treatment options.
In preclinical studies, tumors with constitutive IDO1 expression responded to COX-2 inhibitor celecoxib and improved T-cell infiltration, making them more likely to respond to anti-PD1 therapies. COX-2 inhibitors may reverse IDO1-mediated immunosuppression in some cancers.
Approval rates climbed steadily from 85% to 95% among privately insured patients, with fewer delays in clearance. The ACA provision required private insurers to cover clinical trial participation, benefiting those with insurance.
A study found that PD-L2 protein expression was associated with clinical response to pembrolizumab in patients with HNSCC, independent of PD-L1 expression. Clinical response rates were higher among patients whose tumors expressed both PD-L1 and PD-L2.
The American Association for Cancer Research has published its first set of consensus screening recommendations for children with common cancer predisposition syndromes. The guidelines provide standardized approaches to surveillance and facilitate appropriate monitoring of children affected by these conditions.
A study of Senegalese women found that HIV-positive women were more likely to acquire human papillomavirus (HPV) infection and have it progress to precancerous lesions. The research highlights the importance of targeted cervical cancer prevention efforts for high-risk HIV-positive populations.
The AACR Project GENIE initiative has published its first analysis of nearly 19,000 de-identified genomic records, showing that over 30% of samples had clinically actionable mutations. The data can be used to facilitate clinical research and improve patient care.
High tumor PD-L1 expression after radiation therapy is associated with increased risk of head and neck cancer recurrence in HPV-negative patients. Researchers identified PD-L1 as a biomarker of poor outcomes, suggesting that combining radiation and a PD-1/PD-L1 inhibitor could improve survival rates.
A large study of African-American women found that those who drank seven or more drinks per week were 33% more likely to develop breast cancer than moderate drinkers. The study suggests that black women may benefit from limiting alcohol to reduce their risk, similar to white women.
A noninvasive PET imaging method measuring granzyme B can distinguish responders from nonresponders to immune checkpoint inhibitors. The method accurately predicted treatment outcomes in both mice and human melanoma samples.
A study found that a decrease in circulating tumor cells with increased ALK gene copies is associated with longer progression-free survival in patients with non-small cell lung cancer treated with crizotinib. This biomarker may help predict treatment response and tailor therapies for individual patients.
A vaccine combining with high-dose chemotherapy improved glioblastoma patients' progression-free and overall survival. The vaccine targeted CMV antigen pp65, which is expressed in 90% of GBM tumors.
A study found that while melanoma survivors limit sun exposure, some still seek out tans and get sunburns. Survivors reported suboptimal behaviors, with 20% getting sunburned in the previous year.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that women who consumed a diet high in sugar-sweetened drinks and processed meats during adolescence or young adulthood had a higher risk of premenopausal breast cancer. The researchers recommend consuming a diet rich in vegetables, fruit, whole grains, nuts, seeds...
Researchers found that the activated S6 ribosomal protein P-S6S240 was present in 32% of high-grade tumors and associated with shorter progression-free survival. PI3K/mTOR inhibitors showed promising results in two patient-derived xenograft models, suggesting a potential treatment option for patients with this type of uterine sarcoma.
Cancer mortality rates vary significantly within the growing Hispanic population in the US, with wide variations among major ethnic groups. Key findings include higher mortality rates from stomach and prostate cancer, as well as lower rates for lung and breast cancer compared to non-Hispanic whites.
A study found that adolescents and young adults (AYAs) with acute leukemia had significantly worse survival rates if not treated at specialized cancer centers. AYAs treated at these centers had outcomes comparable to children, suggesting treatment quality can mitigate poor outcomes.
A new study found that women who have a false positive result from a screening mammogram are more likely to delay or forgo their subsequent screening mammogram. This delay can increase the risk of late-stage breast cancer diagnosis, which can lead to poorer treatment outcomes.
A recent study found that normal-weight postmenopausal women who are metabolically unhealthy have a significantly increased risk for colorectal cancer compared to those who are metabolically healthy. This highlights the importance of assessing metabolic health status in women, which can be done using standard clinical tests.
A genetic biomarker, rs28714259, identifies women with breast cancer at increased risk for anthracycline-induced congestive heart failure. The marker is associated with low ventricular ejection fraction and may help oncologists provide more precise predictions of treatment risks.
Researchers found a strong correlation between circulating tumor DNA (ctDNA) and poor outcomes in pancreatic cancer patients. ctDNA levels were associated with disease stage, grade of differentiation, and overall survival. The study suggests that detecting ctDNA could help subclassify cancers and manage treatment.
Global breast cancer mortality rates declined between 1987-2013, with 39 countries showing a decrease, including the US and most developed European nations. However, South Korea experienced an 83% increase, while Latin America saw scattered increases in mortality, except for Argentina and Chile.
A large multicenter cohort study found that radiation therapy increased complications and impaired patient-reported satisfaction with reconstructed breasts in breast cancer patients who received implant reconstruction. However, no worsening of outcomes was observed in those who received autologous reconstruction. The study suggests tha...
Patients with large breast tumors and no axillary lymph node signs before chemotherapy showed low risk of recurrence with SLNB. Follow-up data revealed high disease-free survival rates comparable to ALND, suggesting SLNB as a safe alternative.
Renowned researchers Fergus Couch and Max Wicha are being honored by AACR for their significant work in breast cancer etiology, detection, diagnosis, treatment, or prevention. Their research has led to the identification of inherited genes and mutations that predispose to breast cancer.
A study published in Cancer Epidemiology, Biomarkers & Prevention found that alcohol intake is associated with a higher risk of invasive melanoma, especially among individuals who consume more than 20 grams of alcohol per day. White wine was the most clearly associated with increased risk.
A new optical fiber probe can distinguish between cancer and normal tissues in real-time, allowing for more precise removal of cancerous tissue during surgery. This technology has the potential to reduce the need for additional surgeries to remove leftover cancer.
A recent study published in Cancer Epidemiology, Biomarkers & Prevention found that uninsured women under 65 years of age are more likely to experience delays in receiving follow-up mammograms. These delays can contribute to disparities in breast cancer outcomes, including larger tumor size at diagnosis and reduced survival.
A study found that breast cancer patients receiving chemotherapy with high genetic susceptibility had the highest risk of VTE. The one-year cumulative incidence of VTE was 9.5% in these patients, compared to 1.3% in those without high genetic susceptibility.
A study found that Japanese patients with esophageal cancer who tested positive for DNA from Fusobacterium nucleatum had shorter cancer-specific survival compared to those without the bacterium. The presence of F. nucleatum was associated with poorer outcomes and may serve as a biomarker for prognosis.
A large prospective cohort study found associations between high BMI, waist circumference, and type 2 diabetes with increased risk for liver cancer. The study, published in Cancer Research, adds substantial support to the link between obesity-related cancers, including liver cancer.
A study in the UK found that the rise in oropharyngeal squamous cell carcinoma incidence was not solely driven by human papillomavirus (HPV) positivity. The proportion of HPV-positive and -negative cases remained static, suggesting multiple factors contribute to OPSCC, including HPV infection, smoking, and alcohol consumption.