A Wake Forest Baptist researcher discovered that high levels of the MN1 gene accelerate Acute Myeloid Leukemia (AML) and reduce chemotherapy's effectiveness. The study found that the p53 protein is not functioning properly in cells expressing high levels of MN1, leading to a poorer prognosis.
Researchers at Wake Forest Baptist Medical Center identify a unique rat model of bladder regeneration, which may help understand regenerative processes in mammals. The study found that cells in the bladder lining proliferate and transition into stem cells to repair damaged bladders.
Researchers at Wake Forest Baptist Medical Center have isolated neural precursor cells from skeletal muscle tissue, which can survive in the brain and migrate to areas where neural stem cells originate. The cells also showed no signs of tumor formation, offering a potential alternative source for treating brain tumors and other central...
A study found that variations in the APOL1 gene are associated with non-diabetic kidney disease in African-Americans, but not all carriers develop the disease. Researchers suggest that environmental or viral infections may play a role in triggering the disease.
A study found a shared genetic link between rapid-onset dystonia-parkinsonism, a rare movement disorder, and psychiatric problems like anxiety, mood disorders, and substance abuse. Researchers believe the ATP1A3 genetic mutation may contribute to mental illness in individuals with the condition.
Stem cells found in cord blood have the ability to migrate to the intestine and contribute to its cell population, suggesting a potential treatment for inflammatory bowel disease. The cells' innate ability to form blood vessels may also improve vessel abnormalities found in IBD.
A genetic mutation in the FADS cluster on chromosome 11 allowed early humans to convert plant-based polyunsaturated fatty acids to brain PUFAs, enabling increased brain size and complexity. This trait rapidly spread throughout the African continent under intense selective pressure.
A new study from Wake Forest Baptist Medical Center researchers found no significant differences in injury rates or types of injuries between adolescents and adults who were tased by law enforcement officers. The study, which reviewed 2,026 Taser uses, found most injuries to be mild and superficial.
Researchers will analyze data from a unique NIH-funded repository to identify genetic variants associated with premature cardiovascular disease. The goal is to create new screening strategies and therapeutic targets to reduce the human and financial costs of cardiovascular disease.
Researchers at Wake Forest Baptist Medical Center used an electronic prosthetic system to tap into existing brain circuitry and record neural pulses. The device restored and improved decision-making ability in monkeys, even when exposed to a drug that disrupts cognitive activity.
A recent study found that 61 of 181 North Carolina migrant farmworker camps failed to meet state water quality standards, with high levels of total coliform bacteria and E. coli detected in the water.
A recent study published in JAMA found that coronary artery calcium (CAC) scans are superior to other assessment tools in identifying individuals at intermediate risk of cardiovascular disease. The CAC scan uses a CT scan to detect calcium build-up in the arteries, allowing for more precise prediction of heart disease risk.
A pilot study found that phone calls with a 'stroke coach' can help patients understand their medication regimens, reduce depression, and improve overall health status. The coaching program resulted in higher knowledge of medications and stroke symptoms among participants compared to a control group.
Researchers reviewed clinical trials on calcium and vitamin D supplements for men with prostate cancer undergoing hormone therapy, finding that these supplements did not prevent bone loss. The study suggests that these supplements may actually increase the risk of cardiovascular disease and aggressive prostate cancer.
Scientists have discovered an important clue on how the human brain filters out unimportant visual information and focuses on what's most useful. The study found that the prefrontal cortex is involved in both bottom-up and top-down attention, challenging traditional beliefs about separate areas of the brain controlling these processes.
A new study published in Neuropsychopharmacology suggests that long-term use of ADHD drugs does not affect brain development or increase susceptibility to substance abuse. Researchers found no differences between animals treated with Ritalin and those in a control group, providing reassurance for parents and clinicians.
Researchers at Wake Forest Baptist Medical Center developed lab-engineered muscle implants that can prompt muscle regeneration and repair, resulting in significant functional improvement. Exercising the implants accelerates the recovery process and promotes new muscle tissue growth.
A Wake Forest Baptist study found no cases of cardiac complications related to Taser use, even when probes landed on the chest and may have traveled across the heart. The study analyzed 1,201 real-life Taser uses by law enforcement agencies.
Scientists successfully created 'scaffolds' from pig kidneys to potentially build replacement kidneys for humans. The structure of the nephron was maintained, and blood vessels were able to maintain normal pressure when re-filled with blood in animal models.
A Wake Forest Baptist study suggests Long QT Syndrome may cause unexplained deaths during Excited Delirium. The syndrome can be triggered by agitation, confusion, or psychiatric issues, highlighting the need for law enforcement education to prevent in-custody deaths.
A new study finds that older adults with low vitamin D levels are at a 30% increased risk of developing mobility limitations. Vitamin D plays an important role in muscle function and has been linked to various health conditions that can affect physical performance.
A study by Wake Forest Baptist Medical Center found limited use of family theories in pediatric obesity research, but suggests that increased use could lead to better treatments. The researchers propose a new approach that incorporates the entire family into treatment, rather than just focusing on individual patients.
A recent study published in Sports Medicine found that skin problems are a common complaint among Summer Games athletes. Early correct diagnosis is crucial for athletes to participate and compete at their full potential.
Researchers at Wake Forest Baptist Medical Center have developed a new device called mechanical tissue resuscitation (MTR) that uses negative pressure to reduce cell death and improve brain function after traumatic brain injury. The technology showed significant promise in reducing brain swelling and preserving more than 50% of damaged...
A study at Wake Forest Baptist Medical Center found that patients prefer immediate access to radiology test results, even for complex diagnoses. The study showed that about half of participants preferred instant access, while a third preferred access within three days.
Researchers at Wake Forest Baptist Medical Center explored strategies to protect young children's brains from anesthesia damage. Three tested treatments - NAP, vitamin D3, and low-level ketamine - showed promise in preventing brain injury.
A new study by researchers at Wake Forest Baptist Medical Center found that maternal obesity may contribute to cognitive impairment in extremely premature babies. The study assessed 921 infants born before 28 weeks of gestation and found associations between maternal obesity, lack of high school education, and pre-term thrombosis with ...
Researchers at Wake Forest Baptist Medical Center have identified distinct genetic patterns between cancer of the appendix and colon cancer. The study found that gene expression profiles differ significantly between the two types of cancer, suggesting a need for fresh approaches to treatment.
Researchers at Wake Forest Baptist Medical Center used fMRI to study brain activity before and after monkeys learned new memory tasks. They found that a small group of neurons specialized in the new task were activated while retaining existing information.
Researchers at Wake Forest Baptist Medical Center have developed a nanotube therapy that kills breast cancer stem cells by generating heat using laser treatment. The approach has shown promise in eliminating both differentiated cells and cancer stem cells, offering new hope for a cure.
A study published in the British Journal of Dermatology found that itching sensations vary by body site, with the ankles and backs exhibiting greater intensity and longer-lasting relief through scratching. Researchers suggest specific nerve fibers may be involved in pleasure-related sensations.
A study found that 30 children with bedwetting had excess stool in their rectums, despite normal bowel habits. After treatment with laxative therapy, 83% of the children were cured of bedwetting within three months.
A large regional hospital in Ghana saw a 34% reduction in maternal mortality and a 36% reduction in stillbirth after QI initiatives were put into place. The study highlights the importance of leadership, staff morale, training, patient flow, and basic equipment in improving healthcare standards.
Researchers have discovered a protein called Islet Homeostasis Protein (IHoP) that regulates blood sugar levels by balancing insulin and glucagon. The protein's presence helps maintain healthy glucose levels, while its absence leads to increased glucagon and insulin resistance.
Researchers are conducting a groundbreaking study using magnetoencephalography (MEG) to investigate post-traumatic stress disorder (PTSD) in military veterans. The goal is to define biomarkers for PTSD and TBI, enabling early diagnosis and treatment.
Researchers have combined gene therapy and stem cell transplantation to successfully reverse hemophilia A in large animals, eliminating symptoms and restoring normal activity. However, the treatment's effects may be reduced or shorter due to an immune response developed by the treated animals.
A study found that varenicline (Chantix) is associated with a substantially increased risk of reported depression or suicidal behavior compared to other smoking-cessation treatments. The researchers identified 90% of all reported suicides related to smoking cessation drugs since 1998 implicated varenicline.
A new study from Wake Forest Baptist Medical Center found that teens with acne used their medication more frequently when participating in a weekly Internet-based survey. The study, which included 20 participants aged 13-18, showed a significant increase in adherence rates among those who received the survey.
Researchers have discovered a new therapy that increases good cholesterol and lowers triglycerides, showing promise in combating cardiovascular disease. The treatment, which targets microRNA-33, has been shown to increase HDL cholesterol and lower triglyceride levels in non-human primates.
A new study has identified that using less invasive spinal, epidural, and local/monitored anesthesia care is better than general anesthesia for elective endovascular repair of infrarenal abdominal aortic aneurysms. This results in reduced pulmonary complications and shorter hospital stays.
A new study assesses the effectiveness of bedside geriatric assessments in identifying vulnerable older adults with acute myelogenous leukemia (AML) who can benefit from aggressive treatment. The assessment tool evaluated cognitive function, psychological state, physical function, and co-morbid disease to provide more individualized tr...
African-American donors were more likely to be related to the transplant recipient and to donate to their parents compared to Caucasian donors. The study also found that most African-American kidney donors are men and younger than white donors, which may explain why African-American children are more often able to donate to their parents.
A national study found intensive blood sugar control does preserve brain volume but lacks cognitive benefit in older people with diabetes. The study suggests focusing on diet, exercise and behavioral interventions to improve overall health.
Researchers at Wake Forest Baptist Medical Center have identified 16 genes involved in iron metabolism that provide better prognostic information than conventional markers. These genes, known as the Iron Regulatory Gene Signature, convey valuable information about breast cancer outcomes.
Researchers found that high calcium intake increases prostate cancer risk among African-American men genetically predisposed to poor calcium absorption. This study provides insight into the link between diet and disease, suggesting personalized prevention strategies may be possible in the future.
Researchers at Wake Forest Baptist Medical Center found no association between sickle cell trait and risk of non-diabetic or diabetic end-stage kidney disease. The study contradicts earlier findings that suggested having one copy of the sickle cell gene increased kidney disease risk.
Researchers found that nearly 700,000 people in the US experience ischemic strokes each year, with about 160,000 being recurrent. Despite high compliance rates, medication non-compliance is a major risk factor for stroke and heart disease.
Researchers at Wake Forest Baptist Medical Center found that fludrocortisone, a drug commonly used to treat orthostatic intolerance, reduced debilitating chronic nausea in patients. The study involved 17 children who experienced significant improvements in nausea after treatment.
Engineered from muscle and nerve cells, the functional anal sphincters showed normal tissue function and developed a blood supply when implanted in mice. This breakthrough suggests a potential future treatment for both fecal and urinary incontinence.
Researchers found that certain traits, such as hypertension and extreme high or low body mass index, are predictive of increased risk of sudden cardiac death. These findings could lead to the development of a risk stratification score to identify patients at greater risk of dying suddenly if they experience a heart attack.