A four-year study found that vosoritide increased the average annual growth rate of children with achondroplasia by nearly 2 centimeters per year, bringing it close to average stature. The treatment also showed sustained effects and was generally well-tolerated.
A study found that one-fifth of US surgeons perform the less-recommended AV graft procedure too often, even when unnecessary. The research suggests that older, specialized surgeons are more likely to use this method.
Researchers tested a medication reservoir implant in 220 patients with wet age-related macular degeneration, finding it safe and effective in reducing the need for injections. The study showed significant improvements in eyesight, with patients able to see farther than before, and a longer time between refills.
A new study by Johns Hopkins researchers found that five-star hospitals offer fewer services compared to non-five star hospitals. Five-star hospitals are less likely to have emergency departments, intensive care units, and other specialized services.
Researchers found that smarter, more educated people have a 'cognitive reserve' that helps them perform better at baseline, but this doesn't affect their actual decline rate. Higher education levels are associated with lower rates of Alzheimer's disease in midlife, regardless of age or brain amyloid beta protein levels.
A lack of representation of people with disabilities in the biomedical workforce can lead to limited care improvements. Researchers like Bonnielin Swenor advocate for increased diversity and accommodations to create more inclusive environments.
A pioneering blood test developed by Johns Hopkins researchers, CancerSEEK, will be developed by Thrive.EarlyDetection Corp. to detect multiple cancer types at earlier stages. The technology has received Breakthrough Device designation from the FDA and has shown high specificity and sensitivity in detecting various cancers.
A newly discovered immune cell, the 'X cell', has been found to be a major driver of the autoimmune response believed to cause type 1 diabetes. The X cell can act as both a B cell and a T cell, amplifying the autoimmune response.
A new blood test, DELFI, uses machine learning to identify abnormal DNA patterns in the bloodstream for early cancer detection. The test detected cancer DNA in 57-99% of patients with various stages of breast, colorectal, and other cancers.
Researchers developed two AI methods that decipher complex gene activity controlling cell fate decisions in retina development, relating this gene activity to other tissues and across different species. The findings provide key insights into human disease and highlight the potential for AI to shed light on cancer treatment.
A new laboratory test could accurately predict which breast cancers are likely to spread and help clinicians select optimal treatments. The test, called Microfluidic Assay for quantification of Cell Invasion (MAqCI), assesses three key features of metastasis in cancer cells.
Researchers from Johns Hopkins Medicine found a distinct subtype of primary central nervous system lymphoma suitable for surgical removal, offering improved outcomes and potential cure rates. The study suggests a shift in treatment approach, moving away from traditional biopsy, radiotherapy, and high-dose chemotherapy.
Scientists at Johns Hopkins University have unraveled how the DNA machinery fits together, revealing a paradigm shift in understanding genetic illness. The discovery of how nucleosomes change shape to bind with an enzyme could unveil new treatment opportunities for childhood leukemia.
Researchers have created a method to track gene expression in cells during development, providing unprecedented detail. This technique could be used to develop future regenerative treatments for diseases like macular degeneration and other neurological disorders.
The Johns Hopkins researchers advocate for a 'digital health scorecard' to provide objective validation and ratings for health technology solutions. They aim to address the lack of rigor in evaluating health care technology, which often prioritizes speed over safety and clinical effectiveness.
Researchers identified a key acid-activated protein channel (PAC) that could provide a new target for therapies for stroke, heart attack, cancer, and inflammation. The discovery was made by Johns Hopkins Medicine researchers who found the PAC protein in human cell lines using a novel method.
Scientists from Johns Hopkins Medicine have challenged long-held assumptions about the processing of light in mammalian retinas. The study, published in Proceedings of the National Academy of Sciences, suggests that only 10-20 G protein molecules are activated by one rhodopsin molecule.
Researchers have discovered that gamma/delta T cells are the specific cells mediating the mouse's defense against Staphylococcus aureus (MRSA) infection. In a study published in the Proceedings of the National Academy of Sciences, researchers identified V gamma 6/Vdelta 4+ gamma/delta T cells as the key players in this response.
A new study by Johns Hopkins Medicine researchers found that 10% of people who rated themselves in excellent health had measurable cardiovascular disease without symptoms. Combining self-reported perceptions with definitive risk tools like coronary artery calcium scans provides a more accurate indication of heart health.
New research reveals distinct features of membrane channels in skeletal and heart muscle cells, shedding light on the mechanisms behind inherited arrhythmias and providing a promising avenue for targeted drug development. The study also highlights the vital role of phosphatidylethanolamine in mitochondrial energy production.
Researchers found widespread inconsistencies in antibody use, causing unreliable results and wasting $2 billion per year. They call for industry-wide standards to validate antibodies, especially in human tissue research.
Scientists at Johns Hopkins Medicine identified average brain changes linked to Alzheimer's disease that occur 3-10 years before symptoms appear. Researchers found subtle cognitive test score changes and protein increases in cerebrospinal fluid an average of 34.4 years before cognitive impairment onset.
Researchers at Johns Hopkins Medicine found that physicians in ambulatory surgery centers and physician offices were more likely to schedule different-day procedures, resulting in higher costs. The study suggests that financial incentives may be a contributing factor to this trend.
Researchers at Johns Hopkins Medicine have found that a broccoli sprout compound can restore the brain's glutamate balance, which is linked to schizophrenia. The study suggests that supplementing with sulforaphane, a compound found in broccoli sprouts, may reduce the need for traditional antipsychotic medications.
Researchers found that tumors with a higher degree of microsatellite instability (MSI) are more likely to respond to immunotherapy. MSI-high tumors have a higher amount of indel mutations, which can generate neoantigens recognized by the immune system.
Researchers find that human iPSCs can efficiently produce highly purified extracellular vesicles for treating aging-related diseases. These vesicles contain proteins and other treatments that can help repair damaged cells, and may one day be used to treat progeria and ALS.
Researchers have found that anakinra, a long-standing immunosuppressive drug, can diminish fetal deaths and birth defects in mice infected with the Zika virus. The study suggests that targeting placental immune responses may be a viable treatment approach for reducing Zika-related birth defects.
Researchers found that certain surgeries, such as colorectal and cardiovascular surgeries, increase the likelihood of patients continuing to refill opioid prescriptions. Generalist nurse practitioners and physician assistants may also be overprescribing opioids, suggesting a need for education and better oversight.
Johns Hopkins Medicine researchers have created a 3D image-based model of tumor behavior that captures the complexity of cancer growth. The model uses high-quality imaging data and mathematical formulas to represent blood flow, oxygenation, and structural changes within tumors.
A study by Johns Hopkins Medicine and partners found that a simple performance evaluation letter can reduce unnecessary tissue removal in Mohs micrographic surgery for skin cancer. The intervention led to an improvement in surgical behavior, sustained for one year, with 83% of notified physicians reducing their practice.
Researchers at Johns Hopkins Medicine have created a synthetic soft tissue substitute that encourages growth of new tissue and blood vessels. The material, well-tolerated and retaining its shape, may lessen the need for implants or grafts in reconstructive surgeries.
A study found that eliminating senescent oligodendrocyte progenitor cells can reduce brain damage and inflammation, slowing cognitive decline in mice with Alzheimer's-like symptoms. The treatment, which combines two FDA-approved drugs, was shown to effectively eliminate these cells and protect against cognitive decline.
Researchers at Johns Hopkins Medicine have developed a technique that facilitates precise placement of cancer drugs in the brain using positron emission technology and image-guided drug delivery. This approach shows promising results in improving treatment outcomes for difficult-to-treat brain cancers, such as glioblastoma.
Researchers at Johns Hopkins Medicine found that liver transplant recipients with alcoholic hepatitis have a comparable alcohol relapse rate regardless of their sobriety period. The study's outcomes support waiving the six-month sobriety requirement for selected patients, promoting equal access to lifesaving transplants.
Researchers at Johns Hopkins Medicine have uncovered the role of a neurotransmitter called N-acetyl-aspartyl-glutamate (NAAG) in the spread of aggressive cancers. NAAG is found to be more abundant in higher-grade cancers, making it a potential marker for tumor progression or regression during cancer therapy.
A Johns Hopkins study found that few American adults eligible for diabetes prevention programs are being referred to or participating in these programs. Despite the high health and economic burden of type 2 diabetes, only 4.2 percent of those at risk were referred to a program, with even lower participation rates overall.
A study by Johns Hopkins Medicine found that over half of women with cardiovascular disease do not meet recommended physical activity levels. The researchers suggest targeted counseling could reduce risk and healthcare costs for these women.
Researchers found that over two-thirds of atheists shed their label after a transformative experience, and most attributed long-term positive changes in life satisfaction and purpose. The study also revealed vivid memories of the encounter, with many participants reporting communication with a conscious entity and decreased fear of death.
A new study published in Orthopedics found that pre-operative daily life disability is a significant predictor of poor outcomes after total hip replacement surgery. Patients who cannot perform daily activities independently before surgery are more likely to experience surgical complications, longer hospital stays, and higher rates of r...
A study published in the Journal of Psychiatric Practice found that about half of patients referred to a specialized schizophrenia clinic were misdiagnosed with schizophrenia. Anxiety and hearing voices were common reasons for incorrect diagnoses, highlighting the importance of second opinions from psychiatry specialists.
A study by Johns Hopkins Medicine researcher Junaid Razzak found a 6% increase in deaths due to emergency conditions between 1990 and 2015. The mortality burden was highest in low-income countries, with injuries, heart attacks, lung infections, and strokes being the top causes.
Researchers at Johns Hopkins Medicine developed a gel-like platform that activates and multiplies cancer-fighting T-cells, outperforming traditional methods in mouse experiments. The artificial lymph node technology has potential for regenerative immunology-based therapy.
Scientists successfully blocked cancer-fighting gene silencing protein UHRF1, restoring hundreds of protective genes in human colon cancer cells. The findings suggest a new strategy for fighting cancers by targeting this protein.
Researchers developed a novel cell model of aging-related colon cancer risk by combining genetic and epigenetic factors. The model shows that epigenetic changes are essential for cancer initiation, and can be used to assess cancer risk in human lab-grown cells.
Scientists found no long-lasting, major differences between astronaut Scott Kelly's epigenome and his twin brother Mark's after a year in space. The study suggests that research on additional astronauts may help predict medical risks on long space journeys.
Researchers at Johns Hopkins Medicine have found that AXT107 stops abnormal blood vessels in the eye from leaking vision-blocking fluids. The compound strengthens connections between cells, creating a watertight barrier and preventing fluid permeation into surrounding tissue.
A recent study published in The Gerontologist suggests that the link between caregiving and negative health effects has been overstated. After analyzing data from over three decades of research, Johns Hopkins researchers found a weak association between caregiving and immune system biomarkers.
Researchers found that in metropolitan areas, over a quarter of young African American men reported having sex before age 13, with many experiencing unwanted or mixed feelings. The study emphasizes the importance of better access to sex education, sexual health clinics, and mental health counseling services for inner city male youth.
Researchers found that MDMA reopens a critical period in the brain, allowing mice to learn social reward behaviors at an earlier age. This effect lasted for up to two weeks and was linked to oxytocin signaling in the brain.
Metastatic cancer survivors face unprecedented challenges, including psychosocial burdens, financial strain, and emotional struggles. Experts like Terry Langbaum and Thomas Smith advocate for studying this population and improving care management to ease their journey.