A recent clinical trial found that an IV iron treatment called ferric carboxymaltose works faster and better than oral iron tablets in treating anaemia during pregnancy. The study showed improved haemoglobin levels and iron correction with the IV treatment, with comparable side effects.
Researchers at Karolinska Institutet successfully used gene therapy to improve vision in 11 out of 12 patients with Bothnia dystrophy, a form of hereditary blindness. The treatment involved injecting a specially designed virus under the retina, which produced normal protein and restored visual function.
A new study found that skin cancer incidence in young adults declined in Sweden around 2015. The decrease in incidence and mortality is attributed to increased awareness of sun protection, reduced access to sunbeds, and changes in lifestyle habits such as spending more time indoors. The study suggests that continued emphasis on sun pro...
A large-scale study in Sweden and Denmark found no clear link between the use of GLP-1 analogues and an increased risk of suicide or self-harm. The research analyzed data from over 300,000 adults treated with the medication, concluding that it is reassuring to see no apparent increase in suicidal thoughts or behaviors.
A study published in Nature Medicine reveals a correlation between high temperatures in the final week of pregnancy and an increased risk of stillbirth and early neonatal mortality. High temperatures were associated with a 34% higher risk of perinatal death, which doubled during the six hottest months of the year.
A study at Karolinska Institutet reveals that morphine activates a 'morphine ensemble' of neurons in the brain, leading to pain relief. This understanding may help develop new strategies to treat pain without triggering addiction and overdose.
A comprehensive brain imaging study found that diabetes and prediabetes are associated with accelerated brain ageing, with brains appearing 0.5-4 years older than chronological age. A healthy lifestyle may help counteract this effect, with associations attenuated among people with high physical activity.
A new Swedish registry study found that girls with mental illness or neurodevelopmental conditions have lower HPV vaccination coverage compared to their peers. The study involved over 115,000 girls and found significant differences in vaccination rates among those with psychiatric diagnoses or receiving psychotropic medications.
A new study published in Neurology found that acute kidney injury is associated with an increased risk of developing dementia. The study analyzed data from over 300,000 individuals and found a 49% higher risk of dementia overall, with significant increases for specific types of dementia such as Lewy body dementia and vascular dementia.
A new study published in Alzheimer's & Dementia found that cholinesterase inhibitors (ChEIs) may slow down cognitive decline in dementia with Lewy bodies over five years. ChEIs were also associated with a reduced risk of death in the first year after diagnosis.
A new study published in Nature Medicine shows that precision therapy can improve survival for men with metastatic castration-resistant prostate cancer. The treatment, which involves analyzing the genetic profile of the tumor, has been shown to be more effective than chemotherapy in patients whose tumors have specific mutations.
A new AI model developed by Karolinska Institutet can predict autism in young children with an accuracy of almost 80% for those under two years old. The model uses a combination of limited information to identify patterns and strong predictors of autism, such as age of first smile and eating difficulties.
Researchers at Karolinska Institutet have conducted a Phase 2 UNITY clinical trial involving pregnant women with a history of very severe HDFN. Nipocalimab was found to prevent and mitigate the disease without causing serious side effects in the mother or fetus.
A major new study by Karolinska Institutet has found that women with epilepsy are four times more likely to die during pregnancy and their babies have a 50 percent higher risk of illness or death. Despite the high relative risks, most pregnancies for women with epilepsy go well.
A recent study published in Journal of Clinical Oncology has shown that the Stockholm3 prostate cancer blood test is equally effective in detecting clinically significant cancer across different ethnic groups, including African Americans and Asians. The test reduces unnecessary biopsies by 45% while maintaining high detection rates.
A study found that air pollution in India is extremely high, with daily mortality rates increasing rapidly at lower pollution levels and then leveling off. The study estimated that 7.2% of all deaths in ten major cities were linked to PM2.5 levels exceeding the WHO limit value.
Researchers at Karolinska Institutet developed nanorobots that target and kill cancer cells using a 'kill switch' activated in low pH environments. The study achieved a 70% reduction in tumour growth in mice, paving the way for further investigation into its potential as a cancer treatment.
A randomized clinical study found that a lateral episiotomy reduced the risk of obstetric anal sphincter injury (OASI) by 53% in first-time mothers. The procedure also did not increase the risk of other complications, but may lead to wound complications.
A new molecular test WID-qCIN detects significantly more cancers and precancerous stages than current methods, identifying 100% of invasive cervical cancer and 93% of serious precancerous lesions. The test reduces the need for colposcopy examinations by 40%, improving the effectiveness of screening programs.
A new study from Karolinska Institutet found that stress weakens the association between cognitive reserve and improved cognition in memory clinic patients. Cognitive reserve is built through experiences like higher education and social interactions, but high or persistent stress levels can impair these benefits.
A new study published in Nature Biomedical Engineering shows that targeted cancer treatment using antibody-displaying extracellular vesicles reduces tumour growth and improves survival in mice. The treatment has the potential to be used against other diseases and cancer types, offering a more effective and fewer side effects compared t...
Researchers have developed a new method to detect malignant melanoma using a microneedle patch that measures tyrosinase enzyme levels in the skin. This non-invasive technique has the potential to provide faster and more reliable results compared to traditional biopsies.
Researchers have developed a new technique called molecular pixelation, which allows for the analysis of hundreds of proteins simultaneously in individual cells. This provides a more detailed picture of protein distribution and interactions, crucial for understanding cellular function and signaling.
A new atlas of early brain development has been created, allowing researchers to understand the genetic processes behind brain tumor formation in children. The study's findings may lead to new treatments for this rare but deadly disease.
Researchers at Karolinska Institutet have discovered a new class of drugs that block mitochondrial function and reverse diet-induced obesity, fatty liver, and diabetes in mice. The treatment increased fat metabolism, leading to drastic weight loss and restored glucose tolerance.
Researchers at Karolinska Institutet developed a Single Cell Atlas (SCA) platform to profile human biology through multi-omics technologies. The extensive collection of data provides unique insights into individual cell properties and tissue interactions.
A comprehensive Scandinavian study has found no evidence that popular diabetes medications GLP-1 analogues increase the risk of thyroid cancer. The research analysed data from over 145,000 patients treated with these drugs and compared them to other patient groups.
A new study published in the New England Journal of Medicine found that half of patients discharged from hospital after a heart attack are treated with beta-blockers unnecessarily. The study shows that these patients have suffered a small heart attack and have retained heart function afterwards.
A new study published in New England Journal of Medicine found that preventive angioplasty for heart attack patients does not improve prognosis. The research included 1542 patients and showed no difference between treatment groups in terms of new heart attacks or all-cause deaths.
A large trial enrolling nearly 2,800 patients from five countries has clarified the situation for patients with larger metastases. The study found that leaving most of the lymph nodes intact resulted in similar recurrence rates as completion axillary dissection, but with fewer arm-related complications.
Researchers from Karolinska Institutet show that post-COVID does not mean strict exercise avoidance. Patients with post-COVID can benefit from supervised exercise, with improved fitness and muscle strength found in those who participated.
A new study from Karolinska Institutet found no increased health risks for mothers or children with weight gain below recommended guidelines for women with obesity classes 1 and 2. In contrast, weight loss was associated with reduced risk of adverse outcomes in women with class 3 obesity.
A nationwide Swedish study reveals a bidirectional link between premenstrual disorders (PMS/PMDD) and perinatal depression. Women with PMS/PMDD are five times more likely to experience perinatal depression, while those with perinatal depression are twice as likely to develop PMS/PMDD.
A new study by Karolinska Institutet researchers has identified the protein on cell surfaces that the Crimean-Congo hemorrhagic fever virus uses to enter human cells. This discovery is crucial in developing effective treatments and vaccines for the deadly disease, which can cause up to 40% mortality rate.
Scientists at Karolinska Institutet and Stockholm University have mapped the cellular architecture of MS lesions using advanced methodology. This reveals how immune cells and glial cells interact in the disease.
A study published in Genome Medicine uses digital twins to computationally treat thousands of medications in individual patients with autoimmune diseases, finding promising results in mice and human tissue samples. The technology has the potential to revolutionize precision medicine by providing tailored medication for each patient.
A new study led by Karolinska Institutet reveals the mechanism of sperm entry into the egg, explaining how mutations in egg coat proteins cause female infertility. The research also suggests potential implications for non-hormonal contraceptives.
Researchers found that Kupffer cells in liver respond to high cholesterol by removing excess, revealing the liver's role in regulating cholesterol levels. This discovery suggests atherosclerosis is a systemic disease affecting multiple organs.
Research reveals oestrogen's protective role in preventing fatty liver disease by targeting the TEAD1 protein. The discovery could lead to a new treatment for fatty liver and liver cancer, as well as earlier detection methods.
A new study from Karolinska Institutet has found a clear link between childhood adversity and the risk of mental illness later in life. The research suggests that genetics and environment play a significant role in contributing to adult psychiatric disorders, highlighting the need for targeted health care interventions within families ...
Researchers at Karolinska Institutet discovered that fibroblasts mediate erection by taking up noradrenaline, widening blood vessels, and increasing the number of cells in response to frequent erections. This knowledge may lead to new treatments for erectile dysfunction.
A large study of nearly 200,000 newborns in Sweden and Norway found that COVID-19 vaccination during pregnancy was not associated with any increased risks in newborn infants. In fact, babies born to vaccinated mothers had lower mortality rates and fewer serious complications.
Researchers at Karolinska Institutet developed a method to study liver function and disease using the cornea of mice eyes. They transplanted liver cells into the eyes, creating a non-invasive platform to monitor liver health over time.
A new study has mapped the health risks of heatwaves in India, finding that mild heatwaves are the deadliest, while extreme ones have fewer deaths due to their infrequency. The research highlights the need for policymakers to plan for both common and extreme heatwaves to protect public health.
A nationwide study from Karolinska Institutet found that GLP1 agonists like Ozempic reduce the risk of cirrhosis and liver cancer in people with type 2 diabetes and chronic liver disease. Those who continued taking the medication for ten years were half as likely to develop severe liver disease.
A new epidemiological study reveals that bacterial meningitis can cause significant and lasting neurological disabilities in children. The infection can be cured with antibiotics, but it often leads to permanent impairment. Researchers analyzed data from over 3,500 people who contracted bacterial meningitis as children and found a high...
Researchers at Karolinska Institutet used DNA origami to activate the Notch receptor in a new way, revealing it can be activated 'on demand' with the help of a protein called Jag1. The study opens new avenues for understanding the Notch signalling pathway and its role in serious diseases like cancer and Alagille Syndrome.
A large cohort study in Sweden found that women diagnosed with perinatal depression are twice as likely to die from natural or unnatural causes, with an increased risk of death peaking in the month after diagnosis. The study suggests that providing better screening and care for these women is crucial.
Researchers at Karolinska Institutet have developed a nasal spray with IgA antibodies that can protect mice from SARS-CoV-2 infection. The treatment significantly diminished virus load in infected mice and showed stronger binding to the spike protein compared to original IgG antibodies.
Women with autoimmune disease are 30% more likely to experience perinatal depression, while those with perinatal depression have a 30% higher risk of developing an autoimmune disease. The strongest association is seen with multiple sclerosis.