Researchers found that combining RFA with anti-PD-1 therapy significantly suppressed non-ablated distant HCC tumor growth and prolonged survival in mice. The treatment remodeled the immune microenvironment, promoting durable immune memory against tumor recurrence.
Deep learning models such as CNNs and RNNs have been applied to analyze aquatic species imagery and acoustic data, enhancing identification accuracy. AI-driven automation supports the delineation of protected areas and optimal allocation of conservation resources by leveraging remote sensing technologies and AI algorithms.
The study proposes a modified ResUNet approach for automated liver segmentation from CT images, achieving high precision and accuracy. The model outperforms traditional methods, demonstrating stable performance in cross-dataset tests.
Researchers found that autologous fat grafting can reverse dermal adipose tissue dysfunction by inducing autophagy and mitophagy. This process improves skin architecture and reduces fibrosis in conditions like scleroderma.
Researchers developed an innovative FENCY ligation technique combined with preoperative embolization to remove giant plexiform neurofibromas, reducing risk of complications and improving recovery time. The study results in significant functional improvement and high patient satisfaction rates.
Fucoxanthin reduces oxidative stress, stimulates procollagen production, and inhibits matrix metalloproteinases, suggesting its potential to prevent skin aging and improve skin structure. Animal studies confirm its protective effects against UV-induced damage and wrinkle formation.
Researchers studied the effects of 6-PPDQ on the citric acid cycle in C. elegans, finding disruptions at environmentally relevant concentrations. The study revealed reductions in key metabolites and enzyme gene expressions, contributing to mitochondrial dysfunction and toxicity.
A new silica aerogel has been developed for efficient carbon emission reduction, exhibiting high thermal resistance and gas adsorption capacity. The integration of amine and methyl groups in the aerogel is achieved through a facile and environmentally friendly self-catalyzed sol-gel reaction.
Microbial electrochemical sensors (MESs) exhibit linear correlation with standard BOD₅ and demonstrate validated long-term stability, allowing precise BOD quantification in saline wastewater. However, high salinity impairs sensor performance and requires adapted mechanisms to maintain functionality.
Researchers developed an AI model using FELA and machine learning techniques to assess uplift resistance in cohesive-frictional soils. The model identified embedment depth ratio, load inclination angle, and soil strength ratios as key factors affecting pipeline stability.
A study found that a grandmaternal age difference of ≤-9 years significantly increases the risk of pregnancy cardiometabolic disorders. The researchers analyzed data from 2,235 grandmother-mother pairs and discovered a nonlinear association between age differences and CMDs.
A geostationary satellite has been used to perform robotic surgeries in remote areas, overcoming the limitation of 5G telesurgery's limited coverage radius and high latency. The technology expands a single surgical robot's service radius from 5,000 km to 150,000 km.
Researchers are turning to electron spin to unlock new possibilities for high-performance electrocatalysts. By fine-tuning how electrons spin within catalyst materials, scientists can accelerate reactions such as oxygen reduction, oxygen evolution, carbon dioxide conversion, and nitrogen fixation.
A new study published in KeAi journal Global Transitions found that safe drinking water and sanitation are crucial in preventing cholera. Disparities in WASH access contribute to unequal cholera burden across geographic regions.
Researchers have successfully synthesized a new allohexaploid wheat, Triticum kiharae, by hybridizing Timopheevii wheat and goat-grass. This approach allows for the simultaneous introgression of genetic variations from wild relatives into common wheat, potentially enhancing its intraspecific genomic diversity.
Researchers identify key hormones and genes involved in tomato resistance to dodder, a devastating agricultural parasite. The study reveals a linear model of defense mechanism, providing new possibilities for controlling dodder and other parasitic species.
A new study confirms that dockless bike-sharing significantly increases household consumption, especially in dining-out expenses, by 3.9-6.8%. This boost is attributed to reduced commuting costs, increased leisure time, and improved access to lifestyle services.
Researchers developed AI-Mg@PVDF and AI-Si@PVDF composites with enhanced combustion efficiency, demonstrating superior performance compared to pure metal particles. The study explores the effect of different metal fuel systems on aluminum alloy-PVDF MICs, revealing two distinct pathways for modulating combustion properties.
Researchers develop annotation-free avian population estimation approach using multimodal perception model, achieving high accuracy without explicit object localization. The method is tested on the Wetland-Bird-Count dataset, outperforming existing weakly supervised and unsupervised methods.
A study found that combined low pH and polystyrene microplastic exposure synergistically exacerbated oxidative damage and immune suppression in Chinese mitten crabs. Gut microbiota showed substantial functional alterations despite maintained alpha-diversity.
The SHARE guidelines offer a systematic checklist to report sham acupuncture control in clinical trials, covering elements of sham acupuncture and related contextual factors. This comprehensive reporting promotes accurate interpretation of trial results and enhances the quality of sham acupuncture-controlled clinical trials.
A body-mapping study of nail technicians' occupational health and lived experiences highlights the complexities of their work, revealing emotional, social, and creative aspects beyond occupational hazards.
Researchers discovered microbial communities thriving in glacier habitats on the Tibetan Plateau, interacting with intra- and extra-glacial ecosystems. Human activities and pollution pose a threat to these microorganisms, highlighting the need for conservation efforts.
The article discusses recent advancements in pipeline safety technologies, including defect detection, environmental risks monitoring, and structural integrity assessment. The integration of high-grade steel, large-diameter pipelines, and unconventional energy sources has introduced new complexities to pipeline safety.
Researchers developed a new method to identify hazardous chemicals in sewage sludge and electronic waste, revealing toxic compounds like PFAS, bisphenols, and phthalates. The study highlights the need for better monitoring tools and treatment strategies to address circular economy goals.
Recent advances in triboelectric nanogenerators (TENGs) have led to the development of intelligent sports facilities that monitor athlete status and improve training efficiency. TENG-based wearable devices also demonstrate high stability and adaptability in gait monitoring, enabling the creation of real-time digital human replicas.
Under carbon limitation, trees shift from roots to mycorrhiza for nutrient acquisition. Mycorrhizal colonization and extramatrical hyphal length increase, while root physiological activity declines.
Researchers developed nano-precipitation-strengthened high-entropy alloys, achieving ultrahigh gigapascals yield strength and superb resistance to adiabatic shear failure. Nanoprecipitates act as dislocation barriers and energy-absorbing islands, dispersing strain energy through order-to-disorder transition.
Researchers discovered three fundamental response modes in UHMWPE laminates and developed a predictive model that achieves over 89% accuracy. This breakthrough enables the rapid development of next-generation lightweight armor systems.
A study examines the effects of BOAS on consumers, firms, and the environment. The research reveals that BOAS may decrease consumer surplus when professional consumers dominate, but offers a better experience for consumers. Implementing BOAS can reduce waste and energy consumption.
Research reveals specific mtDNA mutations drive cancer initiation, impairing mitochondrial function and increasing ROS production. Elevated oncogenic potential is observed in cells with low to moderate levels of MT-ND5 heteroplasmy.
A magnitude 7.7 earthquake struck central Myanmar on March 28, 2025, causing 4,900 fatalities and widespread destruction. The event exposed weaknesses in urban planning, preservation, and disaster preparedness, emphasizing the need for reconciliation with seismic resilience.
The new simulator successfully reproduced the main characteristics of tornado-like vortices, including velocity and surface pressure fields. The results showed that fan speed had little effect on vortex structures, while swirl ratio significantly influenced them.
Researchers in India reviewed three families of natural products containing heterocycle cores for their anticancer activities. Promising candidates such as viridin and muricatetrocin B were found to possess sub-micromolar half-maximal inhibitory concentrations, required for effective treatment.
Researchers developed a novel Pt/W@NCNF composite catalyst with enhanced CO tolerance and catalytic stability, achieving higher HOR exchange current density and mass activity than state-of-the-art Pt/C. The unique atomical dispersion of W sites on N-doped carbon nanofibers modifies the electronic structure of Pt.
Researchers from China summarize recent progress in wearable plant sensing devices for intelligent agricultural monitoring. These devices can monitor plant growth rate, leaf surface temperature, humidity, organic volatiles, and electrophysiological signals in real time.
A study found that road networks have a significant effect on the distribution of plant specimens in China, with collection activities becoming increasingly reliant on roads. To improve representativeness and completeness of survey outcomes, future surveys should prioritize areas with limited road network coverage.
A study found a consistent 9–12-year cycle in beetle-related salvage logging across Austria, Czechia, and Slovakia, aligned with solar minima. During low TSI, logging spikes up to 24%, while high TSI drops as low as 3%–5%. This pattern sheds light on climate and solar dynamics converging to affect forest health.
A novel deep-learning approach automatically finds and classifies microcalcifications across different machines and patient populations, achieving 75% overall accuracy at the microcalcification-lesion level. The system enables radiologists to quickly focus on areas of concern, reducing missed diagnoses and unnecessary biopsies.
A new study suggests that boosting copper recycling rates can significantly mitigate resource scarcity and cut down carbon emissions from extraction processes. Recycling rates between 60% and 80% could decrease primary copper demand and ease the burden on natural reserves.
Researchers have discovered terahertz light waves can reduce hyperactivity in brain regions associated with depression, leading to rapid improvements in mood and thinking ability. The treatment works without introducing foreign substances into the brain and is safe for use at therapeutic intensities.
Iron-based magnetic nanomaterials have shown potential in drug delivery, magnetic hyperthermia, and iron deficiency treatment. They influence macrophage reprogramming through enzyme-like activities, modulating intracellular iron metabolism and regulating cell signaling pathways.
China has established itself as a frontrunner in pharmaceutical economics, supported by over 1,000 specialists advancing medical technology evaluations and regulatory innovations. Value-driven pricing models have catalyzed transformative progress, optimizing medication pricing frameworks and insurance coverage discussions.
A study published in Pharmacoeconomics and Policy found that ChatGPT generated a list of article titles with a high rate of fictitious or misattributed content, underscoring the limitations of current AI algorithms. Researchers emphasize the importance of critically assessing and validating information produced by AI tools.
A new study found China's Urgently Needed Overseas Drug (UNOD) policy did not significantly reduce launch delays for new drugs compared to the US. The initiative aimed to narrow the gap in pharmaceutical accessibility but yielded minimal results, possibly due to overlap with existing policies.
Researchers from Tongji University outline the applications of liquid crystal materials in wearable field, particularly in information visualisation. These devices can change shape or color upon external stimuli, giving visible and intuitive information.
A study explores the growing challenges of urban flash floods and waterlogging in coastal cities, highlighting governance failures, inadequate waste management, and climate-induced pressures. Practical solutions proposed include Sustainable Urban Drainage Systems, green infrastructure, and inclusive urban governance.
A new framework assesses climate risks for businesses, revealing the absence of systematic indicators and fragmented risk assessment methods. The study finds that improved corporate risk management can reduce climate-related economic volatility by 23-37%, while greater transparency in information disclosure lowers stock price volatility.
Researchers developed and validated a five-point clinician-rated SMF rating scale in a study of 150 volunteers. The internal and external validation showed good intra- and inter-rater consistency, indicating reliable tool for future research on facial aesthetics.
A study published in Water & Ecology evaluates international practices in water ecological assessment, highlighting its importance for aquatic ecosystems and human activities. The assessment's core indicators and methodologies should retain commonality and uniformity to influence strategies for protection and conservation.