Researchers developed an AAV-mediated gene therapy approach to correct hyperbilirubinemia in a mouse model of Crigler-Najjar syndrome type 1. The treatment achieved significant, long-lasting reductions in bilirubin levels, with 50-70% reductions maintained throughout the study.
Researchers have made significant advancements in additive manufacturing using laser solid forming (LSF) to produce high-performance metallic components. The LSF technique allows for the direct fabrication of metallic components with excellent mechanical properties similar to those produced by casting or forging.
A new review article published in Diabetes Technology & Therapeutics found that internet-based diabetes self-management education can lead to better glycemic control and enhanced diabetes knowledge. The study compared the effectiveness of various methods of delivering diabetes education via the internet and concluded that this method i...
A study published in Violence and Gender explores the link between past sexual violence and distress during routine pelvic examinations. Researchers identified physiologic symptoms of trauma associated with distress among female veterans with a history of sexual violence.
A new study suggests decreased brain connectivity between pain-related and sensorimotor areas may contribute to deficient pain regulation in fibromyalgia. Fibromyalgia patients exhibit impaired normal pain perception due to functional decoupling of pain-processing brain regions.
New research suggests that long non-coding RNAs play a crucial role in regulating the human immune system's response to infection. The study reveals how these molecules can promote, fine-tune, and restrain the body's inflammatory response by controlling gene expression.
The new guidelines emphasize the effectiveness of levothyroxine in most patients with hypothyroidism, but note that some individuals may not regain optimal health. Alternative treatments are also discussed, but no consistently strong evidence supports their superiority.
Researchers describe cassava, also known as tapioca, as an ideal alternative to corn for starch sweeteners due to its high yields and accessibility. The article highlights the potential of converting tapioca starch into sugars using various enzymes and processing steps.
A study published in Population Health Management found that an Emergency Room Decision-Support (ERDS) program can significantly reduce ER visits and hospital admissions among older adults on Medicare. By improving care coordination, the program saved $1.24 in healthcare costs for every dollar invested.
A new MRI technique using Diffusion Tensor Imaging (DTI) can help clinicians predict the likelihood of poor clinical outcomes following mild traumatic brain injury. This technique shows significant differences in white matter between mTBI patients with positive versus negative findings on CT and MRI evaluation.
A study published in Telemedicine and e-Health found that telemedicine can lead to fewer and shorter hospital stays, as well as fewer emergency room visits and even fewer deaths. The integration of telemedicine into healthcare adds great value in managing chronic disease.
Researchers have developed new genomic editing tools to create genetically identical patient-derived iPSCs for disease modeling. These advancements will improve the accuracy of drug testing and cell-based therapies, revolutionizing human disease modeling and treatment.
Researchers at Harvard University and Cornell University have developed a non-rigid, shape-changing robot that can walk on four legs and operate without constraints. The robot can function in snowstorms, move through puddles of water, and withstand limited exposure to flames, with a payload capacity of up to 8 kg.
The Pioneer Award recipients have made significant contributions to gene therapy for retinal degeneration. Their research has led to proof-of-concept studies demonstrating the feasibility of using gene therapy to repair photoreceptor defects in the eye.
A new study reveals that a lifelong gluten-free diet may not be enough to control the complications of celiac disease. Researchers found that patients with celiac disease may experience metabolic disorders and functional abnormalities due to inflammation, which can lead to malnutrition and impaired glucose metabolism.
A new study suggests that focusing on improving utilization rates and quality outcomes could help reduce US healthcare expenditures. Researchers analyzed Medicaid and commercial insurance claims in Vermont to evaluate the impact of patient-centered medical homes on inpatient services and cost of care.
A systematic review and meta-analysis published in The Journal of Alternative and Complementary Medicine found that auriculotherapy may be an effective treatment for chronic constipation. The study analyzed the results of 17 published studies and concluded that auriculotherapy can help alleviate symptoms associated with constipation.
Researchers found that closed-loop insulin delivery systems maintained safe blood glucose levels for 53-82% of the time. The study proposed improvements needed for better design and implementation of these systems in adults and adolescents with type 1 diabetes.
Researchers found MSCs in patient's blood after severe trauma, suggesting they are released from bone marrow into bloodstream following organ damage. The study provides conclusive evidence for the mobilization and migration of MSCs in humans.
A newly discovered ovoid structure in the Nakhla Martian meteorite contains a variety of minerals and shows evidence of shock events, sparking debate about its formation and potential for life on Mars. The study suggests that subsurface hydrothermal alteration could support niche environments conducive to life.
A study examining Medicare hospice discharges found that nearly 1 in 5 patients were discharged alive, sparking concerns about cost-saving measures. The researchers also discovered significant variation in live discharge rates across states and individual hospices.
According to a recent editorial, nearly 6% of US children and teens are severely obese, with a significant increase in prevalence and poor long-term prognosis. Experts recommend more comprehensive strategies, including pharmacotherapy, weight loss surgery, and specialty medical weight management programs.
Researchers explore the link between gut microbiome and autoimmune disorders like multiple sclerosis, highlighting potential therapeutic targets. The study suggests that the gut microbiome plays a crucial role in immune cell activity and cytokine production, which may impact susceptibility to and treatment of autoimmune diseases.
A Roundtable Discussion explores the application of novel toxicology models to predict adverse health effects and environmental exposures. The discussion covers human cell models, high-throughput screening methods, and three-dimensional tissue culture models.
A new reporting standard has been proposed for spinal cord injury experiments to ensure uniformity in scientific reporting. The standard aims to facilitate the development of databases of experimental information, promoting the successful translation of treatments from laboratory to clinical settings.
The article discusses the latest advances in assisted reproduction options for LGBT individuals, including gestational surrogacy and in vitro fertilization. It also explores the economic and legal implications of these options, highlighting the need for greater awareness and understanding among clinicians and policymakers.
The article discusses the role of pills in modern medicine, highlighting both their therapeutic benefits and adverse effects. Coauthors suggest that pills should be used more selectively and viewed as a
Dr. Brenner's work has contributed significantly to advancing the field of gene transfer using retroviral vectors in cancer immunotherapy. He is recognized for his contributions to developing genetically modified T cells that can effectively target tumors.
Mayo Clinic researchers discover a strategy to significantly reduce the risk of tumor development using pretreatment with genotoxic etoposide. This approach establishes an adjunctive therapy to harness the clinical value of iPSC-derived cardiac regeneration, providing a promising breakthrough for heart disease treatment.
Preconditioning stem cells prior to transplantation is crucial for improving their survival and therapeutic function. Current methods include exposing stem cells to microenvironments, creating three-dimensional aggregates, or using hydrogels to prepare them for the environment found in damaged tissue.
A new study found that amyloid buildup in one brain region can impair metabolism and activity in a distant, unaffected region. The findings suggest a long-distance effect of amyloid pathology on brain function.
Researchers have developed a promising new approach to editing gene transcripts, which uses targeted oligonucleotide drugs. This technique has already shown promise in treating diseases such as Duchenne Muscular Dystrophy and spinal muscular atrophy.
A study examined the interest level of over 300 African American adults in genetic testing for alcohol dependence susceptibility, with some expressing concern over privacy and testing methods. The results suggest that more research is needed to address these concerns and establish effective genetic counseling strategies.
A new algorithm-based method uses EMR data to identify patients with newly diagnosed HIV infection, improving clinical outcomes. The method was validated and tested on patients undergoing HIV testing from 2006-2012.
Researchers present integrated approach incorporating pest identification, tracking, and management to mitigate contamination in open pond algae systems suitable for producing biofuel. The solution illustrates its use in cultivating a strain of algae with potential for biofuel production.
A study found that African American women with HIV struggle to manage age-related diseases, social responsibilities, and work-related changes. Researchers suggest increased prevalence of HIV among women of color is a growing concern by 2015.
A group of industry and regulatory scientists released consensus recommendations for assessing the safety pharmacology evaluations of oligonucleotide-based therapeutics. The guidelines emphasize the importance of safety pharmacology studies to evaluate cardiovascular function effects.
Dr. Christof von Kalle has received a Pioneer Award from Human Gene Therapy for his leadership and accomplishments in the field of cell and gene therapy. He is recognized for his seminal contribution to vector integration, a critical feature of retro- and lentivirus-based vectors.
A large-scale search of a national medical database found that St. John's wort is often prescribed with medications that may result in adverse reactions, such as serotonin syndrome or heart disease. The study highlights the importance of caution when combining St. John's wort with other medications.
Researchers have developed a new method to grow zebrafish embryonic stem cells for over 2 years without a feeder cell layer, simplifying their use and expanding their utility. The ability to establish and grow these stem cells enables exciting cellular and molecular genetic manipulations.
The review explores how RNA viruses induce Type I and III interferons, which regulate virus replication and host survival. Different types of interferons have distinct antiviral properties, playing a critical role in maintaining an optimum equilibrium between virus replication and host survival.
A nationwide study found a small but statistically significant cardiovascular risk associated with stimulant treatment in children with ADHD. The researchers also reported on the relationship between specific stimulant dose and risk of a cardiovascular event.
The 2014 World Stem Cell Summit will bring together leading scientists, business leaders, and regulators to discuss the future of regenerative medicine. The summit will feature over 200 prominent speakers from more than 40 nations, exploring the latest scientific discoveries and innovative business models.
Dr. Frederic D. Bushman is recognized for his pioneering work on HIV reproduction and its application to advancing gene delivery methods. His research has contributed to the development of new vectors and targeting methods, informing safety profiles.
Men who have sex with men (MSM) tend to underestimate their HIV risk due to a lack of knowledge about pre-exposure prophylaxis (PrEP). Effective options like PrEP can prevent HIV infection, but MSM often miss out on this treatment. Adhering to daily PrEP and using condoms can slow the transmission of HIV.
The Festschrift issue honors Dr. Koprowski's pioneering work on vaccines, including the oral polio vaccine, and its impact on cancer biology research. Dr. Koprowski's achievements have been recognized by CASIS, which enabled visionaries to explore life science research in microgravity environments.
Researchers have discovered that spiral ganglion stem cells in the inner ear can regenerate and differentiate into mature spiral ganglion cells, neurons, and glial cells. This breakthrough finding makes these stem cells a promising source of replacement cells for therapies aimed at regenerating neural structures in the inner ear.
Researchers have designed RNA aptamers that specifically target and inhibit PAI-1's anti-clot-busting activity. These aptamers demonstrate the potential for blocking PAI-1-associated vascular events, offering a novel therapeutic option for cardiovascular disease prevention.
A new digital fabrication technique enables the construction of mortar-less brick building assemblies at greater scales using 3D-printed ceramic PolyBricks. The PolyBrick system allows for customized, prefabricated ceramic building blocks to interlock and assemble easily into larger units.
The Affordable Care Act (ACA) offers significant benefits for diabetes patients, including non-exclusion of pre-existing conditions and access to preventive services. The law also authorizes the creation of the National Diabetes Prevention Program, delivering evidence-based lifestyle change programs to prevent type 2 diabetes.