A new study reveals the experiences of people traveling to Illinois for abortion care after the Dobbs v Jackson Women’s Health Organization Supreme Court decision. The study found that delays were common, with participants waiting an average of a month for care, and that abortion stigma, information, and resource availability are major...
A new study successfully detected heterotopic ossification (HO) weeks before current imaging techniques, enabling early intervention and potentially transforming HO prevention and treatment. The liquid biopsy method identified a unique gene signature associated with bone formation, achieving high accuracy in predicting at-risk patients.
Researchers analyzed data from nearly 4,300 stable outpatients with chest pain and found that women experienced similar rates of MACE as men despite having smaller plaque volumes. The study suggests incorporating sex into the interpretation of coronary plaque metrics may help advance tailored approaches to cardiac risk stratification.
A study found that patients value AI-based interpretation for routine situations due to its speed and convenience, while remote video interpretation is preferred for emotionally sensitive or high-stakes conversations. Patient trust, autonomy, and perceived control drive interpreter preferences.
A Phase 3 trial found stereotactic radiation targeting individual tumors improved symptom burden, cognitive outcomes, and daily function compared to whole brain radiation. Patients managed with stereotactic radiation also displayed better performance status and could remain more independent with everyday activities.
Researchers at Mass General Brigham have demonstrated the technical feasibility of using ultra-low field magnetic resonance imaging (MRI) for breast imaging, offering an alternative to existing methods and potentially reducing barriers to screening. Further study is needed to establish diagnostic performance and refine technology.
Researchers from Mass General Brigham have identified a neural circuit linking prior experiences with current aversions and preferences when it comes to dining choices. The findings suggest that dysfunction in this brain circuit could be a factor in disordered eating and obesity, providing new potential targets for treatment.
A single injection of an oncolytic virus recruits immune cells to penetrate and persist deep within brain tumors, inducing long-term infiltration of immune T cells. This therapy expands pre-existing T cells in the brain, leading to a therapeutic benefit for patients with glioblastoma.
A new study by Mass General Brigham highlights the efficacy of proton therapy in achieving excellent tumor control rates while minimizing side effects compared to traditional radiotherapy. Proton therapy limits radiation exposure to healthy tissue, potentially preserving cognition and hormone function.
A large prospective cohort study found that consuming 2-3 cups of caffeinated coffee daily or 1-2 cups of tea daily reduced dementia risk, slowed cognitive decline, and preserved cognitive function. Caffeine was identified as the active factor producing these neuroprotective results.
Researchers developed BrainIAC, a robust AI foundation model that analyzes brain MRI datasets to identify key neurological health indicators. The tool outperformed conventional AI models in diverse tasks, including predicting dementia risk and detecting brain tumor mutations.
A study of US veterans has identified a possible link between exposure to Agent Orange and acral melanoma, a rare form of skin cancer. The researchers found that veterans exposed to the herbicide had a 30% higher odds of developing this type of melanoma.
A Mass General Brigham-led study found that integrating feedback and personalized palliative care can improve the quality of life for children with advanced cancer. The study showed significant improvements in symptoms and well-being for patients who received the intervention, highlighting the potential benefits of early palliative care.
A study by Mass General Brigham found that individuals with traumatic brain injury and their caregivers consider recovery of basic communication an 'acceptable' outcome, challenging traditional assumptions about what constitutes a 'favorable' recovery. The study highlights the need for person-centered approaches to TBI outcome research.
A study found that using SGLT2i drugs in patients with gout and type 2 diabetes can lead to lower rates of starting urate-lowering therapy, NSAIDs, and diuretics. This could streamline care and reduce medication burden for these patients.
Research identifies reduction in recovery focus as most prevalent and potent contributor to long-term relapse, emphasizing the importance of ongoing monitoring and proactive interventions. The study highlights the need for integrated biopsychosocial disease-management models to address complex relapse risk factors.
Researchers identify fibroblast TGFβ signaling as a key driver of treatment-resistant rheumatoid arthritis. Advances in technology enable precision medicine approaches, promising to improve patient outcomes and quality of life.
Researchers found a strong link between human genetic factors and the oral microbiome, with specific genes influencing cavity and tooth loss risk. The study analyzed over 12,500 individuals' saliva-derived DNA, revealing genome-to-genome interactions between human and bacterial DNA.
The Kraft Prize for Excellence and Innovation in Community Health recognizes organizations driving measurable improvements in community health. The prize recipient will receive $100,000 and tailored support from the Kraft Center.
Researchers developed an innovative centrifugal system called SpinEx that separates plasma, enriches EVs, and labels proteins in one device. The technology enables fast and automated EV isolation from small blood volumes, accurately distinguishing cancer from non-cancer samples and identifying specific tumor types.
A study published in the New England Journal of Medicine found that children whose parents were injured by firearms experience substantial mental health impacts, with a 42% increase in psychiatric diagnoses and 60% increase in mental health visits. Early, targeted interventions are needed to address this growing need.
Researchers used MRI analysis to measure glymphatic system activity, finding changes related to IIH stage and pressure levels. The findings suggest a noninvasive test could diagnose IIH more reliably, improving treatment options for patients with symptoms including headaches and vision loss.
Researchers at Mass General Brigham report preclinical efficacy and human safety data for high-dose inhaled nitric oxide as a potential antimicrobial therapy. The treatment demonstrated strong antipseudomonal effects and was safe and feasible in early human studies.
A study found that one-third of patients in an at-home hypertension management program could not complete weekly readings, highlighting the need for more convenient and less burdensome monitoring tools. The researchers suggest innovative wearable devices that can passively collect blood pressure readings to reduce patient burden.
Researchers have identified a new method to predict asthma exacerbations using sphingolipid and steroid ratios, allowing for accurate identification of high-risk patients. The method has the potential to revolutionize asthma treatment by enabling clinicians to intervene before an attack occurs.
Patients who undergo unscheduled cesarean deliveries are at substantially increased risk for acute psychological stress during childbirth. Results show that over 1 in 4 patients experienced clinically significant acute stress shortly after birth.
Developed by Mass General Brigham researchers, the autonomous AI system achieves high accuracy in detecting cognitive impairment using routine clinical documentation. The system includes five specialized agents that critique each other and refine their reasoning, just like clinicians would in a case conference.
A new blood test has been developed to predict which patients with lung cancer will benefit from the newly approved immunotherapy drug tarlatamab. The test, based on circulating tumor cells, correctly identified 85% of patients who responded to the drug and 100% of those who did not.
Researchers identified metabolites associated with type 2 diabetes risk, revealing genetic and lifestyle factors that influence these metabolites. A unique signature of 44 metabolites improved prediction of future risk of type 2 diabetes beyond traditional risk factors.
Researchers have developed a nanoparticle platform that enables precise delivery of disease-modifying gene therapies directly to cartilage lesions in osteoarthritis. The particles use biochemical signals to adapt their targeting based on disease severity, ensuring treatment concentrates exactly where it is needed.
A large-scale field trial in Ethiopia found no significant difference between fluorometholone and placebo treatments in reducing postoperative trachomatous trichiasis recurrence. The study, which involved over 2,400 participants, suggests that anti-inflammatory therapy may not be beneficial for improving TT surgery outcomes.
A Mass General Brigham study identifies new mutations that emerge in tumor cells following treatment, driving resistance in patients with different types of cancer. The researchers found two main categories of mutations: those impairing p53 function and others disrupting drug binding, highlighting a path forward for overcoming resistance.
A new study found that more than one-in-four adults worldwide may be eligible for GLP-1 use, with women and older individuals among the most eligible. The research emphasizes the need to prioritize global access to these medications, particularly in low- and middle-income countries where obesity rates are highest.
A study published in Nature Microbiology identified specific gut microbes and metabolic pathways responsible for producing high levels of alcohol in patients with auto-brewery syndrome. The researchers found that stool samples from patients produced significantly more ethanol than those from unaffected individuals or healthy controls, ...
Children with adverse prenatal exposures showed higher rates of behavior problems, faster cortical thinning, and more depressive symptoms than children with fewer APEs. Researchers found a persistent association between multiple APEs and increased odds of mental health problems as kids grew older.
A study highlights the opportunity for orthopedic surgeons to identify patients who have experienced intimate partner violence (IPV), with only 0.3% of referrals compared to 29% from emergency departments. Orthopedic teams can educate and empower patients, providing timely life-saving referrals.
Researchers developed an AI-based noninvasive tool to predict oropharyngeal cancer spread, identifying patients who should receive aggressive treatment or undergo de-intensification. The tool improved risk stratification, enabling more accurate predictions of survival and cancer spread.
Researchers found that early communication between three pairs of brain regions is associated with favorable six-month functional outcomes. The study identified signature patterns in resting-state functional MRI data that can strengthen standard prognostic methods for assessing outcomes after moderate-to-severe brain injury.
A new study by Mass General Brigham researchers found that genetic variants thought to always cause inherited blindness occur in only 28% of people who carry them. The findings challenge traditional models of rare disease genetics, suggesting a need for updated understanding and potentially impacting the development of new treatments.
A new study from Mass General Brigham found that the Brain Care Score is a strong predictor of stroke across different racial groups in the US. Higher scores indicate healthier behaviors and lower risk of age-related brain diseases, including stroke.
A new study by Mass General Brigham researchers found that patients with depression are at higher risk of cardiovascular disease due to stress-related brain activity, nervous system dysregulation, and chronic inflammation. The study also suggests that addressing chronic stress, anxiety, or depression is crucial for heart health.
A new study from Mass General Brigham researchers found that hyperphosphorylated tau may help protect the brain from infection, potentially leading to Alzheimer's disease. The study suggests that tau could serve as an antiviral protein against certain viruses.
A large-scale study identified risk factors and clinical features of ICI-ITP, a rare but serious complication of anti-cancer immunotherapy. The study found that patients with ICI-ITP tend to have lower platelet counts at the start of treatment, experience additional immune-related adverse events, and have a higher risk of death.
A global study found that patients with mature nodal T-cell lymphoma who relapsed within 12 months of initial treatment had worse survival outcomes, but improved survival when treated with targeted therapies instead of chemotherapy. The results suggest the need for personalized treatment strategies for high-risk patients.
A new clinical trial found that varenicline, a medication for quitting nicotine, was effective in vaping cessation regardless of cannabis use. Cannabis use did not appear to be a barrier to successful vaping cessation, and participants who used cannabis had similar odds of achieving abstinence as those who did not.
Mass General Brigham's new AI company, AIwithCare, has developed a software platform that leverages generative AI to screen patients for clinical trial eligibility. The tool, RECTIFIER, was found to accurately identify eligible patients and enroll them in clinical trials at a lower cost than traditional methods.
The company's AI tool, RECTIFIER, uses generative AI to screen patients for clinical trial eligibility, significantly outperforming manual screening in accuracy and efficiency. The tool has been shown to more accurately identify eligible patients and reduce the burden of manual chart review in various healthcare settings.
Scientists from Mass General Brigham and the Broad Institute have identified a genetic modifier for Friedreich’s ataxia, suggesting a potential treatment strategy. By understanding how cells can bypass the need for frataxin, researchers have discovered that reducing FDX2 levels can restore iron sulfur cluster synthesis and cell health.
A new study explores the potential of long-acting injectable treatments for HIV-positive breastfeeding women, finding that they can prevent up to 160 infant infections per year. The research suggests that these formulations could be cost-effective and widely available globally to reach those who need them most.
Researchers at Mass General Brigham developed a modified herpes simplex virus that stimulates the immune system to attack glioblastoma cells, increasing T-cell and natural killer cell responses. The virus, engineered to recognize markers found on glioblastoma cells, also increases overall survival in preclinical models.