Developed by Mass General Brigham researchers, the autonomous AI system achieves high accuracy in detecting cognitive impairment using routine clinical documentation. The system includes five specialized agents that critique each other and refine their reasoning, just like clinicians would in a case conference.
A new blood test has been developed to predict which patients with lung cancer will benefit from the newly approved immunotherapy drug tarlatamab. The test, based on circulating tumor cells, correctly identified 85% of patients who responded to the drug and 100% of those who did not.
Researchers identified metabolites associated with type 2 diabetes risk, revealing genetic and lifestyle factors that influence these metabolites. A unique signature of 44 metabolites improved prediction of future risk of type 2 diabetes beyond traditional risk factors.
Researchers have developed a nanoparticle platform that enables precise delivery of disease-modifying gene therapies directly to cartilage lesions in osteoarthritis. The particles use biochemical signals to adapt their targeting based on disease severity, ensuring treatment concentrates exactly where it is needed.
A large-scale field trial in Ethiopia found no significant difference between fluorometholone and placebo treatments in reducing postoperative trachomatous trichiasis recurrence. The study, which involved over 2,400 participants, suggests that anti-inflammatory therapy may not be beneficial for improving TT surgery outcomes.
A Mass General Brigham study identifies new mutations that emerge in tumor cells following treatment, driving resistance in patients with different types of cancer. The researchers found two main categories of mutations: those impairing p53 function and others disrupting drug binding, highlighting a path forward for overcoming resistance.
A new study found that more than one-in-four adults worldwide may be eligible for GLP-1 use, with women and older individuals among the most eligible. The research emphasizes the need to prioritize global access to these medications, particularly in low- and middle-income countries where obesity rates are highest.
A study published in Nature Microbiology identified specific gut microbes and metabolic pathways responsible for producing high levels of alcohol in patients with auto-brewery syndrome. The researchers found that stool samples from patients produced significantly more ethanol than those from unaffected individuals or healthy controls, ...
Children with adverse prenatal exposures showed higher rates of behavior problems, faster cortical thinning, and more depressive symptoms than children with fewer APEs. Researchers found a persistent association between multiple APEs and increased odds of mental health problems as kids grew older.
A study highlights the opportunity for orthopedic surgeons to identify patients who have experienced intimate partner violence (IPV), with only 0.3% of referrals compared to 29% from emergency departments. Orthopedic teams can educate and empower patients, providing timely life-saving referrals.
Researchers developed an AI-based noninvasive tool to predict oropharyngeal cancer spread, identifying patients who should receive aggressive treatment or undergo de-intensification. The tool improved risk stratification, enabling more accurate predictions of survival and cancer spread.
Researchers found that early communication between three pairs of brain regions is associated with favorable six-month functional outcomes. The study identified signature patterns in resting-state functional MRI data that can strengthen standard prognostic methods for assessing outcomes after moderate-to-severe brain injury.
A new study by Mass General Brigham researchers found that genetic variants thought to always cause inherited blindness occur in only 28% of people who carry them. The findings challenge traditional models of rare disease genetics, suggesting a need for updated understanding and potentially impacting the development of new treatments.
A new study from Mass General Brigham found that the Brain Care Score is a strong predictor of stroke across different racial groups in the US. Higher scores indicate healthier behaviors and lower risk of age-related brain diseases, including stroke.
A new study by Mass General Brigham researchers found that patients with depression are at higher risk of cardiovascular disease due to stress-related brain activity, nervous system dysregulation, and chronic inflammation. The study also suggests that addressing chronic stress, anxiety, or depression is crucial for heart health.
A new study from Mass General Brigham researchers found that hyperphosphorylated tau may help protect the brain from infection, potentially leading to Alzheimer's disease. The study suggests that tau could serve as an antiviral protein against certain viruses.
A large-scale study identified risk factors and clinical features of ICI-ITP, a rare but serious complication of anti-cancer immunotherapy. The study found that patients with ICI-ITP tend to have lower platelet counts at the start of treatment, experience additional immune-related adverse events, and have a higher risk of death.
A global study found that patients with mature nodal T-cell lymphoma who relapsed within 12 months of initial treatment had worse survival outcomes, but improved survival when treated with targeted therapies instead of chemotherapy. The results suggest the need for personalized treatment strategies for high-risk patients.
A new clinical trial found that varenicline, a medication for quitting nicotine, was effective in vaping cessation regardless of cannabis use. Cannabis use did not appear to be a barrier to successful vaping cessation, and participants who used cannabis had similar odds of achieving abstinence as those who did not.
Mass General Brigham's new AI company, AIwithCare, has developed a software platform that leverages generative AI to screen patients for clinical trial eligibility. The tool, RECTIFIER, was found to accurately identify eligible patients and enroll them in clinical trials at a lower cost than traditional methods.
The company's AI tool, RECTIFIER, uses generative AI to screen patients for clinical trial eligibility, significantly outperforming manual screening in accuracy and efficiency. The tool has been shown to more accurately identify eligible patients and reduce the burden of manual chart review in various healthcare settings.
Scientists from Mass General Brigham and the Broad Institute have identified a genetic modifier for Friedreich’s ataxia, suggesting a potential treatment strategy. By understanding how cells can bypass the need for frataxin, researchers have discovered that reducing FDX2 levels can restore iron sulfur cluster synthesis and cell health.
A new study explores the potential of long-acting injectable treatments for HIV-positive breastfeeding women, finding that they can prevent up to 160 infant infections per year. The research suggests that these formulations could be cost-effective and widely available globally to reach those who need them most.
Researchers at Mass General Brigham developed a modified herpes simplex virus that stimulates the immune system to attack glioblastoma cells, increasing T-cell and natural killer cell responses. The virus, engineered to recognize markers found on glioblastoma cells, also increases overall survival in preclinical models.
A daily multivitamin may be beneficial for reducing the risk of hypertension in people with poorer nutritional intake. Multivitamins lowered risk of hypertension in participants with comparatively lower diet quality, as measured by Alternative Healthy Eating Index (AHEI) and Alternate Mediterranean Diet (aMED) scores.
After cannabis sales became legal, rates of cannabis use and cannabis-related disorders increased significantly among adolescents aged 12 to 17 presenting for psychiatric emergencies. The study found a fourfold increase in cannabis use and a similar rise in cannabis-related disorders among this age group.
Researchers from Mass General Brigham Cancer Institute present promising new treatment options for acute myeloid leukemia, autoimmune bleeding disorders, and multiple myeloma. The studies show improved event-free survival, higher overall response rates, and better quality of life for patients treated with novel therapies.
A new study suggests that long-acting injectable treatment can prevent up to 160 infant infections per year in Zimbabwe. The treatment, LA cabotegravir with rilpivirine, could be cost-effective if priced at $156/year or lower for women whose HIV has not been fully suppressed at delivery.
A randomized controlled trial found that home hospital care reduced healthcare costs by 27% and increased physical activity among patients with acute conditions. Patients also reported higher satisfaction rates when receiving care at home compared to traditional brick-and-mortar hospitals.
A new study found that engasertib reduced nosebleed frequency and duration in patients with hereditary hemorrhagic telangiectasia (HHT), a rare inherited bleeding disorder. The trial also showed improved symptoms and safety profile for the drug, paving the way for its potential use as a treatment option.
A study found that 43% of public speakers at FDA advisory committee meetings report a conflict of interest, leading to biased opinions on drug approval. Patients and family members with personal experience using the drug supported approval in most cases, while public health advocates were more likely to oppose it.
A study found that pregnant women who discontinued GLP-1 medications before or early in their pregnancy experienced higher risks of weight gain, diabetes, hypertensive disorders, and preterm delivery. Those who stopped taking the medications gained an average of 7.2 pounds more weight during pregnancy.
A new study by Mass General Brigham researchers found that combining generative AI with ambient documentation technologies significantly reduced after-hours work and note delays. The hybrid program, which included a virtual scribe, showed a 41% decrease in after-hours work and a 66% decline in documentation delays.
A recent study found that TDP-43 protein levels in blood may indicate presence of LATE dementia, a cause often linked to Alzheimer's disease. Researchers hope this discovery could lead to development of simple blood test to diagnose LATE during life.
A federally funded study by Mass General Brigham investigators found that self-reported vision problems and traumatic stress are experienced years after strangulation in women who have experienced intimate partner violence. The study identified three major subgroups: strangulation alone, altered consciousness, and full loss of consciou...
Adolescents and young adults who stayed on medication for at least a year had lower risks of opioid overdose and hospitalization compared to those who discontinued early or took it inconsistently. Consistent, year-long use likely provides the greatest protection against overdose and other serious outcomes.
A recent study published in Annals of Internal Medicine found that over 69,000 US deaths were caused by extreme temperature exposure between 1999 and 2024. The majority of these deaths were heat-related, but cold-related deaths are also expected to rise as climate change intensifies.
A clinical trial found that nicotinamide riboside supplementation improved fatigue, sleep, and depressive symptoms in some people with long COVID. However, the overall results did not show significant differences between groups, suggesting that individual responses may vary.
A study of nearly 30,000 female nurses found that consuming more ultra-processed foods was associated with a 45% higher risk of developing adenomas, precursors to early-onset colorectal cancer. The study's findings support the importance of reducing ultra-processed food intake as a strategy to mitigate the rising burden of early-onset ...
A new study from Mass General Brigham researchers identified distinct T-cell infiltration patterns in colorectal cancer precursor lesions and cancer tissues. The findings suggest that understanding these patterns could help detect CRC earlier by predicting risk and develop therapeutic approaches.
A new study finds that GLP-1 drugs tirzepatide and semaglutide reduce the risk of heart attack, stroke, and death from any cause in patients with type 2 diabetes. Both medications provide strong cardioprotective effects and may be integrated into clinical cardiovascular practice.
Child abuse and neglect rates in the US have declined overall over the last decade, but disparities persist, particularly among Black children and female children. Poverty is identified as a critical target for intervention, and strengthening government financial assistance programs can help reduce disparities.
In a clinical trial of 12,257 patients at high risk, investigators found that adding the drug evolocumab to a patient’s treatment reduced the risk of a first heart attack, first stroke, or coronary heart disease death by 25%. The study also showed a 36% reduction in heart attacks and a nominally lower rate of death in the evolocumab arm.
Researchers found olezarsen significantly reduced acute pancreatitis incidence by 85% in patients with severely elevated triglyceride levels. The drug also lowered triglyceride levels below 500mg/dL in over 85% of participants.
Researchers used high-resolution imaging to map brain regions involved in regulating body's energy needs and sensing internal conditions. The study replicated previous findings and expanded upon them, confirming connections between brain areas that help manage the body's needs and sense what's happening inside.
A new study found that heavy alcohol use is associated with more severe brain bleeds and long-term brain vessel damage at a younger age. Patients who drank three or more drinks a day had larger, deeper bleeds and were twice as likely to have damage in the tiny blood vessels in the brain.
A new study by Mass General Brigham reveals that patients with traumatic spinal cord injuries are at a higher risk of developing chronic health problems, including hypertension, stroke, depression, and diabetes. The study highlights the need for proactive and multidisciplinary long-term care strategies to address these issues.
Researchers at Mass General Brigham have developed a strategy to promote antitumor immunity by inducing cancer cells to produce an immune-activating molecule. This approach was shown to reduce tumor growth and improve survival in mouse models of aggressive melanoma, with potential applications beyond cancer therapies.
A new study published in Nature Medicine found that increasing daily steps by even a little can help slow down the progression of Alzheimer's disease. Cognitive decline was delayed by three years for people who walked 3,000-5,000 steps per day, and by seven years for those who walked 5,000-7,500 steps per day.
A study found a single mutation in the CD36 gene increases risk of dilated cardiomyopathy by 33% in individuals of African descent. This variant is more common in Black individuals and may account for 20% of excess DCM risk.