Aging stem cells lose their ability to make bone and muscle, leading to frailty and falls. Researchers are targeting the metabolite kynurenine and IDO inhibitors to reverse age-related damage and improve healthspan.
Researchers found that HDAC3 inhibitors increase expression of aquaporin-3, a channel that transports glycerin, helping to improve skin health and reducing inflammation. The study's findings suggest that HDAC inhibitors could be an effective therapy for psoriasis.
Researchers have discovered that directly injecting a tumor suppressor activator into a cancer can increase tumor destruction, while reducing toxic side effects. The agent, nutlin-3a, activates the natural p53 gene, which helps immune cells target and kill cancer cells.
A national trial is underway to compare intensive medical management and surgical interventions for asymptomatic carotid artery disease. Researchers at MCG and AU Health are enrolling nearly 2,500 participants in the CREST-2 study to determine which treatment approach reduces stroke risk more effectively.
In liver cancer, Scrib's increased expression suppresses the growth of cancer cells by inhibiting three oncogenes. The study provides the first hard evidence that Scrib functions as a tumor suppressor in human and animal liver cancer.
Researchers at Medical College of Georgia are exploring the potential of (+)-pentazocine to prevent vision damage in glaucoma patients by activating sigma-1 receptors in astrocytes. The study aims to understand how increased pressure affects astrocyte behavior and develop new therapies to protect neurons.
A therapeutic vaccine is being tested to prevent or reduce cervical cancer recurrence in women at high risk. The vaccine has shown promise in extending survival time for patients with recurrent disease, and its safety and efficacy are being evaluated in a phase 3 study.
Researchers are exploring immune cells that normally help the body but can hinder chemotherapy's effectiveness. By understanding how these cells interact, scientists hope to create targeted therapies to preserve chemotherapy's benefits while minimizing unwanted side effects.
High levels of protein Id1 suppresses brown fat's burning ability by binding to key regulators, leading to increased risk of diabetes and obesity. Conversely, lack of Id1 promotes conversion of white fat to healthier beige fat.
Scientists have discovered that cancer can commandeers immature immune cells, called MDSCs, to facilitate its spread. MDSCs are normally part of the immune system's anti-tumor response but, under the influence of tumor-secreted cytokines, they can help tumors grow and metastasize.
The Georgia Cancer Center is part of a national effort to study cancer disparities across racial and ethnic groups. Researchers will collect data from 2,400 patients with early-onset cancers to better understand the underlying causes.
Researchers found that a single dose of millions of adult stem cells can aid stroke recovery if given early, reducing destructive inflammation and the risk for serious infections. Early treatment within 36 hours after stroke symptoms surface also showed benefits in physical recovery and reduced disability one year out.
Researchers found that whole body vibration reduced body fat, improved insulin resistance, and increased muscle and bone strength in a mouse model of morbid obesity and diabetes. Circulating osteocalcin levels also rose, indicating potential benefits for glucose regulation.
Researchers are developing a portable, painless 3-D ultrasound device that can detect swelling in the optic nerve sheath, indicating potential brain damage. The device aims to provide instantaneous evidence of head injuries and is expected to be accurate compared to existing MRI and CT technology.
A free lung cancer screening in the Augusta area found more than double the cancer rate of previous screenings, with 3% of participants diagnosed with lung cancer. The majority of cases were caught early, with a 90% overall survival rate for those detected before symptoms appeared.
Researchers develop Markov model to provide personalized information for women undergoing infertility treatment, considering factors like age, body weight, and AMH blood levels. The model can be updated in real-time and translated into a physician-friendly app.
Researchers are exploring how high salt intake can trigger an immune response contributing to chronic high blood pressure in females. Studies found that female salt-resistant rats produce nitric oxide, a powerful dilator of blood vessels, which takes pressure down and activates a protective immune response.
Researchers are exploring a new infusion therapy that could help smooth out movement for patients with Parkinson's by providing constant levodopa levels and stimulating dopamine receptors. The therapy aims to reduce off-time and increase on-time movement, improving overall quality of life.
Scientists are investigating how increased cell death from high blood pressure leads to inflammation and further increases blood pressure. They aim to identify targets that could block unintended results without suppressing the natural immune response.
In patients with diabetes, an immune system receptor called Toll-like receptor 4 is activated by dying cells and bacteria, leading to inflammation and bladder dysfunction. Preventing this activation enables the bladder wall to remain strong and elastic.
Dr. Sandra B. Sexson, a renowned child and adolescent psychiatrist, has received the Vestermark Psychiatry Educator Award for her leadership and creativity in psychiatric education. She is recognized for her 40-year dedication to advancing the field of psychiatry through various academic and professional roles.
Researchers are studying how receptors are transported from inside the cell to the surface where they function. Small proteins like Rab43 play a crucial role in this process, helping to ensure the proper functioning of GPCRs.
Scientists found that reduced TMEM108 protein expression leads to imprecise communication between neurons, contributing to schizophrenia-like symptoms. Adding AMPA receptor-boosting drug restored healthy spines in mice.
Researchers observed that brain cell powerhouses, called mitochondria, can quickly become dysfunctional after injury like stroke or trauma. However, they often resume their normal shape once blood and oxygen are restored, suggesting a potential new avenue for improving recovery from such injuries.
Scientists have discovered that a man-made version of soluble gp130, or sgp130, can inhibit inflammation in the eye and prevent retinal destruction associated with diabetes. The new molecule, called sgp130-Fc, has been shown to reduce inflammation and improve vision in mouse models of diabetic retinopathy.
Researchers aim to create genetically corrected stem cells to replace the mutated dystrophin gene in Duchenne muscular dystrophy. They plan to use induced pluripotent stem cells to produce healthy muscle progenitor cells, which will repopulate weak muscle mass.
Researchers are exploring the dynamics between a gene that regulates fat metabolism and a protein that makes lipid droplets available for energy in heart cells. They hope to understand how this imbalance can lead to heart failure and find ways to intervene, such as by regulating lipid use and maintaining balance.
Researchers have identified a new adaptor protein on the microtubule roadway that helps motors navigate proteins to their correct destinations. This discovery challenges previous assumptions about motor function and has implications for understanding diseases such as cancer and cardiac disease.
Researchers find that rapsyn helps ensure optimal positioning and functioning of acetylcholine receptors on muscle cells, enabling precise brain-muscle communication. This discovery provides new insight into diseases like muscular dystrophy and offers potential therapeutic targets.
Researchers found a universal principle underlying human intelligence, enabling complex brain computations and generalization of knowledge. The Theory of Connectivity proposes a simple mathematical logic guiding neural connections and communications.
The Sexual Medicine Society of North America renamed its Lifetime Achievement Award to honor Dr. Lewis, a pioneer in treating male sexual dysfunction. He made significant contributions to promoting standards and ethics in sexual medicine, serving as president and chairing various committees.
Researchers are studying the impact of vitamin D and omega-3 supplements on telomere length and cardiovascular risk. The study aims to determine if these supplements can help maintain youthful telomeres and reduce disease risk.
Researchers are enrolling 60 obese children in an eight-week study to examine the impact of vitamin K supplements on their cardiovascular health. The study aims to determine whether vitamin K can improve insulin sensitivity and reduce lipid levels in the blood, potentially reducing the risk of diabetes and cardiovascular disease.
A pediatric otolaryngologist is developing a mouse model to identify the most effective treatment for respiratory papillomatosis, a rare condition that can cause chronic hoarseness and breathing problems in children. The goal is to provide personalized medicine and reduce the need for frequent surgeries.
Researchers investigate whether reducing sodium intake can lower inflammation and oxidative stress, key factors in cardiovascular disease. The study aims to connect the dots between salt consumption and cardiovascular risks.
Researchers are investigating the role of SLC13A3, a likely tumor suppressor gene, in kidney cancer. They hope to understand why its expression is suppressed in African American patients and explore its potential as a therapeutic target.
Researchers have found a way to restore youthful DNA length in aging cardiac stem cells, improving their ability to form new blood vessels and regenerate heart tissue. The treatment uses a drug to temporarily wake up the cells, making them more responsive to low-oxygen conditions.
A review of published studies and FDA reports found that prescription sleep aids can stimulate patients instead of calming them, leading to a rare but serious risk of suicide. The main concern is the first few days after taking the medication, when a paradoxical response is most likely to arise.
Researchers are working to enhance the heat-burning ability of brown fat to combat obesity. They discovered a gene, BSCL2, that regulates brown, white, and beige fat. Deleting this gene in mature brown fat surprisingly increased its efficiency at burning fat, while mice on high-fat diets still lost weight.
Scientists at the Medical College of Georgia have found that vesicles that trap amyloid contribute to Alzheimer's disease. Reducing exosome production may help reduce amyloid accumulation and slow disease progression. However, female mice did not reap similar benefits, suggesting potential gender-specific differences in the disease.
After major trauma, debris from damaged cell powerhouses triggers an immune response in the kidneys, leading to permanent damage or destruction. Researchers aim to prevent this by understanding how formyl peptide receptors activate the immune system.
Scientists found a link between overexpression of the miR-182 gene and increased eye pressure in primary open-angle glaucoma patients. The study suggests that this variation may contribute to the disease's destructive effects on vision.
Scientists have developed a novel combination of an aptamer and siRNAs to target two tumor-dependent genes in prostate cancer cells. This approach shows promise for effective, less toxic gene therapies for various cancers. The strategy uses two 'missiles' to bind to specific proteins, increasing its grip on cancer targets.
A new study suggests that a long version of waxy ceramide, often found in skin creams and shampoos, plays a critical role in supporting brain cells called astrocytes. The researchers aim to understand how this lipid regulates cilia on brain cells and prevent neurodegeneration associated with Alzheimer's disease.
Researchers aim to create more small, energy-burning fat cells that enable the body to use fat as fuel rather than store it as unhealthy padding. By studying the protein HDAC9, they hope to develop new treatments for obesity-related diseases like diabetes and cardiovascular disease.
Researchers have found increased expression of galectin-3 protein in pulmonary hypertension, which causes unhealthy remodeling and constriction of lung blood vessels. They also discovered that a drug already tested for liver fibrosis can block or reverse early disease progression, offering new hope for treatment.
A pain medicine has been shown to preserve vision in a model of severe retinal degeneration by activating a receptor vital to a healthy retina. The drug (+)-pentazocine enables the survival of cone cells, allowing detailed color vision to remain intact.
Researchers found that the LRP4 molecule is crucial for regulating glutamate levels in star-shaped brain cells called astrocytes. Without it, glutamate release is reduced, leading to intellectual impairment and seizures. However, blocking the receptor ATP eventually activates ameliorates the negative impact on mice.
Researchers investigating gestational diabetes aim to understand its impact on offspring's cardiovascular health. They've identified a mouse model with epigenetic changes that mimic human conditions, suggesting environmental factors during pregnancy may shape lifelong risk.
A study comparing robotics and manual approaches to treat ventricular tachycardia found that the robotic system can deliver better outcomes for many patients. The robotic arm enables precise movement and reduces invasiveness, maximizing accuracy in ablation procedures.