A novel study led by NUS linguists reveals that seniors with memory-related mild cognitive impairment exhibit distinct speech patterns, including reduced noun usage and increased abstract thinking. These findings hold promise for developing language-based interventions to address dementia symptoms.
Researchers have developed a method to mask and regulate RNA activity and delivery using post-synthetic acylation chemistry and dynamic disulfide exchange reactions. This strategy allows for efficient RNA delivery into cells without getting trapped in lysosomes.
The NUS team has developed aerogels that can provide cooling to buildings through radiative cooling, reducing energy consumption in tropical climates. The researchers also created aerogels that absorb electromagnetic waves, shielding humans and sensitive equipment from adverse effects.
Researchers at NUS developed a new method to grow two-dimensional transition metal dichalcogenides (TMDs) using molecular beam epitaxy. This approach enables phase engineering and fabricating 2D heterostructure devices with precise control over their properties.
A team of researchers from NUS has developed a novel method to stimulate muscle cells using magnetic therapy, which produces and releases proteins with anticancer properties. The study demonstrates that this non-invasive approach can prevent cancer cell growth and invasion, similar to exercise.
Researchers from NUS have developed a novel technique that converts waste carbon dioxide into value-added chemicals and fuels. The method uses a nickel catalyst and acidic electrolytes, achieving an efficiency rate of over 99%. This innovation has the potential to reduce costs by up to 30% and is adaptable for different industrial needs.
Researchers discovered that variations in macrophages, ancient immune cells, are linked to patients' recovery and survival in diffuse large B-cell lymphoma. The study found subsets of macrophages associated with relapse after chemotherapy, predicting disease progression and potential new therapeutic approaches.
Researchers create butterfly-shaped nanographene with four unpaired π-electrons, demonstrating potential for advancements in quantum computing. The unique structure has highly correlated spins, extending coherence times of spin qubits.
A study by NUS scientists found that a chemical produced when cells break down glucose can cause DNA faults indicating higher cancer risk. High levels of this chemical, methylglyoxal, may be controlled with medicines and a good diet.
Researchers have developed a new antibiotic candidate, COE-PNH2, which demonstrates high efficacy against Mycobacterium abscessus and shows a blend of potency and safety. The molecule targets both replicating and dormant forms of the bacteria, exhibiting robust bactericidal activity and reducing the likelihood of relapse.
Researchers from NUS have developed a method for creating enantioenriched boronic esters using chiral nickel catalysts, offering a new route to complex organic compounds. The approach enables simultaneous control of regioselectivity and enantioselectivity in carboboration reactions.
Researchers identify mitochondrial priming as a key driver of multi-drug resistance in relapsed acute myeloid leukemia. A new technique called dynamic BH3 profiling reveals anti-cancer drugs capable of overcoming resistance.
Chemists at NUS have developed a new iron-catalysed reaction to generate two alkyl-alkyl bonds in crowded environments, enabling the creation of valuable dialkylated compounds. The method harnesses an earth-abundant iron catalyst to combine alkenes with sp3-hybridised organohalides and organozinc reagents.
The National University of Singapore (NUS) team engineered a new cyanate-integrated perovskite solar cell that achieves a certified world-record power conversion efficiency of 27.1%, surpassing other multi-junction solar cells. The triple-junction perovskite/Si tandem solar cell remains stable and efficient even after extended testing.
Scientists at NUS developed an AI-enabled atomic robotic probe to fabricate carbon-based quantum materials at the atomic scale. The CARP concept utilizes deep neural networks to autonomously synthesize open-shell magnetic nanographenes with precise engineering of their π-electron topology and spin configurations.
Researchers at NUS have developed a microporous covalent organic framework for efficient production of hydrogen peroxide through photosynthesis. The new photocatalyst produces H2O2 spontaneously and efficiently from water and atmospheric air when exposed to visible light.
Researchers at National University of Singapore have developed supercritical coupling, a new approach that significantly enhances photon upconversion efficiency. This discovery challenges existing paradigms and opens a new direction in light emission control.
The study demonstrates that deep learning allows for precise observation of single molecules in artificial systems, cells, and small organisms. Deep learning-based methods reduce data requirements by an order of magnitude, enabling faster evaluation times.
Researchers developed a transmissive thin scintillator using perovskite nanocrystals to track and count single protons with exceptional sensitivity. The new detectors offer unparalleled sensitivity and could revolutionize proton therapy and radiography.
A new study reveals that Singapore has lost 37% of its species over the past two centuries, with larger mammals and forest-dependent birds being particularly at risk. The researchers recommend prioritizing landscape-scale conservation efforts for charismatic species, such as tigers and orangutans, to mitigate extinction rates.
A new technique accurately describes high-dimensional data using lower-dimensional smooth structures, overcoming the limitations of traditional methods. The approach achieves cutting-edge estimation accuracy and convergence rates while enhancing computational efficiency through GANs.
Researchers at NUS-SCELSE have discovered a plant hormone, methyl jasmonate, that communicates with beneficial microorganisms in the soil, boosting crop growth by 30%. This finding holds great promise for sustainable agriculture and could lead to the development of nature-based agrochemicals.
Scientists at National University of Singapore developed a hybrid generative machine learning model to explore structural disorders in complex materials. The model unveiled pathways to material disorder, shedding light on factors affecting piezoelectric response. It also found evidence that domain boundaries maximize entropy.
Magnetic graphene has been developed to induce and directly quantify spin splitting in two-dimensional materials. The technology offers a promising avenue for advancing the field of two-dimensional spintronics with applications for low-power electronics.
A new study by NUS provides insights into how BRCA2 mutations impact breast tissue cells, leading to early breast cancer development. The research found that healthy mammary glands are not predisposed to form lesions, but HR- luminal cells with BRCA2 mutations exhibit enhanced organoid formation and survival under replication stress.
Researchers from NUS have developed a novel magnetic gel that heals diabetic wounds by activating dormant skin cells and repairing damaged blood vessels. The treatment has shown promising results, healing wounds up to three times faster than conventional approaches.
Researchers from NUS discovered that caterpillars' prolegs are derived from a genetic program that specifies lobes originally found in crustaceans. This novel trait is reactivated in the abdomen of caterpillars, enabling them to grasp and move on various surfaces.
Researchers at NUS developed a new class of heterogeneous geminal atom catalysts promoting sustainable manufacturing processes for fine chemicals and pharmaceuticals. The novel catalyst improves reaction efficiency, selectivity, and recyclability.
Researchers found that globally abandoned cropland could feed up to 476 million people per year if recultivated and help pull planet-warming carbon dioxide from the atmosphere through reforestation. The study highlights the potential of this often-neglected resource in supporting both food security and climate change mitigation.
Researchers have discovered that NSD2 triggers aggressive myeloma by activating PKCα, leading to excessive lactate production. This study presents potential targets for improved treatment of high-risk myeloma subtypes.
Scientists fabricate QADs with engineered quantum hole states, exhibiting novel transport properties and unique quantum phenomena. The structures' robustness against environmental influences enables exploration of novel quantum phenomena and material technologies.
Researchers at NUS have developed a technique to precisely control the alignment of supermoiêre lattices using golden rules, expanding tunable material properties for diverse applications. They fabricated 20 moiêre samples with accuracy better than 0.2 degrees.
Researchers found that ketogenic diets delay tumour growth but accelerate cachexia, a wasting syndrome that worsens disease prognosis. Dexamethasone may help optimise benefits by delaying cachexia.
Researchers at NUS have developed an aero-elastic pressure sensor called eAir, promising increased precision and reliability in medical applications. The sensor can provide tactile feedback for surgeons during minimally-invasive surgeries, enhancing patient recovery and prognosis.
A NUS study reveals how Wnt signalling regulates colour patterns in butterfly wings, with different ligands and receptors controlling specific areas. The researchers used CRISPR-Cas9 genome editing to test the function of pathway members, showing that they interact and regulate each other.
Researchers have created self-assembling protein-mimics that can selectivity transport water across membranes while rejecting salts, offering a potential solution to improve energy efficiency in industrial water purification. The oligourea foldamers are smaller and more stable than existing artificial water channels.
Researchers at NUS developed a mathematical formula to predict the fraction of cells with a unique oncogenic combination linked to low survival rates in DLBCL patients. This combination involves high MYC and BCL2 positivity, but negative BCL6 expression, suggesting BCL6 plays a protective role.
Researchers at NUS CDE pioneered an innovative 'biological camera' that encodes and stores data within living cells, bypassing current constraints. The team developed 'BacCam', merging biological and digital techniques to emulate a digital camera's functions using DNA.
Researchers at NUS create a novel spinning process to produce strong, stretchable, and electrically conductive soft fibres at room temperature and pressure. The method combines biomimicry with gel solution formulation to overcome conventional challenges.
The PETAL sensor patch measures five biomarkers to assess wound inflammation and infection, providing timely medical intervention. It is a low-cost, versatile, and customizable solution for holistic wound monitoring.
Researchers at NUS have created a new type of solar cell with improved stability and efficiency, paving the way for cheaper and more durable energy solutions. The cells achieve a world record efficiency of 24.35%, making them suitable for large-scale commercialization.
Researchers invent time-resolved assessment of single-cell protein secretion with sequencing (TRAPS-seq) to correlate cell functions with secreted proteins. The technique accelerates the development of new therapeutic strategies for disease treatment, including targeting mechanisms selective for cancer cells.
Researchers found that tiger reserves in India receive additional resources, resulting in reduced deforestation and avoided carbon emissions. This led to the saving of over 5,800 hectares of forest and net avoided emissions of about 1.08 million tons of CO2 equivalent.
A team of researchers from CSI Singapore has identified a transcription factor, TOX2, as a potential target for treating Natural Killer/T-cell Lymphoma (NKTL), an Epstein-Barr virus-associated cancer with poor treatment outcomes. The study found that TOX2 is overexpressed in NKTL patients and negatively associated with patient survival.
Researchers developed a scalable approach to synthesize ferromagnetic single-atom spin catalysts, which exhibit interatomic quantum spin exchange interaction and induce local magnetic moments. The Ni1/MoS2 SASC demonstrates a dramatic enhancement of OER magnetocurrent by 3,000% under a mild magnetic field.
Pharmaceutical scientists from the National University of Singapore have developed multi-functional synthetic peptide nanonets for relieving inflammation caused by bacterial infection. These nanonets trap bacterial endotoxins and pro-inflammatory cytokines, achieving anti-inflammatory activity through selective binding.
A recent study conducted by NUS researchers shows that weekly exposure to proprietary pulsed electromagnetic field (PEMF) therapy using the BIXEPS device can significantly improve mobility and body composition in older adults, with notable benefits found in functional tests and reduced perception of pain.
The NUS team's light field sensor has a larger angular measurement range, high angular resolution and wider spectral response range, enabling higher depth resolution. It can capture 3D images of objects placed far away with accurate reconstructions of depth and dimension.
Scientists at the National University of Singapore have developed a new method for synthesizing organosilanes using eosin Y, a low-cost and readily available dye molecule. This enables stepwise customised functionalisation of multihydrosilanes to access fully substituted silicon compounds.
Researchers developed an ingestible X-ray dosimeter that detects radiation dose in real time, providing accurate monitoring of radiotherapy. The capsule tracks biochemical indicators like pH and temperature, enabling enhanced treatment precision for gastric cancer patients.