Researchers at Osaka University developed an oral device that effectively reduces motor and vocal tics in Tourette syndrome patients. The study found that the oral splint improved tic symptoms for both children and adults, with long-lasting effects.
A team of researchers discovered an effective method for removing lattice defects from crystals, particularly useful for semiconductor materials. By adding hydrogen and then annealing at low temperatures, they created an ordered phase of boron with a large unit cell, overcoming previous difficulties in achieving this structure.
Researchers from Osaka University have identified a gene, GREB1, as a key player in the development of hepatoblastoma. The study found that suppressing GREB1 production using antisense oligonucleotides significantly reduced tumor formation and cell proliferation in mouse liver cancer models.
Researchers at Osaka University used X-ray imaging to visualize Lewy bodies in post-mortem brains and found α-synuclein aggregates with cross-β structure. This discovery supports the idea that Parkinson's disease is a systemic amyloidosis, with implications for diagnosis and treatment.
Researchers from Osaka University found that microRNA methylation levels can discriminate cancer patients from healthy individuals with high sensitivity and specificity. The study suggests that methylation of specific mature microRNAs could be a more powerful indicator of early-stage pancreatic cancer than existing biomarkers.
A research team developed the world's thinnest and lightest differential amplifier for bioinstrumentation, amplifying weak biosignals with reduced disturbance noise. The flexible organic amplifier can be attached to human skin without discomfort, enabling real-time long-term monitoring of electrocardiac signals.
A study published in Journal of Neuroscience reveals that FLRT3 protein, involved in neuron development and cell adhesion, is also critical for pain sensitization. High levels of FLRT3 protein were found in the dorsal horn following nerve injury, leading to touch sensitivity and mechanical allodynia.
A study published in Acta Neuropathologica Communications found that interregional differences in the somatic genetic landscape of glioblastoma affect prognosis. The research analyzed Japanese patients with IDH-wildtype GBM and discovered a biomarker, triple CNA, associated with survival duration.
Japanese researchers propose a novel holographic framework to simulate black holes with a laboratory experiment. This setup can provide insight into the fundamental laws governing the cosmos at both tiny and vast scales.
Researchers from Osaka University developed a comprehensive database of 175 NTM species using multilocus sequence typing. Their new software, mlstverse, can accurately identify NTM to the subspecies level, allowing for targeted therapies and improved cure rates.
Researchers successfully transferred and verified angular momentum basis of quantum information from laser light to an electron trapped on a quantum dot. This achievement marks a significant step towards realizing a quantum internet with secure and rapid quantum information transmission.
Researchers from Osaka University found that lymph node responses to neoadjuvant chemotherapy are more effective in predicting disease recurrence and patient survival than primary tumors. This finding could lead to improved treatment strategies and increased survival rates for patients with metastatic esophageal cancer.
A new method using multiple high-energy laser beamlets accelerates electrons to incredibly fast speeds, improving energy transfer efficiency. This technique can aid laboratory astrophysics and cancer therapy research, enabling more powerful X-ray and ion generation.
Researchers at Osaka University have demonstrated a new mechanism for charge mobility in organic single crystals, challenging previous assumptions. The study's findings show that molecular vibrations caused by flexibility limit the performance of organic semiconductors.
A study published in the Journal of Investigative Medicine found an association between stress and increased serum levels of α-Klotho (αKl). The researchers suggest that elevated sαKl levels may predict stressed conditions, making it a potential biomarker for stress.
A multinational team successfully alters oxygen atoms' charge states and achieves reversible conversion to molecular oxygen using Kelvin probe force spectroscopy. The researchers found that controlled bonding between adjacent oxygen atoms can be induced remotely via surface polarons.
Researchers have created ultra-thin magnetite nanowires with a remarkable 'Verwey transition' from metal to insulator at low temperatures. This unique property could be used to control electronic devices and support green technology.
Researchers developed an AI technology called STEFTR to estimate animal behavioral states and extract features from trajectories. The method achieved over 90% accuracy using only tens of animal trajectories, revealing experience-dependent changes in specific behaviors.
Researchers at Osaka University discover novel mechanism of microbubble implosion, achieving ultrahigh electrostatic field near Schwinger limit. The density during compression reaches several hundred thousand to one million times solid density.
A study published in the Proceedings of the National Academy of Sciences finds that polyphosphate induces the formation of amyloid fibrils from beta-2 microglobulin proteins in dialysis patients. High levels of polyphosphate promote the formation of thicker, more stable amyloid fibrils under normal pH conditions.
Osaka University researchers discovered a key regulatory mechanism in the development of normal pluripotent embryonic cells using the Hippo pathway. They found that TEAD and YAP proteins support pluripotency in blastocysts by activating cell competition, leading to elimination of low-potential cells.
Osaka University researchers enhance thermoelectric material's power factor by over 100% by varying pressure, improving its ability to generate electricity from waste heat. The study reveals the Lifshitz transition plays a crucial role in thermoelectric properties.
Researchers at Osaka University developed a graphene-based biosensor to detect stomach-cancer causing bacteria using microfluidics. The sensor can detect tiny concentrations of bacteria in under 30 minutes, paving the way for faster diagnoses and improved healthcare outcomes.
A Japan first! Osaka University researcher Kie Nakashima won the Academic Prize at Cosmetic Victories 2019 for proposing a new concept for next-generation antiperspirants that directly act on sweat glands. This innovation aims to suppress sweating by making sweat glands inactive, not by plugging their exits.
Osaka University researchers link time-resolved microwave conductivity measurements to photocatalytic performance, enabling rapid screening of clean energy generating materials. This approach accelerates the development of hydrogen-producing materials, increasing efficiency and reducing processing time.
A recent study published in Nature Medicine Letters reveals that specific microbiome organisms are linked to the early stages of colorectal cancer development. The researchers found increases in these microorganisms in fecal samples from patients, which could potentially provide vital diagnostic clues.
Researchers discovered asymmetrical nuclear pore complex outer ring structures in fission yeast, comprising only two types of Nups, with essential roles in normal cell growth. The findings challenge the long-held assumption that these structures are identical across eukaryotic cells.
Straightening single-molecule conductors leads to greater overlap of conjugated bonds, increasing conductivity. The twist conformation hinders charge transport, whereas flat chains facilitate hopping conduction.
A new process uses radicals to oxidize polypropylene's methyl groups, making it reactive without breaking the polymer chain. This selective oxidation results in a hydrophilic surface with carboxylic acid groups, enabling surface modification and dyeing.
Researchers found substantial T cell infiltration and few surviving beta cells in a patient's pancreas after IC therapy, contradicting previous reports of elevated PD-L1 expression
Researchers at Osaka University used angle-resolved photoelectron spectroscopy to probe samarium hexaboride's unusual surface conductivity. The material exhibits both strong electron correlations and topological insulator properties, enabling the development of quantum spin devices.
A research team from Osaka University has developed a novel gene therapy approach that targets α-synuclein, a protein associated with Parkinson's disease. By using amido-bridged nucleic acid-modified antisense oligonucleotides, the treatment effectively decreases α-synuclein production and reduces disease severity in mice models.
A study published in the Journal of Experimental Medicine found that phosphorylation of Regnase-1 allows IL-17 to trigger inflammation. Blocking this phosphorylation process could lead to therapeutic agents for treating autoimmune diseases related to IL-17, such as rheumatoid arthritis and multiple sclerosis.
Researchers discovered a molecule involved in immune cell migration that plays a critical role in establishing immune responses. The COMMD3/8 complex promotes signal transduction of chemokine receptors to facilitate immune cell migration, which is essential for efficient immune responses and proper functioning of the immune system.
Researchers at Osaka University developed a cable-free brain imaging method that measures brain activity associated with social behavior in mice. The LOTUS-V bioluminescent probe provides minimally invasive and long-term recording capabilities without motion artifacts.
Researchers at Osaka University created a new process for producing palladium nanoparticles that enhance hydrogen sensing sensitivity. The new method uses piezoelectric resonance to optimize deposition time, leading to devices that may be vital to the transition to a hydrogen energy ecosystem.
Researchers at Osaka University developed an automatic diagnosis system using deep learning and MEG, achieving high accuracy in classifying patients with neurological diseases. The system outperformed conventional methods using waveforms, offering a promising approach for clinical practice.
Researchers at Osaka University have discovered that zinc oxide (ZnO) thin films exhibit the fastest excitonic radiative decay rate ever recorded, surpassing thermal dephasing rates. This breakthrough could lead to the development of ultra-fast and energy-efficient photonic devices with non-thermogenic properties.
In Arabidopsis thaliana, the location of proteins within a cell and the position of the cell itself play crucial roles in determining cell type. The study found that ATML1 protein accumulation is inhibited in internal cell layers, leading to epidermal cell differentiation. This post-transcriptional regulation enables plants to form a s...
A team of researchers from Osaka University and Kirin Holdings Company, Limited demonstrated that the texture-formation in a pint glass of Guinness beer is induced by flow of a bubble-free fluid film flowing down along the wall of the glass. The phenomenon is analogous to roll waves observed in water sliding downhill on a rainy day.
Researchers at Osaka University developed a fully automated tool to assess α-synuclein aggregation in cerebrospinal fluid using ultrasonication. The HANABI device can accurately detect patients with Parkinson's disease and has potential for early diagnosis and treatment assessment.
The researchers developed a universal beam shaping technique that spatially separates residual and extracted components in the Fourier plane using a virtual diagonal phase grating. This allows for highly uniform flattop beams with improved resolution and accuracy, suppressing edge ripples to 20 μm.
Researchers at Osaka University have measured cellulose's intrinsic birefringence with unprecedented precision, paving the way for sharper TV, computer, and smartphone screens. The team envisions using cellulose nanofiber films as light compensation materials for liquid crystal displays.
Researchers at Osaka University have developed a therapeutic drug that emits highly effective alpha rays to treat refractory thyroid cancer. The study showed promising results, with mice surviving nearly three times longer and tumors shrinking by several-fold after treatment.
Researchers at Osaka University have developed a glue-free bimorph deformable mirror that can be used in vacuum chambers. The new technology uses inorganic silver nanoparticles to bond PZT actuators to a mirror substrate, allowing for precise shape modification and high-precision optics.
Researchers at Osaka University have identified a key protein, RamR, that enables Salmonella bacteria to sense and respond to bile acids in the gut. This allows the bacteria to survive in a highly acidic environment by pumping out toxins and adapting to the conditions.
Researchers used electron accelerators to generate free radicals in water molecules, allowing them to study the damaging effects on biomolecules. This method provides a valuable tool for understanding naturally occurring antioxidants and proteins like vitamin C, with implications for developing new medications to prevent cell damage.
Researchers at Osaka University discovered Ragnase-1's crucial role in regulating hematopoietic stem and progenitor cells. The study reveals how Ragnase-1's post-transcriptional regulation maintains blood cell homeostasis, preventing excessive proliferation associated with leukemia.
A research team at Osaka University has identified a genetic factor essential for the virulence of Streptococcus pneumoniae, a major threat to public health globally. The study reveals that the cbpJ gene is under strict negative selective pressure, making it an attractive target for drugs to combat antibiotic-resistant bacteria.
Researchers from Osaka University developed a tiny DNA reader using microscopic probes and an electrical current to locate anticancer drug molecules. The technology successfully identified individual molecules in short DNA strands, pinpointing exact insertion sites of trifluridine.