A team of researchers has used neutron crystallography to determine the structure of a large oxidase protein with high-resolution structural details. They found unusual proton behavior between a cofactor and an amino acid residue, and established a complete picture of topa quinone 30 years after its discovery.
Researchers from Osaka University and collaborators uncover quasiparticle interactions in CNTs using terahertz radiation. They identify two key mechanisms explaining data, shedding light on ultrafast electrical conduction and advancing optoelectronic devices.
Scientists at Osaka University have developed a new method to isolate and generate human corneal tissue from induced pluripotent stem cells. By using specific proteins and magnetic-activated cell sorting technology, researchers were able to purify corneal epithelial cells and produce highly pure corneal sheets for therapeutic purposes.
A new protein called FIMP plays a crucial role in sperm-oocyte membrane fusion during fertilization, a process critical to creating a new individual. The discovery of FIMP could lead to the development of novel fertility treatments and non-hormonal male-specific contraceptives.
Researchers have identified genes implicated in neurodegeneration throughout the stages of Alzheimer's disease using gene-network analysis. The study found that protein domain networks collapse during the progression of AD, leading to neuronal dysfunction and neurodegeneration.
Researchers used dimensionality reduction analyses to identify fine-scale differences in the Japanese population, revealing greater population structure than previously thought. The study found eight sub-clusters within one of the populations, correlated with distinct islands in the Ryukyu region of Japan.
A recent study published in Immunity identified the protein Rbm7 as a key player in the development of tissue fibrosis. The researchers found that Rbm7 induces cell death after tissue injury, leading to the recruitment of immune cells that form scar tissue.
Researchers discovered that shorter time to receiving ECPR significantly improves neurological function in out-of-hospital cardiac arrest patients, especially those with heart rhythms responding to defibrillation. The study's findings can inform future revisions to international CPR guidelines.
Scientists from Osaka University created a new cellular model of the human eye using hiPSCs, enabling them to isolate specific cells involved in eye development and study related diseases. The novel model uses PITX2, a key protein during eye development, to track cell expression and differentiate between eye cells.
Researchers at Osaka University have developed a thermoelectric device that converts waste heat into electricity to power small, flexible sensors. The device has a maximum output power density of 185 milliwatts per square centimeter and meets standard specifications for portable sensors.
Researchers analyzed genetic and clinical data to find that high blood pressure and obesity significantly reduce lifespan, particularly in European ancestry populations. The study, published in Nature Medicine, identifies these traits as major contributors to reduced human lifespan.
Researchers at Osaka University have developed a marine biodegradable plastic using starch and cellulose, demonstrating excellent water-resistance and high strength. The new material has the potential to significantly reduce marine debris accumulation and contribute to sustainable development goals.
Cancer cells can form large-scale structures in the laboratory, similar to those seen in vivo, allowing researchers to gain insight into the forces behind this phenomenon. The study suggests that understanding these interactions may hold potential for combating cancer.
A study published in Japanese Psychological Research found that users with more mutual connections are more likely to spread dreadful information, possibly intending to share their reactions. By identifying user network characteristics, this study potentially offers a solution to prevent fake news dissemination.
Researchers discovered how electrons in pyrochlore oxide crystals form a 'glassy state' due to distortions in the atomic lattice, leading to a spin-glass phenomenon. This work sheds light on understanding glass transitions and their fundamental role in physics.
Scientists at Osaka University created a flexible computing device from field-programmable gate arrays, increasing circuit density by 12 times and reducing energy usage by 80%. This innovation may lead to custom machine learning hardware with enhanced performance and reduced electricity consumption.
A compound called Naphthyridine-Azaquinolone (NA) has been found to reverse the length of DNA repeat expansions that cause Huntington's disease in a mouse model and cells from individuals affected by the disease. The study suggests NA could be a potential drug therapy for individuals who inherit the disease.
Researchers at Osaka University discovered that the tadpole-like tunicate Oikopleura dioica uses calcium ion oscillation and right-sided Bmp gene expression to develop left-right asymmetry. Notably, the species lacks the Nodal gene found in other chordates.
A team from Osaka University has developed a method to quickly identify optimal parameters for complex reactions, reducing time, materials, and cost. Using machine learning and flow systems, they achieved high yields and purity of a potential therapeutic agent with improved selectivity.
Researchers at Osaka University have reported a straightforward approach to protein modification by targeting the N-terminus, providing a new tool for protein engineering. The method uses a single-step reaction to conjugate functional molecules to proteins, resulting in highly efficient site-specific labeling under mild conditions.
A new study published in The Journal of Allergy and Clinical Immunology found that semaphorin protein contributes to allergic reactions and development of nasal polyps in patients with eosinophilic chronic rhinosinusitis. Elevated levels of semaphorin protein were associated with disease severity.
A team of researchers has begun a doctor-initiated clinical trial for a new cell spray treatment method targeting heart failure. The product, ADR-002K, uses a spraying technique to administer mesenchymal stem cells onto the heart, aiming to improve prognosis and cardiac function in patients with ischemic cardiomyopathy.
A study published in Nature Metabolism reveals that serine racemase enhances the growth of colorectal cancer cells by producing pyruvate from serine. The research provides a novel target for anti-cancer therapies and shows promise in improving treatment efficacy.
Researchers developed a thin, soft magnetic sensor matrix sheet system with tenfold improvement in sensitivity, enabling real-time visualization of magnetism. The system can be attached to the skin without causing discomfort and has high spatial resolution due to its high permeability.
Researchers at Osaka University have designed and synthesized a new molecular emitter for organic light-emitting diodes (OLEDs), using rational chemical design with U-shaped synthetic building blocks. The efficient macrocyclic OLED emitter could potentially be used in tiny, energy-efficient chemical sensors.
Researchers found that prehospital epinephrine administration was associated with improved return of circulation in pediatric patients with out-of-hospital cardiac arrest. However, there was no significant improvement in 1-month survival rates. The study suggests that prehospital epinephrine administration should be included in interna...
Researchers at Osaka University developed a machine-learning algorithm that uses MRI images to predict genetic mutations in glioma tumors. This breakthrough may lead to more suitable treatment for patients, giving better outcomes. The study was published in Scientific Reports.
CryoEM technique reveals structural changes in cardiac muscle thin filaments that regulate heartbeat function. The study provides a molecular basis for novel drug design to treat diseases such as cardiomyopathy.
Researchers at Osaka University have developed a new method for generating nuclear fusion power using ultra-intense laser light, which improves upon current 'fast ignition' methods. This approach shows promise for achieving consistent nuclear fusion and potentially cheaper and emission-free energy production.
Researchers at Osaka University discovered that ESAM, a surface marker for hematopoietic stem cells and vascular endothelial cells, is crucial for the development of definitive hematopoiesis, especially adult-type erythropoiesis. The study found that ESAM-deficient mice had impaired hematopoiesis-supporting ability.
Researchers at Osaka University developed a high precision 3D circuit simulator to quantify electromagnetic (EM) noise and its origin. The simulator allows for the visualization of EM noise generation and propagation, enabling intuitive understanding of why and where noise occurs, leading to noiseless circuit design.
Japanese researchers have developed a Class 1 CRISPR gene editing system that enables efficient DNA repairs in human cells with minimal off-target effects. The Cas3 protein-based approach achieves superior genome editing efficiency compared to traditional Class 2 systems, opening doors for new therapeutic applications.
A team of researchers from Osaka University identified a key protein required for electrical signal sensing in sperm, which is defective in individuals experiencing reduced fertility. The study's findings suggest that the protein regulates ion channel activity, affecting sperm motility and potentially leading to new fertility treatments.
Researchers at Osaka University developed a novel receiver that overcomes obstacles in terahertz radiation, enabling record-breaking transmission speeds of 30 gigabits per second. The new technology has the potential to revolutionize next-generation 6G cellular network technology and various other applications.
Osaka University researchers use electron cryomicroscopy to solve the structure of the bacterial flagellum's 'universal joint,' a crucial component in transmitting rotary power. This breakthrough has important implications for developing new antibiotics and biomimetic self-propelled nanomachines.
A recent study published in Annals of the Rheumatic Diseases reveals a novel link between the gut microbiome and host genome in the pathology of rheumatoid arthritis. The research found that bacteria belonging to the genus Prevotella were abundant in the gut microbiota of Japanese patients with rheumatoid arthritis.
A team of researchers at Osaka University created a novel two-dimensional graphical tactile display that combines visual and tactile information. The display uses temperature-sensitive adhesive sheets to create a 'sticky' sensation, allowing users to feel objects on the screen.
Scientists from Osaka University have discovered a molecular 'light switch' that helps control vision in response to changes in light intensity. The enzyme Cul3-Klhl18 ubiquitin ligase regulates photoreceptor cell adaptation, and its inhibition may help treat conditions like age-related macular degeneration and retinitis pigmentosa.
A new non-invasive microscopy technique uses quantitative phase microscopy and Raman spectroscopy to detect the activation state of macrophage cells and distinguish between different cell types. This approach enables high sensitivity at the single-cell level, revealing cellular heterogeneity and outlier behaviors.
Researchers at Osaka University have discovered a previously unknown type of RA-causing cell within arthritic joints that could be a target for new treatments. The newly discovered cells, dubbed 'AtoMs', have properties that make them amenable to therapeutic targeting.
Osaka University researchers developed equations to quantify and eliminate electromagnetic interference, allowing for the design of EM noise-less electric circuits. Their method enables theoretical calculations of electric circuits with various configurations, confirming that a symmetrical configuration is the only solution to eliminat...
A study published in Nature Communications reveals that cell competition modulates morphogen gradients to eliminate unhealthy cells and maintain tissue patterning. The researchers found that aberrant Wnt/β-catenin signaling leads to changes in membrane expression levels of proteins, resulting in cell death via apoptosis.
A study published in Scientific Reports found that male mice sent to space for 35 days retained their reproductive ability upon return. The research team also reported healthy offspring with no effects from the parents' space stay.
Researchers at Osaka University have developed a new radiation therapy method that targets pancreatic cancer cells directly, reducing side effects. The treatment uses a radioactive molecule that binds to specific proteins on stroma cells surrounding tumors, delivering high-energy doses of radiation to cancer tissue.
Osaka University researchers use in situ environmental transmission electron microscopy to visualize atomic dynamics on metal surfaces under atmospheric conditions. They track progressive changes at the surface of gold electrodes during oxidation reactions, providing new insights into materials science.
The study used the 18F-labelled PSMA-1007 radiotracer to detect recurrent and metastatic prostate cancer, which was not identified by conventional diagnostic imaging. The hospital aims to spread nuclear medicine that uses drugs labeled with α-emitting radionuclides for higher therapeutic effects.
This study reveals how sphingosine-1-phosphate positively influences high endothelial venule function and integrity in lymph nodes. Dendritic cell localization and vascular integrity are maintained through S1P-signalling, ensuring proper immune response and tolerance.
Researchers at Osaka University have developed a palladium-based alloy nanocatalyst that promotes the selective production of deuterium isotope compounds from formic acid. The catalyst enables a cost-effective and scalable process for producing these gases, which are useful in fine chemical production and research applications.
Researchers from Osaka University found that a relatively ancient Haemophilus influenzae drug efflux pump AcrB confers resistance to antibiotics similar to its more evolved counterparts. The study highlights the evolution and mechanism of multidrug efflux systems, suggesting a 'one size fits all' approach is not suitable.
A team of researchers directly observed charge transfer and intermolecular interactions in artificial photosynthesis on a picosecond scale. They used time-resolved attenuated total reflection spectroscopy in the terahertz region to reveal the process, which involves rhenium complexes and Triethanolamine solvent.