Researchers found that mesenchymal-like cells with enhanced contractility guide epithelial cancer cell migration through heterophilic N/E-cadherin complex formation. Inhibiting this complex reduces interaction between mesenchymal-like and epithelial cells, preventing tumor invasion.
A nationwide large-scale study confirms the safety and feasibility of NOSES for CRC, with a low postoperative complication rate and good long-term oncological outcomes. NOSES also presents advantages in postoperative recovery, such as earlier flatus time and shorter hospital stay compared to traditional colon surgery.
Researchers have categorized convergent plate margins into three stages based on geometric structure, dynamic regime, and thermal state. The transformation from subduction zones to rifting zones involves two steps: lithospheric thinning and asthenospheric upwelling.
The study proposes a method to manipulate nanoconfined water through surface chemistry modification, resulting in exceptional high capacitance and outstanding high-rate performance. The atomic scale elucidation of layer-dependent properties of nanoconfined water reveals its crucial role on energy storage.
Researchers discover that malate dehydrogenase 2 (MDH2) is palmitoylated by ZDHHC18, increasing its activity and promoting mitochondrial respiration. This process sustains ovarian cancer cell proliferation both in vitro and in vivo.
A new high-throughput glycoproteomics approach identified signatures for diagnosing liver disease through analyzing IgG N-glycopeptides. The study revealed dynamic changes in IgG glycosylation during liver disease progression and provided a new method for distinguishing between different stages of the disease.
Researchers designed a new material with high density of B, F co-doped Fe single-atom sites, showing efficient oxygen reduction and high discharge power density in liquid Zn-air batteries.
Research reveals individual variation in buffalo somatic cell cloning efficiency is related to differences in glycolytic metabolism and chromatin structure. High-cloning-efficiency cells display robust energy metabolism, looser chromatin structures, and increased acetylation of histone H3K9.
A highly efficient solver for bound states in the continuum has been developed based on total internal reflection of Bloch waves. The algorithm can quickly locate BICs with very high precision in a large parameter space, greatly reducing search time.
A new study suggests China's ability to peak its carbon emissions by 2030 is tied to the country's economic growth rate. To achieve this goal, China must develop non-fossil energy sources rapidly.
Scientists successfully differentiated microglia from human pluripotent stem cells, enabling them to replicate the natural retina environment. The new approach allows for a more efficient protocol to generate microglia and presents a promising toolkit for studying retinal biology and regenerative diseases.
Researchers reconfigured perovskite interfaces using R4NBr addition reaction to improve interfacial stability and open-circuit voltage. The resulting solar cells achieved high efficiency and sustained performance, offering a promising avenue for perovskite surface modification.
Researchers discover protective genetic factors against myopia, a condition characterized by nearsightedness, and related ocular biometric parameters. Genetic variants on ABCC5 and CHAT were found to be associated with reduced risk of myopia and high myopia.
Researchers developed ultralight flexible perovskite solar cells using parylene-C films, exhibiting a remarkable PCE of 20.2%. The device's light weight and outstanding power-per-weight ratio demonstrate great promise for fabricating efficient and portable solar cells.
Researchers found that circular RNA circCCNB1, derived from oncogene CCBN1, is downregulated in nasopharyngeal carcinoma (NPC) and inhibits cell migration and invasion. It does so by stabilizing TJP1 mRNA through interaction with NF90.
Researchers discovered nanoscale ordered/disordered domains in Fe3Pt alloys with enhanced lattice strain control. The work provides structural insights into chemical ordering at the atomic scale, enabling new lattice design strategies.
Researchers found a simple correspondence between interaction strength and statistics parameter in 1D and 2D quantum Bose gases in the quantum critical regime. This emergence of fractional exclusion statistics is confirmed through theoretical computations, numerical simulations, and experimental measurements.
The study reveals hyperextension in the Qiongdongnan Basin's crust with characteristics of magmatic influence from the Hainan mantle plume. Low-velocity conduits indicate crustal magmatic footprints, supporting the plume's impact on rifted margins.
A study found that winter warming reduces chilling accumulation, resulting in a higher temperature requirement for spring phenology, which can lead to an extended time interval between flowering and leaf unfolding. On the other hand, spring warming has the opposite effect, shortening this interval.
A novel optogenetic tool, cOpn5, has been developed for precise control of intracellular Gq signaling. This breakthrough enables temporal resolution down to milliseconds and subcellular control without the need for exogenous chromophore.
A team of archaeologists has uncovered evidence of ancient rice cultivation at the Hanjing site in China, dating back over 8000 years. The discovery suggests that rice was cultivated and domesticated in the region more than 4,000 years earlier than previously thought.
Recent advances in redox mediators (RMs) for lithium-oxygen (Li-O2) batteries have improved specific energies but raised scientific issues. RMs classify into organic, organometallic, and inorganic compounds with unique advantages and selection criteria.
A highly sensitive biosensor system was developed using a strategy that precisely controlled bio-droplets' motion behaviors, enabling ultrasensitive detection of biomarkers such as ATP, miRNA, Thrombin, and Kanamycin. The system's adjustable dynamic range allows for versatile applications in cluster analysis and multi-target detection.
China's terrestrial carbon sequestration is expected to increase significantly over the next few decades, with estimates suggesting it can offset a substantial portion of the country's energy-related CO2 emissions. By 2060, China's terrestrial carbon sequestration could account for 13-18% of peak CO2 emissions.
The Tianwen-1 mission has successfully observed solar wind plasma upstream of Mars, revealing several large-scale solar wind disturbances and consistent tendencies with other Mars missions. The joint observation will bring new opportunities for studying the evolution of the Martian atmosphere and paleoclimate.
Gastric cell-fibroblast interactions mediated by CDH11 induce malignant behaviors in GC cells, including migration and colony formation. The YAP-TNC pathway is activated, leading to aggressive behavior and poor prognosis in GC patients.
Researchers found that Stat5-deficient CD4+ T cells exhibit increased Th17-related molecules and conventional Th17 cells with heightened anti-melanoma activity through the activated Notch1 pathway.
This study bridges oxidase catalysis and oxygen reduction electrocatalysis, finding a linear relationship between the two. The researchers propose model single-atom catalysts as promising candidates for tumor therapy, with cancer cell killing effects following ORR activities.
A nationwide survey reveals a significant increase in the use of modern energy like electricity and gas for cooking and heating in rural China. The study found that households used an average of 3 different types of fuels, with time-sharing of E&G increasing by 69% for daily cooking activities.
Researchers proposed an inverse-design methodology for achieving customized dispersions in acoustic metasurfaces, enabling multiple functionalities of high-efficiency and ultra-broadband acoustic directional energy transmission, energy convergence and ultrasound particle levitation. The study demonstrated the feasibility of realizing a...
Researchers successfully implemented and reconfigured 7 kinds of logic functions into one single nanotrack using magnetic skyrmions-based logic gates. This simplification promotes the potential application of these devices in information processing.
A 36-mer cellulose synthase supercomplex is formed in cotton fibers during the secondary cell wall synthesis period. The supercomplex requires all three subunits for full function and is essential for cellulose microfibril structure and secondary cell wall strength.
The study successfully generates second-harmonic generation (SHG) under low pump power, reducing it by three orders of magnitude. The device also exhibits broadband tuning and self-enhanced SHG, offering potential applications in optical fiber communication and sensing technology.
Researchers analyzed stress perturbation on the Maqin-Maqu segment of the Eastern Kunlun fault after the 2021 Ms7.4 Maduo Earthquake, finding it likely to be substantially stressed and promote earthquakes on the seismic gap. The study predicts increased seismic activity in surrounding faults.
Biomedical polymers show great potential in treating various diseases through targeted drug delivery and precise diagnostics. Recent advances have led to the development of intelligent polymeric carriers that can respond to external or intrinsic signals for enhanced therapeutic efficacy.
Researchers developed a new aqueous electrolyte that enables MXene-based supercapacitors to operate at high voltages (up to 1.6 V) and wide temperatures (-40°C to 60°C), while maintaining energy density of up to 31.7 mWh cm– .
Researchers have identified two major failure mechanisms of lithium metal anodes: short-circuiting and capacity loss. A new classification system proposes five categories of anodes, including stabilized lithium-metal powder and composite lithium-metal anodes, which show promising potential for practical application.
Researchers developed a novel composite solid-state electrolyte with high ionic conductivity, enabling long-life 4.4 V-class solid-state lithium metal batteries. The electrolyte exhibits uniform, reversible Li plating/stripping behaviors and delivers 79.7% capacity retention after 500 cycles.
Researchers introduce a new strategy to produce highly robust COF monoliths through melt polymerization, overcoming issues of low processability and lack of stability. The new method yields olefin-linked COF foams with excellent mechanical properties and high adsorption capacities.
Researchers found a significant shift in gut microbiota and metabolites associated with altitude-induced cardiac hypertrophy in rats. Probiotics treatment improved the condition by altering the abundance of certain microbe genera.
Researchers developed a catalyst using graphdiyne and Cu single atoms, achieving high turnover frequencies and selectivity for benzene oxidation to phenol. The unique structure of graphdiyne enables uniform anchoring of Cu single atoms, resulting in improved catalytic performance.
A genome-wide screening using CRISPR-Cas9 identified KEAP1 and Nrf2 as key molecules in sorafenib resistance. The study found that ML385 can enhance the killing effect of sorafenib, while FGF21 positively regulates Nrf2 expression.
A study on the Three Gorges Dam reveals that it has caused significant reductions in annual average CO2, CH4, and N2O emissions in the Yangtze River. The dam's impact extends thousands of kilometers downstream, challenging previous assumptions about large dams' effects on greenhouse gas emissions.
Researchers developed a novel injectable stem cell assembly system to overcome cartilage tissue engineering challenges. The 3D IHI nanoscaffold-templated system effectively modulates the microenvironment and induces chondrogenesis, leading to accelerated repair of cartilage defects.
The interaction between energetic particles and tearing modes significantly affects burning plasma performance. Analytical theory describes physical phenomena, with experiments and simulations confirming results.
Researchers at USTC create flexible synthetic approach to control diameter and length of ZnSe QWs, achieving ultrathin stacking-fault free QWs. The resulting nanowires exhibit well-defined excitonic absorption in blue-light region with high efficiency for solar-to-H2 conversion.
Researchers found that circRNA rtcisE2F promotes liver tumor-initiating cell (TIC) self-renewal by targeting E2F6/E2F3 mRNAs and interacting with RNA m6A reader IGF2BP2. This interaction enhances E2F6/E2F3 mRNA stability, driving TIC self-renewal and tumorigenesis.
Researchers developed Mn-doped Ni2O3/Ni2P and Mn-doped NiXSy/Ni2P nanosheets as efficient electrocatalysts for alkaline overall water splitting. The nanostructures exhibit high intrinsic activities, abundant active sites, and excellent stability.
Recent advances in wireless epicortical and intracortical neuronal recording systems offer promising solutions for BCIs. The development of these systems faces challenges such as high throughput, power consumption, and heat accumulation.
Researchers have synthesized a high-entropy alloy with 21 uniformly composed elements, improving solar steam generation performance. The alloy's unique structure enhances interband transitions and reduces thermal conductivity, leading to improved photothermal conversion efficiency.