A team from the Technical University of Munich has developed a pH sensor that renders pH values visible through magnetic resonance imaging (MRI) - in a non-invasive, radiation-free manner. This method could provide insights into tumor metabolism and help evaluate the efficacy of tumor treatments.
Researchers at TUM create holographic imaging process using Wi-Fi data to generate 3D images of the surrounding environment. This technology allows for centimeter-scale precision and can be used in industrial facilities to track objects as they move, improving efficiency and accuracy.
Researchers have identified a new approach to protect patients from graft-versus-host disease by activating signal paths in the gut. The key to preventing GVHD is protecting the epithelial cells, which can be achieved by using RIG-I and STING proteins.
Research by TUM found that low zinc levels can affect the heart's ability to deal with oxidative stress, leading to increased risk of heart disease. Zinc deficiency was also linked to upregulation of genes responsible for programmed cell death.
Researchers discovered that microRNA-210 reduces plaque instability and improves fibrous cap stability, potentially reducing the risk of stroke. Local application of microRNA-210 is being explored as a safer alternative to systemic administration, which could minimize side effects.
Researchers used mass spectrometric methods to identify proteins influenced by SNPs relevant to type 2 diabetes and AMD. This study provides insights into the molecular mechanisms modulated by regulatory SNPs, contributing to personalized medicine.
Research at Technical University of Munich found that diabetes causes loss of small blood vessels around the heart, affecting cardiac muscle. Genetic therapy promoting pericyte growth may offer a remedy, providing new perspectives for treating patients.
Researchers at TUM have developed a method to construct custom DNA-protein hybrid structures using genetically encoded proteins and DNA. This approach allows for the creation of complex shapes and spatial arrangements that can be used to investigate fundamental processes in cell biology and biotechnology.
Researchers found that ADHD fosters important entrepreneurial skills such as impulsiveness, hyperfocus, and a high activity level. These traits enable entrepreneurs to take risks, pursue new ideas and stay focused on essential tasks despite difficulties with routine activities.
Researchers at TUM have produced a composite material combining silicon nanosheets and a polymer, creating a stable material with remarkable optoelectronic properties. The polymer-coated silicon nanosheets show promise for applications in flexible displays, field-effect transistors, photodetectors, and rechargeable lithium batteries.
Researchers at Technical University of Munich found a significant proportion of human bodies contain brown fat, which burns energy at an extraordinary rate. This discovery may lead to more effective obesity and diabetes medications that target brown adipose tissue.
Scientists discover a tissue layer with extremely thin protein fibers at the interface between tendons and bones, explaining why athletes can withstand tremendous loads without damaging the bond. This breakthrough could lead to innovative connections in material research and tumour surgery.
A team at the Technical University of Munich has demonstrated that using monoenergetic X-rays from a miniature particle accelerator can significantly reduce the required quantity of contrast agents in coronary angiography. This approach enables sharper images with fewer health risks, especially for patients with kidney insufficiency.
A new study published in Circulation shows that supervised exercise training can improve the pumping function of a damaged heart and reduce hospitalization rates. Patients who performed 3,000 steps in 30 minutes at moderate intensity experienced significant benefits, including decreased strain on the heart and improved oxygen uptake.
Researchers at TUM and Kyoto University demonstrated the transport of spin information in a unique boundary layer between lanthanum-aluminate and strontium-titanate materials. This breakthrough enables the potential for novel functionality in spin electronic components, overcoming limitations in traditional semiconductor technology.
A major milestone in proteomics research has been achieved with the creation of a vast library of over 330,000 synthetic peptides representing all canonical human proteins. This achievement is expected to enhance protein identification and quantification by alleviating current issues in this field.
A study at Technical University of Munich found that antibodies can activate human nerve cells within milliseconds, modifying their function. This knowledge improves understanding of illnesses associated with certain types of cancer and paraneoplastic syndromes, which occur when the body's autoimmune reaction attacks its own cells.
Muscle stability relies on two proteins: titin and α-actinin. The TUM researchers used optical tweezers to measure the forces between these proteins, finding a bonding force of five piconewtons that stabilizes muscles and enables heart function.
Researchers at TUM develop new simulation software that combines flow mechanics and flight dynamics in real-time, allowing pilots to prepare for challenging situations like flying near ships or mountains. The program has been validated with reference models and will be tested with experienced pilots.
Researchers used neutrons to determine the structure of an important enzyme in Helicobacter pylori, offering a new point of attack for medications. The findings provide insights into the enzyme's mode of action, enabling the development of molecules that can block this process and target the bacterium effectively.
Scientists at Technical University of Munich have discovered an important mechanism in the body's defenses against fungi. Vav proteins play a key role in regulating the innate antifungal immunity pathway, particularly when CARD9 is present.
A new method has been developed to identify suitable protein structures directly from patients' tumor cells using mass spectrometry. This approach allows for the identification of mutated peptides presented on the surface of cancer cells with high accuracy and speed.
Researchers have developed a new battery test cell allowing them to investigate anionic and cationic reactions separately. This innovation could lead to the creation of high-voltage lithium-ion batteries with improved energy density, reducing the need for multiple charging cycles and minimizing gas formation.
Researchers at Technical University of Munich are collecting infrastructure data via an open source platform using crowdsourcing. The OpenGridMap app allows volunteers to map wind turbines, solar power plants, transformer sub-stations and power lines, generating a denser network of verified grids.
Researchers at TUM have found a new link between IL-6 and pathogenic T cells in multiple sclerosis, shedding light on the disease's mechanisms. The discovery highlights the importance of blocking IL-6 signaling to prevent the formation of pathological cells.
A study by TUM and 300 scientists found that intensified land use leads to a decrease in species diversity and a loss of unique plant communities on grasslands. Even moderate land use results in the homogenization of species, with only a few species remaining across regions.
Scientists at TUM have determined the molecular mechanisms of inhibitors that can selectively thwart the human immunoproteasome. This could lead to the development of new drugs for autoimmune diseases like rheumatoid arthritis and type 1 diabetes.
A recent study published in Molecular Metabolism has found that cholesterol from animal sources helps mice burn fat, while plant-based fats hinder it. The research suggests a critical link between gut bacteria and energy metabolism, challenging the conventional wisdom on dietary fats and obesity.
Researchers at TUM develop a new method for non-destructive testing using ultrasound that combines a computerized model and experiment to provide precise information on the inner world of objects. This method uses waveform inversion to utilize the entire information content of the wave field measured, providing improved results.
Researchers developed mathematical models to simulate and improve group behavior, demonstrating the feasibility of predicting and controlling crowd movements. The approach involves reducing interactions to a small number of effective ones, allowing for forecasts and interventions in groups with generalized patterns of behavior.
Researchers at TUM report cases of acute and fatal pneumonitis resulting from fuel ingestion in refugees. Symptoms initially resemble bacterial pneumonia, making diagnosis challenging due to language barriers.
A team led by Professor Cordt Zollfrank from the Technical University of Munich created the first controllable random laser based on cellulose paper. The laser uses a biogenic structure to scatter light in different directions, but can still be controlled and localized.
Researchers at the Max Planck Institute and Technical University of Munich have measured photoionization with unprecedented zeptosecond precision, determining the timescale of this process for the first time. This achievement resolves quantum mechanics' impact on ultra-short events in atomic interactions.
The study found that when mitochondria are disrupted, stem cells lose their ability to self-regenerate, but stressed cells initiate a growth program leading to tissue regeneration. This highlights the fundamental role of functioning mitochondria in regulating intestinal tissue renewal.
Scientists at TUM have discovered new mechanisms of action for Imiquimod, a medication used to treat viral skin infections and certain types of skin cancer. The study reveals that Imiquimod activates the NLRP3 inflammasome, which can lead to inflammation and potentially contribute to its efficacy or adverse side effects.
Researchers have identified a highly specific adhesion between Helicobacter pylori and human cells, which could be used diagnostically and therapeutically. This new approach aims to prevent the bacterium's attachment to stomach cells, potentially suppressing its damaging effects.
Scientists from TUM discovered that pancreatic cancer cells create a 'niche' in the liver to grow and spread at an exceptionally early stage. This is facilitated by the protein TIMP1, which interacts with hepatic stellate cells to activate them and initiate metastasis.
Scientists at Technical University of Munich developed a new bioinformatics tool to search all bacterial sequences in databases and find similarities or check existence. The tool allows researchers to explore microbial communities and their habitats in detail, with potential applications in clinical diagnostics.
Researchers at TUM found that brassinosteroids increase plant resistance to frost by regulating a protein called CESTA, which influences gene expression and fatty acid composition. This discovery may provide solutions to climate-related agricultural problems.
Scientists at Technical University of Munich successfully measured base-pair bonding strength for the first time on single base pairs. The results may help understand mechanical aspects of biological processes and aid in constructing precise molecular machines out of DNA.
Researchers found that a protein called NOD2 plays a critical role in determining the strength of anaphylactic reactions to food allergens. A changed immune reaction leads to more Th2 helper cells and increased antibody immunoglobulin E production, triggering allergic reactions.
Researchers at TUM have developed molecular sensors from deep-sea jellyfish proteins to measure electrical activity in heart cells. This allows for the identification of specific cell types and improves disease modeling and drug testing.
Researchers found that killer shrimps drove native amphipods out of hiding places, making them easy prey for round gobies. The invasive crustaceans played an indirect role in the decline of native species.
A team of researchers discovered that chaperones have two classes, each identifying distinct types of hydrophobic amino acid sequences. These sequences can form hazardous clumps in the cell if not eliminated rapidly. The study sheds light on molecular quality control and has implications for biotechnological protein production.
Researchers at TUM have determined the mechanism of G protein switching, providing insights into the design of new active agents. The study reveals that the open form of the protein is more accessible to active agents than its rigid, closed form.
A study published in Nature found that diverse ecosystems populated by many species provide higher levels of ecosystem services, including food production, soil development, pest control, and climate regulation. The research highlights the importance of maintaining species-rich ecosystems for human well-being.
Researchers at TUM discovered that brain cells, specifically astrocytes, regulate sugar intake and adjust metabolism in response to hormones like insulin and leptin. This paradigm shift could lead to new treatments for diabetes and obesity by targeting multiple cell types involved in metabolic processes.
Scientists have established the first public collection of bacteria from the intestine of mice, providing comprehensive information on the mouse gut microbiota. The collection includes 76 cultured bacterial species, including 15 previously unknown taxa, and sheds light on the interactions between gut bacteria and their host.
Researchers found a time-resolved supernova signal in biogenically produced crystals from Pacific Ocean sediment cores, indicating the solar system spent 1 million years transiting through a supernova's debris. The signal was first detectable at 2.7 million years ago and ended around 1.7 million years ago.
Researchers at TU Munich and Weizmann Institute successfully recreated DNA condensation on a biochip, replicating the tightly packed structure found in cell nuclei and viruses. This breakthrough enables better understanding of biological processes and potential applications in artificial cells.