Researchers discovered genetic differences between African Americans and European Americans that affect blood clot formation, providing a potential explanation for the racial disparity in heart disease outcomes. The study highlights the need for personalized treatment approaches based on an individual's genetic profile.
A new online program developed by Thomas Jefferson University researchers has shown that more patients choose active surveillance over therapy when presented with pros and cons of treatment options. The program helps patients clarify their treatment preferences and discuss options with the clinical team.
Researchers at Thomas Jefferson University developed a hologram-like display of a patient's organs using molecular PET/CT images. This approach allows surgeons to plan surgery and visualize tumors in 3D, reducing complications and improving outcomes.
Researchers at Thomas Jefferson University found that an HDL receptor in breast cancer cells may be responsible for the increased risk and aggressiveness of breast cancer. Blocking this receptor could help treat the disease, according to Dr. Philippe Frank.
Researchers at Jefferson Orthopedics have developed a potential treatment for post-traumatic joint stiffness in military personnel, using an antibody that curtails collagen fibril production. The study aims to reduce joint stiffness and prevent osteoarthritis in soldiers who sustain traumatic injuries.
A large multi-generational family study has identified a genetic mutation that increases the risk of developmental dysplasia of the hip (DDH). The researchers found a common variant co-inherited by all affected family members, which may affect cartilage formation and delay development.
A new therapy, magnetic resonance image-guided focused ultrasound (MRIgFU) ablation therapy, has significantly reduced pain in 67% of patients with bone cancer. The treatment uses heat to destroy tumors without invasive surgery.
Researchers have discovered HER2 gene abnormalities in 14 different types of solid tumors, including breast, esophageal, and lung cancers. The study suggests that these irregularities may benefit from existing anti-HER2 therapies, providing new treatment options for patients with advanced cancer.
A study by Thomas Jefferson University researchers found that amplification of the Stat5 gene in prostate cancer cells leads to excess oncogenic protein, driving cancer spread. Gene amplification and protein levels increased with metastasis and castration therapy resistance.
A review of 21 National Comprehensive Cancer Network member institutions found that only four provided nutritional guidelines, while many linked to external sites with inconsistent information. The analysis highlights the need for evidence-based, standardized guidelines on dietary recommendations for cancer patients.
Researchers examined 230 patients with chronic tennis elbow, finding that PRP therapy improved pain scores by 55% at 12 weeks and 71% at 24 weeks compared to the control group.
Researchers at Thomas Jefferson University have found that the traditional thresholds for ESR and CRP may need to be refined to improve accuracy in diagnosing periprosthetic joint infections. The study analyzed 1,993 patients and revealed differences in inflammatory marker elevation between knees and hips.
Researchers at Thomas Jefferson University have created a new anatomically-based classification for diagnosing cervical spinal stenosis, which helps identify patients requiring urgent surgical intervention. The study found that patients with higher grades of stenosis were more likely to receive spinal decompression recommendations.
Researchers found that tailored phone interventions and mailings significantly increased colorectal cancer screening rates. Patients who received these interventions were almost three times more likely to undergo screening six months later compared to those with no intervention.
A new study finds that prostate cancer stigma is a significant barrier to diagnosis and treatment in Ghana, with many men diagnosed at late stages and opting out of therapy. The researchers aim to develop tailored treatment regimens and increase PSA screening rates to improve health outcomes.
Thomas Jefferson University researchers have identified new pathways that drive aggressive forms of prostate cancer. Elevated levels of Cyclin D1b function as a novel biomarker for lethal metastatic disease in prostate cancer patients.
Researchers at the Kimmel Cancer Center at Jefferson developed diagnostic and prognostic genetic tests to better predict prostate cancer survival outcomes. The tests distinguish clinically-relevant cancers from normal prostate tissue in men with elevated PSA levels, offering a superior alternative to existing gene tests and the Gleason...
A study at Thomas Jefferson University found that meditation paired with art therapy significantly reduced stress and anxiety in women with breast cancer. The treatment altered brain activity, increasing emotional centers associated with positive emotions, stress regulation, and reward system function.
Researchers found that GM1 ganglioside improved symptoms and slowed disease progression in patients with Parkinson's disease over a 2.5-year period. The study enrolled 77 subjects and followed them for 120 weeks, with significant benefits observed when participants stopped taking the drug.
Researchers at Thomas Jefferson University have developed a new real-time tracking technique that can better predict and track tumor motion during radiotherapy, sparing healthy tissue. The technique has shown to deliver higher levels of radiation to moving tumors while reducing dose to critical organs.
A study published in PLOS ONE reveals that experienced Brazilian mediums show lower brain activity in certain areas during psychography, a form of writing believed to be guided by spirits. The findings suggest an absence of focus, self-awareness, and consciousness during the trance-like state.
A study by Thomas Jefferson University researchers found that deviating from radiation therapy protocols increases the risk of treatment failure and mortality. The analysis of eight large clinical trials revealed a significant association between protocol deviations and inferior clinical outcomes.
Thomas Jefferson University researcher Scott Waldman receives a $1.2 million NCI grant to investigate the relationship between obesity and cancer, with a focus on guanylyl cyclase C hormone receptor. The research aims to understand how obesity increases colorectal cancer risk and potentially identify a therapeutic target.
Researchers found that combining distal protection devices with prophylactic nicardipine reduces life-threatening complications after PCI in patients with previous bypass surgery. At 30-days post-PCI, mortality and incidence of heart attack were significantly lower in the nicardipine group.
Researchers found that high levels of activated Stat5 protein in prostate cancer after surgery are associated with increased risk of recurrence and death. The study suggests Stat5 could serve as a biomarker to help guide patients and physicians for future treatment.
Researchers at Thomas Jefferson University have found that low levels of the protein S100A1 are associated with critical lower limb ischemia, a condition characterized by reduced blood flow to legs. The study suggests that S100A1 could be a potential therapeutic target in critical limb ischemia to promote revascularization.
Researchers at Thomas Jefferson University found that normalizing the population of protective T regulatory cells in the pancreatic lymph nodes can regenerate insulin-producing beta cells and normalize blood sugar levels in diabetic mice. The study suggests a new approach to confront local autoimmune reactions in type 1 diabetes.
Researchers discovered a new function of PARP-1 that regulates both DNA damage repair and androgen receptor activity, suggesting that inhibiting this enzyme could slow prostate cancer growth. This finding provides a new approach to treating advanced prostate cancer, which currently has limited treatment options.
Researchers at Thomas Jefferson University found that contrast-enhanced ultrasound detected higher-grade prostate cancers in 55% of patients, compared to 17% with conventional biopsy methods. The technique uses microbubbles to measure changes in blood flow and requires fewer needle biopsies.
Researchers at Thomas Jefferson University found that decorin, a naturally occurring substance, induces tumor suppressor genes in the surrounding tissue of triple negative breast cancer tumors. This breakthrough may lead to improved therapeutics for metastatic breast cancer.
A large-scale study confirms that empathic physician-patient relationships are associated with better clinical outcomes, including lower hospitalization rates and fewer complications. The study analyzed data from over 20,000 diabetic patients and 242 physicians in Italy.
A Thomas Jefferson University team found that histone-modifying proteins, such as TrxG and PcG, remain attached to DNA after replication, rather than histones. This challenges the longstanding paradigm of epigenetic marks and has significant implications for understanding gene expression and disease mechanisms.
Researchers found that breast cancer patients lacking the retinoblastoma tumor suppressor gene (RB) had a better pathological response to neoadjuvant chemotherapy. A prospective clinical trial has been initiated at the Kimmel Cancer Center to explore this finding further.
Research at Thomas Jefferson University discovered that senescent cells in the tumor microenvironment produce nutrients for cancer cells via autophagy, supporting their growth. This finding suggests that aging is a key factor in driving tumor growth and metastasis.
Researchers have shown that CCR5 antagonists can prevent the migration and spread of breast cancer cells. Blocking CCR5 also reduces the formation of pulmonary metastases in mice with basal breast cancer, suggesting a new treatment option.
A phase III trial found that men without liver metastases lived 8.2 months longer than those with metastasis, despite similar progression-free survival and response to chemotherapy.
Researchers will investigate Cu-64, a biomolecule that selectively seeks out a prostate tumor biomarker, to stage prostate cancers and detect recurrent disease accurately. The new technique involves PET scans and could significantly reduce the number of confirmation biopsies.
Researchers at Thomas Jefferson University have identified potential new targets for PARP-1 inhibitors, which could lead to more effective cancer treatments. The study revealed specialized 'zinc finger' domains on the protein that can be inhibited without affecting other cellular functions.
A literature review highlights the need for a tailored approach to improving quality of life in subpopulations, including African Americans, Latin Americans, Asians, and men who have sex with men. The authors emphasize the importance of considering demographic, socioeconomic, and sexual preference factors in treatment decision-making.
Dr. Scott Waldman has received a CURE grant to develop a molecular diagnostic test that identifies patients who will benefit from adjuvant chemotherapy, reducing racial disparities in colon cancer mortality. The test uses guanylyl cyclase C as a biomarker and could help stratify patients into more targeted treatment groups.
Researchers at Thomas Jefferson University found that eliminating the 'good cholesterol' receptor SR-BI can decrease breast cancer cell growth and tumor formation in mice. This study suggests a potential new approach to fighting breast cancer, with further research needed to fully characterize its role.
A new biomarker has been identified to detect hepatitis B-infected patients at risk of developing liver cancer. Telomere length analysis revealed a significant association between longer telomeres and increased risk of liver cancer in patients with hepatitis B.
Researchers at Thomas Jefferson University Hospital found carotid artery stenting to be safe and effective in patients over 70, with a low risk of adverse events. The study showed that while the risk increases with age, it remains extremely low even for those aged 85 and above.
A study found that dissections occur most frequently in the right coronary artery and bending areas, causing serious complications. Stenting was successful in treating the dissection in 75% of patients, but major in-hospital adverse events occurred in 54%.
Researchers at Thomas Jefferson University have discovered a powerful new strategy for personalized anti-cancer therapy by linking biomarker MCT4 to tumor metabolism. High levels of MCT4 are correlated with poorer overall survival and increased risk of recurrence in patients with triple negative breast cancer.
A study published in PLoS One found that surgery less than 24 hours after a traumatic cervical spine injury leads to reduced neural tissue destruction and improved clinical outcomes. The research, known as the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS), involved 313 patients with spinal cord injuries.
Researchers found that silencing GC-C weakens intestinal barrier, making body more susceptible to cancer. Stimulating GC-C strengthens the barrier and opposes pathological changes.
Researchers at Thomas Jefferson University found that intraarticular delivery of local analgesic bupivacaine reduces postoperative pain and narcotic consumption, while minimizing complications. The study suggests a potential new option for better pain management following knee replacement surgery.
Researchers at Thomas Jefferson University found that curcumin suppresses nuclear receptor activators, which can bypass androgen deprivation therapy. Curcumin also reduced cell number and inhibited survival in prostate cancer cells, with similar results seen in mice studies.
Researchers at the Rothman Institute have found that measuring C-reactive protein in synovial fluid is extremely accurate for diagnosing PJI. The study of 2,067 cases revealed that serum white blood cell counts and PMN percentages have minimal sensitivity and specificity for infection diagnosis.