Researchers at the Rothman Institute found that epidural steroid injections do not improve outcomes for patients with lumbar stenosis and spondylolisthesis. Patients who received ESI had a higher rate of crossover to surgery, poorer physical function, and more bodily pain compared to those who did not receive ESI.
A prospective study found that leukocyte esterase reagent (LE) strips can rapidly diagnose PJI, showing high sensitivity and specificity. The test is a valuable addition to the diagnostic armamentarium for PJI, providing a quick and affordable method for detecting infection in synovial fluid.
Researchers at Kimmel Cancer Center found that cyclin D1 overexpression associates with chromosomal instability in luminal B breast cancer. Elevated levels of cyclin D1 promote genetic breakdown known as chromosomal instability, which correlates with this subtype.
Research reveals obesity is associated with higher prostate cancer screening rates across all races/ethnicities and lower cervical cancer screening rates in white women. The study also found no correlation between weight and breast or colorectal cancer screening rates. Obesity was linked to lower rates of cervical cancer screening, par...
Scientists at Thomas Jefferson University's Center for Translational Medicine have found that reducing N-cadherin levels in pancreatic cancer cells can slow down their mobility and prolong survival in mice by 25 percent. This discovery could lead to new targeted therapies for pancreatic cancer.
Thomas Jefferson University researchers have created a human immune system mouse model that closely mimics the response to a tick-borne infection in humans. The study found that mice developed B1b-like cells, specialized antibody-producing systems used to fight bacterial pathogens, which helped resolve the infection.
Researchers found that loss of the retinoblastoma tumor suppressor gene (RB) in triple negative breast cancer patients is linked to improved survival rates. This discovery could lead to personalized treatment approaches for these patients.
Researchers at Thomas Jefferson University identified breast cancer cell mitochondria as a key target for therapy, showing that off-patent generic drug Metformin can prevent tumor growth and chemotherapy resistance. The study's findings suggest that targeting mitochondrial metabolism could be exploited in personalized cancer medicine.
Researchers analyzed database of symptomatic patients to investigate optimal timing for carotid artery stenting. The study found no significant difference in outcomes between those receiving CAS at 30 days post-event and those receiving it more than 30 days after stroke or TIA.
Researchers found that carotid artery stenting following prior same-side carotid artery revascularization results in lower incidences of in-hospital death, stroke, and heart attack. The study's findings have the potential to change how carotid artery stenosis is assessed and treated.
Researchers at Thomas Jefferson University have developed a new definition for periprosthetic joint infection (PJI) to help diagnose patients with suspected PJI. The criteria include sterile sampling, biomarker testing, and histological analysis to identify virulent organisms like Staphylococcus aureus.
A new surgical care bundle of 12 measures, including smoking cessation and gown change prior to skin closure, reduced Whipple procedure wound infections by 49% compared to a less comprehensive routine preoperative preparation. The measures also included intraoperative wound edge protection and chlorhexidine-alcohol skin preparation.
Researchers at Thomas Jefferson University have found that two nuclear receptors, EcR/Usp and E75A, work against each other during Drosophila metamorphosis. The study reveals that E75A replaces EcR/Usp to repress genes in the absence of ecdysone hormone.
Researchers found that Wikipedia's cancer information is accurate and comparable in depth to peer-reviewed sites like PDQ, but less readable due to complex language and hyperlinks. In contrast, PDQ is written in simpler English and offers more patient-friendly explanations.
A clinical trial at the Kimmel Cancer Center found a two-step, half-match bone marrow transplant procedure improves overall survival in blood cancer patients, with 45% and 75% five-year survival rates. The unique approach controls donor T cell dosage and timing to minimize side effects.
Scientists at Thomas Jefferson University found that silencing the hormone receptor GCC affects appetite in mice, inducing obesity, while mice expressing the receptor know when to stop eating. This new neural-gut axis provides a potential therapeutic target for controlling appetite and obesity.
Scientists have successfully tested a bivalent vaccine that protects against both rabies and Ebola in mice, offering a promising solution for Africa's healthcare challenges. The vaccine is built on the same platform as the approved rabies vaccine and has several advantages over existing Ebola candidates.
Researchers found a significant increase in CIED-related infections, with a 210% rise over 16 years. Comorbidities such as renal failure and diabetes may contribute to the higher infection risk. The study highlights the need for better understanding of infection risk factors and mitigation therapies.
Researchers at Thomas Jefferson University discovered that blocking a receptor of a key hormone in the renin-angiotensin system reduces cancer cell growth by activating the enzyme AMPK, which inhibits fatty acid synthase. This finding suggests a potential target for chemopreventive agents to fight pancreatic cancer.
A multidisciplinary team led by Dr. Isidore Rigoutsos will investigate pyknon-marked non-coding RNAs in various diseases, including cancers, autoimmune disorders, and type-1 diabetes. The grant aims to uncover the functional relevance of these motifs and their role in human disease.
Researchers found that combining tamoxifen with dasatinib reverses chemo-resistance caused by cancer-associated fibroblasts. The combination normalized glucose intake and reduced mitochondrial oxidative stress, leading to nearly 80% cell death.
Researchers at Thomas Jefferson University have demonstrated the long-term therapeutic effectiveness and safety of S100A1 gene therapy in a large animal model of heart failure. The therapy works by restoring normal levels of the calcium-sensing protein, preventing and reversing cardiac dysfunction.
A new study by Thomas Jefferson University researchers finds that receiving radiation therapy immediately after a radical prostatectomy is a cost-effective treatment for prostate cancer patients. Urologists were less likely than radiation oncologists to recommend adjuvant radiation therapy or believe it improves overall survival.
Researchers found that women with estrogen receptor negative cancers who did not receive radiation were 91% more likely to die from breast cancer. There is a corresponding increase in the use of radioactive implants for these patients.
A new experimental vaccine made from frozen immune cells has shown promise in extending the survival of metastatic prostate cancer patients. The vaccine, APC8015F, was found to increase median survival by approximately 10 months compared to those not treated with it.
Survival rates for wealthier patients with glioblastoma have improved since 2000, while those in poorer areas and older than 70 have remained stagnant. The addition of temozolomide to post-operative radiation therapy has been shown to improve overall survival in younger patients.
Researchers found that cancer cells induce oxidative stress in normal connective tissue to extract vital nutrients, accelerating aging and inflammation. This process can identify breast cancer patients at risk of metastasis and offers a potential therapeutic target via antioxidant and anti-inflammatory drugs.
Researchers at Thomas Jefferson University discovered a biomarker Stat5 in breast cancer that predicts patient response to anti-estrogen therapy tamoxifen. Women with active Stat5 have an increased likelihood of responding to the treatment, while those without it are at a higher risk of dying from breast cancer.
Researchers have identified GM-CSF as a driving force behind autoimmune diseases like MS. Blocking its activity may lead to new treatments for the disease. Dr. Abdolmohamad Rostami and his team found that GM-CSF is responsible for disease manifestation in an experimental animal model.
A new study suggests that damage to surrounding tissue during chemoradiation for high-grade glioma may play a role in determining long-term outcome and overall survival. Patients who experienced fewer side effects lived 4 months longer compared to those who did not.
Breast cancer patients whose cells use ketones and lactate as a food supply can be identified by gene profiling, predicting recurrence, metastasis, and poor clinical outcome. The researchers propose using this approach, called Metabolo-Genomics, to target oxidative mitochondrial metabolism with new anti-cancer drugs.
Thomas Jefferson University researchers show intensity-modulated radiotherapy (IMRT) delivers higher doses to the prostate bed while sparing surrounding tissue, leading to improved PSA levels and reduced side effects. The study fills a gap in documentation of this technique's benefits for post-operative patients.
A decades-long study demonstrates that low doses of estrogen combined with growth hormone in prepubescent girls with Turner syndrome has a synergistic effect on growth, increasing their height and improving cognitive functioning. The treatment also shows benefits for psychosocial development.
A new clinical trial, sponsored by the National Cancer Institute, is testing whether rosuvastatin reduces the risk of recurrent colon cancer. The five-year study involves 1,740 patients and will determine if statins are effective in preventing colon cancer.
A landmark study by Thomas Jefferson University researchers found a direct association between physicians' empathy and their patients' positive clinical outcomes. The study, published in Academic Medicine, suggests that empathic engagement in patient care contributes to better treatment adherence and more desirable clinical results.
Scientists from Thomas Jefferson University have discovered that the protein FADD controls multiple cell death pathways, which could lead to better treatment options for autoimmune diseases and cancer. The study found that FADD regulates apoptosis and keeps necrosis at bay, allowing researchers to develop more targeted drugs with fewer...
Researchers have found that antioxidants can help prevent and treat breast cancer by targeting mitochondrial oxidative stress. The study, published in Cancer Biology & Therapy, used a genetically tractable model to show that loss of the tumor suppressor protein Caveolin-1 leads to increased oxidative stress, which fuels cancer cell gro...
Researchers at Thomas Jefferson University developed a new real-time tumor tracking technique that minimizes radiation delivery to surrounding healthy tissue by up to 50%. This approach enables radiation oncologists to administer more radiation and faster to tumors, potentially decreasing side effects.
Researchers discovered that SIRT1 inhibits prostatic intraepithelial neoplasia (PIN), a precursor to prostate cancer, by promoting autophagy. The study suggests that activating SIRT1 could block prostate cancer and promote longevity.
A study published in The American Journal of Pathology found that mice fed a Western-style diet with high fat and cholesterol developed larger, faster-growing tumors and metastasized more easily. The researchers suggest that measuring blood cholesterol levels may be an effective method of screening cancer development.
Researchers at Kimmel Cancer Center have found that breast inflammation promotes the development and progression of breast cancer. By selectively blocking inflammation in the breast, they were able to prevent tumor formation and reduce cancer stem cells.
A study by Thomas Jefferson University found that bone marrow stromal stem cells can significantly recover motor behavior in laboratory rats after a simulated stroke. Early administration of the stem cells was more effective than late administration, with profound changes in brain structure and long-lasting motor function improvement.
A multidisciplinary clinic approach to treating aggressive prostate cancer has been shown to improve survival rates and reduce distress among patients. The study, conducted over 15 years at the Kimmel Cancer Center, found that a team of specialists working together can provide more effective treatment options and better patient outcomes.
Researchers will test culturally relevant intervention, behavior activation (BA), to prevent cognitive decline in older African-Americans with mild cognitive impairment (MCI). The 24-month study aims to demonstrate that BA can boost public health efforts and encourage active lifestyles.
Researchers at Thomas Jefferson University have been awarded a $100,000 grant from the W.W. Smith Charitable Trust to investigate why African-Americans respond poorly to common chemotherapeutic agents used to treat pancreatic cancer.
Dr. Edith P. Mitchell, a clinical professor at Thomas Jefferson University, has been named Physician of the Year by CancerCare for her expertise in treating gastrointestinal cancers. She is being recognized for her innovative research and teaching on new drug evaluations and chemotherapy strategies.
Demetrius H. Bagley, M.D., a renowned urologist and researcher at Thomas Jefferson University, has received the Karl Storz Lifetime Achievement Award in Endourology for his pioneering work in ureteroscopic management of upper tract pathology.
Researchers at Thomas Jefferson University have successfully tested a semi-synthetic opioid called buprenorphine to treat opioid withdrawal symptoms in infants. The treatment reduced days of hospital stay by 40% and showed promise in reducing healthcare costs, which could save up to $1 billion annually.
Researchers found that inhibiting GRK2 protects heart cells from destruction after a heart attack, while excess GRK2 leads to more damage. The discovery suggests that anti-GRK2 gene therapy may help prevent permanent heart damage.
Researchers are calling for a new focus on hypertrophic cardiomyopathy (HCM), a genetic disorder causing sudden death in young people. A task force of cardiologists and cardiac biologists recommends studying the natural history of HCM, defining all genetic causes, supporting clinical trials, and preventing mutant gene expression.