A UCLA-led study found that adherence to national guideline-recommended therapies for heart failure significantly lowered mortality rates. Six out of seven individual measures were associated with improved patient survival over 24 months.
A new study by UCLA researchers has found that a key regulator of cholesterol and fat metabolism in the liver also plays a crucial role in the development of liver fibrosis and cirrhosis. LXRs, master regulators of cholesterol and inflammatory gene expression, control the fibrosis-making cells of the liver.
Researchers at UCLA have discovered a potential biomarker to track Alzheimer's disease progression and treatment effectiveness. The study found that the immune gene MGAT3 is expressed differently in various patient groups, which may lead to personalized disease prognoses and therapy responses.
A personalized dendritic cell vaccine has been shown to increase median survival time in patients with glioblastoma, a deadly form of brain cancer. The vaccine was found to be effective in patients with the mesenchymal subtype of glioblastoma, which accounts for about one-third of all cases.
Homeless kids who use online social networking sites are more likely to have been tested for sexually transmitted infections and better informed about preventing them, despite increased risk of risky behaviors
Researchers at UCLA and the Veterans Administration may have accidentally discovered a solution to regrow hair by blocking a stress-related hormone, according to an article published in PLoS One. The compound, astressin-B, induced long-term hair growth in chronically stressed mutant mice through a short-duration treatment.
A study by researchers at UCLA Stroke Center found that strokes and cardiovascular disease exacted an enormous toll on Hollywood stars. The team identified 30 actors who suffered strokes and 39 heart attacks among Oscar nominees between 1927 and 2009, with women accounting for 60% of stroke victims.
Researchers found that less than one-third of acute stroke patients treated with clot-busting drug tPA receive it within 60 minutes of hospital arrival. Timely tPA administration is linked to lower in-hospital mortality and fewer complications, with every 15-minute reduction associated with a 5% lower risk of death.
A UCLA study reveals HIV causes rapid aging in CD4+ T-cells, leading to accelerated aging and increased risk of age-related diseases. Researchers found that infected individuals exhibit premature telomere shortening, a hallmark of cellular aging.
A UCLA-led study finds that health care reform can improve coordination between assessing disease risk and providing appropriate tests and follow-up medical services. The law expanded coverage for an annual wellness visit, which includes assessing risk for disease and developing a personalized prevention plan.
Researchers at UCLA found that the Nrf2 protein, thought to protect against oxidative stress, actually promotes atherosclerosis by raising plasma cholesterol levels and increasing plaque formation in arteries. The study suggests that antioxidant therapies targeting this protein may not be as effective due to these additional mechanisms.
Researchers at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research found that neural stem cells maintain high levels of reactive oxygen species (ROS) to help regulate normal self-renewal and differentiation. The findings may have significant implications for brain repair and abnormal brain development.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have found a new mechanism that regulates protein stability in cells, triggered by the GSK3 enzyme. This discovery could lead to potential new treatments for cancer, particularly colorectal cancers and other forms of cancer.
A UCLA-led study found nearly two-thirds of Medicare beneficiaries hospitalized for acute ischemic stroke died or were rehospitalized within a year. Hospital mortality and readmission rates varied widely nationwide, indicating opportunities to improve stroke care.
Researchers at UCLA found that the protein Bmi-1 plays a crucial role in regulating self-renewal of normal prostate stem cells and transforming healthy cells into prostate cancer cells. Inhibiting Bmi-1 slowed the growth of aggressive prostate cancer in animal models.
Researchers have found that patients with BRAF-mutated melanoma develop resistance to targeted treatment PLX4032 through genetic mutations or cell surface protein overexpression, accounting for 40% of cases. The study aims to develop new therapies targeting these mechanisms.
UCLA researchers have pinpointed the culprit behind chronic rejection of heart, lung and kidney transplants. They discovered that HLA molecules on donor tissue provoke an immune response in the patient, leading to overgrowth of cells lining the inner blood vessels of the grafted organ.
A study reports on UCLA's experience with new techniques combining catheter ablation with minimally invasive surgical methods to access hard-to-reach areas of the heart. These procedures significantly improved accuracy in applying ablation therapy, offering more treatment options for high-risk patients.
Researchers found that the protein N-cadherin is upregulated in prostate cancer that does not respond to hormone therapy, making it a potential target for therapy. The study suggests that a monoclonal antibody targeting N-cadherin may be effective in treating this aggressive form of prostate cancer.
A new study led by researchers from UCLA and USC found that pregnant women whose sisters had hyperemesis gravidarum are 17 times more likely to experience the condition. Women with a family history of extreme morning sickness may be aware they may also have it, highlighting the importance of taking a family history into account.
Researchers have identified a promising medical therapy to help overcome the brain's limited capacity for recovery after a stroke. By studying tonic inhibition in mice, they found that blocking this inhibitory brain chemical can improve behavioral recovery after stroke.
Researchers at UCLA used brain imaging and genetic detective work to illustrate how genetic variants alter the brain, behavior, and learning. The discovery could lead to earlier detection of autism and targeted therapies to rebalance brain function.
A study found that a peptide being tested to treat atherosclerosis significantly inhibited the growth of ovarian cancer in human cell lines and mouse models. The peptide, an apoA-I mimetic, was shown to be effective when administered via injection or ingestion, with minimal side effects.
A new study suggests that medical schools can tap into doctors' sense of mission and self-identity to increase the number of primary care physicians in medically underserved areas. Training students in underserved settings during medical school and residency can also improve their likelihood of continuing to serve those populations.
A UCLA team is studying ways to get HIV-positive men released from LA jails into medical care and on sustained treatment. The randomized controlled trial will assess an innovative peer-navigation intervention to improve health outcomes and prevent transmission.
Researchers at UCLA's Jonsson Cancer Center found that combining curcumin with Cisplatin suppresses head and neck cancer cell growth, slowing tumor progression. The study showed that curcumin regulates cell cycling, inhibiting cancer-promoting NFκB.
A UCLA study found that exposing fetal neurons to high levels of the immune protein MHC leads to abnormal brain development in mice. This discovery may provide new insights into factors contributing to human neurological disorders like schizophrenia and autism.
A UCLA-led consortium will compare two approaches to help heart failure patients transition from inpatient to outpatient care, aiming to reduce readmissions. The project aims to identify approaches that can improve quality and reduce cost of care across different communities.
Researchers will study proteins that trigger cell activity and functions, aiming to understand how they malfunction and cause heart disease. The project, led by UCLA, involves seven institutions worldwide and focuses on mitochondria and proteasomes, which may contribute to heart disease when defective.
The UCLA-developed Combat Casualty Care educational program provides critical training for U.S. armed forces medical personnel in traumatic injury management, applicable to both military and civilian settings. The program incorporates cutting-edge video footage, patient cases, and ultrasound training modules to enhance trauma care.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have discovered a new cell signaling pathway that controls cell growth and development. This pathway, part of a global DNA damage response, turns off 136 genes that can promote aberrant cell division and cancer.
A new study found that the effectiveness of anti-HIV drugs darunavir and ritonavir was similar between men and women. However, women dropped out of the trial at higher rates than men due to reasons other than drug failure. The study aims to improve retention of diverse populations in HIV treatment trials.
The UCLA team will remotely monitor firefighters using wireless health technologies, developing metrics to analyze health risks and optimize exercise programs. The results will aid in mitigating fatalities due to cardiovascular events and inform new equipment development for firefighters.
Research found that chronic stress increases cancer spread by 30-fold in stressed mice compared to unstressed controls. Stress alters the biology of immune cells, promoting metastasis to distant organs. Beta blockers blocked this effect, suggesting potential prevention strategies.
Researchers at UCLA found that female induced pluripotent stem cells (iPS) retain an inactive X chromosome, similar to most female human embryonic stem cells. This discovery has critical implications for studying X-linked diseases and could lead to a unique form of gene therapy.
A recent study by UCLA researchers has identified a genetic variation linked to systemic lupus erythematosus (SLE) in Asian men. The findings suggest that this variation on the X chromosome enhances an immune response, increasing the risk of developing lupus in men compared to women.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have found that adult stem cells vital for lung repair are associated with a poor prognosis in patients who develop cancer. These cells may mutate into cancer-causing stem cells, making them a potential target for prevention strategies and new targeted therapies.
Researchers have created comprehensive genetic interaction maps for mammalian cells, revealing which genes work together and their roles in disease. The study, published in Genome Research, offers valuable information for research and potential therapeutic targets.
Research by UCLA and Harvard University found that white children and those from below the poverty level have higher rates of frequent ear infections. The study's findings highlight racial and socioeconomic disparities in access to healthcare for these vulnerable populations.
Researchers at UCLA's Jonsson Comprehensive Cancer Center have uncovered a new role for polynucleotide phosphorylase (PNPASE) in regulating the import of RNA into mitochondria. Reducing PNPASE expression impairs mitochondrial energy production and cell growth.
A new UCLA study suggests that socioeconomic status is a major driver of cardiovascular disease risk disparities in the United States. The researchers found that lower socioeconomic status was associated with higher risk across all racial and ethnic groups.
A study by UCLA researchers found that pancreatic cancer cells can metabolize fructose to generate nucleic acids, driving cell division and proliferation. The study suggests that high fructose corn syrup consumption may be linked to increased cancer risk, highlighting the need for reduced refined sugar intake.
Researchers identified basal cells from benign prostate tissue as a new cell-of-origin for human prostate cancer. This discovery could lead to better predictive and diagnostic tools, as well as the development of targeted treatments. The study provides a novel model system for understanding prostate cancer development and progression.
A UCLA study suggests that a simple approach can cultivate female leadership in medicine and other fields. Subtle encouragement from teachers can increase female students' willingness to identify themselves as leaders, leading to a more balanced distribution of leaders in the classroom.
A new performance intervention improved adherence to national guideline-recommended therapies for heart failure patients in an outpatient setting. The program applied clinical decision support tools, structured improvement strategies, and medical chart audits with feedback to help clinicians better provide evidence-based therapies.
Research shows that IBS is associated with both decreases and increases in grey matter density in key brain areas involved in attention, emotion regulation, and pain inhibition. These findings suggest a 'brain-gut disorder' component and move beyond the traditional view of IBS as a functional syndrome.
A study found that high-dose radiation targeting the neural stem cell niche in brain cancer patients doubles their progression-free survival time. Patients who received higher doses experienced 15 months of progression-free survival, while those with lower or no doses had 7.2 months.
Researchers have isolated the first stage of tissue production in human embryonic stem cells, marking a significant breakthrough in regenerative medicine. The discovery may lead to the development of safer tissues for use in treating various medical conditions, including leukemia and sickle cell anemia.
A study by UCLA researchers found that NF1 genetic mutations disrupt working memory in the brain's prefrontal cortex, hindering communication between brain cells. The excess GABA release hampers neural activity, leading to reduced success rates in memory tasks.
A new study found that a culturally specific intervention program based on the African concept of Eban increased condom use and reduced acts of unprotected sex among heterosexual African American couples with differing HIV status. The program aimed to improve communication, relationship health, and community respect.