A new pediatric obesity program, Guided Self-Help (GSH), was developed to provide a less intensive and more accessible way to treat childhood obesity. The study found that GSH was similarly effective as traditional Family-Based Treatment (FBT) in supporting pediatric weight loss, but with higher attendance rates.
Researchers found significant decrease in national Kawasaki disease cases in 2020, coinciding with school closures and masking mandates. KD cases rebounded after lifting of masks and return of in-person schooling, hinting at respiratory portal of entry as trigger.
A UC San Diego longitudinal study found that most COVID-19 long-haulers continue to suffer from neurological symptoms six months after infection, with memory impairment and decreased concentration being the most prevalent. Researchers identified a new subgroup with advanced symptoms, including tremor and difficulty balancing.
A new study has found that nonalcoholic fatty liver disease (NAFLD) in children significantly increases the risk of developing type 2 diabetes. The study, published in Clinical Gastroenterology and Hepatology, revealed that among 892 children with NAFLD, 6.6% developed type 2 diabetes, with the incidence rate rising by 3% annually.
Researchers used bacteriophage therapy to treat 20 complex, antibiotic-resistant lung infections in a clinical trial, resulting in no adverse reactions. More than half of treated patients experienced symptom improvement or reduced bacterial presence. The study's findings advance the promise of phage therapy as an alternative to traditi...
Researchers at the University of California San Diego have developed a tiny, flexible neural probe that can record and stimulate neural activity while minimizing injury to surrounding tissue. The probe is ideal for studying peripheral nerves or the spinal cord, where traditional probes may not fit due to its small size and flexibility.
Researchers at UC San Diego demonstrated that Bluetooth signals can be used to track individuals' movements with high accuracy. The team developed an algorithm that estimates two values found in Bluetooth signals, providing a unique fingerprint for each device.
The primary causes of liver cancer are changing globally, with advances in hepatitis B vaccinations and antiviral therapies reducing HBV-associated liver cancer. However, alcohol consumption and obesity are rising, leading to increased liver cancer deaths. The incidence of NASH is projected to increase further due to rising obesity rates.
A nationally representative study found that menthol cigarettes increase frequency of smoking among US youth, leading to higher nicotine dependence. The study suggests a strong case for the FDA's proposed ban on menthol flavoring in cigarettes to protect young smokers.
A randomized clinical trial found that smokers who received cigarette packs with graphic warning labels hid their packs 38% more often. However, when they returned to regular packs without the labels, hiding behavior returned to baseline levels. The study suggests that graphic warnings may not be effective in reducing smoking behavior.
A new study reveals that combinations of multiple genetic factors determine the risk and severity of symptoms in Autism Spectrum Disorder. Researchers analyzed 37,375 individuals from 11,213 families to understand how rare mutations and common genetic variation contribute to ASD.
A study by UC San Diego Health found that sending patients a text message when their doctor is ready can reduce wait times and improve patient satisfaction. The 'telemedicine untethered' option showed a 55-minute time savings in clinic operations, with zero late appointments and increased flexibility for both patients and providers.
A study from the University of California San Diego found that expressing gratitude between teammates improved their cardiovascular responses to stress, allowing for increased concentration and confidence. This can have long-term health impacts, including reduced risk of cardiovascular disease and cognitive impairment.
Researchers are assessing cognitive decline in aging Latinos, exploring the long-term impact of COVID-19 and cardiovascular disease on brain function and impairment. The study will gather data to develop real-world therapies and potentially lessen the disease burden of dementia affecting Latinos.
Research suggests that during deep sleep, neurons representing related items fire in close temporal order, triggering synaptic plasticity and forming strong connections. This process strengthens or creates new relational memories, which can be essential for learning connections between objects or people.
Between 2017 and 2019, more than 1 million US youth aged 14 to 17 years became new daily tobacco users, with three-quarters of them vaping e-cigarettes daily. The majority of these young users were introduced to JUUL products, which had high nicotine concentrations and youth-appealing flavors.
Research describes how breast cancer cells impair pancreatic islet function to suppress insulin production, leading to diabetes and increased tumor growth. The study identifies microRNA-122 as a key player in this process.
Researchers found that young people aged 12-20 were more likely to become cannabis users in states with legalized recreational use compared to those without. The study also documented an increased likelihood of cannabis use among adults in these states.
A new study suggests that cutting emissions of carbon dioxide and other largely neglected climate pollutants is crucial to stay below the 1.5°C guardrail and avoid catastrophic climate change. The study finds that adopting a 'dual strategy' can cut the rate of warming in half by 2050.
Researchers discovered and validated the enzymes responsible for producing guanitoxin, a potent neurotoxin associated with freshwater harmful algal blooms. The study revealed that guanitoxin-producing cyanobacteria are more prevalent than known in the US, enabling new molecular diagnostic testing to protect public health.
Researchers at UC San Diego developed a new technology using WiFi sensors to help robots navigate indoors, even in poor lighting. The system accuracy rivals commercial camera and LiDAR sensors.
A new weight-loss intervention has been developed to target the instinctive desire to eat, particularly in individuals who struggle with resisting food cues. The Regulation of Cues program trains individuals to use natural hunger cues, reinforces tolerance of cravings, and inhibits urges to eat palatable foods when not physically hungry.
Researchers at UC San Diego School of Medicine found that COVID-19, MIS-C and Kawasaki disease share similar underlying molecular patterns. The study reveals that MIS-C is a more severe version of the immune response than KD, with potential implications for improved disease diagnosis and treatment.
A recent study published in Journal of the American Pharmacists Association found that pharmacists are at a higher risk of suicide compared to the general population, with a rate of 20 per 100,000 pharmacists versus 12 per 100,000 in the general population.
A new wearable device can simultaneously monitor glucose, alcohol, and lactate levels, providing users with a comprehensive picture of their health. This technology has the potential to improve disease management for individuals with diabetes and other conditions, as well as enhance overall wellness through real-time tracking.
A gene therapy approach has effectively reduced neuropathic pain in mice with spinal cord or peripheral nerve injuries without detectable side effects. The treatment, which targets impaired neurons, resulted in long-lasting benefits persisting for at least 2.5 months.
Scientists have detected an increase in atmospheric helium levels, which is attributed to the release of helium as a by-product of fossil fuel combustion and extraction. This finding has significant implications for understanding industrial activity and the potential uses of rare helium isotopes.
Researchers at UC San Diego describe the underlying signaling pathway that causes PAH and a novel monoclonal antibody therapy that blocks abnormal blood vessel formation. The study reveals two opposing roles of NOTCH ligands and opens a door to a potentially new treatment for PAH.
Researchers have made the first detection of groundwater beneath an Antarctic ice stream, providing new insights into the region's hydrology. The study confirms what scientists had previously suspected but couldn't verify until now, improving our understanding of how the Antarctic ice sheet might affect sea levels.
Researchers developed a comprehensive regional diagnostic method using DNA testing, allowing for precise identification of microorganisms and estimation of their abundance. The technique has the potential to revolutionize our understanding of the ocean's food web and its role in removing greenhouse gases.
Researchers at University of California - San Diego use electrical shocks to manipulate the demographic of bacterial communities, changing the ratio of cell types and controlling biofilm development. This technology offers a new tool to destabilize biofilms in healthcare and agriculture settings.
A new study found a consistent increase in PHGDH expression among Alzheimer's patients and asymptomatic individuals, suggesting increased serine production in the brain. The findings prompt caution against taking serine supplements for Alzheimer's disease treatment or prevention.
Researchers used gene therapy to recover the TCF4 gene's function in human brain tissue, rescuing neural structure and function in brain organoids. The study offers promising insights into treating neurological disorders like autism spectrum disorders and schizophrenia.
Researchers at UC San Diego have developed a smartphone app that uses near-infrared camera technology to track pupil size changes, which can indicate cognitive conditions. The app is designed to be user-friendly for older adults and has shown comparable results to traditional pupillometry devices.
A study from the University of California San Diego reveals that public primary schools were created to reinforce obedience and maintain social order. The research, spanning 40 countries, shows how education reforms were implemented after instances of social unrest, shaping the current controversy over teaching critical race theory.
A new study published in Bioelectronic Medicine found that high-frequency spinal cord stimulation (HF-SCS) was more effective at improving perceived pain reduction than low-frequency SCS (LF-SCS). HF-SCS also showed less subsequent use of opioids to mitigate pain.
A team of researchers has discovered that cowpea mosaic virus, when injected into a tumor, triggers a powerful immune response, preventing cancer recurrence. The unique protein shell and RNA structure of the virus activate toll-like receptors, leading to increased cytokine production and a prolonged anti-cancer response.
Research from the University of California San Diego finds a significant partisan shift in birth rates among Republicans and Democrats after Trump's 2016 election. Republican-leaning counties experienced a sharp rise in birth rates, while Democratic counties saw a baby slump, with differences amounting to 1-2% of national birth rates.
Researchers analyzed 451 bacterial strains of C. difficile, identifying 9,924 distinct gene clusters and categorizing them into 176 genetically distinct groups. The study provides new insights into the genetic diversity and evolution of this pathogen, shedding light on its virulence factors and antimicrobial resistance determinants.
A Scripps Oceanography-led study predicts that climate change is making surface ocean currents faster and thinner, affecting global nutrient transport and carbon removal. This change can have a ripple effect on the ocean's ability to remove heat from the atmosphere.
Scientists have developed novel methods to study human brain cell migration during fetal development by tracking genetic mutations in healthy adult individuals. This allows for the first time to reconstruct brain development and provide key findings on cell type origins and hemisphere separation.
Girls perform better in English than boys from ages three to seven, leading to a possible explanation for the STEM gender gap in adults. Parents who invest more time teaching math to their children show weaker association with later-life math skills.
Researchers have developed a new optical microscopy platform that allows them to visually track the timing and location of fat storage within intact cells of fruit flies. The tool is being used to untangle links between diet and phenomena like obesity, diabetes, and aging.
Researchers found daily e-cigarette use altered inflammatory markers in the brain, colon, and heart, while lungs showed gene expression changes; flavors influenced organ responses to infections like COVID-19.
Researchers at UC San Diego found that ovarian cancer tumors activate FAK protein to regulate CD155 expression, creating a shield against immune detection and evading treatment. New molecular targets may boost immune response and lead to new combinatorial strategies for this disease.
Scientists have constructed a detailed map of lung development after birth, providing insights into the genetic and epigenetic factors that affect lung health. The study used next-generation single-cell sequencing technologies to analyze over 80,000 human and mouse lung cells, revealing clues on how cell types communicate and develop.
Research suggests California's environmental regulations preferentially protect white populations from exposure to air pollution. Asian and Hispanic communities experience significantly more air pollution compared to predominantly white neighborhoods across the state. The study finds that even after accounting for income, disparities i...
A new study found that charitable giving increased significantly in counties experiencing high COVID-19-related deaths, with a 78% increase in overall giving. Human services charities were the most affected, as donors showed increased generosity towards feeding the hungry, sheltering the homeless, and caring for vulnerable populations.
Lockdowns during COVID-19 led to significant increases in depression, anxiety, and exhaustion among women in India, particularly those with vulnerable social positions. The study suggests that policymakers should consider supportive measures to limit economic devastation and target aid to vulnerable households and women.
Scientists at UC San Diego are working on next-generation gene drive systems based on CRISPR technology to combat malaria and reduce mosquito populations. The $1.4 million grant will support the development of new technologies, including a neutralizing system called ERACR, to mitigate risks associated with gene editing in mosquitoes.