Financial markets are highly efficient, making it challenging for investors to predict performance and achieve lasting profits. Research reveals that pockets of predictability are interspersed with periods of little to no evident predictability, self-extinguishing due to competitors emulating edges.
Scientists at UC San Diego develop a method to bind unstable diphosphorus to a single metal ion, creating a relatively stable and selectively reactive form. This breakthrough could enable the development of selective phosphorus-atom transfer reactions and open up new areas of discovery in synthetic chemistry.
The team used a microscale diffuser to distribute ultrasound waves uniformly, reducing the risk of over-exposure or under-exposure. The device successfully stimulated cells in human embryonic kidney cells and neuron cells, as well as mice, with improved targeting.
A pilot study by UC San Diego School of Medicine found that eight weeks of mindfulness training significantly reduced symptoms of trauma and depression in individuals grieving from gun violence. Participants showed notable improvements in life satisfaction, with benefits lasting after the program concluded.
Researchers at UC San Diego's Scripps Institution of Oceanography discovered the enzyme-driven process that activates the anticancer molecule salinosporamide A. The team found that a single enzyme called SalC assembles the warhead, which is responsible for the molecule's anti-cancer properties.
A novel screening platform has successfully detected over 95% of stage 1 pancreatic cancers using artificial intelligence-enabled protein marker analysis, outperforming current liquid biopsy tests in accuracy. This technology holds promise for early cancer detection and reducing mortality from this deadly disease.
A UC San Diego study found that excessive neuropeptide secretion by neuroendocrine cells in the lungs can lead to fluid buildup and poor oxygenation in both infant lung disease and COVID-19. Blocking these neuropeptides may be an effective treatment for conditions marked by excess lung fluid.
Researchers have invented an advanced brain-computer interface with a flexible and moldable backing, allowing for more even conforming to the brain's complex surface. The device records signals from nearby nerve cells evenly across a wide area of the cortex, outperforming existing gold standard technologies.
Scientists have identified three major components of the Asian giant hornet queen's sex pheromone, which can be used as bait to trap and track the insects. The discovery could help locate and remove the invasive species from North America, where it threatens bee populations and crop production.
The 'Agency for All' project aims to develop social and behavioral research to understand how to promote local voices and agency in health and development programming. The five-year, $38 million grant will fund an international network across Africa, South Asia, and other regions.
Researchers at UC San Diego have discovered a novel molecular process in corals that controls the subcellular environment of symbiotic algae. The study provides new understanding of the ecologically important animal-microbe relationship, with potential implications for coral health and disease.
A new protein called NDF has been discovered to enhance gene activation and may be involved in diseases like cancer. Found in all human tissues, NDF works by stimulating RNA polymerase elongation, a key step in gene expression.
Researchers at UC San Diego have designed a flexible protein system that selectively binds to non-copper metals, overcoming universal restrictions on metal selectivity. This breakthrough paves the way for the design of novel functional proteins and metal sequestration agents with potential applications in environmental remediation and ...
A recent pilot program measuring the results of online tutoring for K-12 students has shown positive and promising results. The study found that students who received more hours of online tutoring experienced better results, closing about a quarter to a third of their learning loss during COVID.
Researchers found that daily life movement, including housework and self-care activities, significantly benefits cardiovascular health. Women with at least four hours of daily life movement had a 43% lower risk of cardiovascular disease, 62% lower risk of cardiovascular disease death.
A recent study found that headphones increase perceptions of closeness, warmth, and empathy, making listeners more easily persuaded. The research has significant implications for advertising, remote work, and training programs, suggesting that using headphones can be an effective way to create a sense of attachment with the listener.
Researchers used an ancient fish, elephant sharks, to gain insights into human biology and how a widely used medication works. The findings show that progesterone receptor activation in humans requires a different mix of hormones and steroids than in elephants sharks, with the latter not inhibited by RU486.
Researchers at UC San Diego have made a groundbreaking discovery about the role of fibroblasts, or fat cells, in controlling bacteria and developing acne. These findings could lead to more targeted treatment options for acne, which affects up to 50 million Americans each year.
Researchers at UC San Diego's Kavli Institute for Brain and Mind discovered that fruit flies possess more sophisticated cognitive abilities than previously known. Using virtual reality and real-time brain imaging, they found attention, working memory, and conscious awareness-like capabilities in flies.
A recent study published in JAMA Network Open found that the COVID-19 pandemic led to fewer early-stage and more late-stage breast cancer diagnoses. Researchers at UC San Diego Health surveyed patients with breast and colorectal cancers in 2019 and 2020, finding a significant increase in stage IV diagnoses.
Researchers at UC San Diego found a steep rise in HIV incidence among people who inject drugs in Tijuana, driven by undiminished drug tourism. The rate of infection is 11 times higher than in San Diego residents who do not cross the border.
Researchers developed a new RNA editing technology that makes efficient use of native ADAR enzymes to correct disease-causing mutations in RNA. The technology holds promise as a gene therapy for treating genetic diseases like Hurler syndrome and cystic fibrosis, with promising results in mouse models.
Researchers identified Dh31, a signaling molecule released from the fly's gastrointestinal tract, which switches focus from eating to mating. The study provides mechanistic explanation for how Dh31 acts on brain to change motivational drive of critical behaviors.
A team of researchers identified clusters of mutations in the genome that contribute to cancer progression in about 10% of human cancers. These clustered somatic mutations can be used to predict patient survival, with specific hotspots linked to better or worse outcomes for certain types of cancer.
Researchers found lower functional connectivity between brain areas involved in social and emotional processing in individuals at risk of developing alcohol use disorder. This impairment may affect their ability to interpret facial expressions and respond to their environment, increasing the likelihood of disordered drinking.
A new study from the University of California San Diego's Rady School of Management found that the 2016 Massachusetts Assault Weapons Ban Enforcement Notice resulted in a 560% increase in assault rifle sales within five days, but compliance remained low. The research suggests that stricter enforcement is needed to gain full compliance ...
A US study found that e-cigarettes were less popular as a smoking cessation aid in 2017 compared to FDA-approved pharmaceuticals. However, researchers did not see any reduction in relapse rates among those who quit using e-cigarettes.
A team of scientists has identified hundreds of new genomic loci associated with brain structure, shedding light on how the human brain is shaped. The study used genetically informed brain atlases to uncover the largest number of genetic variants linked to cortex size and thickness.
A recent study published in Frontiers in Psychology found that women score higher on compassion-related items and self-reflection, whereas men score higher on cognitive-related items and emotional regulation. Both genders demonstrated an association with increased mental well-being and resilience.
A new study reveals that social isolation and loneliness can increase cardiovascular disease risk by 8% and 5% respectively. Women who experience high levels of both social isolation and loneliness have a 13-27% increased risk of heart disease, compared to those with low levels.
A new UC San Diego study reveals that overqualified women are more likely to be hired for jobs and ranks compared to sufficiently qualified men. Hiring managers assume overqualified women leave due to gender discrimination, rather than flight risk. This suggests firms may not be utilizing their expertise and experience effectively.
A new study found that daily physical activity increases executive function performance in people aged 50-74, while decreased activity leads to lower cognitive performance. The correlation held even after adjusting for various co-morbidities.
Scientists have identified a peripheral mechanism that allows fruit flies to quickly assess complex odors without costly synaptic computation. The fly's olfactory receptor neurons communicate through electrical interactions, enabling an energy-saving way to process meaningful odor blends.
Researchers developed a new method to screen drugs for treating Alzheimer's disease, shedding light on why current treatments have been ineffective. The study identified new targets for drug development by analyzing disease mechanisms in human neurons.
A study published in Nature Microbiology reveals that a class of microbial enzymes contributes to ulcerative colitis. Researchers identified an overabundance of proteases from the gut resident Bacteroides vulgatus in nearly 40% of patients, which can exacerbate the disease when not treated with protease inhibitors.
A two-year randomized trial found that cannabis use significantly impaired driving ability, particularly in the first few hours after smoking. Despite varying levels of THC content and user history, participants displayed diminished skills on simulated driving tests.
The Microbiome and Metagenomics Center at UC San Diego will analyze stool samples from 10,000 All of Us Research Program participants to develop algorithms predicting individual responses to food. This will enable personalized nutrition recommendations based on an individual's genetics, gut microbes, and lifestyle factors.
A study published in Diabetes Care found that walking regularly at greater intensity and taking more steps can lower the risk of developing Type 2 diabetes among adults aged 65 and older. For every 1,000 additional steps per day, the risk is reduced by 6%, with a 12% reduction possible if an average adult takes 2,000 more steps daily.
The new sensor grids offer 100 times higher resolution than existing technology, allowing for more precise identification of seizure origins and preservation of healthy brain tissue. Longer term, the technology holds potential for permanent implantation to improve life quality for people with paralysis or neurodegenerative diseases.
Researchers developed a mathematical model that can predict resistance outcomes for various drug pairs. The model, called JDFE, characterizes mutations available to bacteria and allows for classification of drug pairs into those that facilitate or hinder multi-drug resistance.
Researchers at the University of California San Diego have developed a method to reverse insecticide resistance in mosquitoes using CRISPR/Cas9 technology. By replacing an insecticide-resistant gene with its susceptible counterpart, they have successfully restored genetic susceptibility to these chemicals.
Researchers successfully engineered mesenchymal stromal cells to carry and deliver therapeutics specifically to targeted tissues, offering a precise and reliable approach for treating diseases. This novel cargo-carrier, dubbed 'Cargocytes,' retains most of its cellular functionality while greatly enhancing therapeutic capacity.
Researchers discovered the ZIP-1 gene acts as a cell's first-line response to infection, controlling immune responses to viruses and other threats. The finding could have implications for identifying similar genes that control immune responses in humans.
Researchers have successfully developed CRISPR-Cas9 inheritance control in male mice by shifting the gene editing window to match the timing of meiosis. This achievement expands the potential for human disease research and environmental applications, offering benefits such as laboratory efficiency improvements and cost savings.
A pioneering program at UC San Diego Health Sciences has trained 23% of faculty between 2017-2020, improving mentoring quality and faculty satisfaction, especially among underrepresented groups. The program's success suggests a universally applicable model for medical schools to improve diversity and success.
Researchers analyzed images from NASA's Juno spacecraft to study the forces driving cyclones on Jupiter. Moist convection drives an upscale energy transfer at Jovian high latitudes.
Researchers discovered that bacterial biofilms employ a developmental patterning mechanism similar to plants and animals. The 'clock and wavefront' mechanism creates intricate composite patterns of repeating segments of distinct cell types.
Research at University of California - San Diego found that infants with ASD have impaired neural responses to motherese speech, which is crucial for emotional bonding and learning. Typically developing children show stronger brain activation and interest in motherese.
Researchers developed a computer model of lipoprotein-associated phospholipase A2, shedding light on its mechanism and substrate specificity. This knowledge creates opportunities for therapeutic interventions against cardiovascular disease.
Scientists have created a new tool that monitors the electrical activity inside individual heart cells using tiny 'pop-up' sensors. The device directly measures signal movement and speed within single heart cells and between multiple cells, offering potential breakthroughs in diagnosing arrhythmia and cardiac fibrosis.