Researchers at UC San Diego will use $6.4 million in NIH funding to study the influence of external signals on insulin production in beta cells. They aim to create a roadmap of genetic variations that can predict changes in insulin output, which may help prevent and treat diabetes.
Researchers at UC San Diego have created a tool called GlyCompare that enables explainable Artificial Intelligence analysis of glycomics datasets. The approach accounts for shared biosynthetic pathways of glycans within and across samples, leading to novel biomarkers in cancer diagnosis.
A recent study found that breastfeeding mothers who received Pfizer-BioNTech or Moderna COVID-19 vaccines experienced temporary symptoms such as pain and swelling at the injection site, chills, muscle/body aches, fever, and vomiting. The study also reported no serious side effects in breastfed infants.
Researchers at the University of California - San Diego have developed COVID-19 vaccine candidates made from plant viruses and bacteriophages, which can be stored and shipped without refrigeration. These vaccines trigger high production of neutralizing antibodies in mice, offering a potential solution for global distribution efforts.
A study of highly vaccinated health workers found that COVID-19 vaccines lost effectiveness in protecting against symptomatic infection by July, with only 65% protection remaining. The emergence of the delta variant and lifting of masking mandates contributed to this decline in vaccine efficacy.
Project 2VIDA! aims to increase access and use of COVID-19 vaccines in San Diego's most heavily affected neighborhoods. The program directly educates the public on vaccine safety and addresses health disparities through a door-to-door outreach approach.
A recent study reveals that protein HSP27 plays a crucial role in regulating blood vessel leakage, which is a hallmark of sepsis. By targeting HSP27, researchers hope to develop drugs that can stabilize blood vessel barriers and prevent fluid loss.
A comprehensive review finds that many respiratory viruses, including SARS-CoV-2, influenza, and measles, can spread through airborne transmission via aerosols. The study's findings suggest that indoor air quality and ventilation play a crucial role in reducing the transmission of infectious virus-laden aerosols.
Researchers have created brain organoids from people with 16p11.2 genomic variations, which exhibit differences in brain size seen in individuals with autism spectrum disorder. The study revealed new information about molecular mechanisms that malfunction when this region is disrupted, providing opportunities for therapeutic intervention.
Adolescents in the US showed stable overall drug use rates during the first six months of the COVID-19 pandemic, but nicotine and prescription misuse increased, while alcohol use decreased. The study monitored 7,842 adolescents and found heightened stress, depression, and anxiety associated with youth substance abuse.
Gastrointestinal stroma tumors (GIST) are rare cancers that can be problematic to detect and treat. Researchers have identified the mutational drivers for GIST in the stomach and found a potential drug therapy, temozolomide, which showed promising results in treating patients with specific mutations.
A new study by UC San Diego researchers finds that moving local elections to on-cycle races increases voter turnout and makes the electorate more representative of the population, particularly in terms of race, age, class, and partisanship. The study analyzed California elections over an eight-year period and found significant effects ...
Researchers at UC San Diego developed a system that splits a single millimeter wave beam into multiple paths to improve reliability and throughput. The technology achieved high speeds of up to 800 Mbps with 100% reliability, even in outdoor tests over distances of 262 feet.
A new study from University of California - San Diego suggests that protein deposits in the retina and brain may be a sign of Alzheimer's disease risk. Retinal imaging may potentially serve as an early biomarker for detecting AD risk, offering a non-invasive alternative to traditional brain scans.
A team of researchers at University of California San Diego School of Medicine discovered that GIV/Girdin plays a critical role in sperm motility, survival, and fertilization success. The protein regulates capacitation and acrosome reaction processes, essential for successful fertilization.
Research by UC San Diego professor Uma R. Karmarkar found that display items from the same category as the target product enhance purchase chances, while mismatched products decrease them. This study used eye-tracking technology to examine how different types of displays influenced visual attention.
Scientists have discovered a hidden 'gate' in the SARS-CoV-2 spike protein that allows the virus to infect cells. The discovery reveals a glycan mechanism that opens the gate, enabling the virus to enter host cells. This breakthrough could lead to new therapeutics to counter COVID infection.
Researchers at UC San Diego have discovered the main components driving amyloid beta-associated synapse degeneration in Alzheimer's disease. They found that blocking a toxic signaling pathway can protect synapses and preserve cognitive function, offering a potential therapeutic agent.
A team of engineers and physicians developed a steerable catheter that can navigate the brain's arteries and blood vessels in any direction. The device was inspired by nature and successfully tested in pigs, with potential to treat brain aneurysms and other neurological conditions.
Scientists at University of California San Diego School of Medicine have developed a method to keep cultured hematopoietic stem cells healthy, positive news for patients seeking stem cell transplants. The findings also hint at a new way to ward off aging by super-activating the heat shock pathway.
Researchers at UC San Diego developed a cancer immunotherapy that pairs ultrasound with CAR T-cell therapy to destroy malignant tumors while sparing normal tissue. The therapy significantly slowed down tumor growth in mice and showed minimal on-target, off-tumor side effects.
Wastewater screening at UC San Diego detects 85% of COVID-19 cases early, enabling timely testing, contact tracing, and isolation. The approach has reduced campus positivity rates to less than 1% during the pandemic.
A recent study published in Transplant Infectious Disease found that COVID-19 vaccination provides strong protection against the virus for solid organ transplant recipients, with an almost 80% reduction in symptomatic cases. The study examined data from over 2,150 transplant patients and showed that nearly 70% of vaccinated patients re...
A randomized clinical trial found that graphic warning labels on cigarette packaging changed the perception of US smokers, making them more likely to recognize the negative consequences of tobacco use and consider quitting. However, it did not significantly increase quit attempts or reduce nicotine addiction.
A new tool called PROPER-seq reveals PPIs among thousands of proteins in a single experiment, allowing researchers to map complex networks within weeks. The technology identifies over 210,000 PPIs involving 8,635 proteins across human cells.
Researchers at University of California San Diego School of Medicine modified remdesivir to create an oral version that can be taken earlier in COVID-19 diagnoses. The revised drug proved effective and safe in cell and animal studies.
The Institute for Learning-enabled Optimization at Scale (TILOS) will explore the interplay between artificial intelligence and optimization to develop methods that can change real-world practice. Foundational research will drive important applications in chip design, robotics, and communication networks.
Researchers found that cardiometabolic abnormality, such as hypertension and high cholesterol, were more strongly associated with cognitive function and decline than obesity alone. Individuals with obesity and cardiometabolic abnormality had lower performance results on testing and greater cognitive decline.
A new study from the University of California San Diego's Rady School of Management found that couples who disagree on savings and investment decisions are less likely to own a home or renovate it. The researchers also discovered that newly formed couples become more alike over time, reducing conflict within marriages.
Researchers at UC San Diego found that mice can manipulate unpredictable dopamine pulses, which occur approximately once per minute, and learn to anticipate and act upon them. This new understanding opens a dimension in the study of dopamine and brain dynamics.
A soft and stretchy ultrasound patch can monitor blood flow and heart function in real-time, detecting cardiovascular conditions like strokes and heart attacks. The patch is non-invasive and can penetrate deep tissue depths, providing a more comprehensive picture of internal organs.
Researchers created a stem cell model demonstrating SARS-CoV-2's entry into the human brain through blood vessels and infected pericytes. Astrocytes were the main target of this secondary infection, leading to complications like inflammation, clotting, stroke, or hemorrhages.
New research reveals that low-income neighborhoods and minority communities experience significantly more urban heat than their wealthier counterparts. The study, published in Earth's Future, found that land surface temperatures in these communities can be up to 4 degrees Celsius warmer during the summer months.
Researchers at the University of California San Diego have developed a new wearable device that can generate electricity from human sweat, even when the wearer is asleep or sitting still. The device, which requires no physical input from the wearer, collects sweat from the fingertips and converts it into electrical energy.
Researchers at University of California San Diego School of Medicine developed a new AI methodology to hunt for disease targets and predict drug success. The approach, which uses machine learning to analyze big data, was tested in a Phase '0' clinical trial and showed high accuracy across diverse IBD patient cohorts.
Researchers at University of California San Diego have found that immunotoxins targeting mesothelin can prevent liver cells from producing collagen, a precursor to fibrosis and cirrhosis. In mouse models, these antibodies killed 60-100% of human mesothelin-producing cells, reducing collagen deposition.
Research found a significant correlation between lower UVB light exposure and higher rates of colorectal cancer across all age groups. Vitamin D deficiency may play a role in this association, particularly for people over 45, who may reduce their risk by correcting deficiencies in vitamin D.
Researchers discovered RNA-binding proteins, particularly YTHDF2, as potential targets for treating triple-negative breast cancer. Inhibiting these proteins may provide a new approach to halting tumor growth and reduce adverse side effects.
A study by University of California San Diego researchers found that lobsters can absorb vaporized THC through their gills and exhibit reduced locomotor activity. However, the effects on detection of hot water stimuli were minimal, leaving it unclear whether this constitutes feeling pain.
Researchers created a CRISPR-Cas9-based gene drive that cuts and copies genetic elements in Arabidopsis plants, transmitting specific traits from a single parent. This technology could help plants defend against diseases and grow more productive crops, addressing global food security concerns.
Researchers developed a bio-inspired hydrogel to prevent post-operative adhesions in the heart, with promising results in rats and pigs. The hydrogel creates a protective barrier while allowing for movement and is designed to be easily removable and dissolveable.
Researchers have discovered how yeast cells seamlessly incorporate unnatural base pairs into their genetic code, a breakthrough that may lead to more effective next-generation therapeutics.
A study from University of California San Diego demonstrates the possibility of re-creating a bird's song by reading its brain activity, laying the foundation for building vocal prostheses for humans. The approach uses machine learning algorithms to map neural patterns to mathematical equations modeling the physical changes in the bird...
Researchers developed immune cell-mimicking nanoparticles that target inflammation in the lungs and deliver drugs directly where needed. The study showed complete treatment of inflammation in mice, at a drug concentration where standard delivery methods were ineffective.
A University of California, San Diego study uses AI to analyze gene expression patterns associated with pandemic viral infections. The analysis reveals two telltale signatures that help define patients' immune responses and measure disease severity. These findings provide a map for predicting patient outcomes and testing therapies.
Researchers found that metformin prevents pulmonary inflammation, a major factor in COVID-19 severity and mortality, by inhibiting inflammasome activation and reducing IL-1β production. Metformin may have therapeutic potential for treating severe COVID-19 and other forms of acute respiratory distress syndrome.
A novel prediction model predicts US counties at high risk of future overdose death outbreaks, allowing for preemptive deployment of public health resources. The tool improves on existing methods by incorporating neighboring county data, predicting geographic spread of the overdose epidemic.
Researchers found SARS-CoV-2 on hospital floors and surfaces, especially after patient onset of symptoms. The virus was often accompanied by the bacteria Rothia, which strongly predicted its presence.
A recent study used cell phone apps, wearables, brain activity, and lifestyle factors to generate individualized predictions of depression. The results could lead to tailored treatment plans for mental health, moving beyond one-size-fits-all approaches.
Researchers at UC San Diego developed a high-throughput 3D bioprinting technology that can produce 96-well arrays of living human tissue samples in just 30 minutes, accelerating preclinical drug screening and disease modeling. This could potentially reduce the time and cost associated with drug development.