Researchers at UC San Diego School of Medicine identified a novel molecular pathway that causes gout and its progression to joint tissue erosion. The findings position lubricin as a novel therapeutic target for both the prevention and treatment of the disease.
Researchers at UC San Diego have developed a CRISPR-based therapy that targets and destroys mutant RNA molecules causing Huntington's disease. The approach improved motor coordination and reduced toxic protein levels in mouse models, suggesting a potential new treatment direction.
Scientists have discovered a long-sought plant water loss-regulating sensor, composed of two proteins working together to regulate stomatal movements in response to changing CO2 concentrations. This finding has significant implications for trees, crops, and wildfires, as well as efficient plant water use and CO2 uptake.
Research highlights the critical link between island and marine ecosystems, identifying six essential environmental characteristics to guide prioritization of conservation efforts. Restoring islands can maximize returns for conservation management investments in ocean health and biodiversity.
UC San Diego researchers have developed a self-powered ingestible biosensing system that provides continuous monitoring of gut metabolites, unlocking new understanding of intestinal health and its impact on human health. The battery-free sensor is powered by glucose and can measure glucose levels in the small intestine for up to 14 hours.
The researchers have developed an AI algorithm called M3GNet that can predict the structure and dynamic properties of any material. The algorithm was used to create a database of over 31 million yet-to-be-synthesized materials with predicted properties, facilitating the discovery of new technological materials.
Researchers at UC San Diego School of Medicine identified PKCα as a potential therapeutic target for Alzheimer's disease. The study found that a subtle increase in PKCα activity was sufficient to produce biochemical, cellular and cognitive impairments in mice, similar to those observed in human AD.
A University of California San Diego study found that both Democrats and Republicans would rather take away funding from their party than give money to the other party. This preference was also seen in gun rights and reproductive rights issues, with participants willing to hurt their own cause over supporting an opposing side. The stud...
The UC San Diego Alpha Stem Cell Clinic will receive $8 million in funding to launch new clinical trials and improve accessibility of stem cell therapies. The clinic has already launched 59 clinical trials and treated 277 patients with various diseases.
A new study using human brain organoids reveals that prenatal alcohol exposure impairs brain cell development and functioning. The findings confirm the harm inflicted by alcohol on the developing fetus, with effects including faulty brain architecture and impaired electrical activity patterns.
Researchers found that artificial neural networks learn better with occasional periods of inactivity, similar to the human brain's benefits of sleep. This approach mitigates catastrophic forgetting and allows for continuous learning, like humans or animals.
Researchers found that genetic copy-number alterations drive HPV-negative head and neck cancers, providing new insights for immune checkpoint inhibitors. The study identified key determinants of resistance and suggests a novel diagnostic biomarker test, potentially leading to improved treatment outcomes.
Researchers developed a non-invasive device to measure cervical nerve activity, which could potentially improve treatments for patients with sepsis and PTSD. The device recorded electrical activity across different nerves, grouping patients into distinct biotype groups based on their response to stressors.
Researchers at UC San Diego have shown that vibrational polaritons alter molecular dynamics, leading to changes in chemical reactions. The study uses 2D infrared spectroscopy to separately excite and follow polariton modes and dark modes, revealing a new way to control reactions.
The UC San Diego TREDS program aims to educate drivers and pedestrians about road safety with a new self-paced online program targeting underage drivers. The initiative seeks to reduce traffic-related injuries and deaths, particularly among teens aged 15-20 who are at higher crash rates.
A multi-campus research team has created a novel device that can non-invasively measure cervical nerve activity in humans, with potential applications for personalized treatments of sepsis and mental health conditions like PTSD. The device features a flexible array of electrodes that capture electrical activity across different nerves.
Researchers used human brain organoids to show how SARS-CoV-2 infects and destroys synapses in cortical neurons. Sofosbuvir effectively inhibited viral replication and rescued impaired neurons, suggesting a potential treatment for Long COVID.
A new study by the University of California School of Global Policy and Strategy found that credible trade agreements help U.S. firms invest in new export markets during economic downturns. The research suggests that trade agreements can mitigate the impact of a global recession, particularly for industries dependent on exports.
Researchers found that first-degree relatives of patients with advanced fibrosis are at a 15% risk of developing nonalcoholic fatty liver disease. Early screening for advanced fibrosis among siblings and offspring of patients can help prevent the progression to cirrhosis or liver failure.
Researchers have developed a preclinical model of appendiceal cancer, which accurately recapitulates the disease's cell mix and behavior. The organotypic slice culture model offers promising new avenues for studying the pathobiology of this rare tumor and testing potential treatments.
Researchers developed a polygenic hazard score based on 290 genetic variants to predict genetic risk of lethal prostate cancer. The study analyzed nearly 591,000 men and found that the score adds considerably more information for individualized risk assessment, potentially benefiting high-risk men with accurate screening.
Researchers tracked COVID-19 symptoms in 158 untreated participants for 29 days and found that more than one-third experienced a return of symptoms after at least two consecutive days of being symptom-free. The most common relapsing symptoms were cough, fatigue, and headache.
Researchers found that intensive physical therapy and implanted neural stem cells increased tissue growth, repair, and functionality in rats with cervical lesions. The combination of treatments outperformed each individual treatment alone, suggesting a new potential combination therapy for spinal cord injuries.
Researchers at UC San Diego identified a new signaling process involving GPCRs, suggesting untapped potential for therapies, including for multiple forms of cancer. The study challenges traditional views on GPCR-mediated signaling, revealing a new mechanism that originates at endosomes and propagates into the nucleus.
Researchers identified specific transcription factors involved in RA's heterogeneity and stratified cell lines into subtypes with distinct predicted activated pathways. This could help pave the way for personalized treatments tailored to individual patients' needs.
UC San Diego researchers found that providing detailed information on probabilities can make risks seem less risky. Detailed knowledge of individual probabilities reduces the subjective perception of risk and causes individuals to estimate its occurrence more accurately.
Researchers discovered that dormant bacterial spores can evaluate their environment without waking up, using stored electrochemical energy to determine favorable conditions. They found that spores release their energy to perform a computation about their surroundings, similar to how neurons operate in the brain.
Researchers found that the quality and mix of collagen in pancreatic ductal adenocarcinoma tumors affects prognosis. Patients with tumors containing cleaved Collagen I experienced poor survival prospects, while those with non-cleaved Collagen I had better outcomes.
A team from the University of California San Diego has developed a new system of algorithms that enables four-legged robots to walk and run on challenging terrain while avoiding obstacles. The system combines vision with proprioception, allowing the robot to move efficiently and smoothly in various environments.
Researchers found mutated PKCγ enzyme leads to elevated activity, disrupting Purkinje cell function and driving cerebellar pathology. The study suggests inhibiting the enzyme may have therapeutic potential for spinocerebellar ataxia type 14 and potentially other subtypes.
The first-ever mycobiome atlas describes associations between cancers and fungi, revealing differences in community compositions across cancer types. The study found significant correlations between specific fungi and age, tumor subtypes, smoking status and survival measures.
Researchers at UC San Diego's Q-MEEN-C are exploring quantum materials for neuromorphic computing, which could lead to faster, smaller, and more energy-efficient devices. The center aims to develop brain-like networks and pattern recognition capabilities with minimal energy input.
Researchers found no link between R&D costs and high drug prices in the US, contradicting industry claims. Despite $83 billion spent on R&D in 2019, drug prices are driven by market demand rather than investment costs.
Researchers discovered a pattern of DNA mutations that links bladder cancer to tobacco smoking using a powerful new machine learning tool. The tool identified four mutational signatures, including one tied to tobacco smoking, which could lead to more customized treatments for patients with specific cancers.
A study published in JCI Insight has found that genetic variation plays a crucial role in the racial disparity of esophageal cancer cases. Researchers used artificial intelligence-guided tools to pinpoint a specific type of immune cell as the disease driver, and a protective genetic factor associated with African Americans.
Scientists at the University of California San Diego have developed a new biodegradable polyurethane material that can break down in seawater, reducing plastic pollution. The material was tested in marine environments and found to be degraded by microorganisms, which consume the chemicals as nutrients.
Researchers at the University of California San Diego developed microscopic robots called microrobots that can swim around in the lungs and deliver medication. The microrobots safely eliminated pneumonia-causing bacteria in mice, resulting in 100% survival rates, whereas untreated mice died within three days.
The devices, made from a combination of stretchy material and dinoflagellate-infused culture solution, trigger light emission through mechanical stress. They can be recharged with sunlight and are maintenance-free, making them suitable for soft robots exploring dark environments.
UC San Diego researchers created the first diagnostic tool to differentiate between Kawasaki Disease and Multisystem Inflammatory Syndrome in Children (MIS-C) using a novel artificial intelligence-guided algorithm. The algorithm achieved accuracy exceeding 90% with simple test results and physical exam features.
A multidisciplinary team at UC San Diego received NSF funding to create a system that remotely monitors patient posture, movement, and physical therapy treatments using wearable technology and machine learning. The goal is to enable personalized physical therapy treatments and improve health outcomes.
The aviation industry faces radical solutions to address its growing impact on climate change, with cleaner fuels and carbon offsetting deemed inadequate. The industry needs to invest in new technologies, such as hydrogen and electricity-powered planes, to reduce emissions and mitigate contrails' warming effects.
A UC San Diego study found that cancer patients experiencing housing instability had a significantly increased risk of mortality. The research suggests that integrating health and social care can improve patient outcomes by identifying and addressing underlying social risk factors.
A new University of California San Diego study reveals collaboration between the US and China on low-carbon technologies poses little national security risk and manageable economic risks. The study's findings challenge common assumptions that decoupling from China harms global efforts to mitigate climate change.
Healthy older adults exhibit greater mental well-being despite poorer cognitive performance than younger adults. The study reveals that neural mechanisms underlying these findings may inspire new therapeutic interventions to promote healthy brain function.
The University of California, San Diego is part of the National Institutes of Health's Bridge to Artificial Intelligence program, aiming to create comprehensive AI-ready datasets. The program will support researchers in developing interpretable and trustworthy AI technologies to improve human health.
A study from UC San Diego finds increased depression, anxiety, and perceived stress in Latina mothers, particularly those in border cities, due to reduced coping resources. The researchers attribute these findings to the increasing hostility of the political climate towards Latinx Americans.
The California Study on Violence Experiences across the Lifespan reveals that more than one in six Californians experienced physical or sexual violence in the past year. Demographic disparities highlight potential contributing factors exacerbated by the pandemic, including socioeconomic vulnerabilities and gendered nature of violence.
Scientists at UC San Diego have illuminated the role of key neurons that alter function in response to seasonal changes in light exposure. The study found that neurons change expression of neurotransmitters in response to day length stimuli, triggering behavioral changes.
Researchers found that ants and robots can be modeled using the same algorithms, despite differences in slipping motions. The discovery provides a universal model for location that applies to various movements, including walking and slithering.
A new study from the University of California San Diego's School of Global Policy and Strategy finds that countries with bold pledges are more likely to achieve their goals. Europe takes the lead, while the US is not expected to meet its commitments. The study suggests that better systems for checking on country compliance are needed.