A new study reveals that households experiencing high inflation are more likely to buy a home due to concerns about future price hikes. The research found that personal experience with inflation is a key driver of home ownership, with those who have lived through high inflation more likely to invest in real estate.
Researchers discovered how the Epstein-Barr virus exploits genomic weaknesses to cause cancer by cleaving human chromosome 11, triggering a cascade of genomic instability. The study highlights the potential risk factors for EBV-associated diseases and suggests that blocking EBNA1 binding can prevent their development.
Researchers at University of California - San Diego found that vertebrates acquired a special protein from bacteria more than 500 million years ago. This discovery reveals a new piece of genetic material introduced from foreign bacterial genes, leading to unique functionality in vertebrate eyes.
Researchers found that a protein associated with liver cancer, ATF4, protects the liver by promoting the expression of SLC7A11, which suppresses ferroptosis and slows liver cancer progression. This unexpected result could inspire new treatments for preventing liver disease and cancer.
A team at UC San Diego developed a biodegradable polymer system to treat rheumatoid arthritis by working with the immune system. The method uses encapsulated all-trans retinoic acid (ATRA) that transforms disease-causing cells into regulatory T cells.
Researchers at UC San Diego and UC Merced developed a high-throughput method to study the circadian clock in real time, shedding light on its internal functions. The study found that kinases play a crucial role in relaying the circadian rhythm from the core oscillator to gene expression.
Researchers at University of California San Diego School of Medicine found a significant reduction in disease growth when combining immunotherapy with chemotherapy in patients with advanced endometrial cancer. The study resulted in a 70% risk reduction in the deficient mismatch repair group.
The latest CDC report highlights changing demographics of autism and its impact on early detection. In California, 2.8% of 8-year-old children have been identified with ASD, while the median age of first diagnosis is just over 4 years.
A new study by UC San Diego researchers found that COVID-19 subvariants like BA.4 and BA.5 evaded the body's natural defense, leading to rapid spread. Early treatment with Paxlovid may have left patients more susceptible to re-infection due to a weakened immune response.
Researchers found that hematopoietic stem cells use aggrephagy to collect and destroy misfolded proteins, a process that is critical for maintaining stem cell fitness and longevity. Boosting this pathway could help preserve stem cell health and mitigate blood and immune disorders.
A DNA designer drug restored levels of stathmin-2, a protein necessary for motor neurons to function, in both mouse and human studies. This finding could lead to clinical trials to delay paralysis in ALS patients by maintaining stathmin-2 levels.
A comprehensive global assessment of oxygen loss on coral reefs reveals widespread hypoxia, with over 84% of reefs experiencing 'weak to moderate' hypoxia. The study predicts that ocean warming and deoxygenation will increase the duration, intensity, and severity of hypoxia by 2100.
Scripps Oceanography researchers developed a machine learning method to separate fish chorusing sounds from the overall ocean noise, enabling faster analysis and identification. The 'SoundScape Learning' technique can be applied to other soundscapes to learn more about animals like frogs, birds, and bats.
Researchers found a strong association between high levels of telomerase reverse transcriptase (TERT) expression and an elevated immune response in patients with head and neck squamous cell carcinoma. This link suggests a potential new target for cancer immunotherapies, which may lead to improved outcomes for patients.
Researchers at the University of California - San Diego found that honey bees use a 'waggle dance' to communicate the location of food sources, and that this behavior is improved by learning and culturally transmitted. The study demonstrates the importance of early social signal learning in non-human spatial referential communication.
Researchers detected and targeted a type of childhood leukemia that becomes resistant to treatment by focusing on a process called splicing. The study suggests a new approach to detecting and targeting therapy-resistant leukemia stem cells, offering hope for improved treatments.
New research confirms that coastal water pollution transfers to the atmosphere in sea spray aerosol, contaminating air for people inland. Bacteria and chemicals from sewage-polluted Tijuana River are detected in ocean aerosols.
Researchers at UC San Diego develop new bioink with iodixanol, reducing light scattering and enabling high cell density printing. The technique creates functional human-like tissues with improved resolution and perfusion systems for long-term culture.
The new technology enables wireless communication and battery-less operation using a custom chip that can be powered by LTE signals. This approach reduces e-waste and increases device lifespan by up to several decades.
UC San Diego researchers study smallest dust particles in interstellar medium using JWST, gaining insights into star formation and ISM physics. High-resolution images reveal details of gas filaments and 'bubbles' blown by newly formed stars.
A new UC San Diego model uses internet search data to predict housing price declines, with a national forecast of a 5% decrease. Cities like San Diego and Phoenix are predicted to experience significant price drops, while others, such as Scranton-Wilkes-Barre-Hazleton and Kansas City, are expected to see stable prices.
Researchers have discovered a late-stage small molecule inhibitor called rebecsinib that reverses ADAR1-induced cancer stem cell cloning capacity. This breakthrough has significant implications for treating various types of cancers, including acute myeloid leukemia and chronic myeloid leukemia.
Men are more likely to interpret uncertain information optimistically and make riskier financial decisions, especially with increasing amounts of available information. Women, on the other hand, show a more cautious approach in uncertain situations, with missing information bothering them more than men.
Researchers have made progress toward fast-charging lithium-metal batteries by growing uniform lithium crystals on a lithiophobic nanocomposite surface. This approach enables charging in about an hour, competitive with today's lithium-ion batteries and overcoming a significant roadblock to widespread use.
Researchers developed an eye-tracking test that accurately identifies toddlers with ASD based on their level of attention to motherese. Toddlers with low attention to motherese showed weaker social and language abilities.
Scientists will investigate the properties of coastal marine clouds, including their radiative effects and role human-made particles play in shaping Earth's energy balance. The study aims to inform numerical models used to represent ocean-cloud processes.
A new biomaterial has been developed that can be injected intravenously to promote cell and tissue repair, reducing inflammation in damaged tissues. The material has shown promising results in treating heart attacks and traumatic brain injury in animal models.
UC San Diego scientists developed an AI-based strategy for discovering high-affinity antibody drugs, identifying a new antibody that binds 17 times tighter than an existing one. The approach accelerates the discovery process, reducing failure rates and enabling faster development of novel cancer and COVID-19 treatments.
Researchers from UC San Diego and Yale University are exploring the therapeutic potential of
Researchers created an atomic-level computer model of the H1N1 virus, revealing dynamic movement of HA and NA proteins. This discovery provides new insights into the flu vaccine's target sites, suggesting possible strategies for designing future vaccines and antivirals.
Engineers and physicians developed a portable, postage-stamp-sized wearable ultrasound device for cardiac imaging. The device measures blood pumping activity in real-time, even during exercise, providing continuous insights into heart health.
A new study led by the University of California San Diego found that daily walking and moderate-to-vigorous physical activity significantly reduced the risk of developing mild cognitive impairment or dementia in senior women. With each additional 1,865 steps per day, the risk was lowered by 33%, while moderate-to-vigorous physical acti...
Researchers at University of California San Diego have identified a new host-cell factor, PCIF1, which plays a crucial role in SARS-CoV-2 infection. The study suggests that targeting PCIF1 could lead to more effective and sustainable COVID-19 treatments.
Researchers at UC San Diego describe how pancreatic cancer stem cells leverage SMARCD3, a protein that normally suppresses tumors, to boost resistance to treatments and drive growth. Deleting SMARCD3 reduces tumor growth and improves survival rates.
Excessive brain folding is associated with neurodevelopmental delay, intellectual disability, and epileptic seizures. A recent study identified a gene called TMEM161B as the cause, which controls cellular skeleton and polarity and affects neural cell interactions.
Researchers found altered cognitive function months after the Camp Fire, including increased activity in brain regions involved in cognitive control. Climate trauma may impair daily functioning and reduce wellbeing by weakening interference processing abilities.
Researchers developed a flexible genetic hacking system to convert split gene drives into full gene drives, enabling safe testing and potential real-world applications. The new system revealed surprising fitness costs of full drive systems, with slower-than-predicted spread rates in cage experiments.
Researchers found that UV nail polish dryers cause cell death, mitochondrial damage, and DNA mutations, leading to cancer-causing effects. Chronic use of these devices poses a significant public health risk.
A study from the University of California San Diego found that publicly available salary information prompts universities to compensate women more fairly, with a 4% increase in female pay. Top-ranked institutions responded most quickly and aggressively to reduce the gender pay gap.
Researchers discovered a molecular pathway critical to the initiation of pancreatic tumors, which can contribute to disease resistance and metastasis. Targeting this pathway could limit tumor progression, relapse, and spread by disrupting the interaction between cancer cells and their microenvironment.
Researchers have identified genetic somatic mosaicism as a cause of mysterious cases of epilepsy in children. The study found 69 different genes carrying somatic brain mutations that disrupt cellular function and stimulate epileptic seizures. These findings could lead to new molecular classifications for MCD disease and personalized th...
A study published in the Journal of the American Geriatrics Society found a sharp increase in cannabis-related emergency department visits among California adults ages 65 and older from 2005 to 2019. The rate increased by 1,808%, with more than 12,000 visits reported in 2019.
UC San Diego researchers analyzed plankton samples from the Continuous Plankton Recorder Survey to reconstruct historical marine pollution trends. They found rising levels of manmade chemicals in oceans, which may be used to monitor ecosystem health and study connections between ocean pollution and human chronic illnesses.
A new computer program, DeepMosaic, uses artificial intelligence to detect mosaic mutations in genetic sequences. This method enables accurate detection of mosaic mutations, which cause hundreds of unsolved and untreatable disorders, including epilepsy.
Researchers have successfully demonstrated that human brain organoids implanted in mice can establish functional connectivity and respond to external sensory stimuli, including visual cues. The breakthrough uses a combination of transparent graphene microelectrode arrays and two-photon imaging, enabling real-time observation of neural ...
Scientists at UC San Diego School of Medicine identified distinct patterns of cytokine and granzyme expression in tissue-resident memory T cells, highlighting their complex biology. These findings pave the way for a new branch of precision therapeutics targeting infection, cancer, and autoimmune diseases.
UC San Diego researchers have developed a simple quantitative formula to interpret how cells regulate transcription and translation processes. This breakthrough provides insight into how cells process environmental information and modulate behavior, enabling the precise manipulation of protein levels. The study's findings have signific...
The device can monitor hemoglobin levels in deep tissues with high spatial resolution, providing critical information for timely interventions. It overcomes limitations of existing methods, such as MRI and X-ray-computed tomography, which are bulky and only provide immediate status information.
A global registry for gene-drive modified organisms could facilitate transparent communication, monitor ecological impacts, and inform local decision-making. Experts agree that a registry is necessary for the fair development, testing, and use of gene-drive technologies.
Researchers discovered significantly elevated plasma TDP-43 levels in patients with Limbic-predominant age-related TDP-43 encephalopathy (LATE), a newly recognized form of dementia. This finding could lead to the development of new diagnostics for LATE, currently poorly understood and difficult to identify in living patients.