Researchers have found a possible link between a genetic variation and atrial fibrillation in zebrafish, suggesting a structural defect in the heart muscle and mitochondria. Early treatment with antioxidants may prevent the disorder in fish, but more research is needed to understand its human implications.
Assistant Professor Søren Grubb has discovered precapillary sphincters in mice, which regulate the resistance between arterioles and capillaries. The findings suggest a potential link to diseases like migraine, Alzheimer's, and vascular dementia, which are associated with blood vessel defects.
Researchers successfully sequenced and annotated the giant squid's genome, providing a unique opportunity to explore its evolutionary history. The genomic draft reveals insights into the giant squid's size, growth rate, and age.
Researchers have successfully extracted a complete ancient human genome from birch pitch used as 'chewing gum' 5,700 years ago. The findings reveal genetic information about an individual's physical characteristics, including dark skin, hair, and eyes, as well as their diet and oral microbiome.
A specialized system of ducts transports bile and enzymes from the liver and pancreas to the intestine. The study revealed a multi-step process for duct formation, with key genes controlling the development of these ducts.
Researchers have found that dietary supplements can improve the clean-up process in cells called mitophagy, which breaks down defective mitochondria, thereby delaying aging processes in animal models with Werner Syndrome. This study provides promising results for potential treatments and understanding of the mechanisms of aging.
Researchers have discovered that Pseudomonas aeruginosa bacteria send out warning signals when attacked by antibiotics or viruses, allowing them to survive and potentially evade treatment. This communication mechanism may hold the key to developing new treatments and improving existing ones.
Scientists have successfully linked the extinct giant ape, Gigantopithecus blacki, to its closest living relative, the orangutan. Genetic material from a 2-million-year-old fossil was retrieved using ancient protein sequencing, revealing key insights into human evolution.
Researchers at the University of Copenhagen have discovered that stress hormones, such as corticosterone, play a crucial role in controlling the circadian rhythm of brain cells. By using test rats and a new method involving medical micropumps, they were able to restore the rhythmic activity of clock genes in the cerebellum even after t...
Researchers from University of Copenhagen have discovered how stem cells can 'forget' their past and develop into specific cell types. The study reveals that transcription factors play a key role in regulating gene expression, rather than driving cellular development.
Researchers from the University of Copenhagen have identified five new GPCRs activated by 17 peptide ligands, expanding the known peptide-GPCR network. This discovery has high translational potential as therapeutic targets for various diseases, including genetic, nervous system, and neoplastic disorders.
Researchers found that severe infections in pregnant mothers can impair brain development, leading to psychiatric disorders such as schizophrenia and autism spectrum disorders. The study showed immediate and long-lasting effects on neuronal cells, including impaired cortical GABAergic interneuron development.
Scientists from the University of Copenhagen have identified two proteins, 53BP1 and RIF1, that orchestrate the repair of damaged DNA by building a three-dimensional scaffold around broken strands. This scaffold concentrates special repair proteins, enabling cells to prevent collateral damage and maintain genetic stability.
Researchers have discovered how certain proteins orchestrate repair of damaged DNA by building a three-dimensional scaffold that concentrates special repair proteins. This discovery has significant implications for understanding how DNA damage causes disease and designing treatments for patients with unstable DNA.
Researchers at the University of Copenhagen have mapped proteins secreted by adult human brown and white fat cells, revealing they send distinct signals to the rest of the body. Brown fat plays a key role in regulating the cellular immune system, while white fat promotes tissue plasticity.
A study of 3000 egg cells reveals that chromosome errors, which increase with age, can lead to infertility and chromosomal syndromes. As women age, the eggs' maturity and fertility decline, with younger girls experiencing more errors during maturation.
A study has identified key proteins in signaling pathways that control tumor growth in lung tissue, paving the way for personalized cancer treatment and new drug development. The research, published in Cell, also reveals new proteins activated by cancer mutations contributing to tumor growth.
The UN-appointed panel emphasizes the need for collective understanding of systems and their interactions to achieve global goals. While individual goals may counteract others, cross-disciplinary research can help address these challenges.
Researchers from the University of Copenhagen have made a groundbreaking discovery in understanding bacterial immune systems. The study reveals how bacteria activate their defence mechanisms against viruses and other attackers using COA molecules, which activate CSX1 protein complexes.
Researchers from the University of Copenhagen and Memorial Sloan Kettering Cancer Center have discovered six proteins essential for directing PRC2 to specific areas in the genome. These findings provide insight into how cells maintain their identity, normal embryonic development, and may impact cancer treatment.
Scientists have gained a better understanding of how movements are generated in the spinal cord, revealing that it's a large network of cells rather than a single command center. This finding may lead to advances in treating neurological disorders such as ALS and spinal cord injuries.
A study published in Molecular Biology and Evolution reveals that the Icelandic walrus went extinct shortly after Norse settlement around 870 AD, likely due to commercial hunting and ivory trade. The research used ancient DNA analyses and C14-dating to demonstrate the existence of a unique population of Icelandic walruses.
A large register study shows that refugee children with parents having PTSD are at a significantly higher risk of contact with the psychiatric system before turning 18. The researchers highlight the need for greater focus on this problem and early measures to support these vulnerable children.
Researchers found a significant correlation between financial challenges and early ageing, using data from 5500 middle-aged persons. The study suggests that poor finances can lead to premature ageing, with effects on physical capability and cognitive function.
Researchers extracted genetic info from a 1.77 million-year-old rhino tooth, revealing an almost complete set of proteins and expanding the possibilities of retrieving reliable genetic information from mammal fossils. This breakthrough could solve long-standing mysteries of ancient animal and human biology.
Researchers from the GLOBE Institute found that massive fluctuations in ocean oxygen levels during the Cambrian explosion were influenced by animal behavior. The discovery suggests that animals may have controlled their own development through adjustments to oxygen levels, shedding light on Earth's 'heartbeat' and its impact on life.
The Novo Nordisk Foundation has awarded EUR 93.5m to the University of Copenhagen's Center for Protein Research to map proteins in the human body and understand their function. This will enable the development of new drugs and improve diagnostics.
Researchers developed an app called MedBlockChain that uses blockchain technology to prescribe optimal medicine doses for individual patients. The app also detects counterfeit products, providing a safer and more efficient way to manage pharmaceuticals.
Researchers have invented an affordable solution to measure tremor in mice using a smartphone, potentially leading to new treatments. The method uses a cage with rubber bands and a mounted smartphone to detect vibrations, producing comparable results to expensive equipment.
Research from the University of Copenhagen found that remnant particle cholesterol in the blood is constantly increasing and often remains at a high level for life. Maintaining a normal body weight is key to reducing remnant cholesterol and triglycerides, according to experts.
Researchers from the University of Copenhagen have gained new insight into how sebaceous glands form and are maintained throughout life, shedding light on their role in skin development. The study reveals that a common cancer mutation affects normal cell behavior, leading to unchecked growth of the gland.
Researchers found that antibiotics can reduce the number of cancer cells and diminish cancer in patients with CTCL, a rare type of lymphoma. The study suggests that aggressive antibiotic treatment may inhibit not only the bacteria but also the cancer cells.
Researchers found that a specific carbohydrate attaches to a peptide hormone called atrial natriuretic peptide (ANP), regulating fluid balance and blood pressure. The study may lead to improved medications for high blood pressure.
Researchers found that morning exercise increases metabolic response in skeletal muscle, while evening exercise boosts energy expenditure for an extended period. The effects of exercise timing may differ due to the body's circadian clock.
A study published in Scientific Reports reveals that cats with diabetes have altered gut bacteria compositions compared to healthy cats. The researchers found reduced diversity of gut bacteria in diabetic cats, which aligns with human findings and challenges previous studies.
Researchers develop a new algorithm using over 230,000 patient records to predict mortality risk and survival chances. The algorithm uses disease history from the past 23 years to make more accurate predictions than existing methods.
A new study at the University of Copenhagen found that immature intestinal cells can develop into stem cells based on their surroundings. The discovery may lead to more effective stem cell therapy for non-healing wounds and tissue repair.
Researchers from University of Copenhagen identify genetic variant on chromosome 2 that increases the risk of fainting. The study analyzed data from over 400,000 individuals and found that women under 35 are more likely to faint due to this gene variant.
Researchers have mapped the structure of a chloride channel in muscle cells, providing new information on its regulation. The findings may lead to more efficient drug development for neuromuscular diseases such as ALS and SMA.
Researchers discovered how a specific TET2 gene mutation obstructs healthy blood cell maturation in mice. The study provides crucial knowledge to develop treatments for haematological disorders and targets the common mutation found in leukaemia patients.
Researchers from University of Copenhagen and EMBL found consistent changes in gut bacteria across seven countries, providing a universal signature for colorectal cancer. These microbiome changes may play a role in developing the cancer and could be used as biomarkers for diagnosis and therapeutic targets.
Researchers have discovered autoreactive cells in narcolepsy patients, providing new proof that the sleep disorder is an autoimmune disease. Autoreactivity was found not only in patients but also in healthy individuals, suggesting a trigger for the disease.
A new study reveals that the development of progenitor cells depends on protein quantity and interaction with other cells. Cells with high P120ctn expression remain in the central part of the pancreas, while those with low expression migrate to the peripheral area, where they acquire their final fate.
A comprehensive study found that women are diagnosed later than men for most diseases, with significant differences in patient care courses. The study analyzed data from 6.9 million Danish people and found an average difference of 4 years across 770 types of diseases.
A new study reveals a specific mechanism in human cells that delay propagation of DNA damage, giving cells a chance to stop piling up mutations. The discovery relies on precise timing and control inside the cells and identifies key molecular proteins involved in repairing DNA lesions.
The Proteomic Skin Atlas maps human skin molecules and functions, shedding light on skin diseases like psoriasis and eczema. Researchers hope to accelerate research and develop new treatments for the 3,000 known skin diseases.
A new study from the University of Copenhagen has identified a key mechanism behind the repair of human DNA damage, which can lead to cancer. The researchers have discovered a protein called BARD1 that acts like a 'scanner' to launch the flawless DNA repair system.
A new study suggests that impaired mitophagy, the process of removing defective mitochondria from brain cells, is a key contributor to Alzheimer's disease. By boosting mitophagy, researchers were able to slow down the accumulation of toxic proteins and reverse cognitive deficits in animal models.
The discovery of glucose-regulated protein GRP94 as a chaperone assisting proinsulin folding has significant implications for understanding insulin production. Removing GRP94 from beta cells impaired insulin secretion, suggesting its specialized function in maintaining cellular response to misfolded proinsulin.
Scientists have discovered two methods to mend DNA-protein crosslinks and established how DNA replication triggers these repair processes. The researchers hope their findings can be used to develop more efficient combination treatments for cancer cells.