A team of researchers from the University of Copenhagen has successfully completed a phase one clinical trial of their malaria vaccine, demonstrating its safety and ability to induce the desired antibody response in humans. The vaccine is now poised for further testing and potential use in vulnerable populations.
A new study of 25,000 Danes reveals that cholesterol levels are 20% higher after the Christmas break, increasing the risk of high cholesterol by six times. The research suggests that festive food may contribute to elevated cholesterol readings, highlighting the importance of monitoring cholesterol levels during the holiday season.
A new study by researchers from the University of Copenhagen reveals that glial cells play a crucial role in the development of Huntington's disease. The study found that glial cell maturation is severely impaired in patients with the disease, leading to behavioral and motor changes.
Researchers from the University of Copenhagen found that folate deficiency creates far more damaging chromosomal abnormalities than previously known. This can lead to problems with cell division and DNA replication, increasing the risk of diseases like infertility, mental health disorders and cancer.
A team of researchers has created a computer model using cancer patient data to predict the course of disease for prostate cancer. The model, currently being implemented at a clinic in Germany, can identify key mutations that trigger the disease.
Researchers have developed a deeper understanding of the CRISPR-Cas12a mechanism, enabling fine-tuning of the gene-editing process. By mapping the molecular structure and sequence of events, scientists can optimize the technology to achieve desired effects while minimizing side effects.
A new study published in Obesity found that children and adolescents with common obesity gene variants can still lose weight through lifestyle interventions. The researchers examined 754 participants, aged 11.6 years, who underwent a series of behavioral lifestyle changes, including dietary changes, physical activity, and sleep habits....
The LEO Foundation Skin Immunology Research Center will bring together leading researchers to provide new knowledge for better diagnoses and treatments of psoriasis and eczema. The center aims to strengthen the immune system's fight against over 3,000 known skin diseases.
Research suggests that reducing nitrogen dioxide pollution in Copenhagen could increase average lifespan by an entire year and lead to improved quality of life. The study found that by 2040, the number of men suffering from cardiovascular diseases could be reduced by 680 per 100,000 men.
Researchers found that a low-gluten, fibre-rich diet changes the community of gut bacteria and decreases gastrointestinal discomfort such as bloating. The study suggests that dietary fibres, not the absence of gluten alone, are the primary cause of these changes.
A new study conducted by researchers at the University of Copenhagen has shown that faeces transplantation can significantly reduce the incidence of necrotizing enterocolitis (NEC) in pigs born prematurely. The treatment involves transferring faeces from healthy donor pigs to the rectal opening, resulting in a 75% decrease in NEC cases...
Researchers found a link between colectomy and increased risk of developing type 2 diabetes. The study, analyzing data from over 46,000 patients, suggests the colon plays a crucial role in regulating blood sugar levels.
Researchers at the University of Copenhagen have developed a new treatment that stimulates the body's cold and nicotinic receptors to improve metabolism, suppress appetite, and promote weight loss. The treatment, tested on mice, results in a 12% weight loss over 20 days.
Researchers found that antibiotics can almost completely eradicate gut bacteria in healthy adults, but most species recover over time. However, a significant portion of beneficial bacteria remain missing, and the diversity of the gut ecosystem is diluted.
Researchers from the University of Copenhagen have developed a new vaccine for hay fever that targets specific sugar molecules to improve vaccination efficacy. The vaccine has been tested on mice and in vitro tests, showing potential for increased effectiveness and reduced treatment time.
A new study finds that injecting insulin into the rectum can effectively treat chronic bowel inflammation in humans like Colitis Ulcerosa. The treatment strengthens bowel cells' own defence, reducing inflammation and improving symptoms such as weight loss and bloody diarrhoea.
A new study reveals METTL13's role in controlling protein formation and preventing serious disorders like cancer and Alzheimer's. The researchers' breakthrough could lead to the development of targeted methods and drugs to ensure the enzyme functions correctly.
The Center's new grant will accelerate research on mechanisms involved in metabolic health and disease, aiming to develop new prevention and treatment strategies. The funding will also enable the establishment of technology platforms to empower scientists to conduct cutting-edge research.
Researchers studied pancreas duct formation in mice and found that the network resembles road networks, with stronger ducts expanding and weaker ones shrinking. This study may lead to better understanding and treatment of cystic fibrosis and other diseases involving abnormal duct formation.
A new study published in the Journal of Clinical Investigation - Insight found that cardio exercise increases the production of the hormone FGF21, which has positive effects on metabolism. In contrast, strength training with weights had no significant impact on this hormone or another muscle-building hormone called FGF19.
Researchers develop technique SCAR-seq to study epigenetic cellular memory transmission and find key protein MCM2. They discovered a controlled process in DNA replication ensuring symmetry between two new DNA strands.
Researchers at the University of Copenhagen have developed a new method to diagnose cancer at its early stages using a malaria protein. The method retrieves individual cancer cells from blood samples, catching them in greater numbers than existing methods, allowing for earlier detection and improved treatment outcomes.
Researchers have created a comprehensive library of sugar structures using genetically engineered cells and CRISPR/Cas9 gene scissors. This tool allows for the examination of specific sulfation patterns and GAG modifications, holding promise for drug development and disease research.
Researchers discovered a new lead compound that could improve existing treatments for cancer, diabetes and obesity. The study identified the HDAC11 enzyme as a crucial target for developing new drugs.
A large international study has identified 41 genes that increase the risk of developing hay fever, including 20 new to science. The study found a significant overlap between risk genes for hay fever and autoimmune diseases, suggesting a common underlying mechanism.
Researchers found over 70% of implants colonized by bacteria, fungi, or both, without causing infections. The discovery opens up a new field of understanding the interplay between the body and microbiomes.
Researchers have identified TLK2 enzyme as a key player in several diseases, including breast cancer and intellectual disability. The study suggests that inhibiting the enzyme may be an effective therapy approach.
A new study found a hitherto unknown error in the transport of glutamine between astrocytes and neurons in mice with Huntington's disease. The researchers believe this area holds potential for developing a future treatment.
A new study examines the effect of HPV vaccine on a population level, finding a significant reduction in severe dysplasia. The vaccine has been shown to work effectively in reducing cervical cancer risk, with a 40% lower incidence rate compared to unvaccinated women.
Researchers at the University of Copenhagen have discovered a new mechanism for transporting water to the brain, challenging the long-held belief that osmosis is responsible. The co-transporter process could potentially be targeted with medicine to treat conditions like brain haemorrhage and hydrocephalus.
Researchers found that cardiolipin production in brown fat cells increases calorie-burning and improves insulin sensitivity. Low levels of cardiolipin are linked to obesity and type 2 diabetes.
Researchers discover that people with monogenic obesity can lose weight with liraglutide, a modified form of GLP-1 hormone. The medicine has a positive effect on reducing hunger and body weight, even for those who respond poorly to existing treatments.
A new study from the University of Copenhagen found that foetuses with balanced chromosomal aberrations have a higher risk of developing brain disorders such as autism and mental retardation than previously thought. The risk is 20% for these foetuses according to the study.
Researchers discovered that a person's risk of developing type 2 diabetes can be predicted based on their partner's BMI. The study, published in Diabetologia, found that women have a heightened risk due to their husband's BMI, regardless of the woman's own weight.
Researchers have identified over 100 potential new targets for cancer treatment using state-of-the-art mass spectrometry technology, which could lead to the development of personalized medicine and targeted therapies.
Researchers found that mice lacking NAMPT in fat tissue gained no weight on high-fat diet and maintained better blood glucose control compared to normal mice. This study challenges the general view of NAMPT as an enzyme that should be boosted, and may pave the way for new treatments for obesity and metabolic disease.
Researchers discover a new protein called ZUFSP that plays a key role in maintaining genetic stability, which is crucial for preventing cancer and other diseases. The study highlights the potential of ZUFSP as a target for drug development, particularly in treating cancer.
A study by researchers at the University of Copenhagen has confirmed a connection between the circadian rhythm and aggression in Alzheimer's patients. The team identified a circuit linking the brain's circadian clock to an aggression centre, suggesting a potential target for pharmacological intervention. This discovery may lead to new ...
Researchers found that fat cells from obese patients with type 2 diabetes were epigenetically reprogrammed after exposure to palmitate and TNF-alpha. Healthy precursor fat cells also exhibited reprogramming after 24 hours of exposure, suggesting a potential link between diet and metabolic health.
Researchers at the University of Copenhagen have identified a new protein shield called Shieldin that helps repair damaged DNA and affects resistance to PARP inhibitor drugs used for breast cancer treatment. This discovery may contribute to making decisions for treating cancer patients and understanding mechanisms of resistance.
Research found that a genetic variation in FGF21 is associated with lower body fat percentage and increased blood pressure. The study of over 450,000 individuals suggests that people with this genetic predisposition tend to consume more sugar than others.
Research from the University of Copenhagen found a U-shaped relationship between HDL cholesterol levels and risk of infectious diseases. Individuals with both very low and very high HDL cholesterol had high risks of hospitalization and death from infectious diseases, including gastroenteritis and pneumonia.
Researchers discover protein CEP128 regulates critical cellular processes, including heart development, and its inactivity causes severe malformations in zebrafish. Human cells also show similar effect, providing potential insights into treatments for birth defects and diseases.
Researchers at University of Copenhagen develop edible QR code technology that enables precise dosing and storage of medical data, reducing wrong medication and fake medicine. The technology has the potential to transform the pharmaceutical supply chain and enable innovative production of personalized medicine.
Researchers identified midbrain 'start neurons' that control locomotion speed and context-dependent behaviors. The study uses optogenetics to activate specific neuronal groups, revealing the complex role of the Cuneiform Nucleus and pedunculopontine nucleus in controlling locomotor movements.
Researchers have identified a specific gene, ADCY3, that predisposes Greenlanders to obesity and diabetes when it is inactive. The study, published in Nature Genetics, found that 4.4% of test subjects had the gene inactive, leading to significant weight gain and increased risk of diabetes.
Researchers have discovered a way to prevent the Ebola virus from spreading by inhibiting a specific enzyme that allows it to copy itself. By blocking this enzyme, the virus's ability to produce more infection is reduced, suggesting potential breakthrough in treatment.
Researchers mapped genetic mutations in GPCRs and found that 3% of population have receptors with altered drug effects. The study estimates an economic burden of at least 14 million pounds annually on the UK National Health Service.
Researchers from the University of Copenhagen developed a new vaccine technique that can fight HER2-positive breast cancer in mice with a 50-100% prevention rate. The vaccine works by inducing large amounts of antibodies targeted at cancer cells, preventing tumors from developing and slowing down cancer progression.
A new study from the University of Copenhagen reveals that a garlic compound can destroy important components in bacteria's communication systems, which involve regulatory RNA molecules. This discovery has led to further development of a potential treatment for patients with cystic fibrosis and other chronic infections.