A new study found that COVID-19 lockdowns led to a dramatic increase in fires within globally-important protected areas in Madagascar, with excess fires rising by 76-248%. The team used decades of past data to estimate the impact of the pandemic on fire patterns.
Researchers developed a genetic-risk score to identify women most at risk for gestational and postpartum diabetes. Intensive lifestyle intervention reduced their risk, but only benefited those with the highest genetic risk.
A study at the University of Helsinki found that a strong saline solution can quadruple morphine concentration in the spinal cord, intensifying pain relief. The glymphatic system enables faster drug delivery when administered with hypertonic solutions.
A recent study found that a single course of antibiotics disrupts the balance of gut bacteria and fungi in infants, leading to increased competition for space. This disruption can result in long-term adverse effects on human health, including antibiotic-associated diarrhea and chronic inflammatory diseases.
The Uralic language family's history is reevaluated, with research suggesting the languages' westward spread began in western Siberia during the early Metal Age. The dispersal of the family is linked to three episodes: a natural environment shift, cross-cultural archaeological phenomena, and contact with Indo-Iranian languages.
A study by University of Helsinki researchers suggests that some Stone Age ornaments were deliberately fragmented as part of social relations, bartering, or ritual activities. The analysis of geochemical composition and use traces revealed fragments from the same ornament found in different locations, indicating they were worn by two i...
The pandemic significantly increased study burnout among university students, with engagement in studies dropping to its lowest level in late 2020. The conflict between demands and resources was a central factor, while basic psychological needs such as autonomy, relatedness, and competence played a crucial role in student wellbeing.
Researchers discovered that lipid droplets play a crucial role in mitochondrial recycling, and impairing DGAT1 activity leads to reduced recycling and increased cell stress. The study provides new insights into iron homeostasis and its impact on cellular metabolism.
A study at the University of Helsinki found that in utero exposure to mother's antiepileptic or antidepressant medication can lead to widespread changes in cortical networks, affecting local and global brain function. This may have implications for infants' neuropsychological development and future research on environmental factors.
A University of Helsinki research team used holographic duality to model early universe phase transitions and their potential impact on gravitational wave signals. The study, published in Physical Review Letters, suggests that such collisions could create powerful ripples in spacetime detectable by satellite missions like LISA.
A study found that small genetic variations impact an organism's ability to utilize energy from various nutrients. Researchers identified several genes contributing to sugar tolerance in fruit flies, which are also present in humans and linked to obesity and type 2 diabetes.
A study by University of Helsinki researchers found that the immune system attacks itself in rare type of blood cancer. The immune system plays a role in the development and growth of cancer cells, making current therapies less effective.
Finnish researchers created a comprehensive map of molecular interactions between 58 human receptor tyrosine kinases (RTKs), revealing key insights into their functions and roles in disease. The study's findings can aid understanding of diseases linked to abnormal RTK activity, particularly cancer.
A new study provides strong evidence that periodic volcanic activity in the Karoo province triggered multiple Jurassic extinctions. The research reveals that volcanism occurred over a longer period than previously thought, with three distinct stages of activity, and had a significant impact on the environment.
Neural speech processing matures significantly in infancy, but certain abilities like sound discrimination still develop. A study found that children from birth to 2.5 years show varying levels of maturation in auditory skills essential for language learning.
A study published in Nature Communications found that male Caspian terns carry the main responsibility for teaching young birds the secrets of migration during their first journey. Young birds always remained close to an adult bird and died if they lost contact, highlighting the importance of experienced adults guiding them to survive.
Scientists have identified diagnostic features of circulating tumour DNA (ctDNA) in blood samples, which can predict treatment response and patient outcome in aggressive lymphoma. The study reveals significant heterogeneity among patients, with high ctDNA levels associated with poorer survival rates.
Scientists have successfully produced fully functional pancreatic beta cells from stem cells for the first time, offering a breakthrough in treating type 1 diabetes. The study's findings demonstrate that these stem cell-derived beta cells can regulate insulin secretion and manage glucose metabolism in both cell cultures and mice studies.
A study using machine learning identifies climatic thresholds driving vegetation distribution, highlighting the importance of extreme climate conditions for savannas and deciduous forests. The findings provide valuable insights for improving process-based vegetation models and their coupling with Earth System Models.
A study of Finnish agility dogs reveals differences in training and competing between dog sizes and skill categories. Most dogs trained for under 20 minutes per week, but those at the highest level trained less to maintain their skills.
Researchers at the University of Helsinki found that a cellular stress state predicts a poor chemotherapy response in ovarian cancer patients. High-stress tumours with an inflammatory microenvironment may resist chemotherapy, making combination therapies a potential solution.
A study of 850 competing dogs found that most injuries were related to obstacle performance, particularly bar jump and tunnel obstacles. Many dogs experienced soft tissue injuries, lameness, and pain, but could recover in a few weeks.
A new study from the University of Helsinki found that providing individuals with their personal genetic risk for cardiovascular disease motivates them to take better care of their health. The interactive web-tool KardioKompassi helped participants understand their risk and make lifestyle changes.
A research group at the University of Helsinki has discovered the logic controlling gene regulation in human cells. They found that individual transcription factors contribute to gene regulation in an additive manner and identified regulatory elements that function within closed chromatin regions.
A new study found that Amazonian forests are impacted by high maximum temperatures, causing tall trees to shed their leaves and branches. The study, led by the University of Helsinki, used LiDAR to track the effects of fragmentation and climate change on plant phenology.
Scientists at University of Helsinki found that older mitochondria determine cell fate, controlling daughter cell differentiation and self-renewal. Studying cellular respiration, researchers identified key metabolic changes influencing stem cell identity.
Researchers at the University of Helsinki discovered that tumour cells in ovarian cancer hide from the body's immune system by interacting with specific gene mutations. Tumours with BRCA1/2 mutations are more effectively targeted by killer T-cells, leading to better patient outcomes.
A Finnish twin study found that individuals with lower education are more susceptible to the negative effects of cardiovascular risk factors on late-life cognition. The study suggests that higher education can act as a cognitive reserve, helping to mitigate dementia risk.
A comprehensive study has revealed over 7,000 human transcription factor (TF) protein-protein interactions, with most playing important roles in transcriptional regulation. The study identifies groups of TFs with specific biological functions, such as chromatin remodelling and RNA splicing.
Researchers discovered that deficient mitophagy leads to human disease and developed a method to analyze mitochondrial recycling in diseased muscle. Pharmacological activation of mitophagy reversed the progression of mitochondrial muscle disease, offering potential treatment for this condition.
A groundbreaking genome-wide association study identified 123 genetic regions linked to migraine risk, including two specific genes targeted by recently developed drugs. The study provides insight into the biological basis of migraine and its subtypes, paving the way for new treatments.
A study at the University of Helsinki identified a link between early sexual maturation and improved aerobic performance in juvenile salmon. Genetic variations associated with early maturity were found to enhance basal metabolism and energy production, leading to better overall performance.
Research provides first direct evidence of volatilization of control rods during the FDNichi meltdowns, suggesting that boron remains in the fuel debris. This could limit fission reactions, but extensive follow-up studies are needed to characterize boron species across debris fragments.
A new study by University of Helsinki researchers shows that boreal forests can mitigate climate change through aerosol formation and growth, influencing cloud properties and regional climate. The study found that aerosol particles produced by the forests alter cloud reflectivity, potentially cooling the climate.
Researchers at University of Helsinki have developed a faster and more reliable method for converting adult skin cells into pluripotent stem cells, known as induced pluripotent stem cells (iPS). The new technique uses CRISPRa gene-editing and produces high-quality iPS cells with improved accuracy and reliability.
A recent review highlights the devastating impact of permafrost thaw on infrastructure in the Arctic region, with damages ranging from less than 10% to as high as 80%. The region's transport and pipeline networks are particularly vulnerable, with costs projected to exceed 30 billion euros by 2060.
Researchers at the University of Helsinki and VTT Technical Research Centre of Finland have developed a biotechnology-based solution to produce ovalbumin, a key protein in egg white powder. The fungus-produced ovalbumin reduces greenhouse gas emissions and land use by up to 72% compared to traditional chicken-based production.
A study at the University of Helsinki found that the APOE4 allele may increase cerebral microhaemorrhages and mental fatigue in COVID-19 patients. The risk of developing severe COVID-19 more than doubled in carriers of this allele.
A research team identified a general macroecological mechanism that challenges global conservation strategies, finding that remote fish communities are vulnerable to coral loss and other ecological dependencies
Researchers discovered a new simple mechanism of tooth class transformation in vertebrate lizards, affecting teeth size and attachment type. The EDA gene mutation led to significant changes in dental features, shedding light on tooth development in non-mammalian lineages.
The University of Helsinki is leading a three-year €3.5 million funded project FOODNUTRI to promote digitalisation and green transition in Finland's food system. The project will develop innovative solutions for sustainable food production, processing, and consumption.
A meta-analysis of trials on digital interventions for depression found that computer- and smartphone-based treatments are effective but require human support to achieve outcomes similar to face-to-face therapy. The study also highlights the potential role of AI and wearable devices in preventing mental illness.
Researchers at University of Helsinki have developed a new method to speed up calculations on quantum computers, reducing the number of measurements required and increasing efficiency. This breakthrough could lead to faster and more sustainable quantum computing.
Researchers at the University of Helsinki have developed a method to precisely and rapidly correct genetic alterations in cultured patient cells. The new technique combines two Nobel Prize-winning approaches to produce genetically corrected autologous pluripotent stem cells, paving the way for potential therapeutic applications.
Researchers at the University of Helsinki and Aalto University have developed a gel-grown mini-breast cancer model that can effectively treat hormone-dependent breast cancers. The discovery opens new avenues for hormonal therapies, individual drug responses, and drug resistance mechanisms.
A study by Katariina Koivusaari found that high cow's milk consumption is associated with a higher risk of developing preclinical type 1 diabetes in genetically predisposed children. The study also linked high-temperature treated infant formula to an increased risk of asthma in children.
Researchers studied 4022 dogs fed different diets as puppies to see if it affected allergy and atopy related skin symptoms in adulthood. They found that puppies fed raw tripe, organ meats, and human meal leftovers had fewer allergies and skin issues.
The Lef1 gene is found to suppress the development and growth of colorectal cancer by restricting cancer stem cell niches. Blocking this gene leads to increased tumor stem cell niches and accelerated tumor growth.
A functional precision medicine study demonstrates that treatment selection based on results from drug sensitivity testing can be clinically useful in patients with aggressive hematological cancer. The approach combines deep molecular profiling with comprehensive drug sensitivity testing to advance the therapy decision-making system.
A major Finnish–Norwegian study found that obesity does not lower the risk of subarachnoid haemorrhage, as smoking habits are a significant factor in the condition. The study analyzed over 200,000 individuals and comprehensively considered confounding factors.