Researchers have discovered a new class of compounds that kill adult and egg stages of the human whipworm, a parasite infecting 500 million people. These compounds could lead to effective treatments and vaccines for whipworm infections, which cause physical and mental damage.
A review of worldwide studies found that high-dose B-vitamins significantly reduce schizophrenia symptoms. The research suggests that B vitamins are most beneficial when implemented early on and used with higher dosages or combined several vitamins.
Researchers have discovered that an important chemical bonding principle, inverse-trans-influence (ITI), operates in metal complexes across the periodic table, including lanthanides and actinides. The finding has potential implications for waste clean-up and treatment of cancerous tumors.
A recent study found that disabling the Golgi apparatus, a protein regulation part in brain cells, causes developmental delay, severe ataxia, and postnatal death in mice. This suggests a potential link to neurodegenerative diseases such as Alzheimer's and Parkinson's.
A recent study revealed that climate change is expected to disrupt the balance of nutrients in mountain ecosystems, potentially leading to changes in plant growth and biodiversity. The research found that decreasing elevation can serve as a surrogate indicator for climate warming, leading to increased nitrogen availability in soil.
Researchers at The University of Manchester developed a braiding technique to create tighter and more complex molecular knots, leading to potential breakthroughs in material strength and elasticity. This achievement has the possibility of generating new types of materials, such as lighter and more flexible polymers.
Researchers at The University of Manchester have made a major step forward in nuclear waste recycling technologies by describing the electronic structure of uranium nitride compounds. A family of 15 complexes was synthesized, and advanced techniques were used to gain insight into their electronic states. This research has the potential...
Researchers developed a model to forecast volcanic eruption impacts, analyzing past Mount Etna's eruption. This will help civil defence agencies prepare for potential UK threats.
Cancer Research UK is investing £39 million over five years into the Manchester Centre, focusing on translational research and training the next generation of cancer researchers. This funding will support innovative approaches to treating cancer, including radiotherapy and personalised medicine, with the aim of improving patient outcomes.
A University of Manchester study of 2,000 UK doctors found no link between performance-related pay and GP job satisfaction. Despite concerns over its impact on morale, the study suggests that dropping performance-related pay may not increase satisfaction.
Researchers at the University of Manchester have discovered a potential new drug that reduces brain cell death and promotes neurogenesis after a stroke. The drug, interleukin-1 receptor antagonist (IL-1Ra), is already licensed for use in humans for other conditions and has shown promise in early clinical trials.
A team of scientists has completed research into radioactively contaminated material to gain further understanding around safely decommissioning nuclear facilities. The study identified the specific location of radioactive isotopes in a concrete core, which could lead to more efficient decontamination and cost savings.
The UK government has invested a further £12.5 million in Greater Manchester's devolved health system to expand pioneering clinical research across three NHS sites. This new award will enable the expansion of existing clinical research capacity and make research more accessible to people of all ages and backgrounds.
A new study warns that the UK's fungal asthma problem is much worse than previously thought, with an estimated 300,000 adult cases. Invasive fungal infections, such as invasive aspergillosis and Candida bloodstream infections, are common and often fatal if left untreated.
Researchers at the University of Manchester have identified two gene mutations that trigger a rare retinal disease causing blindness in males. These findings offer promising insights into the development of gene therapy and potential treatments for X-linked Retinoschisis, a genetic disease leading to macular degeneration.
Researchers at The University of Manchester have discovered a potential therapy for alleviating chronic pain by tuning the brain's frequency. This new approach uses visual and auditory stimulation to reduce pain intensity in patients.
Researchers found no significant increase in mortality rates over weekends when severity is accounted for. A higher proportion of patients admitted by ambulance had more severe conditions, contradicting previous studies that showed a 'weekend effect'.
A new study from the University of Manchester explains the process of post-breastfeeding tissue remodeling, discovering that milk-producing cells are transformed into cannibalistic cell-eaters. The study found a key role for the protein Rac1 in this cellular switch, which helps reshape the breast back to its normal state after weaning.
A University of Manchester study found that people with bipolar disorder are 2.63 times more likely to have experienced emotional, physical, or sexual abuse as children compared to the general population. This strong link has implications for treatment and personalized therapy plans.
Researchers at the University of Manchester developed a universally applicable method to assess senescence across biomedicine. The new biomarker provides unprecedented advantages over existing products, being sensitive, specific, and easy-to-use.
Researchers at the University of Manchester have developed a method to create artificial capillaries with atomic-scale precision, opening up new avenues for filtration, desalination, and gas separation. The technology uses graphene as a template to produce ultra-thin cavities with tailored properties.
A mass participation study involving over 9000 UK participants found a correlation between sunny days, rainfall, and pain levels. The study suggests that understanding how weather influences pain could lead to new treatments.
Research from University of Manchester shows link between extended GP hours and fewer A&E visits, but cost savings may not outweigh benefits.
A new study challenges the traditional efficacy trial model by using real-world patients and GP practices to test COPD treatments. The Salford Lung Study found that a once-daily treatment regimen was associated with lower rates of exacerbations without increased risk of serious adverse events.
A strong correlation has been found between parental psychiatric disorder and the increased risk of suicide attempts and violent behavior in their children. The study, published in JAMA Psychiatry, reveals that risks for offspring suicide attempt and violent offending were raised across almost all parental psychiatric disorders.
Two newer antiepileptic drugs, levetiracetam and topiramate, show no discernible impact on childhood intellectual development. However, valproate is linked to a lower IQ in children whose mothers took high doses during pregnancy.
A single mutated gene, SNORD118, has been found to cause leukoencephalopathy with calcification and cysts (LCC), a progressive white matter degeneration in the brain. This discovery opens up possibilities for genetic testing and future treatments.
Researchers discovered that the shape and dimensions of graphene nano-bubbles provide information on its elastic strength and interaction with substrates. The balloons can be created intentionally to make tiny pressure machines capable of withstanding enormous pressures.
Research identifies three pathways where sleep problems contribute to suicidal thoughts and behaviors, including heightened risks at night and prolonged failure to achieve good sleep. The study emphasizes the need for nighttime service provision and restored healthy sleep in relation to coping with mental health problems.
Researchers at the University of Manchester have discovered a new test that can detect cancerous cells in the blood, offering a promising breakthrough in diagnosing and treating childhood leukemia. The test uses special structures called extracellular vesicles that are released by cancer cells and can be traced in the blood.
A new study has found that GPs lack knowledge and confidence in dealing with parents who have lost a child to suicide, leading to feelings of isolation and stigma. The research highlights the need for training and support for primary care practitioners to better respond to these vulnerable families.
Research from University of Manchester found that aerobic exercise training can significantly improve patients' brain functioning and reduce cognitive deficits associated with schizophrenia. The study showed that exercise programs combined with medication led to better outcomes in areas such as social understanding, attention spans, an...
Researchers have successfully treated an experimental model of Alzheimer's disease with mefenamic acid, a commonly used anti-inflammatory drug. The study found complete reversal of memory loss and brain inflammation in mice, paving the way for human trials.
A study identified two genetic variants associated with an increased risk of radiotherapy side-effects in prostate cancer patients, including rectal bleeding and urinary frequency. The findings suggest that these variants are located in genes expressed in tissues exposed to radiation.
A new study from the University of Manchester found that suicide deaths by mental health patients are lower at the weekends, contradicting previous government claims. The study analysed 5,613 suicide deaths between 2001 and 2013 and found a reduced risk in all groups, including those admitted at the weekend.
A molecule believed to indicate good cancer prognosis has been shown to cause genomic instability and promote tumor growth. The study, published in Nature Cell Biology, suggests that targeting p21 could lead to new cancer treatments.
A new study found that community pharmacy staff deviate from standard procedures to provide tailored patient care, citing high workload and conflicting pressures. The research highlights the tension between standardizing practice and delivering effective patient care.
Researchers at the University of Manchester have developed a composite material that combines graphene with natural rubber and polyurethane, resulting in increased strength and elasticity by up to 50%. The added graphene enhances the materials' ability to stretch and withstand force without breaking.
Researchers have identified a new connection between inflammatory signals and cell division, revealing how cells adapt to environmental changes. The discovery sheds light on the underlying mechanisms of diseases such as Crohn's disease and cancer.
Researchers at the University of Manchester have devised a method to selectively deliver drugs to a pregnant woman's placenta without harming the foetus. This breakthrough could help prevent some premature births and treat conditions such as pre-eclampsia by improving placental function and benefiting the growing baby.
Scientists have developed a technique using optogenetics to suppress nervous system activity in genetically-altered fruit fly embryos, showing promise in preventing the onset of epilepsy symptoms when treated early enough.
A new study from the University of Manchester found that children treated with growth hormone for deficiency show varying rates of growth depending on their latitude and summer daylight exposure. The study of 118 children aged 5-11 from 14 countries suggests a complex relationship between sunlight, genetics, and bone growth.
Researchers have successfully implemented time-of-flight PET scanning technology, reducing the radiation dose for cancer patients and staff by up to 30%. This has allowed an additional 100 scans per year at Central Manchester University Hospitals.
Scientists at the University of Manchester have shown that the number of opiate receptors in the brain increases to combat severe pain in arthritis sufferers. By applying heat, they found a correlation between higher receptor numbers and increased ability to withstand pain.
Researchers have demonstrated the relative safety and effectiveness of eltrombopag in children with persistent immune thrombocytopenia (ITP). The treatment stabilizes platelet counts, enabling children to participate in social activities without frequent nose bleeds.
Researchers at the University of Manchester and Nottingham are developing a gel that mimics human breast tissue, enabling the growth of breast cell models in the lab. This will help understand the influence of the breast matrix on breast cancer progression, potentially leading to new approaches to prevention and treatment.
A UK-based study has found that babies born underweight or overweight are more likely to experience hearing and vision problems in adulthood. Better childhood growth, as measured by adult height, is associated with improved sensory function, highlighting the importance of prenatal care.
Researchers have identified a potential new way to predict which patients with head and neck cancer may benefit most from chemotherapy. The use of dynamic contrast-enhanced MRI scans has shown that tumour blood flow can predict response to treatment, with patients having high blood flow more likely to respond.
Researchers at the University of Manchester have discovered a potential new approach to overcome hormone therapy resistance in ER+ breast cancer by targeting breast cancer stem cells driven by NOTCH4. This approach shows promise in improving treatment outcomes for patients with hormone therapy-resistant breast cancer.
Researchers used ex-vivo lung perfusion (EVLP) to recondition poorly functioning lungs, removing donor white blood cells and reducing the risk of acute rejection. This technique can increase access to transplantation and shorten waiting list times.