A blood test identified patients with advanced colorectal cancer who could benefit from a more intensive chemotherapy regimen, reducing hair loss and other side effects. The study found that patients with higher counts of circulating tumour cells in their blood responded better to treatment.
Scientists found small square crystals of ice at room temperature in a transparent nanoscale capillary made from graphene, which allowed them to see individual water molecules. The researchers used computer simulations to find that thin layers of water can form square ice independently of the material's chemical makeup.
A pilot study in six primary schools in Panama City found a marked improvement in children's behavior after parents received a parenting intervention. The intervention, based on the Triple P method, addressed issues such as encouraging good behavior and reasons for disobedience, resulting in improved parent-child relationships.
A new report by the University of Manchester found that inadequate staffing and protocols contribute to suicidal deaths among mentally ill patients under observation. The study suggests that more experienced staff and improved observational practices are needed to reduce such incidents.
Scientists at the University of Manchester have created an enhanced surface for silicone breast implants that mimics the body's own skin cells. This new surface reduces foreign body reactions and may help lower the risk of capsular contracture, a common complication after breast implant surgery. The study suggests that this biomimetic ...
Scientists at the University of Manchester discovered that inflammation in the brain causes and worsens damage after a stroke, contradicting previous theories. The study found that inflammasomes such as NLRP3 are not involved in brain injury caused by stroke, but rather NLRC4 and AIM2 inflammasomes contribute to this damage.
A study published in Patient Education and Counseling journal found that the title and font of participant information sheets can significantly influence pregnant women's perceptions of written information. Pregnant women perceived a program as less complex and easier to understand when presented with an easy-to-read font, while traine...
A recent study published in Nature journal Scientific Reports found that the Asian monsoon played a crucial role in the evolution of African mole rats and bamboo rats. The researchers discovered that changes in monsoon strength over 24 million years influenced the rodents' teeth, head shape, and digging behavior.
New research from the University of Manchester finds that people who lose their jobs experience a decade-long decrease in trust, even after finding new employment. This phenomenon is due to the traumatic effect of redundancy on an individual's outlook and can have significant implications for society as a whole.
A new study reveals that patients' perceptions of GP safety are crucial to reaching successful diagnosis and treatment. The research found that trust issues, alienation, and impersonal processes can lead to problems in improving patient safety within GP services.
A recent study has explored the effect of mutations in PKC on tumour growth, revealing that most 'loss of function' mutations stop PKC from working. The study found that correcting these mutations in bowel cancer cells resulted in a reduction in tumour growth.
A £10 billion pay-for-performance incentive scheme for GPs had no effect on reducing premature deaths in England, according to a study published in the British Medical Journal. The researchers analyzed data from 2007 to 2012 and found that GP performance indicators did not correlate with lower mortality rates.
Researchers at the University of Manchester developed a protocol to grow and transform embryonic stem cells into cartilage cells, which could be used to treat osteoarthritis. The study showed that cartilage formed from embryonic stem cells was partially repaired in rats and demonstrated healthy, functional tissue after 12 weeks.
Researchers at the University of Manchester and DSM have developed a single-step method for producing pravastatin, a widely used cholesterol-lowering drug. This breakthrough reduces the cost and complexity of statin production through reprogramming of the Penicillium chrysogenum fungus.
Researchers have created a new method to monitor the effect of anti-cancer drugs on rare leukaemia stem cells, enabling personalized treatment and potential cure. The approach involves testing small samples of cells with a novel technology platform.
Researchers at the University of Manchester have discovered that graphene oxide can selectively target and neutralize cancer stem cells (CSCs), which are responsible for cancer spread and recurrence. The study suggests that graphene oxide could be used as a non-toxic anti-cancer agent in combination with existing treatments.
A new species of Ichthyosaurus has been identified in a British marine reptile fossil, shedding light on the diversity of ichthyosaurs during the early Jurassic period. The discovery was made possible by advances in analysis and comparison with other groups of reptiles.
A new study found that healthcare workers are 4.5 times more likely to suffer from irritant contact dermatitis after increased hand washing efforts, highlighting a potential counter-productive effect on infection reduction campaigns.
Researchers at the University of Manchester developed heat-activated liposomes with antibody targeting capabilities, showing improved drug delivery to tumour tissue in mice. The combination approach resulted in a moderate improvement in animal survival, offering potential for novel targeted drug delivery strategies.
Researchers discovered that the heart of bluefin tuna adjusts its electrical activity and calcium cycling to maintain constant heartbeat despite temperature changes. This unique adaptation allows the fish to survive in cold waters, shedding light on how animals react to rapid environmental shifts.
A recent study has identified a gene that increases the risk of developing psoriatic arthritis, a condition where patients often experience both skin psoriasis and joint pain. The researchers found genetic changes that distinguish PsA from its counterpart psoriasis.
Research by the University of Manchester's National Confidential Inquiry into Suicide and Homicide by People with Mental Illness found that high staff turnover and complaints were associated with higher patient suicide rates. The study suggests that mental health services should closely monitor these factors to ensure patient safety.
Researchers at the University of Manchester have identified a possible cause of IVF failure in some women, which may be treated with therapies targeting microRNA-145 and its effects on IGF1R. The study's findings suggest that manipulating this biological process could lead to improved rates of embryo attachment during implantation.
Researchers at University of Manchester and University of Sheffield create see-through and efficient electronic devices using graphene and related materials. The new technology enables the creation of light-emitting devices that are incredibly thin, flexible, durable, and semi-transparent.
A new study published in Archives of Sexual Behavior found that more than half of men and almost a third of women over 70 reported they were still sexually active. The research also highlights the diversity of late-life sexualities and emphasizes the importance of discussing sexual health with older people.
Researchers have discovered a way to eradicate cancer stem cells using antibiotics, opening up the possibility of a new treatment for cancer. The study found that four types of antibiotics eradicated cancer stem cells in every test, including glioblastoma and other aggressive forms of cancer.
A study of 198,247 opioid users in England found that they were six times more likely to die prematurely than the general population. The risk of death increased with age, with older users facing a staggering increase in homicide rates.
Researchers at the University of Manchester and University of Bari have created a biosensor that can differentiate between mirror image smells. The system uses odorant binding proteins to detect unique chemical changes, approaching human nose detection limits.
Scientists from the University of Manchester discovered that ATF2 protein suppresses tumour growth in liver cancer models. The study suggests that ATF2's tumor-suppressing function may be more widespread than previously thought.
A new tool assesses radiotherapy-related toxicities in lung cancer patients using patient-reported outcomes, revealing strongest agreement with quality-of-life measures. The study found that clinicians' recorded toxicities underestimated their severity, highlighting the potential for early detection and improved treatment.
Researchers created a computer model to understand how animals learn from feedback, revealing how brain signals work together to choose actions. The study provides new insights into motor disorders like Parkinson's Disease and abnormal learning in conditions such as addiction.
Researchers have discovered that small changes in blood acidity can lead to inaccurate calcium level monitoring, resulting in higher PTH levels and increased risk of artery damage. This affects patients with chronic kidney disease, who already face a high risk of fatal calcification.
A new study has found that the 'Rayleigh Jet' technique can increase cloud reflectance by 5% with minimal energy consumption, using 30 megawatts of power, about equivalent to two large ships. This method is a reversible geoengineering approach proposed to mitigate rising global temperatures.
Researchers from the University of Manchester believe rising sea levels, not direct competition with jaws, led to the extinction of jawless fish. The study found that these ancient fish were reliant on shallow water environments and ecosystems, which declined as sea levels rose.
A study of 414 people with severe dementia and their carers found that depression was more prevalent in community-dwelling individuals (37%) compared to those in care homes (23%). The research suggests that better support for carers could help identify and cope with depressive symptoms in dementia patients.
Researchers at the University of Manchester discovered a molecular 'tag team' controlling cell division in yeast cells. This relay system ensures proper regulation of mitotic exit, a critical step in preventing abnormal growth and cancer development.
A recent study by the University of Manchester has investigated the effects of weak magnetic fields on human proteins, including those crucial for health. The research found no detectable impact on key proteins, suggesting that power lines and other electrical devices may be safer than previously thought.
A recent study published in the New England Journal of Medicine found that crizotinib significantly improves symptoms and delays cancer growth in patients with ALK-positive non-small cell lung cancer. The trial involved 343 previously untreated patients, showing promising results without unexpected side effects.
A new study has identified the SUFU gene mutation as a major contributor to Gorlin syndrome-associated childhood medulloblastoma, significantly increasing the risk of brain tumors in children with this condition. This finding has major implications for treatment and screening protocols for children with Gorlin syndrome.
Researchers discovered that protons pass through ultra-thin graphene crystals surprisingly easily, making them attractive for proton-conducting membranes. This breakthrough could improve the efficiency and durability of fuel cells, which use oxygen and hydrogen to convert chemical energy into electricity.
The authors argue that public health interventions should focus on breaking social habits rather than individual behavior changes. By re-shaping socially acceptable norms, policymakers can tackle non-communicable diseases such as heart disease, cancer, and diabetes.
A new study reveals the vast diversity of life below-ground, with rapid responses to climate change having far-reaching impacts on future ecosystems. The research suggests that healthy soil is essential for healthy crops, and that integrating knowledge of soil biodiversity into land management decisions could help mitigate climate change.
Researchers discovered that mitochondria are crucial for the survival of cancer stem cells and found sixty-two mitochondrial-related proteins showing increased levels. The study suggests new avenues for treatment by restricting cancer's ability to come back after treatment using MCT inhibitors.
Researchers discovered that immune cells secrete molecules across a small gap, which larger drugs struggle to penetrate. Smaller molecules are key to targeting immune cells, offering new ideas for treating auto-immune diseases and increasing cancer reactivity.
Researchers at the University of Manchester have identified factor H-like protein 1 (FHL-1) as a new target for treating age-related macular degeneration (AMD). The study suggests that insufficient FHL-1 in the eye's back may lead to inflammation and vision loss.
Researchers are developing AI-powered software to automatically outline bones in X-ray images, a system that can already identify hips and will now be adapted to map out knees and hands. The goal is to reduce the workload of human researchers and enable faster diagnosis for patients with conditions like arthritis.
Researchers at the University of Manchester have found that combining AZD3965 with radiotherapy reduces tumour growth in mice and increases anti-tumour effects. The study suggests a new treatment approach for cancer patients by targeting tumours through metabolism
Researchers have identified a key role for the FAK molecule in controlling breast cancer stem cell survival and predicting disease recurrence. Blocking FAK activity with a new drug significantly improved treatment outcomes, suggesting a potential method to predict which patients are most likely to experience recurrence.
A recent study published in Biological Psychiatry found that infants' preference for human faces over objects is associated with reduced callous and unemotional behaviors in toddlerhood. The research also showed that mother-child interactions during playtime can influence a child's emotional development.
A new test developed by researchers at the University of Manchester can identify congenital hyperinsulinism in some patients without known genetic causes. The test measures hormone levels and may influence treatment options, including avoiding pancreatic removal.