Researchers at the University of Manchester have discovered that the placenta stores and gradually releases oxygen to support the growth of early embryos. The new study reveals how the placenta solves the problem of supplying oxygen to the embryo in its first few weeks after implantation.
The five-year grant aims to create prototype nanomaterials with designed functional properties through the assembly of atomic planes from various bulk crystals. Researchers led by Sir Andre Geim will explore flexible optoelectronics, energy harvesting, gas separation and water desalination applications.
Researchers successfully joined two separate pieces of embryonic mouse intestine using growth supports, allowing nerve signals to pass through and promoting growth. The breakthrough could lead to treatment for conditions like short bowel syndrome, a condition causing damage to the bowel that prevents nutrient absorption.
Manchester University researchers have developed a method to stabilize previously unstable 2D crystals, allowing for the study of their properties and potential applications. The breakthrough enables the isolation of these materials in thin stacks, enabling control over their properties and opening up new possibilities for industry.
A University of Manchester study found that most hospital management strategies for self-harm are associated with higher risk of death, especially psychiatric admission. Routine aspects of care can be helpful in addressing underlying issues contributing to self-harm.
Researchers discovered a small RNA molecule called miR-148a plays a role in lung cancer resistance to TRAIL, and inhibiting NF-κB makes it more effective. This study suggests a way to overcome resistance and develop new treatments for lung cancer.
Research from The University of Manchester found that English people who upgrade their social status experience greater autonomy and control, leading to increased happiness. In contrast, Americans who rise in society's ranks are less satisfied than those who remain at lower levels.
A new study found that a test can predict which rheumatoid arthritis patients will fail to respond to biologic drugs. Detecting low drug levels and anti-drug antibodies in the bloodstream can help adjust treatments.
A team of scientists studied the genetic basis of human olfaction and reconstructed the sensory world of our distant ancestors. They found that different populations have varying abilities to detect specific smells, with some populations being more sensitive than others.
A new approach to diagnose pneumonia in critically ill patients has been identified through a breath analysis method. The study found that chemically analyzing breath specimens can reveal bacterial infection in ventilated patients at risk of developing pneumonia, providing a potential game-changer for clinical practice.
Researchers have pinpointed the genetic cause of a rare form of blindness, which can present itself as a key-hole shaped defect in the eye. The miR-204 gene mutation has been linked to inherited retinal dystrophy associated with ocular coloboma.
Research with thieving puppets shows that three- and five-year-old children will return stolen cookies to victims, prioritizing the victim's welfare over punishing the thief. This early sense of justice highlights toddlers' ability to act out of concern for others.
Researchers at the University of Manchester have identified the mechanism and structure of enzymes that produce hydrocarbons from yeast moulds. This discovery provides a new route to producing alpha-olefins, a key intermediate in various industrial applications.
A new psoriasis drug, ixekizumab, has shown significant improvement in treating the condition, with 40% of patients clearing all symptoms within 12 weeks. The treatment was found to be more effective than a placebo or widely used drug etanercept.
A faulty calcium channel in heart cells can cause a rare but potentially fatal heart condition called CPVT. When someone with the faulty gene exercises, adrenaline release can flood into the heart cells, causing a fatal arrhythmia.
Researchers have discovered the 'bicycle spoke' structure of healthy heart cells, which carries an electrical signal through the cell. After a heart attack, this structure is lost and leads to damaged heart muscle and potential heart failure. The study aims to find out why this process happens and develop strategies to intervene.
Scientists have identified a key role for gut tissue in programming immune cells, known as monocytes, to either repair or protect the body. The discovery has implications for treating conditions such as inflammatory bowel diseases and certain cancers.
Researchers have discovered a new treatment approach targeting tiny blood and lymphatic vessels inside the kidneys, which improves renal function and slows disease progression in mice. This innovative therapy may offer hope for patients with polycystic kidney disease, particularly those with rare forms of the condition.
Researchers from the University of Manchester have identified a new sauropod dinosaur fossil from the Middle Jurassic Period in Yorkshire, UK. The 176-million-year-old vertebra is the earliest skeletal record of this type of dinosaur in the United Kingdom and sheds light on the country's 'Jurassic World' reputation.
Research suggests that implementing a full seven day service in the NHS would cost up to £831m, exceeding initial estimates. The study found that removing weekend risks would eliminate some deaths, but not all, and may move problems to other days of the week.
A study published in BMC Family Practice reveals that South Asian individuals with diabetes often struggle due to conflicting views on the causes of their condition. However, strong family support networks can help manage the disease, highlighting the need for culturally sensitive treatment plans and education guidelines.
A recent UK study found that 40% of rheumatoid arthritis patients scored low on an adherence questionnaire, indicating inconsistent medication use. The research highlights the need for healthcare professionals to better inform patients about the importance of taking drugs as prescribed.
Researchers accelerate wound healing using electrical pulses, significantly reducing recovery time. The technology has potential to be applied to various situations where faster healing is desired.
Scientists at the University of Manchester discovered that desmosomes achieve their strength through flexibility rather than rigidity. This finding has significant implications for understanding diseases such as sudden cardiac death and skin conditions.
Scientists at the University of Manchester have identified crucial molecules that allow regulatory T cells to function and cure active inflammation. This discovery could lead to improved therapies for autoimmune diseases such as type I diabetes, rheumatoid arthritis, and inflammatory bowel disease.
A study by Manchester researchers has identified genetic subtypes in high-risk endometrial cancer patients, allowing for more targeted treatments. The classification of these subtypes can predict patient relapse and identify specific mutations that can be targeted with anti-cancer drugs.
Researchers found that relatives play a crucial role in encouraging loved ones to seek medical help for lung cancer, while online information poses problems. A new website is planned to provide tailored guidance for those experiencing symptoms.
Researchers at the University of Manchester have developed a new genetic profiling approach to identify patients with right lung cancer who are eligible for targeted therapies. The method uses smaller tissue biopsies and has been shown to detect genetic changes in over 95% of samples.
Researchers reveal that gland cells in uterine lining store glucose as glycogen and deliver it to placenta with glycoproteins for energy conversion. Early nutrition plays a crucial role in successful pregnancy and child health.
A new study has discovered specific genetic variants associated with higher risks of increased disease severity in rheumatoid arthritis. Certain amino acid positions in the HLA-DRB1 gene were found to be strong predictors of radiological damage, enabling early identification and potential treatment optimization.
A recent study analyzed 58 papers on inflammatory bowel disease and found inconsistent methods reporting, leading to difficulties in reproducing experiments. The researchers developed a critical checklist to address the issue, recommending its adoption as a publication requirement to improve study quality and standardization.
A team of scientists from the University of Manchester has identified a new protein called Mbd2 that plays a key role in controlling inflammation during worm infections and allergies. By understanding how this protein functions, researchers hope to develop targeted therapies for these conditions.
A UK National Cancer Research Institute trial suggests that a PET scan after chemotherapy can identify patients who don't need additional radiotherapy, reducing late effects. The study found that 90.8% of patients without further treatment remained disease-free compared to 94.6% in the radiotherapy group.
Scientists at the University of Manchester have made a groundbreaking discovery that could lead to an early test for kidney disease. They found significant differences in protein composition and structure between mice with different genetic backgrounds and sexes, which may contribute to susceptibility to kidney disease.
Research reveals color has a major impact on how our body clock measures time of day, outperforming brightness as a reliable method. The study found that changes in light color between blue and yellow are more sensitive to the body clock than changes in brightness.
Researchers develop a new drug combination that targets both estrogen-sensitive cells and cancer stem cells causing treatment resistance in breast cancer. The therapy combines Evgen's Wnt pathway-suppressing drug Sulforadex with standard hormonal treatments.
A new tool has been developed to improve dementia care for south Asian people, addressing cultural barriers to diagnosis. The adapted BEMI-C tool takes into account sensitivities that can act as barriers to effective diagnosis and treatment.
Researchers at the University of Manchester have identified two genes that can drive cell division in tree stems, allowing them to grow larger and more quickly. This discovery could lead to generating trees that produce more biomass for biofuels, chemicals, and materials while minimizing CO2 release.
A study by University of Manchester researchers has identified four subtypes of ductal carcinoma in situ (DCIS) that relate to disease recurrence. Patients with certain tumour characteristics, such as oestrogen receptor and progesterone receptor positivity, are less likely to experience cancer progression, while others are at higher risk.
A European study involving over 7,000 participants provides new insight into public interest in medicines research and development. The survey found that those with previous experience were almost five times more likely to have good knowledge of medicines R&D.
Despite significant genetic mutations, Ebola's functional level has remained the same over the past four decades. This suggests that vaccines and treatments developed during current outbreaks may be effective against future outbreaks.
A recent study found that a good therapeutic alliance is crucial for improving wellbeing, while poor relationships can harm treatment outcomes. The researchers discovered that patients who received effective therapy benefited from the therapist-patient connection, regardless of the therapy type.
Researchers at the University of Manchester have created a synthetic pathway for biosynthesis of renewable propane, paving the way for its commercial production. The breakthrough uses an engineered enzyme variant to redirect microbial pathways, producing propane as a clean-burning alternative to fossil fuels.
Researchers have made significant progress in understanding the complex relationship between bacteria and the deadly frog disease chytrid fungus. The study found that only a small proportion of bacteria inhibited all forms of the disease, highlighting the need for diverse probiotic treatments to combat its shifting targets.
A new study from The University of Manchester found that Viagra and similar drugs do not completely cure impotence in older men, with many still expressing concern over their sex lives. Despite positive effects on sexual activity, users reported higher levels of dissatisfaction with relationships and overall sexual function.
A previously known gene has been found to act as a tumour suppressor by regulating accurate chromosome segregation. Reduced expression of the glucocorticoid receptor is associated with certain cancer cell types and malignant progression.
New research reveals stark variation in genetic testing services for inherited eye disease in England, with the South-east ahead of other regions. The study shows that genetic tests have been available on the NHS for over a decade and next-generation sequencing technology has made it possible to map many genes simultaneously.
A team of scientists found that cheater amoebae produce fewer high-quality spores, which survive better, suggesting a more balanced system than previously thought. This discovery has implications for developing therapies using socially successful bacteria to fight diseases.
Researchers mapped how neurons fired in the brain of a sea slug while it moved, revealing large groups of co-active neurons that can be dramatically simplified and interpreted. This approach may help understand how brain networks change in disease states and how drugs act to restore normal brain function.
A new review of 5,903 participants found limited evidence supporting xylitol's ability to prevent tooth decay, particularly with fluoride toothpastes. The review concluded that xylitol-containing products showed little to no benefit in preventing dental cavities.