Researchers identified macrophage migration inhibitory factor (MIF) and its related protein D-dopachrome tautomerase as closely related cytokines associated with progressive MS. A genetic test could identify patients at risk of developing the disease, accelerating drug development for precision medicine.
A Yale-developed videogame improved sexual health knowledge and attitudes among minority youth, while also reducing risky behavior and STI transmission rates. The game, PlayForward: Elm City Stories, was designed with teen input and showed sustained positive changes in attitudes and knowledge over a year.
A Yale-led study found that nearly half of older adults admitted to hospice during their last year of life experienced symptoms for months prior to admission. The most common conditions leading to hospice admission were cancer and advanced dementia.
Researchers have created antibody-recruiting molecules targeting fungi (ARM-Fs) that can attach to fungal cell walls and recruit human antibodies to combat infections. These small molecules offer a new strategy for treating fungal diseases affecting thousands of people each year.
A new study reveals a clear relationship between the frontal bones and forebrain as well as parietal bones and midbrain in dinosaurs and birds. The research used CT scanning techniques to analyze embryos of lizards, alligators, and birds, confirming the link found in reptiles.
Researchers identified gene signatures associated with a stronger flu vaccine response in younger adults but not in older adults, highlighting age-related differences in immune response.
A new Yale University study reveals that women undergoing IVF to become pregnant report a more intense bodily experience compared to those donating eggs for money. Researchers found a direct correlation between the intensity of bodily experiences and the motivation for harvesting eggs.
A Yale University study finds that caregiver attitudes and subjective norms significantly influence the use of safe sleep positions for infants. Only 44% of mothers practice the recommended back-to-birth position consistently, highlighting the need for targeted interventions.
A Yale University study found that ED-initiated buprenorphine treatment was the most cost-effective approach for individuals screening positive for opioid addiction. The treatment resulted in lower healthcare costs and better patient outcomes compared to referral alone or brief intervention with facilitated referral.
A Yale-led team has identified specific gene combinations that cause deadly brain cancer glioblastoma and found two mutations that make tumors resistant to chemotherapy. The new technology can also pinpoint triggers of other types of cancers.
A new Yale-led study reveals that people with schizophrenia and other psychotic illnesses exhibit altered brain activity when induced to hallucinate. The study suggests that the ability to learn these hallucinations are not real may help identify those in need of psychiatric treatment.
Researchers from Yale University studied 840 patients with curable cancers and found that those who used only alternative therapy had a higher risk of death. The study suggests that conventional cancer treatment is more effective in improving survival rates.
A new mobile program significantly improved adherence to recommended safe sleep habits for infants, including back sleeping and room-sharing without bed-sharing. The program's rates were higher than those achieved by interventions tested in previous research.
Healthy skin cells have been found to actively correct tissue flaws created by cancerous cells, eliminating tumors in mouse models. The study highlights the importance of normal cells in maintaining tissue health and functionality.
New research reveals that Arctic sea ice loss can play an active role in altering the Atlantic Meridional Overturning Circulation (AMOC), a major water circulation system. The study found that a 30-50% loss of AMOC strength due to Arctic sea ice loss could accelerate its collapse.
Researchers found that fruit fly males prioritize courtship over sleep when aroused, while females can't afford to pass up an eligible suitor even if they're tired. The study revealed underlying connections between neural centers mediating sex and sleep in both males and females.
Scientists coaxed early stage stem cells to create two types of organoids from different brain regions to show how the developing brain maintains proper balance of excitatory and inhibitory neurons. This imbalance has been implicated in neurodevelopmental disorders such as autism and schizophrenia.
A Yale-led study analyzing data from 2008-2014 found that reducing hospital readmission rates for heart attack, heart failure, and pneumonia does not increase mortality rates. The research suggests that hospitals' efforts to keep patients out of the hospital may have actually improved mortality outcomes through better preparedness, tim...
Researchers at Yale University have discovered 60 new potential 'hot Jupiters,' gas giant planets that orbit extremely close to their stars. The discovery was made possible by a novel application of machine learning algorithms and the analysis of more than 140,000 star observations from NASA's Kepler mission.
The study found that wildebeest carcasses play a crucial role in the ecosystem, providing food for various animals and supporting fish populations. The nutrient-rich carcasses also decompose over time, releasing phosphorus that supports algae, insects, and fish.
Researchers at Yale University developed a brief and reliable survey tool to measure resilience in children and adolescents displaced by the Syrian conflict. The tool identifies individual, family, and cultural sources of strength and asks respondents to rate statements on a five-point scale.
Research found that slow-growing breast cancers with favorable biologic factors have an excellent prognosis, often outliving patients. The study suggests that large, aggressive tumors are more likely to cause harm and should be prioritized for screening.
Researchers identified mutations in the KDSR gene, which disrupts ceramide production, leading to dry, scaly skin. Isotretinoin, a commonly used acne medication, counteracts this effect, allowing patients to produce ceramides and alleviate symptoms.
Researchers at Yale University have developed a novel chemical process to create a new class of antibiotics, which could help combat growing resistance. The discovery uses simple commercial chemicals to produce molecules related to the natural product pleuromutilin.
A new fossil discovery in New Mexico reveals that the earliest primates, known as plesiadapiforms, were adapted to living in trees. The 62-million-year-old skeleton shows flexible joints for climbing and clinging to branches, contradicting previous theories of terrestrial lifestyles.
A new study suggests that setting aside an additional 5% of land to protect key species can triple their protected range and safeguard their functional diversity. This approach prioritizes global representation over local conservation, offering a more effective strategy for biodiversity conservation.
A new Yale University study found that even 'dumb' AI can help human groups by boosting their performance. The experiment, which used an online game with human players and robotic AI players, showed a significant improvement in the median time for groups to solve problems.
The Gruber Foundation has awarded $1.5 million to three top scientists for their groundbreaking work in cosmology, genetics and neuroscience. Sandra Faber, Stephen Elledge, and Joshua Sanes have been recognized for their pioneering research on galaxy structure, DNA damage response pathway, and synapse formation.
A Yale University study found that 32% of new drugs were flagged for a safety issue after approval, with biologic therapies and accelerated approvals being more likely to be associated with concerns. The findings highlight the need for ongoing surveillance of new drugs in the post-market period.
Yale researchers have developed a 'genetic scalpel' to regulate gene activity in the gut microbiome, enabling precise control over bacterial communities. This breakthrough tool may help understand the microbiome's impact on health and disease, including infectious diseases and behavioral disorders.
A Yale University study found that areas restricting trans fats in foods had fewer hospitalizations for heart attack and stroke. The finding suggests limiting trans fats could have a widespread impact as the FDA's ban takes effect nationwide.
A Yale researcher found that the FDA reviews and approves new medicines in a shorter timeframe than its peer agency in Europe. The study compared review times for new drugs approved by the FDA and EMA between 2011 and 2015, classifying them by therapeutic areas and 'orphan' drugs.
A Yale study warns that if federal funding for CHIP is not extended, over 8 million children could face substantial cost increases in health insurance. Children with chronic conditions are most vulnerable to these cost increases.
A recent Yale-led study found that marathon running can cause short-term kidney injury in runners, with 82% of participants showing signs of Stage 1 Acute Kidney Injury after the event. The researchers attribute this to sustained rises in core body temperature, dehydration, and decreased blood flow to the kidneys.
Researchers at Yale University have created a new material that can be applied to any sulfur cathode, improving battery stability and cycle life. The gel-like coating increases the number of cycles to over 1,000, making it suitable for high-energy-density batteries.
A new study by Yale researchers found that over 40% of veteran-surrogate pairs lacked advanced care planning, leading to disagreements about end-of-life decisions. The study emphasizes the importance of facilitating discussions between patients and surrogates to ensure understanding of patient preferences.
A 20-year demographic study of wild chimpanzees in Uganda's Kibale National Park revealed that favorable ecological conditions, including abundant food supplies and low predation risk, drive high life expectancy. The study establishes an average life expectancy of about 33 years, nearly twice as high as other chimpanzee communities.
Researchers from Yale University and the Centre for Mathematical Sciences created a mathematical framework to explain phenomena where climate processes interact with daily weather. This new framework helps understand how seasonal variability affects predictability and public safety.
A Yale-led study found racial disparities in Alpha Omega Alpha (AA) membership selection, with black and Asian medical school students less likely to be chosen than white students. The disparity suggests bias in the AA membership process, which could limit opportunities for minority medical students.
A Yale-led team has created one of the highest-resolution maps of dark matter ever produced, providing a detailed case for its existence. The map, derived from Hubble Space Telescope Frontier Fields data, closely matches theoretical predictions and offers insights into the universe's structure and galaxy formation.
A recent study suggests that a ketogenic diet can protect against gout flares in rats by increasing levels of ketone bodies and inhibiting the NLRP3 inflammasome. This could potentially improve treatment outcomes for humans with the disease.
Researchers found that genetic variants linked to autism spectrum disorders are also associated with enhanced cognition and intellectual achievement, suggesting positive selection during human evolution. The study analyzed over 5,000 cases of ASD and identified common variants that contribute to both conditions.
Researchers at Yale University and Vanderbilt University have discovered a common bacterium that can be used to sterilize male insects, potentially controlling disease-bearing mosquitoes and agricultural pests. The discovery of two genes encoded by Wolbachia bacteria can completely sterilize male fruit flies.
Researchers at Yale University have discovered that fructose is converted in the human brain from glucose, raising questions about its effects on eating behavior. The finding highlights the need to reevaluate the impact of fructose on chronic diseases.
A new study published in JAMA and J AMA Internal Medicine found that testosterone therapy improved bone density and strength, as well as reduced anemia in older men with low testosterone levels. However, the therapy had no impact on cognitive function and may worsen plaque in coronary arteries.
A new study published in Cell Metabolism found that changes in the size of mitochondria in a small subset of brain cells play a crucial role in maintaining safe blood sugar levels. The researchers discovered that these mitochondrial changes are critical for activating counter-regulatory responses to hypoglycemia, which can help prevent...
A Yale University review of animal studies found that therapies successful in animals fail in humans due to early intervention timing and narrow study designs. The researchers highlight the need for more accurate translation from animal models to human trials.
Researchers discovered a subpopulation of beta cells that resists immune attack and acquires stemness to persist despite immune attack. This finding may lead to therapies targeting these cells to restore insulin production in type 1 diabetic patients.
Scientists have unearthed a 480-million-year-old creature named Calvapilosa, an early offshoot of the line leading to modern coat-of-mail shells or chitons. The discovery sheds light on the evolutionary history of mollusks, which includes squids, octopuses, snails, and clams.
A novel genetic defect in brain tumor cells has been identified by Yale researchers, which renders the cancers sensitive to a specific DNA repair mechanism. The team found that using an FDA-approved drug, olaparib, can cause a significant increase in brain tumor cell death.