Articles tagged with Randomization
A study published in JAMA found that both proton pump inhibitor therapy and laparoscopic antireflux surgery are effective in achieving long-term remission for most patients with GERD. At 5 years, estimated 92% of esomeprazole patients remained in remission, compared to 85% of laparoscopic surgery patients.
A recent meta-analysis of 40,000 critically ill patients found no statistically significant difference in hospital mortality between those who received ICU telemonitoring and those who did not. The study suggests that telemonitoring may not be an effective solution for addressing the shortage of intensivist physicians.
A recent study published in The Lancet found that treating acute appendicitis with antibiotics is not as effective as surgically removing the appendix. In the study, patients who received antibiotics were more likely to develop post-intervention peritonitis, a serious inflammation of the abdominal cavity.
A new study suggests that systematic reviews should evaluate a broad range of study designs, including randomized controlled trials and observational studies, to build a complete picture of potential harm. This approach may improve the generalizability of the review without loss of validity.
A new study suggests that group doctor visits could be an effective way to manage Parkinson's disease, allowing patients more time with their doctors and providing education on managing the condition. The study found no difference in quality of life between those receiving usual care and those participating in group visits.
The US Coast Guard has begun trials of the PROTECT system, a computer application developed by USC-engineered that randomizes response vessel schedules to prevent adversaries from exploiting patterns. The system, designed to optimize deterrence effects, is being tested in Boston Harbor with a force of five to ten response boats.
A study found that injection of a bulking agent into the anal canal improved symptoms of faecal incontinence more than sham treatment. The treatment was shown to be safe with minimal adverse events.
A study published in Social Science and Medicine found that online peer support groups had a mixed effect on the well-being of participants with severe mental illnesses. While there was no significant improvement in their condition, participants reported feeling supported and benefited from online connections with peers.
A study found that nitroglycerin ointment increased bone mineral density and decreased bone resorption in postmenopausal women. The researchers also observed increases in bone-specific alkaline phosphatase and decreases in urine N-telopeptide, markers of bone formation and resorption.
A study of over 2,700 runners found that stretching before running neither prevents nor causes injury. However, runners who normally stretch and suddenly stop or switch routines are more likely to experience injuries, particularly groin pulls, foot/ankle injuries, and knee injuries.
Researchers found no reduction in preterm delivery or neonatal morbidity in twin pregnancies treated with 17-hydroxyprogesterone. The study, presented at the Society for Maternal-Fetal Medicine's annual meeting, involved over 240 mothers and 480 babies.
A randomized clinical trial found that early amniotomy in labor induction can shorten delivery time by over 10 percent and increase the likelihood of delivery within 24 hours without adverse effects. This method also greatly increases the comfort of the mother.
Two trials found that intermittent preventive treatment provided substantial additional protection against clinical malaria, severe malaria, and hospital admissions. A third trial demonstrated the effectiveness of community-based delivery by volunteer village health workers in rural areas.
A study by the University of Helsinki found that vitamin E supplementation reduces mortality by 24% in participants aged 71 or older. However, it had no effect on life expectancy for those between 65 and 70 years old with high dietary vitamin C intake.
A study published in BMC's Reproductive Health journal found that a pill containing essential oils significantly reduced premenstrual syndrome (PMS) symptoms. Women taking the supplement reported eased PMS symptoms at 3 and 6 months, with few adverse events recorded.
A study analyzing the Infectious Diseases Society of America's practice guidelines found that more than half are based on opinion rather than evidence from clinical trials. The researchers recommend cautious use of current guidelines and prioritizing critical thinking in patient care.
A new study found that doctors' metaphors used to explain Phase III clinical trials played a significant role in whether patients agreed to participate. Most participants struggled to understand randomization, but those who paid close attention were unaffected by the metaphor used.
The Lancet Series on Critical Care assesses the future of intensive care services amid increasing demand. Authors highlight the need for improved productivity, prevention efforts, and better-designed studies to address challenges in rationing care.
Researchers used low-intensity pulsed ultrasound (LIPUS) to treat patients with delayed unions of the tibia, resulting in a 34% increase in bone mineral density. This non-invasive treatment modality shows promise as a viable option for patients suffering from these injuries.
A new study from the University of California, Berkeley, found that women who receive regular dental care have a lower risk of heart attacks, stroke, and other cardiovascular problems by at least one-third. The study used data from nearly 7,000 people ages 44-88 and ruled out self-selection bias using instrumental variables.
Researchers developed a novel water method to reduce discomfort during unsedated colonoscopy, enhancing cecal intubation and patient willingness to repeat procedures. The study showed significant improvements in these outcomes compared to traditional air insufflation methods.
A randomized trial of chest physiotherapy in infants hospitalized with acute bronchiolitis found no reduction in recovery time. The study suggests that routine chest physiotherapy may not be necessary for this population.
A new study published in JAMA found that self-management counseling for patients with mild to moderate heart failure did not reduce the rate of death or hospitalization compared to educational materials alone. Despite advances in therapies, patient nonadherence remains a significant challenge.
Recent studies suggest that supplemental oxygen therapy may not be beneficial for patients with acute MI who have normal oxygen levels, potentially leading to worse outcomes. Guidelines are needed to address this issue and ensure safe treatment practices.
A randomized controlled trial found that routine resite of IV devices every 3 days did not reduce complications compared to clinically indicated resite. In fact, it increased patient discomfort and healthcare costs.
A randomized controlled trial found wrist splints to be as effective as casts for treating distal radius fractures in children. Patient satisfaction with splint treatment was higher than with cast treatment.
A cognitive-behavioral intervention to reduce substance use and sexual risk behavior among men who have sex with men was partially successful, but further research is needed to identify better methods. After one year, participants reported a 32% reduction in unprotected anal sex and similar reductions in other risk behaviors.
A study suggests that chronic sleep restriction can have lasting effects on neurobehavioral deficits, even with adequate recovery sleep. Researchers found that participants who experienced severe sleep restriction showed persistent impairments in attention and reaction times after a single night of extended sleep.
A Johns Hopkins review of nearly 150 randomized controlled trials on children found that 40-60% of the studies failed to minimize risk for bias or properly describe those measures. The study urges pediatricians to critically read studies, asking how researchers reached conclusions and whether analysis was unbiased.
Researchers found that mortality rates were significantly lower among patients who received DOT from a nominated treatment supporter compared to self-monitored ART. The study suggests that social capital and emotional support provided by these supporters contributed to improved survival outcomes.
Researchers tested bosentan for idiopathic pulmonary fibrosis and found no significant improvements. In contrast, two-day neuromuscular blocking agent therapy improved survival in patients with severe acute respiratory distress syndrome (ARDS). Oral iloprost showed promise in preventing lung cancer among former smokers.
A single-center study found that early percutaneous tracheotomy (EPT) in ICU patients on mechanical ventilation did not reduce mortality, hospital length of stay, or frequency of infectious complications. However, EPT was associated with fewer unscheduled extubations and earlier bed-to-chair transfer.
A study published by the American Thoracic Society found that long-term vitamin E supplementation may decrease the risk of chronic obstructive pulmonary disease (COPD) by about 10% in both smokers and non-smokers. Vitamin E may protect lung tissue from damage caused by free radicals, according to researchers.
A recent study suggests that the risk of brain hemorrhage from unruptured or accidentally discovered brain AVMs may be lower and less severe than initially believed. The Rush University Medical Center's ARUBA trial aims to determine whether a hands-off approach is sufficient for managing these malformations, or if intervention using en...
A randomized controlled trial of early vs late tracheotomy in mechanically ventilated adult ICU patients found no significant reduction in ventilator-associated pneumonia (VAP) with earlier tracheotomy. The study also showed a higher number of ventilator-free and ICU-free days in the early tracheotomy group.
A Phase 2 study demonstrated that BOTOX provides a clinically meaningful benefit for idiopathic OAB patients with urinary urgency incontinence. The study found that doses of 100U-150U provided the optimal balance between efficacy and safety, with significant reductions in symptoms and increases in PVR at higher doses.
Two studies presented at the International Liver Congress 2010 found that extracorporeal liver support therapy may not improve overall survival, but shows positive effects on dialysis and severe hepatic encephalopathy in patients with cirrhosis. A significant survival benefit was observed in patient subgroups with hepatorenal syndrome ...
A new study by Harvard researchers found that replacing saturated fat with polyunsaturated fat can reduce the risk of coronary heart disease by 19%. Increasing polyunsaturated fat consumption as a replacement for saturated fats may significantly reduce the rate of heart attacks and cardiac deaths in the population.
US PSA screening detected fewer prostate cancers compared to a European randomized trial, with lower sensitivity being the main cause. The estimated sensitivity of PSA testing followed by biopsy was significantly lower in the US (0.26) than in the European trial (0.94).
Researchers found that sutures resulted in significantly lower rates of wound separation and composite wound complications compared to staples. The use of staples was associated with a higher risk of wound complications and post-operative physician visits.
Patients with symptomatic paroxysmal AF who didn't respond to antiarrhythmic drugs showed better outcomes with catheter ablation, achieving higher success rates in rhythm control and quality of life. Catheter ablation demonstrated a favorable safety profile, making it an attractive alternative for treating this condition.
Patients with resectable esophageal adenocarcinoma benefit from neoadjuvant chemoradiotherapy, showing improved overall survival and complete resection rates. However, the treatment is connected to a higher mortality rate after surgery.
Researchers found that biomarker-stratified designs provide complete information on the relationship between treatment effects and biomarkers. This design enables unbiased estimates of benefit-to-risk ratios across different subgroups.
A cluster randomized trial found that school playgrounds with granite sand surfacing significantly reduced the risk of arm fractures compared to wood fibre surfaces. The study concluded that updating safety standards to recommend granite sand will reduce common and severe injuries seen on modern playgrounds.
A randomized controlled trial found that prone positioning in patients with acute respiratory distress syndrome (ARDS) did not significantly reduce mortality rates compared to supine positioning. Despite higher complication rates in the prone group, outcomes were similar for both groups at 28 days and 6 months.
A study found that on-demand chest radiographs for mechanically ventilated patients resulted in a third fewer radiographs without compromising patient care. The on-demand strategy was associated with significant cost savings and decreased radiation exposure.
A study found that cancer patients value honesty from their oncologists about treatment outcomes, with prostate cancer patients showing a stronger preference for candor. The study also reveals that patients prefer casual clothing and informal communication styles, such as being called by their first names.
A new study found that a shorter, five-week course of hypofractionated radiation is as effective as standard radiation therapy in reducing prostate cancer recurrence. The treatment delivered higher doses of radiation in fewer sessions, resulting in no significant difference in cancer recurrence or side effects between the two groups.
Researchers found no significant difference in visual outcomes between Bevacizumab and Ranibizumab treatments for age-related macular degeneration after 6 months. The study suggests that both drugs are effective, with Bevacizumab being a more affordable option.
A recent study published in The Lancet found that using a drain after surgery to release a chronic subdural hematoma significantly reduces both mortality and hematoma recurrence. The study assessed 215 patients with chronic SDH who underwent burr-hole surgery, with a significant benefit observed in the group using a drain.
A new type of sirolimus-eluting stent successfully demonstrated greater neointimal suppression and vessel wall integrity compared to paclitaxel-eluting stents. This study, presented at the TCT scientific symposium, confirms the superiority of the sirolimus-eluting stent for treating coronary artery disease.
Researchers found that adding high-dose cytarabine to methotrexate therapy improved complete remission rates (46%) and overall response rates (69%) in patients with primary central nervous system lymphoma. The combination also resulted in a lower risk of relapse and improved progression-free survival.
Improving toilets and hand hygiene can reduce tropical enteropathy and lead to substantial decreases in stunting among children. Dr Jean Humphrey hypothesises that preventing faecal-oral transmission by providing safe disposal of stools and promoting handwashing with soap can normalise child growth.
The PROTECT trial found that rolofylline had no significant effect on primary or secondary end-points in patients with acute heart failure, including dyspnea improvement and persistent renal impairment. The study did show an increased risk of neurological events in rolofylline-treated patients.
A new study published in JAMA suggests that immediate intervention for patients with acute coronary syndromes (ACS) may not provide a significant advantage in terms of outcomes. However, the strategy can still reduce hospital stay duration. The study evaluated data from 352 patients with ACS and found that both immediate and delayed in...
The PRAGUE-7 study, a randomized trial, investigated the effect of routine upfront administration of abciximab on outcomes in acute myocardial infarction (AMI) patients complicated by cardiogenic shock. The study found no significant benefit from this approach, with similar results seen between groups receiving standard or selective ab...
Resolvyx Pharmaceuticals announced positive Phase 2 clinical study results for RX-10045, a resolvin administered as a topical eye drop for treating patients with chronic dry eye syndrome. The 28-day trial showed dose-dependent improvements in symptoms and signs of dry eye.
A randomized study found that a program combining electronic health records and proactive patient outreach kept lipid and blood pressure levels at controlled, healthy levels for two years after discharge. The study's results suggest that using technology can help support patients in maintaining treatment goals and medication adherence.
Patients who underwent lung reduction surgery showed a significant survival benefit compared to medical treatment, with an average time until a 'composite event' of two years. The procedure also improved quality of life for at least five years post-operative period, especially in patients with upper-lobe-predominant emphysema.
Researchers found that Attention Process Training (APT) improved attention in 78 stroke survivors, with average improvements of 2.49 standard deviations higher than standard care patients on full-scale attention scores. APT is a viable and effective way to improve attention deficits after stroke.