Articles tagged with Randomization
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A randomized trial of chest physiotherapy in infants hospitalized with acute bronchiolitis found no reduction in recovery time. The study suggests that routine chest physiotherapy may not be necessary for this population.
A new study published in JAMA found that self-management counseling for patients with mild to moderate heart failure did not reduce the rate of death or hospitalization compared to educational materials alone. Despite advances in therapies, patient nonadherence remains a significant challenge.
Recent studies suggest that supplemental oxygen therapy may not be beneficial for patients with acute MI who have normal oxygen levels, potentially leading to worse outcomes. Guidelines are needed to address this issue and ensure safe treatment practices.
A randomized controlled trial found that routine resite of IV devices every 3 days did not reduce complications compared to clinically indicated resite. In fact, it increased patient discomfort and healthcare costs.
A randomized controlled trial found wrist splints to be as effective as casts for treating distal radius fractures in children. Patient satisfaction with splint treatment was higher than with cast treatment.
A cognitive-behavioral intervention to reduce substance use and sexual risk behavior among men who have sex with men was partially successful, but further research is needed to identify better methods. After one year, participants reported a 32% reduction in unprotected anal sex and similar reductions in other risk behaviors.
A study suggests that chronic sleep restriction can have lasting effects on neurobehavioral deficits, even with adequate recovery sleep. Researchers found that participants who experienced severe sleep restriction showed persistent impairments in attention and reaction times after a single night of extended sleep.
A Johns Hopkins review of nearly 150 randomized controlled trials on children found that 40-60% of the studies failed to minimize risk for bias or properly describe those measures. The study urges pediatricians to critically read studies, asking how researchers reached conclusions and whether analysis was unbiased.
Researchers found that mortality rates were significantly lower among patients who received DOT from a nominated treatment supporter compared to self-monitored ART. The study suggests that social capital and emotional support provided by these supporters contributed to improved survival outcomes.
A single-center study found that early percutaneous tracheotomy (EPT) in ICU patients on mechanical ventilation did not reduce mortality, hospital length of stay, or frequency of infectious complications. However, EPT was associated with fewer unscheduled extubations and earlier bed-to-chair transfer.
Researchers tested bosentan for idiopathic pulmonary fibrosis and found no significant improvements. In contrast, two-day neuromuscular blocking agent therapy improved survival in patients with severe acute respiratory distress syndrome (ARDS). Oral iloprost showed promise in preventing lung cancer among former smokers.
A study published by the American Thoracic Society found that long-term vitamin E supplementation may decrease the risk of chronic obstructive pulmonary disease (COPD) by about 10% in both smokers and non-smokers. Vitamin E may protect lung tissue from damage caused by free radicals, according to researchers.
A recent study suggests that the risk of brain hemorrhage from unruptured or accidentally discovered brain AVMs may be lower and less severe than initially believed. The Rush University Medical Center's ARUBA trial aims to determine whether a hands-off approach is sufficient for managing these malformations, or if intervention using en...
A randomized controlled trial of early vs late tracheotomy in mechanically ventilated adult ICU patients found no significant reduction in ventilator-associated pneumonia (VAP) with earlier tracheotomy. The study also showed a higher number of ventilator-free and ICU-free days in the early tracheotomy group.
A Phase 2 study demonstrated that BOTOX provides a clinically meaningful benefit for idiopathic OAB patients with urinary urgency incontinence. The study found that doses of 100U-150U provided the optimal balance between efficacy and safety, with significant reductions in symptoms and increases in PVR at higher doses.
Two studies presented at the International Liver Congress 2010 found that extracorporeal liver support therapy may not improve overall survival, but shows positive effects on dialysis and severe hepatic encephalopathy in patients with cirrhosis. A significant survival benefit was observed in patient subgroups with hepatorenal syndrome ...
A new study by Harvard researchers found that replacing saturated fat with polyunsaturated fat can reduce the risk of coronary heart disease by 19%. Increasing polyunsaturated fat consumption as a replacement for saturated fats may significantly reduce the rate of heart attacks and cardiac deaths in the population.
US PSA screening detected fewer prostate cancers compared to a European randomized trial, with lower sensitivity being the main cause. The estimated sensitivity of PSA testing followed by biopsy was significantly lower in the US (0.26) than in the European trial (0.94).
Researchers found that sutures resulted in significantly lower rates of wound separation and composite wound complications compared to staples. The use of staples was associated with a higher risk of wound complications and post-operative physician visits.
Patients with symptomatic paroxysmal AF who didn't respond to antiarrhythmic drugs showed better outcomes with catheter ablation, achieving higher success rates in rhythm control and quality of life. Catheter ablation demonstrated a favorable safety profile, making it an attractive alternative for treating this condition.
Patients with resectable esophageal adenocarcinoma benefit from neoadjuvant chemoradiotherapy, showing improved overall survival and complete resection rates. However, the treatment is connected to a higher mortality rate after surgery.
Researchers found that biomarker-stratified designs provide complete information on the relationship between treatment effects and biomarkers. This design enables unbiased estimates of benefit-to-risk ratios across different subgroups.
A cluster randomized trial found that school playgrounds with granite sand surfacing significantly reduced the risk of arm fractures compared to wood fibre surfaces. The study concluded that updating safety standards to recommend granite sand will reduce common and severe injuries seen on modern playgrounds.
A randomized controlled trial found that prone positioning in patients with acute respiratory distress syndrome (ARDS) did not significantly reduce mortality rates compared to supine positioning. Despite higher complication rates in the prone group, outcomes were similar for both groups at 28 days and 6 months.
A study found that cancer patients value honesty from their oncologists about treatment outcomes, with prostate cancer patients showing a stronger preference for candor. The study also reveals that patients prefer casual clothing and informal communication styles, such as being called by their first names.
A study found that on-demand chest radiographs for mechanically ventilated patients resulted in a third fewer radiographs without compromising patient care. The on-demand strategy was associated with significant cost savings and decreased radiation exposure.
A new study found that a shorter, five-week course of hypofractionated radiation is as effective as standard radiation therapy in reducing prostate cancer recurrence. The treatment delivered higher doses of radiation in fewer sessions, resulting in no significant difference in cancer recurrence or side effects between the two groups.
Researchers found no significant difference in visual outcomes between Bevacizumab and Ranibizumab treatments for age-related macular degeneration after 6 months. The study suggests that both drugs are effective, with Bevacizumab being a more affordable option.
A recent study published in The Lancet found that using a drain after surgery to release a chronic subdural hematoma significantly reduces both mortality and hematoma recurrence. The study assessed 215 patients with chronic SDH who underwent burr-hole surgery, with a significant benefit observed in the group using a drain.
A new type of sirolimus-eluting stent successfully demonstrated greater neointimal suppression and vessel wall integrity compared to paclitaxel-eluting stents. This study, presented at the TCT scientific symposium, confirms the superiority of the sirolimus-eluting stent for treating coronary artery disease.
Researchers found that adding high-dose cytarabine to methotrexate therapy improved complete remission rates (46%) and overall response rates (69%) in patients with primary central nervous system lymphoma. The combination also resulted in a lower risk of relapse and improved progression-free survival.
Improving toilets and hand hygiene can reduce tropical enteropathy and lead to substantial decreases in stunting among children. Dr Jean Humphrey hypothesises that preventing faecal-oral transmission by providing safe disposal of stools and promoting handwashing with soap can normalise child growth.
The PROTECT trial found that rolofylline had no significant effect on primary or secondary end-points in patients with acute heart failure, including dyspnea improvement and persistent renal impairment. The study did show an increased risk of neurological events in rolofylline-treated patients.
A new study published in JAMA suggests that immediate intervention for patients with acute coronary syndromes (ACS) may not provide a significant advantage in terms of outcomes. However, the strategy can still reduce hospital stay duration. The study evaluated data from 352 patients with ACS and found that both immediate and delayed in...
The PRAGUE-7 study, a randomized trial, investigated the effect of routine upfront administration of abciximab on outcomes in acute myocardial infarction (AMI) patients complicated by cardiogenic shock. The study found no significant benefit from this approach, with similar results seen between groups receiving standard or selective ab...
Resolvyx Pharmaceuticals announced positive Phase 2 clinical study results for RX-10045, a resolvin administered as a topical eye drop for treating patients with chronic dry eye syndrome. The 28-day trial showed dose-dependent improvements in symptoms and signs of dry eye.
A randomized study found that a program combining electronic health records and proactive patient outreach kept lipid and blood pressure levels at controlled, healthy levels for two years after discharge. The study's results suggest that using technology can help support patients in maintaining treatment goals and medication adherence.
Patients who underwent lung reduction surgery showed a significant survival benefit compared to medical treatment, with an average time until a 'composite event' of two years. The procedure also improved quality of life for at least five years post-operative period, especially in patients with upper-lobe-predominant emphysema.
Researchers found that Attention Process Training (APT) improved attention in 78 stroke survivors, with average improvements of 2.49 standard deviations higher than standard care patients on full-scale attention scores. APT is a viable and effective way to improve attention deficits after stroke.
A randomized trial in Uganda found that circumcision of HIV-infected men did not reduce HIV transmission to female partners. The study enrolled 922 uncircumcised men and their female partners, with a higher proportion of women infected in the intervention group.
A major electronic collection of articles about uterine artery embolization is now available, providing information on the treatment's benefits and technical aspects. The collection includes studies that demonstrate the procedure's lower cost compared to traditional surgery.
A recent genetic association study failed to support a causal relationship between C-reactive protein levels and coronary heart disease (CHD). The study, published in JAMA, found that variants associated with lower CRP levels were not linked to reduced CHD risk.
A new study by Dr. Thao Huynh analyzes the best way to treat patients with heart attacks, suggesting that reducing delays in providing primary PCI can maximize its effectiveness. The study also highlights the importance of optimal medical therapy after discharge to prevent repeat heart attacks.
A meta-analysis of 190,000 patients from 56 studies found no overall differences in death and myocardial infarction between drug-eluting stents (DES) and bare metal stents (BMS), with significant reductions in target vessel revascularization procedures.
A genetic analysis found that high levels of lipoprotein(a) are associated with an increased risk of heart attack, even after adjusting for other factors. The study suggests that reducing lipoprotein(a) levels may help lower the risk of heart attack.
Researchers confirmed that transplanting autologous muscle-derived cells into the bladder improves symptoms and quality of life in patients with stress urinary incontinence. The treatment has few side effects and significantly improved symptoms, with 76.5% of patients reporting a reduction in stress leaks at 12 months.
A review of 146 prospective cohort studies and 43 randomized controlled trials found strong evidence for a causal relationship between protective dietary factors such as vegetable, nut, and monounsaturated fatty acid intake and lower heart disease risk. The Mediterranean diet was significantly associated with coronary heart disease.
A Lancet study evaluated Mexico's universal health insurance program, Seguro Popular, in dozens of communities. The experiment found a 23% reduction in catastrophic health expenditures and identified areas for improvement. Researchers suggest this model could inform US healthcare reforms.
A study by Harvard researchers found that Seguro Popular, a Mexican health care program instituted in 2003, has reduced catastrophic health expenditures among poorer households by almost 60%. The program's primary goal is to reduce healthcare costs for the poor, and its success may have implications for other countries.
A Mexican health care program created in 2003 has been found effective in reducing crippling health care costs among poorer households. The Seguro Popular program was developed to provide health care to 50 million Mexicans who otherwise would lack coverage, and its success could provide lessons for other countries.
A randomized assessment of Mexico's Seguro Popular program reveals a significant reduction in household-crippling expenditure, with poorest individuals benefiting most. The study also introduces innovative approaches to evaluate public policies and provides a validated architecture for delivering health services to the poor.
The study found that administering eptifibatide in the emergency room or during procedures to open blocked arteries does not significantly affect patient outcomes for those at high risk of complications after a heart attack. Researchers also noted an association between earlier use of eptifibatide and non-life-threatening bleeding.
A randomized trial found that frequent treatment of children under 10 years old with azithromycin can decrease infection prevalence in older individuals and adults, demonstrating herd protection. Treatment frequency four times a year is comparable to treating the entire population once a year.
Research suggests that aspirin can reduce the risk of polyps forming in the colon or rectum, a precursor to colorectal cancer. Studies have shown mixed results regarding the optimal dose and duration of use, but experts call for more evidence on the effects of aspirin on cancer.
A recent study comparing coronary artery bypass graft surgery (CABG) with catheter/balloon/stent percutaneous intervention (PCI) found that CABG may be a better option for patients with diabetes and those aged 65-75 years. The research, involving 7812 patients, revealed lower mortality rates in these subgroups.
A Phase III study found that fampridine improved walking speed and leg strength in patients with multiple sclerosis. The drug also showed promise in reducing fatigue and improving endurance. However, adverse events were reported in some patients, highlighting the need for further research on its treatment profile.
A randomised trial found that kyphoplasty treatment significantly improved quality of life, function, mobility, and pain in patients with acute vertebral fractures compared to non-surgical management. The procedure was also safe and effective, with no significant differences in adverse events between the two groups.
A new review of randomized controlled trials has found that radiofrequency ablation significantly improves patient survival compared to percutaneous ethanol injection. Radiofrequency treatment offered a greater survival benefit due to improved local tumor response and more predictable tumor ablation.
Mortality rates for acute respiratory distress syndrome (ARDS) have remained relatively stable since 1994, with a benchmark mortality of 40-45% according to a comprehensive review of major studies. The findings highlight the need for effective therapeutic interventions for this highly lethal syndrome.
A new trial found that orlistat, a common fat absorption inhibitor, does not help patients with fatty liver disease lose weight or improve liver enzymes. However, moderate weight loss was associated with significant improvements in liver symptoms.