Articles tagged with Analgesics
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Scientists have discovered a potential solution to chronic pain by identifying the key ingredient responsible for painlessness in people born with a rare genetic mutation. By combining low-dose opioids with Nav1.7 blockers, researchers hope to replicate the effect and develop new treatments for millions of patients worldwide.
A new study found that patients who undergo hip-replacement surgery experience a surge in pain medication use before and immediately after surgery, but this trend reverses in the long term. Medication use for insomnia and anxiety also increases before surgery and decreases afterward.
A study found that aspirin's breakdown product salicylic acid blocks cell death associated with Alzheimer's, Parkinson's and Huntington's disease by inhibiting the GAPDH enzyme. Derivatives of salicylic acid may hold promise for treating multiple neurodegenerative diseases.
Researchers have created a comprehensive catalog of known animal toxins and their physiological effects on humans, summarizing nearly 42,723 effects on the body. The Venom Knowledge Base (VenomKB) may spur the discovery of new compounds and medical treatments for various diseases.
A new review of 45 years of medical literature found relatively few cases of meperidine-associated seizures, with coexisting conditions often contributing to the increased risk. The study concludes that meperidine's role as an effective anti-shivering agent should continue to be explored.
Researchers have identified a biochemical pathway regulated by aspirin, which decreases the level of 2-hydroxyglutarate, a driver of cancer development. This study adds to the evidence for aspirin's importance in cancer prevention and highlights a new pathway worth further investigation.
A nationwide study found that minorities are less likely to receive analgesic medications for abdominal pain at US emergency departments. Black and Hispanic patients experience prolonged ED lengths of stay and were less likely to be hospitalized for their ailments.
A new study by Brigham and Women's Hospital found that minority patients with acute abdominal pain are less likely to receive analgesic medications, with black patients experiencing the greatest undertreatment. The study also found disparities in hospital waiting times and admission rates among minority groups.
Researchers at CU Anschutz Medical Campus discovered that patients given opioid pain medication on discharge had a 25% higher risk of becoming chronic users. The study found that medical patients were more likely to progress to chronic use compared to surgical patients.
A new study presents a regenerative agent, Cacicol, that speeds up the healing of corneal tissue after surgery, reducing recovery time by up to 70% and minimizing complications. The treatment also alleviates eye pain, burning, and light sensitivity.
A Vanderbilt University Medical Center study found that COX-2 drugs may cause cardiovascular problems due to prostaglandin production by macrophages. The researchers hope to develop new, targeted painkillers without the vascular effects of existing medications.
A study published in The AAPS Journal suggests that medication degradation does not differ significantly between space and Earth. Nine medications were analyzed after being stored for up to 11 months in space, with some remaining viable beyond their expiration dates.
A recent study published in the Journal of Neuroscience found that mindfulness meditation reduced pain intensity by 27% and emotional aspect of pain by 44%, compared to a 11% reduction in sensation of pain and 13% reduction in emotional aspect with placebo cream. Mindfulness meditation also activated brain regions associated with self-...
A study on medicines stored in space for up to 550 days revealed that they do not degrade faster than on Earth. The research found that some medications were still viable beyond their expiration dates, while others showed minimal degradation.
Patients undergoing atrial septal defect closure experienced fewer migraines with dual antiplatelet therapy, showing a lower incidence of attacks and less severe symptoms. Researchers observed no significant increase in adverse events between dual and single antiplatelet therapy.
A study published in the journal Biology of Sex Differences found that over half of female methadone clinic patients reported doctor-prescribed painkillers as their first contact with opioid drugs. The study highlights the importance of considering gender differences in treatment options for opioid addiction. Researchers noted that wom...
A study found that more than half of female methadone clinic patients started with doctor-prescribed painkillers, while men were more likely to be working and smoke cigarettes. The researchers highlighted the need for better treatment options tailored to women's demographics and health needs.
A recent study by the American College of Allergy, Asthma, and Immunology found that 34% of patients with cardiovascular disease were incorrectly labeled as having an aspirin allergy due to gastrointestinal symptoms. In reality, only 2.5% of patients had a true aspirin hypersensitivity.
Researchers found that middle-aged white Americans have seen a sharp increase in death rates after 1998, primarily caused by drug and alcohol poisoning, chronic liver disease, and cirrhosis. This trend reverses decades of progress and is not seen in other rich countries or minority groups.
A retrospective survival analysis of 229 patients with late-stage cancer found that those who received methylnaltrexone lived twice as long and had fewer tumor progression reports compared to placebo groups. The study suggests methylnaltrexone may play a role in cancer therapy, but the exact mechanism is unclear.
Scientists at the University of Manchester have shown that the number of opiate receptors in the brain increases to combat severe pain in arthritis sufferers. By applying heat, they found a correlation between higher receptor numbers and increased ability to withstand pain.
The world's largest clinical trial on aspirin to prevent cancer recurrence has launched in the UK. The Add-Aspirin trial will recruit 11,000 patients and run for up to 12 years to determine if daily aspirin intake can stop or delay cancers from returning.
A study published in JAMA found that combining a muscle relaxant or opioid with an NSAID did not provide better pain relief for patients with acute low back pain. Despite this, nearly two-thirds of patients demonstrated clinically significant improvement in LBP and function within one week.
Researchers identified salicylic acid as a powerful inhibitor of HMGB1, a protein linked to various diseases. The findings may lead to the development of more effective aspirin-like drugs.
A majority of Americans support policies to control opioid painkiller abuse, including better medical training, patient verification, and treatment. The study found that most people blame doctors and abusers for the crisis, with broad backing for most policy recommendations.
A large study found that aspirin use after a cancer diagnosis significantly increases overall survival rates for patients with gastrointestinal tumours. The researchers analysed data from nearly 14,000 patients and discovered a strong association between aspirin use and improved survival.
The ESMO Global Opioid Policy Initiative reveals disparities in opioid access across the globe, with the Middle East, Latin America, and Asia showing limited access to essential pain relieving medication. The addition of new Designated Centres brings polices tailored to patient needs, promoting a multidisciplinary approach to cancer care.
A randomized trial will recruit 3,000 women with Stage II and III breast cancer to receive either aspirin or a placebo. The study aims to determine if aspirin can prevent breast cancer recurrence and death, with potential benefits including enhanced survival and reduced costs in developing nations.
Boston Medical Center (BMC) has significantly reduced the average wait time for pediatric patients experiencing severe pain from sickle cell disease from 56 minutes to 23 minutes. The hospital's quality improvement initiative also improved care by reducing the time to administer pain medication and increase patient-controlled analgesics.
Research finds that rural adolescents are 35% more likely to abuse prescription painkillers in the past year compared to urban teens. The study suggests that limited medical care and emergency room prescriptions contribute to this issue.
A study published in JAMA Pediatrics found racial disparities in pain management among children with appendicitis in emergency departments, with black children receiving less pain medication and opioids. The study analyzed data from 2003 to 2010 and suggested that more research is needed to understand why such disparities exist.
Researchers isolated machinery for producing cancer-fighting drug etoposide from endangered Himalayan plant and applied it to a common laboratory plant, producing the chemical. The technique could lead to less expensive and more stable sources of drugs.
The National Association of Science Writers announced the winners of its 2015 Science in Society Journalism Awards, recognizing outstanding reporting on science and society. Winners include Judy Foreman for her book A Nation in Pain: Healing Our Biggest Health Problem, and Erik Vance for his article Why Nothing Works.
A new study reveals that patients with lumbar spinal stenosis prefer pain relief to improved mobility, defying medical community assumptions. Researchers surveyed 269 patients and found that 79% chose pain reduction over increased physical function.
The new ESC guidelines offer improved management of pericardial diseases, including acute pericarditis and constrictive pericarditis. The guidelines provide specific diagnostic criteria and treatment recommendations, aiming to improve outcomes and quality of life for patients with these conditions.
A Boston University School of Medicine program educates clinicians on safe opioid prescribing, resulting in improved knowledge, attitudes, and clinical practice. The program has empowered clinicians to make informed decisions about opioids for chronic pain sufferers.
A study at Mount Sinai Hospital found that antidepressants regulate chronic pain and depression through actions in the nucleus accumbens, a key brain reward center. The research discovered a gene (RGS9) controlling molecular adaptations for recovery from pain and depression.
A population-based case-control study found that long-term, continuous use of low-dose aspirin and nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with decreased colorectal cancer risk. The study also suggests that higher COX-2 selectivity in nonaspirin NSAIDs may offer greater protection.
A new Canadian guideline has been published to help manage pain during vaccination in both children and adults. The guideline includes recommendations for various age groups and settings, such as physician's offices and public health settings.
A new study using bionic liver micro-organs explains the off-target toxicity of acetaminophen, a breakthrough that could transform drug development. The device detected small changes in cellular respiration, revealing a faster and lower-dose mechanism than previously thought.
A recent study analyzed prescription claims data in Florida and Georgia, finding modest decreases in opioid prescribing and use after implementation of the state's pill mill law and prescription monitoring program. The reductions were most pronounced among patients and providers with high levels of opioid use at baseline.
Researchers found that the simultaneous use of heroin and prescription painkillers is increasing dramatically among whites, particularly young white men. Heroin abuse has also expanded to groups not traditionally seen as widespread opiate users, highlighting the need for tailored treatment approaches.
A regular dose of aspirin reverses the long-term risk of cancer in those who are overweight, according to a study published in Journal of Clinical Oncology. The research found that being overweight more than doubles the risk of bowel cancer in people with Lynch Syndrome.
Researchers at Stanford University have genetically engineered yeast to produce hydrocodone and other opioid painkillers, enabling a faster and potentially less expensive way to produce plant-based medicines. The breakthrough could lower costs and increase access to pain medications for 5.5 billion people worldwide.
A new study found that 77% of dentists ask patients about illicit drug use and 54% believe screenings should be their responsibility. Dentist attitudes toward substance misuse screening vary by age, gender, and prior training, but more educated and younger dentists are more likely to accept such screenings.
A comprehensive review of available evidence confirmed that listening to music before, during, and after surgery reduces postoperative pain, anxiety, and the need for painkillers. The study involved nearly 7,000 patients and found music to be effective even when patients were under general anaesthetic.
A comprehensive review of 7000 patients found that listening to music significantly reduces pain medication use and reports more satisfaction after surgery. Patients who selected their own music experienced a slight but non-significant reduction in pain, highlighting the importance of patient choice.
A study at Loyola University Medical Center found that knee replacements can treat degeneration caused by Blount disease, resulting in stable knees and no pain medications. Researchers used a scoring system to evaluate the success of the surgery, with mean scores indicating excellent range of motion and low disability.
A new initiative to add price tags to medicines worth over £20 in England may have unintended consequences, warns an editorial in the Drug and Therapeutics Bulletin (DTB). The move could lead vulnerable patients to worry about being a burden on society, while others may view cheaper drugs as less important. Furthermore, the added cost ...
Researchers will evaluate existing Cathepsin S inhibitor as new potential Chagas disease therapeutic, addressing a neglected tropical disease with no FDA-approved therapies. The grant aims to confirm the antiparasitic activity and test safety and effectiveness in humans.
Researchers found that subjects who knew they were receiving a fake pain treatment still experienced pain relief after multiple sessions. The study suggests that conditioning can create independent placebo effects that require both belief and consistent experiences. This could lead to new treatments for drug addiction or pain management.
Researchers found that US health care providers perceive South Asians as being more reluctant to report pain and seek medications. This is partly due to cultural differences in medical practice in South Asia, where patients are often not asked about their pain and may be given low-dose pain medications after surgeries.
A study by Georgetown University Medical Center researchers found that acupuncture blunts activity in the hypothalamus-pituitary-adrenal axis, reducing production of stress hormones. This mechanism is similar to that of antidepressants and anti-anxiety drugs, which exert their therapeutic effects on these same pathways.
A study found that non-chronic opioid users with low prescribed doses are at risk of overdose, contradicting current guidelines. Concurrent sedative use also contributes to overdose risk.
SLU pain researcher Daniela Salvemini has been awarded the NIH's Cutting-Edge Basic Research Award to develop new painkillers that can quell terrible pain while minimizing debilitating side effects. The two-year grant will support her search for innovative ways to mitigate opioid side effects and preserve their pain-relieving ability.
A Tel Aviv University study found that hyperbaric oxygen treatment can drastically reduce or eliminate fibromyalgia symptoms, enabling patients to discontinue pain medication. The research also identified the primary factor causing fibromyalgia: brain mechanism for processing pain disruption.
A recent study published in The BMJ found that taking a combination of antidepressants and common painkillers increases the risk of bleeding. The researchers analyzed data from over four million patients and found a substantially increased bleeding risk with combined use of antidepressants and NSAIDs, especially in men.
A nationwide study found that individuals of any age who used illicit drugs had a higher likelihood of misusing prescription pain relievers. Adults aged 50 and above were more likely to acquire pain relievers through multiple doctors, while younger individuals relied on friends, relatives, or drug dealers.
Researchers have discovered thousands of new peptide toxins in the venom of a single type of Queensland cone snail, opening up promising leads for new pain and cancer treatments. The study's innovative method allows for deeper analysis of venom toxins than ever before.
Scientists at UC Davis have identified endoplasmic reticulum stress as the significant driver of neuropathic pain. The discovery opens new avenues for treating chronic pain from various conditions, such as diabetes and multiple sclerosis.