Articles tagged with Cancer Treatments
Children treated for cancer before age 4 experience delays in vocabulary, cognitive functions, and motor skills compared to their healthy peers. However, social and emotional development remains unaffected.
Researchers will focus on inhibiting cancer cell metabolism by targeting Mct1 and Mct4 proteins, which transport lactic acid out of cancer cells. The goal is to develop broad-spectrum anti-cancer therapeutics for breast cancer and lymphoma.
Dr. Kari Alitalo receives the award for his outstanding contributions to lymphatic science and advancement of VEGF-C lymph node transplant research, which shows promise in treating lymphedema and improving lymphatic function.
Chinese Minister of Health Dr. Zhu Chen will hold talks with leading cancer researchers from the US and China to develop a stronger platform for Sino-US research collaboration. The goal is to fast-track cancer research and create deeper ties among researchers.
Researchers found that vitamin D reduced the size of uterine fibroids in laboratory rats by an average of 75% compared to untreated groups. This study provides promising evidence for vitamin D as a potential treatment for fibroids, which affect millions of women worldwide.
New research highlights the importance of nurses in alleviating concerns and existential issues in newly diagnosed lung cancer patients. Nurses can provide supportive care, address death-related concerns, and help patients locate resources to manage end-of-life affairs.
A UK study provides insight into the relationship between manganese superoxide dismutase (MnSOD) and cancer progression. The research found that MnSOD expression was suppressed early in skin carcinogenesis but increased at late stages, highlighting its role as a p53-regulated gene.
Professor Mike Stratton discusses the evolution of the cancer genome at the AAAS annual meeting, highlighting advances in whole genome sequencing and the development of COSMIC catalogue. This research provides insights into cancer causation, prevention, and treatment, with potential global solutions through international collaboration.
Researchers at Polytechnique Montréal developed a new transfection method that changes the genetic material of cancer cells, allowing for precise nanometric-scale surgery. This breakthrough could lead to new therapeutic approaches in oncology, neurology, and cardiology, with promising applications.
Malnourished cancer patients who received oral nutritional support showed improvements in aspects of quality of life, including emotional functioning and loss of appetite. However, the interventions had no impact on mortality rates or consistent effects on weight gain.
A new study published in The Lancet Oncology shows that cognitive behavioural therapy (CBT) significantly reduces hot flushes and night sweats in women after breast cancer treatment. CBT improves symptoms by 46-52% compared to usual care, with sustained benefits at 26 weeks.
Researchers at Stanford University have identified a sequential treatment regimen that enhances the effectiveness of trastuzumab in xenotransplant models of breast cancer. Trastuzumab activates natural killer cells to kill HER2-overexpressing tumor cells.
Researchers have discovered a new way to enhance trastuzumab treatment in HER2-positive breast cancer patients by stimulating natural killer cells. Additionally, the activation of FoxO1 has been linked to the development of diabetic cardiomyopathy, offering a promising therapeutic target. Leptin's direct action on POMC neurons may also...
Researchers at Thomas Jefferson University found that curcumin suppresses nuclear receptor activators, which can bypass androgen deprivation therapy. Curcumin also reduced cell number and inhibited survival in prostate cancer cells, with similar results seen in mice studies.
A study published by the NIH shows that Kineret therapy is effective in stopping the progression of organ damage in people with neonatal-onset multisystem inflammatory disease (NOMID). By preventing organ inflammation, scientists were able to preserve organ function in most patients.
Researchers found a gene, LTA4H, that influences inflammation to TB infection, predicting drug therapy effectiveness. This discovery suggests tailoring treatment based on patients' genetic sequences could improve patient outcomes.
Cancer tumors' metabolic profiles vary based on genes and tissue origin, necessitating individualized treatment approaches. The metabolome, in addition to the genome, is crucial for predicting metabolic changes and guiding therapy.
Researchers at LSU Health Sciences Center have identified a new protein called ARD1 that plays a critical role in the development and growth of prostate cancer. Inactivating this protein completely suppresses cancer growth, making it a potential target for new treatments.
A study published in Cancer Prevention Research found that soy isoflavone supplements did not decrease breast cancer cell proliferation. The results are consistent with previous studies on the effectiveness of dietary supplements in preventing cancer.
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor resistant to current therapies. Researchers at the University of California, San Francisco, have identified PDGFR-alpha and SULF2 as potential therapeutic targets for GBM treatment. Knocking down SULF2 expression decreased cell growth in human GBM cell lines.
A study published in Science Translational Medicine found that massage reduces inflammation and promotes the growth of new mitochondria in skeletal muscle after intense exercise. The research provides evidence that massage could be a valuable treatment option for individuals with chronic inflammatory diseases or musculoskeletal injuries.
Researchers identify 'gatekeeper' ADAM17 involved in regulating immune response and preventing inflammatory skin disease. Reactivation of Notch signaling rescues local skin inflammation and abnormal immune cell proliferation.
A novel molecular process linked to neddylation has been found to be involved in the development of hepatocellular carcinoma, a type of liver cancer with poor prognosis. The study suggests that targeting this process could lead to potential therapeutic applications for patients with HCC.
Despite significant progress in treating chronic myeloid leukemia, a cure remains elusive for all patients. Research and adherence to treatments are crucial to advancing the field.
A study published in the Journal of the National Cancer Institute found that younger breast cancer patients experience more severe mental health issues and physical impairments than older women. Researchers recommend educating these patients about potential post-treatment effects to reduce anxiety and improve quality of life.
A UCSF team has developed methods to reveal a molecular marker in tissue samples from brain tumors that has been linked to better survival odds. Monitoring this marker could provide doctors with a better way to follow their patients after surgery and assess how they respond to recommended treatments.
Researchers used human embryonic stem cells to treat macular degeneration in two patients, with some improvement in vision observed. The study showed that the transplants were safe and led to successful engraftment of cells into the retina.
A study published in the Journal of the National Cancer Institute found that younger women with breast cancer experience decreased health-related quality of life, including increased psychological distress, weight gain, and early onset menopause. Personalized treatment approaches are crucial to mitigate these side effects.
Researchers at Dana-Farber Cancer Institute discovered a mechanism by which micronuclei disrupt chromosomes, leading to cancer-causing gene mutations. The findings suggest that whole chromosome aneuploidy may promote cancer in a similar way to other genomic alterations.
A new study found that poor smokers are more likely to relapse after quitting, with those on lower rungs of the socioeconomic ladder facing the toughest odds. The research suggests that financial difficulties, discrimination, and job insecurity contribute to their struggle.
Researchers developed a new combination drug therapy that successfully suppressed hepatitis C genotype 1 infection in a significant proportion of patients. The study, published in the New England Journal of Medicine, focused on treating patients who had not responded to previous treatment with PEG-interferon alfa and ribavirin.
Researchers have identified a novel connection between two RNA-binding proteins, Musashi1 and HuR, which plays a significant role in glioblastoma development. The study suggests that disruptions to these regulatory processes can contribute to tumor formation.
Researchers at Columbia University Irving Medical Center identified the origin of esophageal adenocarcinoma as the gastric cardia, where bile acid and inflammatory cytokines activate stem cells. The study highlights possible targets for new clinical therapies, including inhibiting notch signaling.
A retrospective analysis of 1,500 patients showed that live interactive teledermatology consultations resulted in diagnostic changes for nearly 70% of patients. Patients also received recommendations to change their skin disease management, leading to improved clinical outcomes.
Researchers at UBC have found a way to block infection from the hepatitis C virus (HCV) in the liver, leading to new therapies for those affected by this and other infectious diseases. The approach could benefit millions of people globally.
Research finds that multicentric lung adenocarcinoma often shares the same genetic mutation, indicating a possible common origin for these tumors. The study identified genetically distinct molecular subsets using EGFR and KRAS genes.
Researchers found sorafenib to be effective in patients with non-small cell lung cancer and a KRAS mutation, achieving a 52.6% rate of no progression at six weeks. However, median overall survival was only 5.3 months, indicating unsatisfactory outcomes.
A University of Illinois study found that personalized prognostic tools and gene-based therapies can improve the survival and quality of life of glioblastoma patients. The researchers discovered new general and clinical-dependent gene profiles that can be used to predict patient outcomes and select targeted therapies.
A new study explores the fertility and parenthood concerns of young female cancer survivors, finding that they are often unaware of the impact of treatment on their future fertility. The researchers identified six themes from focus group discussions, highlighting the need for better information, continuity of care, and guidance to addr...
A prospective surveillance model for breast cancer treatment has been shown to significantly reduce costs and improve outcomes. The model, which involves early identification and intervention of lymphedema-related impairment, has been associated with direct treatment costs of $636.19 per year compared to traditional care at $3,124.92.
The Damon Runyon Cancer Research Foundation and the Sohn Conference Foundation have partnered to support young scientists tackling childhood cancers, with a focus on preventing devastating illnesses in children and young adults. The partnership aims to recruit top young minds to research childhood cancers, leveraging the success of exi...
Most patients who survive oesophageal cancer surgery recover an average quality of life, but one in six experience significant deterioration. Hospitals must improve identification and follow-up for these patients to prevent persistently low quality of life.
A new study shows that targeting a specific microRNA, miR-221, can prolong the lives of mice with human liver cancer. The treatment also boosted activity of tumor-suppressor genes in these animals.
Researchers have identified mutations in the ATM gene as a potential risk factor for increased pancreatic cancer risk. Studies found that ATM gene mutations were present in four of 166 patients with pancreatic cancer, but absent in healthy spousal controls.
The study reveals a DNA repair mechanism that can mitigate oxidative damage, which is linked to various diseases including cancer and Alzheimer's. This discovery holds promise for developing less invasive cancer therapies and early detection tests.
A new study has discovered a way to prevent septic shock by blocking a specific form of cell death called necroptosis. The approach fully protects mice against the fatal inflammation, offering a potential new target for therapy. Researchers found that eliminating RIPK molecules led to full protection against sepsis.
Researchers found that patients with initial metastatic breast cancer tend to be older and have lower-grade tumors, while those with early relapse after treatment are younger and have more aggressive cancer. The study emphasizes the importance of increasing awareness about breast care and the need for novel therapeutic strategies to im...
A study analyzing lung and spleen tissue from patients who died of sepsis revealed biochemical, cellular, and histological findings consistent with immunosuppression. The research found evidence of impaired immunity in patients with sepsis, which could have important therapeutic implications.
The Academy of Nutrition and Dietetics recommends expanding Medicare coverage for medical nutrition therapy (MNT) services, which demonstrate significant health benefits and cost-effectiveness. MNT can help manage chronic conditions, such as hypertension, obesity, and cancer, and improve quality of life.
Researchers found that blocking EETs production can eliminate blood vessels that feed cancer tumors, promoting metastasis. Increasing EET levels may help patients with vascular conditions, but excessive levels promote tumor growth and metastasis.
The Leonard Wolfson Experimental Neurology Centre will accelerate the development of treatments and identify future therapeutic targets for neurodegenerative diseases, aiming for earlier intervention for patients. The centre will be based at UCL's National Hospital for Neurology and Neurosurgery.
Researchers identified a high-risk subgroup among older AML patients with mutated ASXL1 gene, showing significantly shorter survival and lower complete remission rates. The study's findings could lead to more effective targeted therapies for these patients.
Researchers have discovered that administering aspirin after standard therapy for venous thromboembolism (VTE) may prevent the recurrence of potentially deadly blood clots. The WARFASA study found that low-dose aspirin reduced VTE recurrence by 6.6% compared to placebo, with a similar incidence of major and non-major bleeding.
Researchers found that between 1992 and 2005, the percentage of patients who had multiple imaging visits nearly quadrupled, from 4.9% to 19.4%. A single imaging visit increasingly includes multiple types of imaging, with the rate rising from 4.3% to 27.1%.
The addition of zoledronic acid to adjuvant endocrine therapy increased bone mineral density and reduced disease recurrence among postmenopausal women with early hormone receptor-positive breast cancer. Immediate zoledronic acid use also improved survival outcomes, particularly in women who were truly menopausal at diagnosis.
Researchers confirm zoledronic acid's continued effectiveness in reducing breast cancer recurrences and improving survivorship rates among premenopausal women with estrogen receptor-positive breast cancer. The study found a 28% reduced risk for recurrence and a 36% reduction in mortality risk, with no toxic side effects.
Researchers developed a multigene test to identify high-risk patients with ductal carcinoma in situ (DCIS) and differentiate between lower-risk and more aggressive forms. The DCIS Score algorithm predicts individual risk for recurrence, allowing physicians to provide tailored treatment programs.
A new predictive tool has been developed to assess the risk of recurrence in gastrointestinal stromal tumours (GIST) following surgery. The tool provides more accurate prognosis for individual GIST patients compared to conventional models, helping to identify those most likely to benefit from additional treatment.
Researchers will collect cancer incidence data from 13 Appalachian states to identify differences in relative survival and avoidable death between sub-regions and non-Appalachian areas. The findings will inform the development of effective evidence-based cancer control interventions for the region.
Sulfomucins, secreted by intestinal goblet cells, provide critical protection to the intestinal mucosa. Inflammatory cues from microbes and host inflammatory cells modulate sulfomucin production, which is associated with both inflammatory bowel disease and colorectal cancer.