Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
A study published in European Journal of Epidemiology found that cancer survival rates in Germany have aligned significantly since reunification. While there are still slight differences, they have decreased compared to the pre-reunification era.
Researchers at the University of Strathclyde have developed a new approach to delivering green tea extract, epigallocatechin gallate, directly to tumors. In initial laboratory tests, nearly two-thirds of treated tumors shrank or disappeared within one month with no side effects to normal tissues.
Investigators found that low oxygen levels increase SMN2 exon 7 skipping, reducing survival motor neuron protein levels. Higher oxygen treatment improved motor function and reduced disease severity in a mouse model of severe SMA.
Researchers have successfully integrated RNA switches into viral genetic material to control gene expression, increasing the production of therapeutic genes by ten times. This technology has vast potential for various research and medical applications.
A retrospective study published in Archives of Dermatology found that patients with psoriasis treated with tumor necrosis factor (TNF) inhibitors have a significantly lower risk of heart attack compared to those not treated with TNF inhibitors. The study included 8,845 patients and adjusted for other MI risk factors.
The FastStitch device, developed by Johns Hopkins undergraduates, features a cross between a pliers and a hole-puncher to guide stitch placement and prevent accidental punctures. The device has already received recognition and funding to move forward, aiming to simplify and improve the closure process for surgeons.
Researchers found that B cells from patients with chronic GVHD are more active and resistant to programmed cell death. The study identifies BAFF as a promising target for developing new therapies, such as anti-BAFF agents or small molecule inhibitors.
The University of Delaware is part of a $2.5 million NIH-funded project to create artificial salivary glands. Researchers hope to develop new solutions for Xerostomia, a side effect of radiation treatment for head and neck cancers. The project involves developing hydrogels that can guide salivary cells to form functional glands.
Scientists have discovered that high iron levels can cause bowel cancer in people with a faulty gene, increasing the risk by two to three times. A diet low in iron prevents bowel cancer from developing altogether.
Researchers identified a previously unknown subtype of Ewing sarcoma with genetic factors related to long-term survival. A specific gene change between primary and metastatic stages may lead to better treatment.
Research finds that TRPM7 protein plays a critical role in breast cancer cell metastasis. High levels of TRPM7 expression are associated with poor patient outcomes and increased risk of distant metastases. The study suggests that targeting this protein could block metastasis, offering new therapeutic opportunities.
Researchers found tristetraprolin (TTP/ZFP36) to be a tumor suppressor that impairs lymphoma development and maintenance. The study's findings suggest TTP could be a key target for treating cancers with MYC involvement, including relapsed and refractory tumors.
A recent study in Pakistan found limited awareness of breast cancer among most women, with many unaware of self-breast exams and clinical breast exams. However, willingness to address health issues was high, and the majority of general practitioners understood major risk factors and importance of early detection.
Researchers found that herbal agents can prevent sunburn and limit UV damage, with golden serpent fern and Asian ginseng showing promising photoprotective properties when taken orally. Green tea applied topically also offers photoprotection in sufficient doses.
Researchers at Ohio State University found that liver cancer cells lose the ability to produce glucose due to microRNA-23a overexpression. Suppressing miR-23a might reverse this process and offer a new treatment for hepatocellular carcinoma, the most common form of liver cancer.
Two men with longstanding HIV infections have no detectable traces of HIV after bone marrow transplants, suggesting protection under anti-retroviral therapy. Researchers plan to study additional HIV-positive patients and explore tracing HIV in tissues.
Researchers from the British Columbia Cancer Research Center analyzed lung tumors exposed to arsenic, highlighting genetic and epigenetic changes driving carcinogenesis. These findings may help prevent arsenic-related cancer in regions with low exposure levels.
A meta-analysis of 10 studies found that cognitive behavioral therapy and pharmacologic interventions decrease depressive symptoms in cancer patients. The study also identified effective interventions for different stages of cancer and cultural subpopulations.
Directly targeting microRNA-125b to block androgen receptor activity represents a novel approach for treating castrate-resistant prostate cancer. The study provides new insight into the mechanism of miR-125b regulation of castrate-resistance prostate cancer.
The AACR-Kure It Grant will support innovative kidney cancer research, aiming to improve patient survival and quality of life. The grant recipient will receive $250,000 over two years and recognition at the AACR Annual Meeting.
Researchers at Stanford University have created a collection of compounds called bryologs that can activate latent HIV reservoirs with equal or greater potency than the original substance. The discovery holds promise as a practical way to flush out dormant viruses, offering hope for a cure for AIDS patients.
Researchers at Dana-Farber Cancer Institute have identified a new type of energy-burning fat cell, called 'beige fat,' which may have therapeutic potential for treating obesity and diabetes. Beige fat cells can burn off calories rather than store them, unlike 'white fat' cells.
A national survey of physicians found that patient fears and misinformation are major barriers to treating menopausal symptoms. The Endocrine Society has developed the Menopause Map, an online tool to guide women through treatment options and assess individual risk factors.
Researchers at HZDR demonstrate proton acceleration in the direction of the laser light, achieving unprecedented high energies. This breakthrough enables future cancer therapy applications with ultra-short pulse lasers.
A study published in The Journal of Nuclear Medicine found that imaging progesterone receptor (PR) status can identify responders and nonresponders to endocrine therapy in early stages. PR imaging with F-18-FFNP PET may help distinguish between patients who will benefit from hormone-based therapies.
Rheumatoid arthritis patients face significant challenges including disability, life expectancy drops, heart attack risk, and joint destruction. Mayo Clinic researchers offer guidance on diagnosis, treatment, and management to improve outcomes for patients.
A study published in Cancer Research found that increasing coffee consumption is inversely associated with the risk of developing basal cell carcinoma, the most common form of skin cancer. The study's results suggest that caffeine may be responsible for this decreased risk.
Researchers found that inhibiting a key immune response early on can shorten TB treatment time and prevent relapse. In a study, mice treated with standard TB medication plus a TNF-alpha inhibitor had a significantly lower bacterial burden than those receiving only the standard treatment.
A new study found that the federal government made $13 billion in duplicative payments to provide health-care services to veterans enrolled in Medicare Advantage plans. The researchers analyzed over 1 million veteran records and found that 61% used both VA and Medicare Advantage coverage.
A new animal study finds that oxytocin helps regulate food intake and energy metabolism without causing adverse effects. Oxytocin administered through daily injections or implanted mini pumps reduced food consumption, body weight, and liver fat, improving glucose tolerance and reducing abdominal fat.
Scientists have identified genetic heart conditions as a possible cause of unexplained stillbirths, with up to 8% of cases attributed to cardiac channelopathies. The research, led by Ms Alice Ghidoni, used molecular screening to detect disease-causing variants in stillborn fetuses.
A study in Nature Medicine reveals that boosting a protein pathway in the body's blood-making system can protect against radiation poisoning. The researchers found that pharmacologic enhancement of the Thbd-aPC pathway can accelerate recovery of hematopoietic progenitor cell activity and reduce harmful effects in mice.
The American Association for Thoracic Surgery task force recommends expanded lung cancer screening guidelines using low-dose computed tomography (LDCT) for high-risk individuals. The new guidelines increase the recommended age range to 79 and expand eligibility to smokers and former smokers with specific risk factors.
A molecule believed to suppress tumor growth is found to accelerate anaplastic thyroid cancer cell growth when active. Researchers discovered a potential therapeutic target by identifying a gene promoting growth in cancer cells.
A study by Steffen Torp and colleagues found that long-term cancer survivors take significantly more sick leave than their non-cancer counterparts. Socio-demographic factors, such as education level and family status, were key predictors of sick leave, rather than the type or severity of cancer.
The number of Americans with a history of cancer is expected to reach 18 million by 2022, with 45% of survivors aged 70 or older. Improved cancer survival rates have led to the growth in survivor prevalence despite decreasing cancer incidence rates.
Researchers at Johns Hopkins University have developed a lab-on-chip platform that can sort microscopic particles and bits of biological matter using gravity or simple forces. The device, similar to speed bumps on a road, separates particles based on weight, size or other factors, holding promise for early cancer detection.
Researchers identified a molecular marker that quickly distinguishes between fast- and slow-progressing forms of chronic leukemia. The finding enables patients with aggressive disease to start treatment sooner.
A joint research project between Aarhus University and the Danish Cancer Society shows that mindfulness-based psychological therapy helps reduce anxiety and depression in cancer patients. Mindfulness teaches patients to be more conscious of life as it happens, reducing negative thoughts and worries.
Researchers found African-American survivors have unmet needs in dealing with fears of recurrence, while spouses report concerns about stress and anxiety. The study highlights the importance of culturally appropriate interventions, including improved communication and symptom management for better outcomes.
Researchers have identified new therapeutic targets for cancer treatment by studying the interaction between natural killer cells and tumor cells. A study found that targeting JAK1 and JAK2 kinases may aid in eradicating tumors resistant to NK cell killing. Additionally, another study revealed that periostin plays a crucial role in chr...
A new analysis found that many adolescent and young adult cancer survivors experience chronic medical conditions, poor quality of life, and barriers to healthcare access. The study suggests that these negative behaviors are potentially modifiable through proper follow-up care and promotion of healthy habits.
Researchers at UT Southwestern Medical Center have mapped the atomic-level architecture of the CLOCK complex, a key component of the body's circadian rhythm. The study provides insights into how this protein works and may lead to better treatments for insomnia, diabetes, and cancer.
A Mayo Clinic-led study found that high doses of American ginseng reduced cancer-related fatigue in patients more effectively than a placebo. The herb showed significant improvement in general exhaustion at eight weeks, with no apparent side effects.
Fox Chase researchers found that patients' socioeconomic status influences their treatment choices, with those having higher incomes opting for more effective but expensive treatments. This study highlights the need for policymakers to consider cost sensitivity in cancer care.
Researchers at the University of New South Wales have discovered a potential new way to regulate the immune response, increasing good regulating cells to treat autoimmune diseases. The treatment involves injecting cell-signalling proteins called cytokines, which boost the body's immune system without causing overdrive.
A randomized controlled trial found that using mobile technology, remote coaching, and financial incentives improved patients' diet and activity levels. The study's interventions leveraged handheld technology to make self-monitoring more convenient and extend decision support into life contexts.
Researchers at Ohio State University Comprehensive Cancer Center discovered a small inherited change in DNA responsible for overactivating the BAALC gene, which is associated with poor treatment response in acute leukemia. The study found that high levels of RUNX1 protein are linked to high BAALC gene expression.
Researchers developed a new method to identify vaccine targets for Streptococcus pneumoniae, the most common cause of bacterial meningitis. Gene therapy has shown promise in treating adenosine deaminase deficiency by correcting B cell tolerance problems and supporting treatment options for patients with severe combined immunodeficiency.
Researchers developed a stapled BIM BH3 peptide that competitively binds to anti-apoptotic proteins, leading to enhanced apoptosis in cancer cells. The compound suppresses tumor growth in mice and works synergistically with other pharmaceutical agents.
Mayo Clinic researchers present studies on adjuvant hormonal therapy for prostate cancer patients, finding no negative impact on overall survival. They also release results of a study on safe intervals for PSA screening in young men.
Research in Psychological Science explores public reaction to task force recommendations, citing factors such as anecdotes and perception of medical treatments. The study suggests that changing the public's view on prostate-cancer screenings may require pictorial displays to help evaluate data more effectively.
Researchers compared chest tube drainage and talc slurry for pleurodesis to indwelling pleural catheters in treating lung effusions. The study found no significant difference in dyspnea between the two treatments, but IPCs reduced hospital time despite increasing adverse events.
The American Gastroenterological Association will showcase innovative data and advancements in treating gastrointestinal (GI) disorders during the Digestive Disease Week 2012. The presentation of exciting, cutting-edge information will help physicians diagnose and treat GI disorders more effectively.
A nurse practitioner-driven consultation improved cancer patients' emotional health and quality of life, with a significant improvement in those who received the intervention. The study suggests that incorporating palliative care discussions into oncology practices can lead to better patient outcomes.
Researchers investigated whether preoperative imaging differed between black and white women with breast cancer. They found no disparity in the use of imaging, contrary to some earlier studies. However, they did note that women from more educated areas were more likely to receive certain types of imaging.
A meta-analysis confirms statins reduce major vascular events by 21% in those with low risk of vascular disease. Statin therapy outweighs known side effects, suggesting current guidelines may need revision.
A recent study from Fox Chase Cancer Center found that nearly half of the research presented at ASCO's annual meeting came from researchers with industry ties. The study suggests a growing dependence on industry funding for cancer research, highlighting the need to investigate potential conflicts of interest.
A new study found that safer partial nephrectomy surgery is less common among older, sicker, and poorer patients who rely on Medicare or Medicaid for care. This disparity may be due to limited access to care or lower proficiency in performing the advanced surgical technique.
A new study by Henry Ford Hospital urologists finds that robot-assisted partial nephrectomy (RAPD) offers fewer complications than laparoscopic partial nephrectomy (LPN), but notes limitations due to data availability on surgical expertise and cancer complexity. The procedure has become the standard treatment for kidney cancer, with co...