Research on new and better ways to treat cancer. Covers radiotherapy, targeted microdroplets, nerve-injury protection, drug combinations, and tumor models.
Researchers argue that the NY-ELCAP program cannot determine if screening saves lives due to a lack of control group. The study may harm participants, lead to overdiagnosis and make it harder to learn the true effect of spiral CT screening.
Researchers at Temple University discovered that the Rb2 gene's lack of expression could be an early indicator of prostate cancer. A study found lower expression levels of Rb2 in prostate tissue as it progresses from normal to cancerous, suggesting its potential use as a diagnostic marker.
A study by University of Virginia researchers reveals that journals and authors are protected by various measures, including court rulings, state shield laws, and constitutional provisions. This protection helps prevent corporate power and pressure from tainting peer review.
A survey of oncologists reveals that most enroll patients in clinical trials for access to advanced treatment options rather than advancing future therapy. This challenges the conventional view that research is conducted primarily for scientific progress and improving treatments.
Scientists have overcome technical difficulties by linking ribozymes to helicases, allowing for efficient inhibition of target RNAs and enabling the development of a method for investigating random RNA functions.
Research findings link insulin-like growth factor I (IGF-I) to decreased lung cancer risk when bound by IGFBP-3. Environmental factors influence DNA methylation patterns in tumor suppressor genes, which may impact cancer incidence. Electro-gene therapy enhances IL-12 protein delivery, triggering long-lasting antitumor responses.
A case study highlights the importance of early detection of testicular cancer, with a 17-year-old patient's death attributed to delayed medical advice. Medical professionals and men need to be educated to recognize testicular lumps as medical emergencies.
Researchers found a 16% increased risk of death for blacks compared to whites with comparable treatment, which narrowed to 7% after adjusting for other causes. The disparity was eliminated in most cancers, except for breast and two rare types.
Research suggests that defects in 'orphan' inositol polyphosphates may contribute to diseases such as manic depression and cancer. Dr. York's work identifies biological roles for these molecules and provides a basis for designing more specific drugs with fewer side effects.
A combination treatment of Pegasys and ribavirin has shown an unprecedented 61% sustained virologic response rate, the highest ever recorded. The treatment regimen should be based on hepatitis C virus genotype rather than traditional weight-based methodology.
Postmenopausal women with higher serum concentrations of estrogen and testosterone have twice the risk of developing breast cancer as those with lower levels. This is according to an international study published in the Journal of the National Cancer Institute.
A new study has found that women with the highest levels of sex hormones are at roughly twice the risk of developing breast cancer compared to those with lower levels. Additionally, researchers have discovered a potential therapy for glioblastomas using a fusion protein that shows little toxicity. Reproductive hormones have also been l...
A University of Pittsburgh Medical Center study reveals that the protein cdc42 plays a crucial role in suppressing dendritic cell activity in cancer. The findings provide a new direction for therapeutic molecular immunopathology and may lead to the development of highly efficient vaccines for cancer therapy.
Researchers investigate the remarkable resilience of the mummichog fish to chronic pollution in the Elizabeth River. The study reveals that these fish have adapted through genetic changes, but this comes at a cost, such as increased cancer risk and reduced ability to thrive in clean environments.
Researchers found that when treatment outcomes were impaired quality of life, such as severe functional or cognitive impairment, a significant number of patients (74.4% and 88.8%) lost their willingness to receive treatment. In contrast, the impact on preferences was more nuanced with mortality, where only when the likelihood increased...
A new study found that hormone replacement therapy, particularly estrogen alone, may increase the risk of epithelial ovarian cancer in postmenopausal women with an intact uterus. Women who used sequential progestins with estrogens had a higher risk of developing ovarian cancer compared to those who never used HRT.
A recent study found that women with lower incomes and those insured by Medicaid had worse breast cancer treatment outcomes, including later-stage diagnoses, reduced radiation therapy, and higher mortality rates. Socioeconomic factors accounted for most of the disparities in these outcomes.
A long-term follow-up study of over 800 postmenopausal women found that stopping hormone replacement therapy resumes bone loss at a rate similar to those who never took the drugs. The study showed that while bone mass increased in the first 36 months after starting hormone replacement therapy, there was little gain after that.
Scientists have developed a test to identify breast abnormalities that are more likely to develop into breast cancer. The test analyzes biological signals in cells and can help doctors determine whether certain women should receive prophylactic anti-oestrogen treatment or more frequent screening.
A new booklet aims to improve communication and support between doctors, patients, and partners in cancer care. The booklet was developed with input from patients and healthcare professionals, resulting in a user-friendly document that enhances patient understanding of research and clinical trials.
Researchers found that thrombocytosis correlates with more aggressive ovarian cancer and poorer response to treatment. Patients with thrombocytosis had higher CA-125 levels, advanced stage disease, and greater tendency of cancer spread.
A study of 224 children found that young children were more likely to acquire H. pylori infection, particularly those from black communities. Early childhood appears to be the critical period for acquiring most infections, and racial differences may impact the risk of developing related health issues.
Researchers have developed a portable ultrasound device that uses high-intensity focused ultrasound (HIFU) to target and destroy unwanted tissue or cauterize lesions. The device has the potential to revolutionize emergency medical care, particularly in remote areas or on battlefields where traditional treatment is not possible.
Researchers found that clot-busting drugs were associated with increased mortality in elderly patients, particularly those over 80 years old. The study highlights the need for more selective use of these drugs and alternative treatments like primary coronary angioplasty.
A study published in The Lancet found that simian virus 40 (SV40) was present in 43% of non-Hodgkin lymphoma patients, with lower rates in Hodgkin lymphoma cases. Researchers discovered a potential link between SV40 and human cancer, which could lead to new detection and treatment methods.
A study by Dr. Jennifer Grandis and colleagues identified a protein associated with lung cancer also expressed in head and neck cancer, leading to potential therapeutic strategies. The researchers found increased GRPR expression in head and neck cancer tissues compared to healthy controls.
A recent study found racial and ethnic disparities in the receipt of cancer treatments, with white patients often receiving more aggressive therapy than minority groups. The study analyzed data from 87 studies and found consistent differences in therapy, including less frequent surgery for lung and colorectal cancers among minorities.
Researchers at the University of Sydney found that cancer patients' informational and emotional needs are often not detected or addressed by oncologists. Despite this, patients' satisfaction with consultations and anxiety levels remain unaffected, highlighting the importance of doctors actively encouraging emotional disclosure.
A study found that relaxation techniques learned prior to cancer treatment reduced anxiety more effectively than those taught during treatment. These techniques also eased symptoms of nausea, pain, and emotional adjustment issues, helping patients feel more in control of their treatment.
Researchers at Memorial Sloan-Kettering Cancer Center developed a nomogram to predict sarcoma patient outcomes, combining age, tumor size, and other factors to provide more accurate prognosis. The tool enables doctors to tailor treatments based on individual patient risk, potentially leading to better outcomes.
A team of researchers has identified the entire series of proteins that relay a message of survival from a neuron to a glial cell in the fruit fly Drosophila melanogaster, shedding light on how cells 'know' whether to survive or perish. This discovery may lead to novel treatments for diseases such as Alzheimer's and cancer.
Researchers used Sangamo's ZFP technology to repress a specific gene variant, preventing fat cells from developing. This breakthrough demonstrates the precision of ZFPs in regulating gene expression and may lead to new treatments for diseases related to fat cell development.
Researchers used gene modification to deliver Interleukin 12 directly into glioma, a deadly type of brain cancer resistant to treatment. The study showed significant prolonged survival in mice and improved immune system's ability to infiltrate and kill tumor cells.
Researchers at Fred Hutchinson Cancer Center discovered that single mismatches in DNA typing are well-tolerated by patients, increasing the chances of successful transplantation. This breakthrough enables patients to find suitable donors without a perfect match.
A new study contradicts European clinical trials that excluded stroke patients with early ischemic changes from thrombolytic treatment. After analyzing CT scans, the study found no association between t-PA treatment and increased risk of adverse outcomes in patients with early ischemic changes.
Researchers discover that compounds in garlic, such as disulfides, can inhibit malaria infection and kill cancer cells due to their similarity in glucose metabolism. These findings suggest potential uses for garlic-derived compounds in treating malaria and certain types of cancer.
In two studies, VEGF gene therapy significantly reduced angina episodes and improved exercise tolerance in patients with end-stage coronary heart disease. The treatment has shown impressive clinical results, with most patients experiencing continued improvement in daily life after treatment.
Researchers have developed a new liver cancer treatment using electrolysis, which destroys tumors and surrounding tissue with minimal impact on healthy liver cells. The technique has shown promising results in an ongoing trial, with eight out of ten patients showing no evidence of residual tumor.
Researchers have discovered that synthetic catalytic anti-oxidants can rescue a severe neurological phenotype and enhance lifespan of mice engineered to undergo oxidative damage. Treatment with these compounds resulted in a dramatic improvement in survival rate and reversal of neurodegenerative disorders.
Screening for colorectal cancer could lead to a 20% reduction in mortality rates, but its effectiveness depends on various factors. The UK government has set up pilot centres to evaluate the potential of faecal occult blood testing (FOBT) as a screening method.
Professor Julian Peto warns that current data protection legislation is hindering cancer research by withholding medical records and tissue samples. Researchers face obstacles in tracking disease development and identifying genetic factors due to lack of access to historical data.
A recent analysis published in The Lancet suggests that routine breast cancer screening through mammography may not be effective in reducing deaths. The study found that the two best trials failed to show an effect of screening on deaths ascribed to breast cancer after 13 years, and that screening leads to more aggressive treatment.
A study published in General Hospital Psychiatry found that guided imagery relaxation with body relaxation reduced psychological distress in cancer patients. The benefit was most pronounced in those with higher levels of distress before the intervention.
The new guidance aims to address the under-treatment of heart failure by providing step-by-step recommendations for prescribing ACE inhibitors and beta-blockers. It is expected to encourage more doctors to adequately treat patients, improving survival and quality of life.
Scientists have identified an important parallel between C. elegans and human NMD pathways, revealing a potential therapeutic strategy for masking genetic mutations. Inactivation of the human homolog of the C. elegans smg-1 gene inhibits NMD, allowing truncated proteins to accumulate and potentially compensate for genetic disorders.
Daily functioning and psychological symptoms improved in patients participating in a meditation training program, with benefits lasting up to one year. The program, known as MBSR, included mindfulness meditation training and group therapy, leading to reduced stress, anxiety, and depression.
A new study by Harvard Medical School researchers suggests that complementary and alternative medicine (CAM) is here to stay for the foreseeable future. The use of CAM therapies has steadily increased in popularity since the 1960s, with the largest growth rate occurring during the transition from the 1960s to the 1970s.
The Fred Hutchinson Cancer Research Center has received a $2.5 million gift from the Avon Products Foundation to support innovative breast cancer research and clinical care initiatives, including immune response-based treatments and access to quality care for medically underserved women.
A Mayo Clinic study published in Cancer journal reveals that daily alcohol consumption by women whose mothers, sisters or daughters have breast cancer may increase their risk for getting the cancer. The study found an increased risk among first-degree relatives of women with breast cancer, but less evidence among second-degree relatives.
The new imaging device provides a larger bore diameter, allowing patients with large or obese bodies to receive scans in treatment position. This enables oncologists to obtain more accurate views of the patient's body dimensions and calculate radiation doses for cancer treatment.
Scientists found that weakening cell death signal and blocking engulfment increases cell survival rates, with some cells surviving outright. This finding suggests modulating engulfment machinery could be an effective therapy for neurodegenerative diseases, stroke, and cancer.
A new study led by Thomas Jefferson University researchers found that once-a-day injections of the blood thinner enoxaparin sodium are just as safe and effective as twice-daily treatments in treating blood clots. This finding has significant implications for medical cost savings.
Researchers review vitamin C absorption and metabolism, suggesting re-evaluation of its use in treating cancer. New insights reveal differences between intravenous and oral administration routes.
A study by UK fertility experts found that natural cycle IVF can achieve comparable results to conventional treatment in 60-70% of cases, while reducing costs and risks. The approach is suitable for women with regular menstrual cycles and fallopian tube problems, but not for those with irregular ovulation or ICSI requirements.
A study by Dr. Vivek Goel and colleagues found that women with early-stage breast cancer treated in specialized teaching hospitals had a higher 5-year survival rate than those treated in community hospitals. The results suggest that initial treatment at specialized centers may be advantageous for women with small tumors.
The Canadian Medical Association Journal has published new clinical practice guidelines for managing lymphedema related to breast cancer treatment. The guidelines include an updated patient version for women battling the condition. These updates aim to improve patient care and outcomes.
A cost-effectiveness study finds radiofrequency ablation effective in treating supraventricular tachycardia, improving quality of life and reducing hospital visits. However, the online availability of hydrazine sulfate, touted as a cancer treatment with few side effects, has raised safety concerns after a fatal case report.
A study in Alcoholism: Clinical & Experimental Research examines gender-specific reasons for treatment retention in private substance abuse treatment programs. Women's staying power is linked to being unemployed, married, and having higher incomes, while men's staying power is related to receiving employer pressure and having a goal to...
A study by Texas A&M University researcher Dr. Jeff Guidry reveals that non-treatment problems hinder successful cancer treatment and cure for patients in rural areas. The study shows that barriers to overcoming cancer include lack of transportation, proper information, access to treatment, and a support system.
Researchers predict personalized breast cancer treatments using genetic profiles, with potential annual reduction of recurrence risks. Up to 100,000 genes in each cell are being studied for predictive value, leading to a future of tailored therapies.