Articles tagged with Clinical Trials
A phase 2 trial of the experimental drug adagrasib showed a 42.9% objective response rate and median overall survival of 12.6 months in patients with KRAS-mutated non-small cell lung cancer. The treatment also achieved a 33.3% response rate in patients with stable brain metastases.
A randomized, placebo-controlled pilot study found that NB-UVB phototherapy decreased mortality in hospitalized COVID-19 patients with no adverse events reported. The treatment was effective in both vaccinated and unvaccinated patients, with reduced pathologic inflammation and improved intracellular killing of pathogens.
A new drug combination of ramucirumab and pembrolizumab significantly extended overall survival in advanced non-small cell lung cancer patients who had progressed on prior immunotherapy. The study found a 31% reduction in risk of death compared to standard therapy, with median overall survival times of 14.5 months.
A systematic review of 155 head and neck cancer clinical trials from 2010 to 2020 revealed that only 57% of studies reported race or ethnicity. Black and Asian or Pacific Islander patients were disproportionately underrepresented in these trials, highlighting a significant issue in the field.
The NIH has launched a clinical trial testing dupilumab, an approved treatment for moderate-to-severe asthma, in children with poorly controlled allergic asthma living in low-income urban neighborhoods. The study aims to define the activity levels of gene networks associated with asthma attacks and improve lung function.
Researchers found a significant rise in proportion of patients in SWOG cancer trials insured by Medicaid after ACA's Medicaid expansion. The proportion increased by 20% each year following the expansion, resulting in a threefold increase over expected levels.
Researchers found that the effectiveness of exercise depends on the time of day, with morning exercise reducing belly fat and blood pressure in women, while evening exercise increasing muscular performance. For men, evening exercise lowers blood pressure, burns more fat, and improves heart disease risk.
A cohort study found that moderate coffee consumption, especially unsweetened coffee, is associated with a lower risk of death. The results suggest that adults who drink 1.5 to 3.5 cups of coffee per day may be less likely to die during a 7-year follow-up period compared to non-coffee drinkers.
A new game called QuitBet is being tested to help people quit smoking by providing a fun and engaging way to adopt healthy habits. Players commit to quitting smoking over four weeks and bet $30, with winners typically doubling their money.
The ECOG-ACRIN Cancer Research Group presented promising trial results at ASCO 2022, including an 8-year survival rate in the CHAARTED prostate trial. The research also explored outcomes by tobacco use in head and neck studies, shedding light on cancer treatment effectiveness.
A new study from researchers at Dell Medical School found that providing caregivers with four weeks of free tastings of produce and grocery gift cards can lead to improvements in kids' diets. The study, published in JAMA Network Open, showed that children ate healthier foods two additional times per day compared to the control group.
Children from marginalized groups and those with public insurance had poorer five-year survival rates, even when receiving standardized treatment. The study highlights the need for healthcare delivery and supportive care interventions to mitigate racial and ethnic disparities in childhood cancer.
MD Anderson research highlights new treatments for skin cancers, including novel therapies. The institution also showcased improved goals of care programs, which demonstrated significant reductions in ICU mortality and improved patient outcomes during the COVID-19 pandemic.
Researchers used cell-free DNA methylation patterns to identify patients with muscle-invasive bladder cancer who would benefit from chemotherapy before surgery. The approach showed promise in accurately predicting tumor response, with a correct prediction rate of 79%.
Researchers found that neoadjuvant immunotherapy with pembrolizumab significantly shrunk tumors in patients with desmoplastic melanoma, potentially allowing for less extensive surgery and radiation. The study showed a high response rate to treatment, with over half of patients achieving a pathologic complete response.
A large Japanese trial found that daily vitamin D supplements had no clinically meaningful effect on preventing type 2 diabetes in people at high risk of the condition. However, results suggested a potential benefit for those with insufficient insulin secretion, warranting further research.
New data analyses from RedHill's Talicia H. pylori eradication clinical trials program showed high eradication rates and favorable safety and efficacy profiles in patients with diabetes. The study found that Talicia maintained high eradication rates of 91.7% and 84.1% in patients with and without diabetes, respectively.
Researchers at Keck School of Medicine of USC are testing the efficacy of 3K3A-APC as a cerebroprotectant to reduce brain bleeds in acute ischemic stroke patients. The experimental drug has shown promising results in Phase 2 clinical trials, reducing incidence of brain hemorrhage by nearly 20%.
Stepped wedge cluster randomized trials offer statistical power, incentivized recruitment, and staggered resource allocation. However, challenges include time-sensitive recruitment, retention issues, and the Hawthorne effect.
A study published in AJR found that COVID-19 mRNA vaccination-induced axillary lymphadenopathy resolves after a mean of 97 days. Longer resolution times were observed with Moderna vaccination, receipt of second doses, and thicker cortical thickness at presentation.
A multi-center study evaluates the Alleviant System, a transcatheter technology that reduces pressure in the left atrium without implantation. The device demonstrates procedural safety and feasibility, with promising efficacy signals through six months.
A one-year study validated the Harmony transcatheter pulmonary valve (TPV) system's safety and efficacy in treating congenital heart disease patients with severe pulmonary regurgitation. The study showed favorable clinical and hemodynamic outcomes, including low mortality rates and minimal interventions.
A randomized clinical trial found that a specific probiotic supplement accelerated the maturation of the microbiome in extremely preterm infants, leading to reduced intestinal inflammation and improved feeding tolerance. The study also showed potential benefits for reducing the risk of food allergies in these vulnerable infants.
The Disrupt PAD III trial found intravascular lithotripsy (IVL) to be effective in treating severely calcified peripheral artery lesions, with high patency rates compared to percutaneous transluminal angioplasty (PTA). IVL also showed reduced severe complications and need for additional interventions.
A new weight-loss intervention has been developed to target the instinctive desire to eat, particularly in individuals who struggle with resisting food cues. The Regulation of Cues program trains individuals to use natural hunger cues, reinforces tolerance of cravings, and inhibits urges to eat palatable foods when not physically hungry.
A multicenter trial found that brensocatib did not reduce clinical deterioration or mortality in severe COVID-19 patients. However, a sub-study revealed an anti-inflammatory effect of DPP1 inhibition on neutrophil protease enzymes, which may be beneficial for treating bronchiectasis.
The HIV Vaccine Trials Network is launching a new registry to connect people interested in supporting HIV vaccine research with clinical trials in their communities. The 'Help End HIV' campaign aims to raise awareness about the urgent need for HIV clinical trial volunteers, particularly among young people.
A new mathematical model predicts the efficacy of phage therapy against pathogenic bacteria, highlighting key parameters for effective treatment. The model incorporates data on bacteriophage interactions with the immune system and suggests optimizing administration routes to improve outcomes.
The substudy of the ADVOCATE trial found avacopan reduced glucocorticoid use by 86% in ANCA-associated vasculitis patients with respiratory and ENT involvement, while also showing superiority in remission compared to prednisone.
This study analyzed supportive evidence for FDA approvals of 49 novel drugs in 2020. The study's findings provide insight into the key design characteristics of pivotal trials supporting these drug approvals.
A global study found a combination of two drugs dramatically reduces the chances of suffering an asthma attack. The combination of albuterol and budesonide lowers the number of sudden episodes of shortness of breath, wheezing, and coughing in patients.
A clinical trial found that robotic surgery for bladder cancer removal and reconstruction significantly reduced recovery time, hospital stays, and readmissions. The study showed a 77% reduction in blood clots and improved physical activity and quality of life for patients.
A new study has found that robotic surgery reduces the chance of readmission by half and reveals a four-fold reduction in blood clots compared to open surgery. Patients also experience increased physical activity, stamina, and quality of life.
A randomized clinical trial found that expanding common medical abbreviations increased overall comprehension, suggesting automated expansion can enhance patient understanding of their health information. Researchers observed significant improvements in patient comprehension after the expansion of 10 common medical abbreviations.
A new lymphoma treatment, zanubrutinib, has been found to be effective in 80% of patients with marginal zone lymphoma, resulting in significant cancer shrinkage. However, its impact on follicular lymphoma is less pronounced.
The Cardiovascular Research Foundation (CRF) announced that TVT: The Structural Heart Summit will feature 12 studies as Late-Breaking Clinical Science and Featured Clinical Research. These studies highlight advances in transcatheter aortic valve replacement, mitral, tricuspid, and left atrial appendage occlusion therapies.
Researchers are developing a novel MRI nanotechnology that targets specific markers in solid tumours, including high-grade brain cancers. The new imaging technology has shown promising preclinical results and is set to be tested in a first-in-human clinical trial.
Researchers found that targeting both tumor and lymph node microenvironments with nanomedicine improves treatment response for metastatic triple negative breast cancer. Long-term tumor remission was achieved in mice models using nanoparticles to deliver immune-modulating drugs.
A combination of aerobic, strength, flexibility, and balance exercises alongside personalized nutritional counselling reduced mobility disability by 22% over three years. The intervention also improved physical performance and reduced muscle loss in older adults.
A systematic review and meta-analysis compared traditional strength training with power training for improving physical function in older adults. Power training showed similar benefits to strength training in terms of muscle power and functional ability.
The TVT 2022 program features cutting-edge research on transcatheter aortic valve replacement (TAVR) and other structural heart therapies. The meeting will focus on patient evaluation, imaging modalities, and therapeutic options.
A mailed at-home disposal kit increased self-reported rates of disposal of unused opioids after common surgical procedures. The study found that patients who received the kit reported a higher rate of opioid disposal compared to those without access to such kits.
The NIH has launched a Phase 1 clinical trial to evaluate an investigational preventative vaccine for Epstein-Barr virus (EBV). The study aims to assess the safety and immune response of the EBV gp350-Ferritin nanoparticle vaccine with a saponin-based Matrix-M adjuvant.
Scientists discovered that intermittent dosing of PI3Kδ inhibitors can reduce toxicity while maintaining anti-tumor immunity in patients with head and neck cancers. This finding holds promise for improving treatment outcomes and saving lives.
The S1216 study showed an unprecedented median OS of 70 months in the control arm, outperforming previous results by 24 months. This extended survival was attributed to additional life-prolonging treatments patients received after completing the trial therapy.
A new type of cardiac defibrillator implanted under the skin has been found to significantly reduce patient complications, including lead-related complications and blood clotting. The subcutaneous ICD has shown promising results with an average age of patients included in the study ranging from 18 to 60 years old.
A new study published in the New England Journal of Medicine found that treating even mild forms of high blood pressure during pregnancy is safe and beneficial for both mother and developing baby. The study's results demonstrated a significant decrease in pregnancy complications, including severe preeclampsia and preterm births.
The NIH-funded study will enroll 1,050 patients with periodontitis to collect data on the efficacy of antibiotics in treating the condition. The goal is to develop evidence-based clinical guidelines and advance oral health, particularly given the critical need to reduce antibiotic misuse and combat superbugs.
The study compares current recommendations for ventilation and chest compression versus ventilation during neonatal resuscitation using an ovine model. The findings suggest that optimizing ventilation could reduce the need for chest compressions and improve gas exchange in neonates, potentially improving overall outcomes.
Researchers have engineered a tiny living heart chamber replica to study disease progression and test new treatments. The miniPUMP device mimics the real organ's mechanics, allowing for accurate tracking of how the heart grows in embryos and studying the impact of disease.
Researchers investigated the use of intranasal human milk as a stem cell therapy for preterm infants with intraventricular hemorrhage. The study found that preterm infants could tolerate nasal milk therapy without major safety events, paving the way for further research on long-term outcomes.
A UCLA-led team found that an abnormally suppressed immune system, not a persistently hyperactive one, may be to blame for some cases of long COVID-19. The study suggests boosting immunity in those individuals could be a treatment option.
A randomized clinical trial found that outreach messages were minimally effective at promoting scheduling of adolescent well care visits, but had limited impact on completing visits. Efforts to address widening disparities are needed.
Researchers found no evidence that early selective treatment with ibuprofen reduces death or moderate to severe bronchopulmonary dysplasia in extreme preterm infants. However, treatment reduced the risk of an open patent ductus arteriosus and surgical treatment for a symptomatic PDA.
A surgically implanted device has been found to safely and effectively reduce sleep apnea in adolescents with Down syndrome, with significant improvements in daily functioning, behavior, and language. The device, called a hypoglossal nerve stimulator, was tested in a phase I clinical trial and showed promising results.
A new University of Gothenburg study has found that a drug treatment can reduce the frequency of breathing pauses in sleep apnea by an average of over 20 per hour. The treatment, which involves carbonic anhydrase inhibition, showed promising results with minimal side effects.
A new cell therapy has shown promising results in slowing the progression of Duchenne muscular dystrophy, a rare genetic disorder. The treatment uses heart cells to improve skeletal muscle and heart function, offering a potential cure for advanced disease cases.
Researchers at MD Anderson have made significant advancements in treating neuroendocrine tumors with combination therapy, identified consensus subtypes for hepatocellular carcinoma to improve treatment selection, and found a targetable vulnerability in urothelial cancer due to MTAP loss.
A new study published in PLOS ONE finds that high and very high cardiovascular risk are associated with depressive symptoms, especially in women. The researchers used data from a Mediterranean Diet trial and found that participants with higher cardiovascular risk had lower depressive status scores after following the diet.
The ATS 2022 International Conference features extensive programming on the latest advances in pulmonary, critical care, and sleep medicine. The conference will also provide access to on-demand recordings of sessions.