Articles tagged with Clinical Trials
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A first-of-its-kind study from the University of Pennsylvania School of Nursing clarifies the post-trial needs of patients who withdraw from cancer clinical trials. The study defines what constitutes responsible transitions when patients exit CCTs, providing insights into patient experiences and care after withdrawal.
SK bioscience's GBP510 vaccine candidate has shown promising safety and immunogenic response in Phase I/II clinical trials. IVI will partner with SK on global Phase III trials to accelerate development and WHO approval of the vaccine.
The NIH has launched a pilot study to assess the antibody response of kidney transplant recipients to a third dose of an mRNA COVID-19 vaccine. The trial aims to determine if a third dose can overcome the immune suppression caused by lifelong immunosuppressive therapy in this population.
The study analyzed 444 cancer treatment trials and found that 8.4% of patients enrolled were in the 15-39 age range, more than double the national average. AYA patients were also found to be more racially and ethnically diverse than older patients.
The article considers the ethical issues surrounding enrolling children with neurodevelopmental conditions, such as autism spectrum disorder and fragile X syndrome, in clinical trials. Parents may face difficult decisions about whether to enroll their children due to concerns about potential loss of positive aspects of their condition.
A phase II clinical trial of remetinostat gel found a 69.7% response rate to the topical treatment, with complete responses observed across multiple BCC subtypes, and a durable response in nodular BCCs.
Cardiovascular diseases affect women just as much, if not more, than men, yet current guideline-directed therapies are based on data predominantly including male patients. The European Society of Cardiology calls for increased diversity in research teams and targeted interventions to boost attendance.
A study from the University of South Carolina's Environmental Health & Disease Laboratory found that andrographolide successfully restored bacteriomes and viromes, increasing beneficial bacteria and decreasing harmful bacteria. The treatment also decreased gut inflammation and neuroinflammation in veterans with Gulf War Illness.
A new clinical trial will test a simple breathing exercise for adults with obstructive sleep apnea and hypertension. The study aims to reduce blood pressure and improve cardiovascular health through inspiratory muscle training.
Researchers discovered that almost half of patients who received personalized information about community resources shared them with at least one other person. Individuals in poorer health were more likely to report sharing the information, and those who visited or used a resource on their list were also more likely to share it.
A randomized clinical trial found that graphic warning labels on cigarette packaging changed the perception of US smokers, making them more likely to recognize the negative consequences of tobacco use and consider quitting. However, it did not significantly increase quit attempts or reduce nicotine addiction.
A clinical trial shows that full-dose blood thinner treatment reduced the need for organ support and improved hospital outcomes in moderately ill COVID-19 patients. However, this benefit was not seen in critically ill patients requiring intensive care.
Despite initial drops in enrollment, cancer clinical trials in the US showed significant resilience during the 2020-2021 COVID-19 pandemic. Treatment trial enrollments remained remarkably stable, while cancer control and prevention studies were disproportionately affected.
Patients with cancer who experience clinically significant fatigue before treatment have shorter overall survival times and more side effects. Researchers analyzed four clinical trials testing lung and prostate cancer treatments, confirming that pretreatment fatigue may be an important prognostic factor in oncology.
The NIH has launched Outreach Pro, an online tool designed to improve recruitment of underrepresented populations in Alzheimer's clinical trials. The platform provides customizable participant recruitment communications and culturally appropriate outreach materials.
Researchers at Boston Children's Hospital report positive results with risplidam, a small-molecule drug that treats SMA by correcting the root cause: a mutated gene. Infants receiving risplidam showed improvements in motor function and lived longer than expected.
A recent study examines the one-year experience of cancer clinical trial enrollment after the COVID-19 outbreak in the US. Researchers found that participation rates declined significantly during this period.
The National Institute on Aging (NIA) has launched Outreach Pro, a new online tool to help increase awareness and participation in Alzheimer's clinical trials among traditionally underrepresented communities. The tool allows researchers to create customizable recruiting materials with an emphasis on reaching diverse populations.
The study aims to compare two interventions: Intensive Tailored Telehealth Management (ITTM) and Intensive Clinic Management (ICM). Researchers hope to answer how to effectively manage blood pressure among stroke survivors and whether telehealth is the most effective strategy.
Researchers found that targeted behavioral science messages significantly increased COVID-19 vaccination registration among healthcare workers. The study showed a substantial increase in vaccine uptake after receiving personalized email nudges.
Patients who underwent bariatric surgery reported improved physical health, energy, and reduced body pain compared to those on medical therapy alone. Significant weight loss and insulin independence drove these improvements in general health measures and quality of life.
A study found that antibodies produced to fight Covid-19 can trigger platelet activity, leading to fatal blood clots. Researchers developed a lab-based test to replicate this process, and suggest that existing medications may be able to inhibit platelet response.
A phase 2 trial of Loncastuximab tesirine demonstrates efficacy in treating relapsed or refractory Diffuse Large B-Cell Lymphoma (DLBCL), with a response rate of 48% among patients. The drug, an antibody-drug complex targeting CD19, provides a novel mechanism of action for this patient population.
A randomized clinical trial found that semi-annual application of 5% sodium fluoride varnish significantly reduces approximal caries development in primary teeth compared to 38% silver diamine fluoride and placebo controls. The study evaluated 4-6 year-old children with at least one sound approximal surface.
A novel method predicts COVID-19 clinical trial success rates by analyzing features from clinical trial reports, including keywords and drug information. The model achieved high accuracy in predicting trial status, indicating a potential tool for optimizing research efforts and reducing costs.
A clinical trial found pimavanserin significantly improves sustained symptom benefit and reduces relapse rate in people with dementia-related psychosis. The treatment also showed fewer serious side effects compared to other antipsychotics.
The Coalition for Epidemic Preparedness Innovations (CEPI) has partnered with the International Vaccine Institute (IVI) to conduct clinical trials of Sinopharm's BBIBP-CorV vaccine in African populations. The ECOVA programme aims to generate data on vaccine efficacy and safety against variants of concern, enabling expanded access to va...
The global Phase 2/3 study with opaganib in patients hospitalized with severe COVID-19 pneumonia has completed patient treatment and follow-up. The company expects to report top-line results in the coming weeks, which will determine the efficacy of opaganib in treating COVID-19.
Zeynep Eroglu, MD, assistant member of the Cutaneous Oncology Department at Moffitt Cancer Center, received the 2021 Cancer Clinical Investigator Team Leadership Award from the National Cancer Institute. The award recognizes outstanding clinical investigators working to improve cancer care.
A randomized clinical trial found physician messaging campaigns increased COVID-19 knowledge, information-seeking, and self-reported protective behaviors among diverse groups. The campaign was effective in promoting adult's practices related to COVID-19.
A groundbreaking treatment using 3D printed implants has received approval to be trialled in UK patients, aiming to provide relief for knee osteoarthritis sufferers. The bespoke titanium alloy implants are designed to reduce discomfort and improve surgical accuracy, with the first trials expected to begin once clinical centres reopen.
The RAPID Trial found that administering a full dose of heparin early to moderately ill hospitalized patients with COVID-19 could reduce the risk of severe disease and death. The study showed a significant reduction in all-cause death with therapeutic heparin compared to low-dose treatment.
A study published in the Journal of the American Medical Association found that PRP injection provides no benefit for patients with debilitating Achilles tendon pain. The researchers recommend against using PRP treatment for these patients due to its lack of effectiveness and potential short-term harm.
A gene therapy trial has shown significant improvements in children with primary AADC deficiency, a devastating genetic disorder characterized by severe motor disability and developmental delay. The treatment targets neurons that produce dopamine, resulting in improved motor function, better mood, and longer sleep.
Researchers found that a synthetic meniscus implant provided superior relief from post-meniscectomy knee pain compared to non-surgical care. Patients treated with the implant experienced higher Knee Injury and Osteoarthritis Outcome Scores, indicating improved function and quality of life.
The CoronaVac COVID-19 vaccine has demonstrated an efficacy of 83.5% against symptomatic disease in a phase 3 trial, with a robust antibody response and mild adverse events reported. The vaccine uses an inactivated whole virus and has been approved for emergency use in 22 countries.
A study by CU researchers found that choline deficiency in Black pregnant women is linked to increased risk of developmental and behavioral issues in their children's later lives. The research also highlights healthcare disparities in caring for Black mothers and their children in the US.
A new study suggests that varying virus dynamics among patients may contribute to inconsistent clinical trial results for COVID-19 drugs. Recruiting participants shortly after symptom onset could reduce the number of participants needed to detect significant antiviral drug effects.
A clinical trial found that casts are not more effective than removable braces for treating broken ankles, with patients reporting similar levels of pain and functionality. The choice between the two should be down to cost and patient preference.
Researchers found that a single targeted message didn't affect the return to in-person visits within a month, but resulted in a small increase in re-engagement through telemedicine and rescheduling of future visits. The study suggests that alternative communication strategies may be more effective for promoting in-person care.
Scientists at UCL GOS ICH and Great Ormond Street Hospital have developed a precision gene therapy that has been shown to relieve defects in DTDS brain cells, potentially offering a cure for the condition. The therapy was tested on laboratory models and mice, showing promising results and paving the way for a clinical trial.
Researchers from Massachusetts General Hospital found that the BCG vaccine significantly lowers blood sugar levels in type 1 diabetics, with faster response times and greater changes in HbA1c for younger patients. The vaccine also restores gene expression in regulatory T cells over three years.
Scientists have developed a pioneering material that can turn plastic sheets into powerful noise-cancelling panels, weighing four to six times less than traditional solutions. The technology is set to be trialled in hospitals and other noisy locations to reduce stress caused by excessive noise.
Researchers successfully replicated traditional clinical trials using virtual patient populations, speeding up the trial process by months. The in-silico approach shows huge potential for optimizing medical device design and reducing risks associated with treatment.
The Prevent COVID U study has expanded to enroll young adults ages 18-29, including those who choose not to receive a vaccine. The trial aims to test the effectiveness of the Moderna COVID-19 Vaccine in preventing infection and transmission of SARS-CoV-2.
A smartphone-based eye screening and referral system improved access to care for people with eye problems, tripling attendance rates at primary care. The system also increased appropriate hospital services uptake, while reducing unnecessary hospital visits.
Researchers at UTHealth are investigating pairing patients with PTSD undergoing treatment for peer support and exposure therapy to improve treatment completion rates. The study aims to reduce the high dropout rate of 25-50% by providing a supportive network for patients to overcome triggers and work towards recovery.
A decade-long study found that personalized medicine, considering patient needs and environment, is more effective than one-size-fits-all approaches. The research team recommended a tailored approach for distal radius fractures, taking into account the patient's social environment and risk tolerance.
Researchers from the University of Texas Health Science Center at San Antonio developed a new tool to stop hiccups, FISST, which showed nearly 92% success rate in relieving symptoms. Users reported high degrees of effectiveness and ease of use, with most finding it easy to use and very happy with results.
A new study shows that personalized online coaching can help women improve their lifestyle behaviors before and after pregnancy, particularly in overweight women. The coaching program resulted in significant reductions in smoking and drinking alcohol, as well as increased odds of becoming pregnant.
A clinical trial conducted at the University of Louisville showed that cell therapy using cells derived from a patient's own bone marrow and heart improved quality of life and reduced major adverse cardiac events. The treatment resulted in a significant reduction in hospitalizations and improved outcomes for patients with heart failure.
Two studies demonstrate the impact of gender-neutral HPV vaccination on overall protection against HRHPV infections, even with low vaccination coverage. In Finland, communities with both boys and girls vaccinated saw a significant decrease in cervical HPV16/18 infections, including among unvaccinated women due to the herd effect.
The Murdoch Children's Research Institute is conducting a global study to better understand COVID-19 variants and the effectiveness of vaccines in preventing their spread. The BRACE trial, funded by the Bill & Melinda Gates Foundation, investigates biomarkers that indicate protection against COVID-19 infection.
A new study reveals that malicious bots are the primary pathogen of COVID-19 misinformation on social media, amplifying false claims and conspiracies. Bots were found to spread misinformation at a rate far greater than ordinary users, leading to widespread harm to public health.
A large clinical trial has shown that pembrolizumab after surgery significantly lowers the risk of disease recurrence in patients with high-risk melanoma. This treatment also results in fewer serious side effects compared to standard therapies like ipilimumab or high-dose interferon.
A nationwide clinical trial found no benefit from antibiotics in preventing hospitalization or death for patients with idiopathic pulmonary fibrosis. The study collected biological samples that will advance the understanding and treatment of the disease.
A new study found that clinical trials often neglect to report sociodemographic characteristics like income, literacy, and education level, limiting their applicability. The study analyzed 10% of randomized clinical trials published between 2014 and 2020, revealing that only 14.3% reported education level or literacy.
Moffitt Cancer Center experts present phase 2 results from several clinical studies evaluating the efficacy of CAR T-cell therapy, ixazomib maintenance therapy, and immunotherapies for various types of cancer, including acute lymphoblastic leukemia, multiple myeloma, prostate cancer, and triple-negative breast cancer.
A Phase 1/2 clinical trial has begun at the NIH to assess the safety and immunogenicity of different COVID-19 vaccine booster regimens. Participants will receive a single booster dose of the Moderna COVID-19 vaccine, followed by telephone check-ins and in-person follow-up visits for one year.
A clinical trial found an implantable device is more than three times more effective in detecting atrial fibrillation in ischemic stroke patients. The device could prevent disabling strokes by almost 70% if detected early.