Articles tagged with Clinical Trials
The KEYNOTE-811 trial demonstrates a significant improvement in objective response rate (74.4%) and tumor size reduction compared to trastuzumab and chemotherapy. The combination of pembrolizumab, trastuzumab, and chemotherapy markedly reduces tumor size and induces complete responses in some patients.
A small clinical trial found that high-pressure hyperbaric oxygen treatment resolved severe COVID-19 breathing difficulties faster than standard therapy, with significant improvements in oxygen saturation and reduced risk of complications. However, further larger trials are needed to confirm the treatment's effects on survival.
A new treatment combination of dasatinib, blinatumomab, and prednisone has shown promise in treating older patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia. The trial achieved a three-year DFS rate of 80 percent and an overall survival rate of 85 percent for enrolled patients.
Researchers found that up to one in five patients experience increased troponin levels after major surgery, indicating potential heart damage. These patients were also more likely to be anaemic before the operation.
Researchers found a novel therapy called AVID200 safe and well-tolerated, with modest improvements in symptom burden, anemia, and spleen enlargement. The therapy needs to be combined with other drugs to optimize impact in patients.
A new study published in the New England Journal of Medicine found that using CAR T therapy as a second-line treatment provided better outcomes compared to standard care in patients with diffuse large B-cell lymphoma. The two-year follow-up data showed a median event-free survival of 8.3 months in the CAR T arm versus 2 months in the s...
A new NRG Oncology clinical trial found that bupropion did not improve sexual desire in female cancer survivors. The trial evaluated the effects of extended-release bupropion on postmenopausal women with low baseline sexual desire scores.
A case study published in Nature Medicine reports a patient experiencing progressive neurological features resembling Parkinson's disease after CAR-T cell therapy, suggesting potential neurotoxicity. The study highlights the importance of monitoring for neurotoxicity in patients receiving BCMA-targeted CAR-T therapies.
Researchers discovered that the SET2,3 index provides complementary prognostic information about breast cancer outcomes, particularly for patients with hormone receptor-positive breast cancer. The study suggests that using both clinical and molecular information from a patient's tumor can guide treatment decision-making.
The Liberty Asthma VOYAGE trial found that dupilumab significantly reduced the rate of severe exacerbations by nearly 60% and improved lung function and asthma control in children ages 6 to 11. Dupilumab was also shown to be safe, with minimal adverse reactions.
A study found that US clinical trials of new drugs and biologics lack adequate representation of racial and ethnic populations. The research highlights the need for greater diversity in clinical trial participation to ensure the safety and efficacy of treatments for all patients.
A randomized clinical trial investigated the effects of a Mediterranean diet and mindfulness-based stress reduction on preventing small-for-gestational age birth weights. The study found that these interventions significantly reduced the risk of this adverse pregnancy outcome.
A $3.1 million NIH grant will fund a trial testing multidisciplinary telehealth intervention to reduce racial disparities in blood pressure control and stroke recurrence among adult stroke survivors. The study aims to identify social determinants of health that impact outcomes and explore ways to address them.
A phase II clinical trial at St. Jude Children's Research Hospital found significantly higher survival rates for children with high-risk neuroblastoma treated with chemoimmunotherapy and the humanized monoclonal antibody hu14.18K322A, resulting in a three-year disease-free survival rate of 73.7% and an overall survival rate of 86%.
A small clinical trial found that eating during the nighttime increased glucose levels, while restricting meals to the daytime prevented this effect. The study suggests that better alignment between internal and external circadian rhythms may drive these benefits.
A study by the CDC found a strong association between obesity and diabetes, both of which are widespread in the U.S., and severe COVID-19 disease. In South Carolina, chronic diseases disproportionately affect Black communities, increasing their risk of developing severe COVID-19.
A multicenter clinical trial demonstrates insulin secretion from engrafted stem cells in patients with type 1 diabetes. The study shows 20% reduced insulin requirements and 13% more time spent in target blood glucose range over a one-year follow-up period.
The $4.6 million NIH grant will help implement a telehealth-enabled audit and feedback process to monitor adherence to recognized standards of care in 14 Intermountain Healthcare ICUs. This study aims to reduce the time patients spend on mechanical ventilators, improving lung protective mechanical ventilation best practices.
A large clinical trial has found that postmenopausal women with hormone receptor-positive, HER2-negative breast cancer and a 21-gene recurrence score of 25 or lower can safely skip chemotherapy. In contrast, premenopausal patients with positive nodes and low RS scores benefit from chemotherapy.
The study found that the Moderna vaccine offered a lower risk of documented infection (21% reduced), symptomatic COVID-19 (44% reduced), hospitalization (55% reduced), ICU admission (10% reduced), and death (2% reduced) compared to the Pfizer vaccine. The results suggest that either vaccine is effective, but Moderna may be slightly mor...
The FDA has approved Cytalux, which enables surgeons to identify and remove cancerous lesions with greater precision. In a Phase 3 study, nearly 27% of women with confirmed ovarian cancer found at least one undetected lesion during surgery.
A new study published in the Journal of Experimental Medicine showed that a fast-tracked stroke drug, 3K3A-APC, protected mice from injury to the brain's white matter, a leading cause of dementia. The drug may also be effective in slowing down progression of cognitive impairment.
A phase 3 clinical trial found that teriflunomide reduced new or enlarged lesions in children with multiple sclerosis, suggesting potential benefits. However, the medication did not delay time to the next clinical relapse.
Recent clinical trials showed promising results with cardiosphere-derived cells, improving heart parameters in patients with Duchenne muscular dystrophy. Researchers investigate using cell-derived products like exosomes to boost endogenous repair pathways, while aiming to reverse cardiomyocytes' proliferation limitations.
Researchers found that high avocado consumption led to reduced caloric energy intake, lower dairy and meat consumption, and improved fiber and nutrient intake. However, unexpected decreases in calcium and certain minerals were also observed.
A team at Osaka University has initiated the world's first in-human investigator-initiated clinical trial of sodium astatine ([ <sup> 211 </sup> At]NaAt) injection for refractory differentiated thyroid cancer patients. The phase I trial evaluates safety, pharmacokinetics, and efficacy of astatine for use in alpha therapy.
A systematic review and meta-analysis of 18 clinical trials found that prevention programs may be effective in reducing teen dating physical violence. However, the evidence for reducing sexual violence among adolescents is still inconclusive.
Researchers found that video-based, telehealth-delivered exercise and weight loss programs improved pain and function in people with knee osteoarthritis and overweight or obesity. The intervention with dietary component led to substantial weight loss and additional benefits.
A clinical study found that severe COVID-19 patients exhibit impaired microvascular function, which correlates with disease severity. Non-invasive near-infrared spectroscopy monitoring may help predict disease course and select responders to novel therapies.
Despite increases in inclusion, certain groups remain under-represented in cancer clinical trials. Black and Hispanic patients showed improved participation, while women and older adults continued to be under-represented.
Researchers at UConn Health have discovered that eliminating senescent cells in human fat tissue can alleviate signs of diabetes and improve insulin sensitivity. The study suggests that clearing away these dysfunctional cells could lead to game-changing new treatments for Type 2 diabetes.
A new study provides preliminary data for a human clinical trial of a treatment that targets the root cause of Alexander disease. The treatment has shown promising results in halting the progression of the disease and even reversing some symptoms in rat models, which better represent the human condition.
A multicenter clinical trial is underway to evaluate the efficacy of a novel immunosuppressant in reducing organ rejection after lung transplantation. The study involves 330 patients and aims to improve health outcomes for thousands of lung transplant patients.
A new AI model has been developed to classify colorectal polyps, demonstrating accuracy and sensitivity at a level comparable to practicing pathologists. The model was tested in a clinical trial involving 15 pathologists, showing significant improvements in accuracy compared to traditional methods.
A recent study found that low-, middle-, and high-income countries hosting COVID-19 vaccine trials received proportionately more doses of vaccines. High-income countries were able to fully vaccinate their populations due to the higher dose allocation, raising concerns about unequal access to life-saving vaccines.
A clinical trial found that long-term weight loss was similar for those who received 5:2 diet or standard weight management advice, with 18% and 15% of participants losing at least five per cent of their body weight. However, the 5:2 diet group was more likely to recommend the intervention to others or continue with it.
A novel gene therapy has shown sustained expression of clotting factor VIII, leading to a reduction or complete elimination of bleeding events in patients with hemophilia A. The trial demonstrated improved production of coagulation factor VIII over prolonged periods.
A fasting-mimicking diet was found to be safe and biologically active in cancer patients, with potential benefits for modulation of metabolism and enhancement of antitumor immunity. The study demonstrated significant reductions in blood glucose and growth factor concentrations, as well as enhancements in intratumor T-cell infiltration.
A new nasal vaccine, Protollin, is being tested in humans for the first time to prevent and slow Alzheimer's disease progression. The trial aims to determine safety and tolerability, as well as its effects on the immune system.
A two-year follow-up of participants found that those who had both their mitral valve and tricuspid valve repaired at the same time experienced better outcomes, including less progression to moderate or severe leakage. This study provides high-level evidence for surgeons on how to perform tricuspid valve repair in these patients.
Researchers at the University of Kent identified strong evidence-based benefits of preimplantation genetic testing for aneuploidy (PGT-A) in IVF. Live birth rates per embryo transferred and per treatment cycle were significantly higher with PGT-A compared to regular IVF, especially in women over 40.
A phase 2 clinical trial found that losartan, commonly used to treat high blood pressure, did not significantly slow down the progression of Alzheimer's disease in people with mild-to-moderate symptoms. However, the drug may still be beneficial for those with early-stage disease if prescribed for longer periods.
Researchers at the Texas Heart Institute have made significant breakthroughs in treating persistent heart failure with a novel stem cell therapy. The phase 3 clinical trial results show that this treatment has the potential to alter the natural history of heart disease, reducing hospitalizations and improving patient outcomes.
A NIH-funded study found that patients with a two-step surgical approach for 'leaky heart valves' had better short-term outcomes, but were more likely to need a pacemaker. The procedure involved repairing the tricuspid valve at the time of mitral valve surgery, and results showed reduced risk of death, reoperation, or severe regurgitat...
A new trial shows that the novel surgical device venous external support (VEST) may improve outcomes of coronary bypass grafting using leg veins by preventing intimal hyperplasia, a key factor in vein graft failure.
Researchers found that green tea catechins EGCG and ECG enhance fitness and lifespan in C. elegans by inhibiting complex I activity, reducing fat content and enhancing antioxidant defenses. This study provides evidence for the potential health benefits of green tea consumption in extending human lifespan.
A recent study analyzed 59 US stem cell clinics and found that most rely on weakly scientifically credible marketing tactics, including technical descriptions of stem cells and patient testimonials. Only a minority invokes stronger forms of evidence, such as registered clinical trials or scientific peer-reviewed articles.
The BBV152 COVID-19 vaccine demonstrated robust antibody response and induced 77.8% protection against symptomatic COVID-19 in a phase 3 trial. No severe vaccine-related adverse events or deaths were reported among participants.
Patients with advanced renal cell carcinoma treated with checkpoint inhibitor combination nivolumab plus ipilimumab experienced longer treatment-free survival compared to those receiving targeted therapy sunitinib. The analysis revealed significant differences in how patients spent their overall survival time between the two treatments.
A new anti-diabetic compound, Montbretin A (MbA), has been approved by Health Canada for Phase 1 human trials. MbA works by inhibiting the alpha-amylase enzyme, slowing down starch breakdown and reducing blood sugar spikes in Type 2 diabetics.
The use of dexamethasone has been confirmed as an effective treatment for COVID-19, reducing ICU admissions and deaths by 56%. However, the treatment can increase blood sugar levels in patients with diabetes, highlighting the need for monitoring and potential co-treatments.
The WVCTSI will deploy a mobile clinical trials unit in West Virginia, addressing health disparities and increasing participation in clinical research. The 39-foot Winnebago will provide on-site clinical trials and follow-up visits to rural residents.
St. Jude researchers have identified a possible risk for late effects of treatment with the experimental cancer drug CX-5461, which targets topoisomerase II beta (TOP2β) instead of RNA polymerase 1. The study highlights the need for close monitoring of patients enrolled in ongoing clinical trials.
A phase 2 clinical trial shows durvalumab immunotherapy combined with standard chemotherapy significantly improved overall survival for patients with previously untreated malignant pleural mesothlioma. The study's findings provide insights into patient selection methods for this novel chemo-immunotherapy regimen.
Researchers are modifying an arm of a worldwide clinical trial to evaluate a combination of drugs targeting two brain proteins: amyloid and tau. The Tau NexGen Trial aims to test the effectiveness of these treatments in slowing disease progression by targeting both Alzheimer's disease pathologies.
Paxlovid demonstrates significant efficacy against SARS-CoV-2 virus, reducing hospitalization and death risks in adult patients by up to 89%. The treatment's development involved cutting-edge X-ray technology from the Advanced Photon Source.
Researchers at Johns Hopkins Kimmel Cancer Center found a new treatment option for inoperable pleural mesothelioma using immunotherapy agent durvalumab combined with platinum-based chemotherapy. Patients with epithelioid tumors experienced higher survival rates, including some who remained tumor-free after completing the trial.
A new study found that QFR-guided PCI resulted in lower one-year rates of heart attack and a lesser chance of needing additional PCI, with a 35% reduction in mortality. The technology helped eliminate unnecessary stents and identified more obstructive lesions.
A five-year study from Columbia University found that a single dose of ketamine improved thinking and reasoning, independent of depressive symptoms, making those in suicidal crisis less likely to harm themselves. The study also showed greater cognitive improvements in those given ketamine compared to midazolam.
A study suggests sacubitril/valsartan is no better than valsartan alone in patients with severe heart failure, but may be slightly safer. The treatment showed no improvement in biomarker levels or clinical outcomes for sickest patients.