Articles tagged with Clinical Trials
Combining radiotherapy with androgen deprivation therapy significantly improves overall survival for men with locally advanced prostate cancer. The study, published in The Lancet, found that patients receiving both treatments had a higher 7-year survival rate compared to those receiving ADT alone.
A recent clinical trial conducted by the University of California - San Francisco indicates that a vaccine against HPV can effectively reduce anal infections and precancerous lesions, leading to a nearly 75% reduction in cancer precursors among those who had not been previously exposed. The vaccine is expected to prevent anal cancer in...
A recent study involving over 150,000 participants found that annual chest radiographic screening did not significantly decrease lung cancer mortality compared to usual care. The researchers examined the effect of screening on mortality using data from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
The Patient Protection and Affordable Care Act of 2010 promotes a national comparative outcomes research project agenda to optimize evidence-based medicine. High-quality associations will identify research topics for pragmatic clinical trials, while systematic reviews of clinical trials provide optimal evidence-based medicine.
A Phase III trial of RTS,S, a malaria vaccine candidate, has shown significant protection against clinical and severe malaria in young African children. The vaccine reduced the risk of malaria by 56% and 47% after three doses, with an acceptable safety and tolerability profile.
Researchers believe that timing has finally come to support the conduct of human clinical trials for stem cell therapy in spinal cord injuries. Currently, research is largely stuck at the animal model stage. Studies evaluate 11 different cell types/sources and provide evidence justifying their use.
A study published in the Journal of the National Cancer Institute found that African-American patients with resected stage II and III colon cancer experienced poorer overall and recurrence-free survival compared to whites. The five-year relative survival rates for black and white colorectal cancer patients were 57% and 68%, respectively.
A small study found that gantenerumab, a medication for Alzheimer's disease, reduced brain amyloid levels. The treatment led to dose-dependent amyloid reduction in patients with mild-to-moderate AD.
A new drug combination of gemcitabine and nab-paclitaxel has shown impressive results in a clinical trial for patients with advanced pancreatic cancer. The study, led by Dr. Daniel Von Hoff, found that about half the patients showed reductions in tumor size and about 50 percent lived at least a year.
A study using MRI techniques has identified patients with recent strokes who can benefit from timely thrombosis treatment. The technique, combining diffusion-weighted imaging (DWI) and fluid-attenuated inversion recovery (FLAIR), enables the pinpointing of the stroke's onset time, which is crucial for determining treatment efficacy.
A newly published Cochrane systematic review reveals that the transtheoretical model stages of change (TTM SOC) method is ineffective in achieving significant weight loss. The study found that TTM SOC resulted in only 2kg or less weight loss, and no conclusive evidence of sustained weight loss was observed.
Researchers developed an internet-based multimedia informed consent resource to make it easier for cancer patients to understand and feel comfortable enrolling in clinical trials. The tool, accessed via the Internet, contains a video version of the traditional informed consent process and a PDF of the written materials, allowing patien...
Researchers found that a DNA vaccine expressing a key H5N1 protein enhanced the immune response to an H5N1 avian influenza vaccine. The prime-boost regimen produced high levels of protective antibodies and broadly neutralizing antibodies against the HA stem, a region relatively constant across many strains of influenza viruses.
CrossJect's Zeneo needle-free injection device addresses real market need with precise and reliable technology. The company has received significant funding from venture capital firms and the Eurostars Programme to accelerate development and bring its product to market.
A new stratified approach to managing back pain in primary care has been shown to improve patient outcomes and reduce healthcare costs. The trial found that this tailored approach can significantly reduce disability scores, fear, depression, and improved general health compared to conventional care.
A new NIH-funded study confirms that saw palmetto extract does not reduce urinary problems associated with prostate enlargement. The study found no significant improvement in lower urinary tract symptoms for men with benign prostatic hyperplasia (BPH), regardless of dose.
Research found that drug company stock prices increased by 13.7% before positive phase III clinical trials and decreased by 0.7% before negative trials. The study also showed that stock prices of established companies with positive trial results were more likely to increase than those of smaller companies with negative trial results.
A randomized trial found that a shorter radiation course for prostate cancer with hypofractionation is as effective as conventional radiation therapy at five years after treatment. The study used intensity modulated radiotherapy (IMRT) to limit dose to normal tissues, reducing side effects.
A new 'CAP50' regimen combining chemotherapy and radiation before surgery shows promise in reducing rectal cancer recurrence risk by 88% three years after treatment. The study found that the increase in radiation dose did not extend treatment duration, while avoiding side effects.
A 12-year update of the Breast International Group 1-98 trial shows that letrozole reduces the risk of breast cancer relapse by 18% and death by 21% compared to tamoxifen after surgery. The study provides long-term reassurance on the efficacy of aromatase inhibitors in preventing breast cancer recurrence.
Researchers suggest that smaller, faster trials with relaxed evidence criteria could lead to improved cancer patient survival and quicker access to new treatments. This approach would allow for the testing of more treatments and potentially reduce the time it takes to bring new therapies to patients.
Based on current trends, only 31 developing countries are expected to achieve the under-5 mortality rate reduction goal by 2015, while 13 will reach the maternal mortality ratio goal. The study used crucial data sources not included in previous analyses.
A small clinical trial suggests that cognitive bias modification (CBM) may be as effective as in-person therapy or drugs in treating social anxiety disorder. Participants showed significant improvements on a standardized measure of anxiety and public speaking task after completing two exercises twice a week for four weeks.
A new study suggests that Cervarix vaccine may be as effective in preventing cervical cancer with fewer than three doses, offering potential cost and logistics benefits. The researchers found similar protection levels among women receiving one, two, or three doses of the vaccine.
A recent brain stent study found aggressive medical treatment without stenting may be better for high-risk stroke patients, but experts at Cedars-Sinai Medical Center believe the procedure is appropriate for certain patients who haven't responded to medication. The study's limitations and exclusions have raised concerns among researchers.
Early results suggest that virtual reality (VR) human-computer interfaces can improve arm function and daily activities in adult stroke patients compared to traditional therapy. VR training has been found to have positive effects on these outcomes, but more data is needed to assess the long-lasting benefits of this approach.
A new University of Toronto study highlights the need for improved communication with high-risk communities about HIV vaccine trials. Researchers found that misinformation, distrust, and misunderstanding persist, affecting participants' willingness to participate.
A multi-country analysis shows that ITN ownership reduces child malaria parasites by 20% and child deaths by 23%. The findings support the widespread provision of ITNs as a key intervention in controlling malaria.
A world-first viral therapy trial has shown promising results, with 87% of patients experiencing viral replication in their tumours and tumour-selective expression of a foreign gene after intravenous delivery. The treatment was well-tolerated, with mild flu-like symptoms as the most common side effect.
Researchers at UTHealth report using a patient's own bone marrow stem cells as a safe and feasible treatment for acute stroke. The study, published in Annals of Neurology, showed no severe adverse events among the 10 patients enrolled.
The CRISP AMI trial found that intra-aortic balloon counterpulsation does not reduce infarct size in patients with ST segment elevation myocardial infarction (STEMI) without cardiac shock. The study showed no significant difference in infarct size between the groups, but IABC was associated with lower mortality rates.
Health Canada should make clinical trials registration mandatory to increase transparency and protect consumers. The lack of openness about trial designs and results puts patients at risk, according to recent analysis.
A multicentre randomised trial in France investigated the safety of long-term daily remote monitoring using a home monitoring system compared to conventional in-clinic follow-up. The results showed that remote ICD monitoring is non-inferior to traditional follow-up, with significant reductions in inappropriate shocks and hospitalizations.
A new trial by the European Society of Cardiology suggests that remote follow-up of implantable cardioverter defibrillator (ICD) patients could be a safe alternative to traditional in-clinic visits. The study found that remote monitoring resulted in fewer inappropriate therapies and similar outcomes compared to conventional follow-up.
A lack of well-conducted research on widely used acne treatments could be limiting their effectiveness and putting patients at risk of ineffective treatment. The authors call for new studies to test the comparative effectiveness of common therapies and improve understanding of the natural history of acne.
The California Institute for Regenerative Medicine approved five UC Davis Health System teams with research planning grants worth up to $20 million each. These grants aim to develop human clinical trials for treatments of Huntington's disease, critical limb ischemia, airway disease, HIV/AIDS and osteoporosis.
Zinc lozenges have been found to reduce the duration of common cold episodes by an average of 42% for trials using zinc acetate in high doses. However, low-dose zinc lozenges showed no effect on cold duration.
A study analyzing results from multiple international clinical trials of beta-blocker drugs found significant differences in survival rates among patients treated in different regions. US patients showed a lower survival rate compared to patients outside the US, while other countries demonstrated more substantial reductions in mortality.
A new Cochrane systematic review shows that music can reduce anxiety in cancer patients, with positive effects on mood, pain, and quality of life. The results also suggest that music therapy may increase patients' quality of life and have smaller beneficial effects on heart rate and blood pressure.
The US Food and Drug Administration approved Anascorp, a scorpion antivenom produced in Mexico, to treat patients suffering from scorpion sting. The drug was tested in clinical trials conducted through the University of Arizona and showed dramatic results in alleviating symptoms and reducing scorpion venom levels.
The International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) will enroll 8,000 patients with stable ischemic heart disease. The study aims to determine whether a routine early invasive strategy is superior to a conservative approach in improving angina-related quality of life.
Mattress Firm Foundation is committed to raising awareness and funding for TGen's globalCure clinical trials, focusing on funding research and clinical trials. The company has already raised over $400,000 through employee donation programs and online fundraising platforms.
The search for biomarkers has made significant strides in disease diagnosis and treatment monitoring, with some tests already incorporated into everyday medicine. However, recent studies have shown that promising cancer biomarkers are no better than existing ones, highlighting the need for new approaches.
A meta-analysis of 13 trials found that zinc lozenges shortened the duration of common colds by an average of 32%, with higher doses showing greater reductions. Zinc lozenges were generally well-tolerated, with no significant long-term harm observed.
Researchers at Thomas Jefferson University have demonstrated the long-term therapeutic effectiveness and safety of S100A1 gene therapy in a large animal model of heart failure. The therapy works by restoring normal levels of the calcium-sensing protein, preventing and reversing cardiac dysfunction.
A large clinical trial in Latin America found a standard three-drug regimen for treating H. pylori more effective than four-drug regimens in Europe and Asia. The study, published in The Lancet, suggests that geographic variations in H. pylori resistance to antibiotics may account for the discrepancy.
A double-blind clinical trial is underway at UTHealth, studying the safety and efficacy of an innovative stem cell therapy for patients up to 19 days after ischemic stroke. The therapy, developed by Aldagen, uses a patient's own bone marrow stem cells to enhance recovery.
A new study published in the New England Journal of Medicine found that combining short-term hormone therapy (ADT) with radiation therapy significantly improves overall survival rates for men with intermediate-risk prostate cancer. The treatment also resulted in a 10% reduction in disease-specific deaths among high-risk patients.
Researchers found evidence of a trial effect during earlier periods but not later ones, attributing the lack of demonstrable effect to improved antiretroviral therapy and changing attitudes towards HIV.
The NOSCAR study compares NOTES cholecystectomy to conventional laparoscopic cholecystectomy, with approximately 200 patients enrolled. Covidien's funding supports the development of this minimally invasive technique, aiming to improve patient outcomes and reduce hospital stays.
Clinical trials show half-matched bone marrow or cord blood transplants have comparable survival rates and lower relapse rates compared to fully matched donors. This advancement in transplant technology may increase access to life-saving treatments for leukemia and lymphoma patients worldwide.
Researchers found that one-to-one therapy sessions to teach pelvic floor exercises were no more effective in managing urinary incontinence after prostate surgery than standard care. In fact, the intervention resulted in higher costs per patient without a significant impact on quality of life.
A new psychotherapy intervention, dignity therapy, significantly improves quality of life and enhances the dignity of patients at the end of life, while helping their families. The study found that dignity therapy reduces distress and enriches the end-of-life experience compared to standard palliative care and client-centred care.
A systematic review found that vitamin D3 supplementation increased survival in elderly women, particularly those at risk of falls and fractures. The study analyzed 50 randomized trials involving over 94,000 participants and suggested a reduced risk of mortality by approximately 6% with long-term treatment.
A group of scientists reviewed nine trials involving 503 participants and found no evidence that Botulinum toxin injections reduce chronic neck pain. The study suggests that further research is needed to clarify whether the dose can be optimized for neck pain.
The study found a significant reduction in lung cancer deaths among heavy smokers screened with low-dose helical CT, with a 20% decrease compared to those screened with chest X-ray. The screening test identified adenocarcinomas and squamous cell carcinomas at early stages of disease, providing valuable insights for future patients.
The University of Texas M.D. Anderson Cancer Center has introduced a comprehensive lung cancer screening program to detect the disease early. With computed tomography (CT) scans, the program reduces lung cancer-specific mortality by 20%, improving health outcomes for high-risk individuals.
A trial found that sending motivational and supportive text messages to smokers doubled their chances of quitting at six months. The study, led by the London School of Hygiene & Tropical Medicine, showed that continuous abstinence rates were significantly increased in participants who received personalized text messages.
A study published in The Lancet shows that smokers are twice as likely to quit when receiving motivational text messages compared to placebo texts. Biochemical testing confirms the effectiveness of the txt2stop intervention, which doubled smoking quit rates.
A new study published in New England Journal of Medicine found that CT scans can detect lung cancer at an early stage, reducing death rates by 20%. The trial involved over 53,000 current or former heavy smokers and showed improved survival rates for those who received the CT scan.