Articles tagged with Clinical Trials
A large multiethnic population study found that low vitamin D levels are associated with increased coronary heart disease events among white and Chinese participants but not black or Hispanic participants. The findings suggest that the risks and benefits of vitamin D supplementation should be evaluated carefully across race and ethnicity.
The lack of transparency in clinical trials has been criticized by Ben Goldacre, who calls for the sharing of Clinical Study Reports to ensure informed decisions about medicines. The problem of missing trials is one of the greatest ethical challenges facing medicine today.
Researchers at the Walter and Eliza Hall Institute have discovered that BH3-mimetics, currently in clinical trials for leukaemia, could offer hope for treating aggressive oestrogen receptor-positive (ER-positive) breast cancers. The compounds were effective when combined with tamoxifen in preclinical models, improving treatment outcomes.
A home-based walking exercise program improved walking performance and physical activity in patients with PAD. The study found significant improvements in 6-minute walk distance, maximal treadmill walking time, and pain-free walking time.
Researchers created educational materials to empower Spanish patients to make health care decisions, addressing language barriers and cultural ideas that hinder participation. The study aims to improve knowledge and participation for Hispanic patients in clinical trials.
A clinical trial of a DNA vaccine has delivered promising results, suggesting that it may selectively counter the immune response that causes Type 1 diabetes. The vaccine reduced levels of immune cells believed responsible for the disease and maintained insulin production levels in patients.
A novel clinical trial is evaluating the use of patient-derived stem cells to improve blood flow and prevent major amputations in patients with severe peripheral arterial disease. The trial aims to reduce mortality rates associated with limb loss, which affects over 160,000 people annually.
Researchers found that an antibiotic can trigger its own production, increasing levels by dramatically. This breakthrough could enable faster and more cost-effective production of antibiotics.
The study found that the median time to activation of phase 1-2 trials decreased from 541 to 442 days, and for phase 3 trials from 727 to 395 days. The reforms led to faster initiation of NCI-sponsored trials, ultimately benefiting patients in need of new treatments for cancer.
A Yale project has made all of Medtronic's clinical trial research data for a bone growth product available for independent reanalysis. The project, known as the Yale University Open Data Access Project (YODA), aims to address the problem of unpublished and selectively published clinical evidence.
A group of experts proposes restoring unpublished and misreported clinical trials to publish previously confidential trial documents, ensuring accurate treatment information. The effort aims to address the issue of unreported trials that have misled public health decisions and wasted public money.
Researchers are testing whether a drug called aldesleukin can reduce the number of insulin injections needed for type 1 diabetes patients. The trial aims to slow disease progression and give patients more control over their condition.
Researchers have found that interferon-beta treatment significantly improves the physical condition of animal models of spinocerebellar ataxia 7, a fatal genetic disorder characterized by coordination problems. The treatment reduces the load of mutant ataxin-7 and leads to increased PML nuclear bodies involved in protein degradation.
The Leukemia & Lymphoma Society (LLS) and Dana-Farber Cancer Institute are partnering to establish a network of sites for clinical trial testing in community oncology settings. This partnership aims to increase trial enrollment and advance innovative blood cancer therapies, ultimately saving lives.
The EORTC BOS 2 trial aims to improve outcomes for patients with resectable liver metastases from colorectal cancer by testing the efficacy of bevacizumab or panitumumab added to standard peri-operative FOLFOX 4 chemotherapy. The trial plans to accrue 360 patients in 50 sites across ten countries.
The NIH is funding a new clinical research network focused on antibacterial resistance, led by Duke University. The network will design, implement and manage the clinical research agenda to strengthen existing research capacity and address pressing scientific priorities.
A new formula predicts when brain haemorrhage patients need surgery for the best outcome, helping ensure the right treatment at the right time. This study aims to improve patient survival rates and independence.
A University of North Carolina study found that 47% of medical decisions in radiation oncology were made without available randomized clinical trial data. This highlights the need for well-designed observational studies and alternative clinical trial designs to inform patient care.
A new international study found that prolonged, intense initial treatment in children with multi-system Langerhans cell histiocytosis (MS-LCH) can achieve survival rates as high as 84 percent. The study also showed a significant reduction in disease reactivation rate compared to shorter treatment periods.
The EORTC 62024 trial found that adjuvant imatinib impacts short-term freedom from relapse in patients with localized, surgically resected, high/intermediate-risk GIST. The trial showed a non-statistically significant trend in favor of the adjuvant arm for Imatinib failure-free survival.
The first-ever enterovirus 71 vaccine has been shown to be highly effective in protecting young children against the potentially deadly hand, foot, and mouth disease. The vaccine demonstrated 90% protection against clinical EV71-associated HFMD and 80.4% against EV71-associated disease for at least 12 months.
The Lotus Valve System demonstrated successful valve implantation in all 60 patients, meeting the primary device performance endpoint. The rate of moderate or greater aortic regurgitation decreased significantly, while mortality rates remained low.
A new study confirms low-dose computed tomography (LDCT) detects more early-stage lung cancers than chest X-ray (CXR), supporting a 20% reduction in mortality. Compliant imaging facilities performed 98.5% of studies within protocol specifications.
A large observational study questions whether bivalirudin is superior to heparin in the absence of GPIIb/IIIa blockade, showing similar 30-day mortality rates. The study found no evidence that treatment with bivalirudin improves outcome compared to heparin alone.
A study of veterans at high risk for developing lung cancer shows that low-dose computed tomography (LDCT) can effectively spot tiny lung nodules indicating the earliest stages of disease. LDCT uses less than a quarter of the radiation of a conventional CT scan, resulting in a higher detection rate compared to chest x-rays.
A recent substudy found that the biodegradable stent Orsiro was non-inferior to the drug-eluting Xience Prime for in-stent late lumen loss at nine months, with similar rates of target lesion failure and reduced neointimal hyperplasia.
A study found that early provision of intravenous nutrition to critically ill patients with contraindications did not improve survival or reduce ICU length of stay. However, it resulted in a significant reduction in days of invasive mechanical ventilation.
Researchers at University Hospitals Case Medical Center Seidman Cancer Center present findings from two studies on new technologies designed to improve patient enrollment in clinical trials. A web-based intervention and an automated matching program showed significant improvements in knowledge, attitudes, and efficiency for oncologists.
A study evaluates long-term effectiveness of abdominal sacrocolpopexy surgery, finding that it effectively provides relief from POP symptoms but deteriorates over time. The procedure also decreases the risk of stress urinary incontinence, but mesh erosion remains a problem.
A new study found that patients who underwent cardiac device surgery without interrupting warfarin treatment had a 80% lower risk of developing significant hematomas compared to those bridged with heparin. This approach also reduced prolonged hospital stays, re-interruption of anticoagulation, and re-operations.
Researchers at H. Lee Moffitt Cancer Center & Research Institute found that using a centralized warehouse of patient-donated biological data expedites participant accrual, reduces trial size, saves money, and speeds up test drugs through the drug development pipeline. The study used data from recent clinical trials conducted at Moffitt...
A study found that increasing detection intervals in ICDs reduces unnecessary therapies, shocks, and hospitalizations while maintaining appropriate shock frequency. The long-detection strategy may be a useful approach for ICD recipients to reduce unfavorable outcomes.
A new clinical trial found that patients with severe and enduring anorexia nervosa improved significantly with a modified treatment approach that focused on quality of life and social adjustment. The study's results showed high retention rates and meaningful positive change, offering hope for those suffering from the disorder.
A randomized controlled trial found that naturopathic lifestyle counselling and enhanced usual care reduced the prevalence of metabolic syndrome and cardiovascular risk score by 17% and 3 percentage points respectively over a year. Naturopathic doctors provided diet and lifestyle advice to patients who lost weight through caloric restr...
A new scoring system defines patients who achieve the most benefit from TACE treatment, differentiating those who may benefit from repeat sessions and those who are unlikely to respond. This finding presents a challenge for the design of phase III trials for intermediate-stage HCC.
A randomised trial found that intensity modulated radiotherapy (IMRT) significantly reduced skin telangiectasia and improved cosmetic effect in patients with early breast cancer. IMRT delivers an even dose of radiation, reducing undesirable side-effects.
The H5N1 vaccine candidate induced a solid immune response in all three configurations of adjuvant and route of administration, exceeding the CHMP immunogenicity criteria. The results demonstrate the potential for significant 'dose-sparing' with the intradermal delivery device.
Researchers developed a website to recruit potential subjects for a clinical pain trial, offering multiple methods for attracting and interacting with participants. The site contains prescreening questionnaires, informational videos, and allows study coordinators to view accrued applicant information.
A $1.5 million clinical trial will test book reading as a potential treatment for Specific Language Impairment (SLI) in kindergarten children. The study, led by University of Kansas researcher Holly Storkel, aims to develop an effective treatment by optimizing interactive book reading.
IDRI and Medicago present data on their H5N1 Avian Influenza VLP vaccine candidate, combining IDRI's GLA adjuvant with Medicago's proprietary manufacturing technology. The trial shows promising results in evaluating the safety and immunogenicity of the vaccine.
Current diabetes research prioritizes treatment over prevention, with most trials focusing on drug therapies rather than preventive measures. The studies excluded older people and those under 18, limiting the applicability of findings to these groups.
Researchers are enrolling 4,000 participants in a 5-year trial to determine whether routine dementia screening reduces individual and societal burdens. The study aims to provide critical data on the effectiveness of routine screening for adults aged 65 and older.
A randomized trial found that tonsillectomy significantly reduced episodes of severe pharyngitis in adult patients. The procedure improved quality of life and reduced lost work or school days compared to non-surgical treatment.
A new study by McGill University researchers finds that bone marrow transplantation treatment reduces MS relapse activity by diminishing Th17 cell function. The treatment has been shown to be effective in patients with aggressive forms of MS, providing new insights into the disease's mechanisms.
A study found that azithromycin improved symptoms and lung function in patients with non-cystic fibrosis bronchiectasis, but at the cost of increased antibiotic resistance. The treatment also raised gastrointestinal side effects.
A randomized trial found that chelation therapy with disodium EDTA modestly reduced the risk of a composite of adverse cardiovascular outcomes, but did not support routine use for treatment of patients who have had a heart attack. The study included 1,708 patients and showed no effect on total mortality.
A study published in New England Journal of Medicine shows that physical therapy is just as effective as surgery for patients with meniscal tears and arthritis of the knee. The study found no significant differences in functional improvement between patients who underwent surgery with postoperative physical therapy and those who receiv...
A controlled clinical trial found that interventional endovascular therapy for multiple sclerosis (MS) does not improve patient outcomes. The treatment was safe but made symptoms worse in some cases. The study's findings lead to caution against the general acceptance of this invasive procedure for MS patients.
Researchers developed a novel multimodal imaging approach to detect frontotemporal degeneration, showing improved diagnostic specificity and accuracy. The method integrates measures of white matter and grey matter, enabling the screening of patients for clinical trials.
A Swedish study found that females with university-educated parents were 15 times more likely to receive an HPV vaccine before age 20. The researchers also noted a decrease in genital warts incidence among unvaccinated women over 20 years old, suggesting a self-selection bias where high-risk women preferentially sought vaccination.
The study found that hybrid revascularization had a similar rate of major adverse events in the first year compared to percutaneous intervention. Hybrid revascularization combines coronary bypass surgery and stenting, offering a minimally invasive approach for treating multi-vessel coronary artery disease.
Griffith University's Institute for Glycomics has launched a human trial for a Streptococcus A vaccine, targeting a protein on the surface of Strep A bacteria. The year-long trial aims to ensure the vaccine's safety and effectiveness in preventing rheumatic fever, particularly in remote Aboriginal communities with high infection rates.
A study found that elderly patients are significantly underrepresented in clinical trials, with only 33% of highly cited trials excluding them. Researchers recommend increasing age diversity to better represent the median age of advanced NSCLC patients.
Researchers at Case Western Reserve University are enrolling participants in a pilot clinical trial to assess the safety and feasibility of recording brain activity for control of assistive devices. The goal is to bypass severed connections between the brain and paralyzed muscles using brain-computer interfaces.
Researchers are conducting an early-stage human clinical trial of two related candidate vaccines to prevent infection with Shigella bacteria, which causes diarrheal illness particularly among children. The Phase I trial aims to evaluate the vaccines for safety and immune response induction in healthy adults.
A systematic review and meta-analysis of randomized controlled trials found that hydroxyethyl starch was associated with a significant increased risk of death, acute kidney injury, and renal replacement therapy. The study excluded studies conducted by an investigator whose research was retracted due to scientific misconduct.
Scientists at EPFL have made significant progress in developing prosthetic limbs that can be controlled by the nervous system, paving the way for more realistic sensory feedback and improved function. The new technology has already shown promising results in clinical trials, with potential to restore dexterity and sensation to amputees.
A recent study found that radical prostatectomy (RP) lowers prostate cancer deaths in a subgroup of patients with a significant absolute mortality difference. However, another trial showed non-statistically significant results, raising questions about the impact of more frequent screening detection.
A randomized controlled trial found that community health workers led by a nurse case-manager improved blood sugar levels among Samoans with type 2 diabetes. The intervention, which included culturally tailored education and home visits, resulted in clinically significant improvements in HbA1c levels.
A study found that nulliparous women with a short cervix who have intra-amniotic debris are at a higher risk of early preterm birth. The presence of debris was associated with worse outcomes for the babies, likely due to earlier delivery. Women with debris had a longer funnel and a higher body mass index than those without debris.