Articles tagged with Human Donor Tissues
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A team of international scientists successfully 3D printed functional human islets using a novel bioink, paving the way for more effective and less invasive treatment options. The bioprinted constructs maintained their structure without clumping or breaking down and showed promising results in laboratory tests.
Researchers at UCSF have discovered that human lung tissue contains hematopoietic stem cells (HSCs) capable of producing red blood cells, platelets, and immune cells. The finding suggests the lungs could be a potent source for life-saving stem cell transplants, particularly for patients with leukemia.
Researchers identified early cellular changes associated with Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy (MDPL) syndrome, a rare genetic aging disorder. MDPL syndrome is characterized by premature aging of mesenchymal stem cells, which can form tissues like bone and fat.
A new study demonstrates the potential of stem cell therapy to treat Hirschsprung disease by generating nerve cell precursors that produce missing nerves in the intestine. Transplanted gut samples showed improved functionality, suggesting a breakthrough for this rare condition.
Researchers investigate organ donation practices after extracorporeal cardiopulmonary resuscitation (ECPR), finding delayed organ procurement intervals and lower lung graft survival rates in ECPR groups. The study suggests using ECPR may address the organ shortage crisis by increasing viable organs for transplantation.
Scientists from Tokyo Medical and Dental University successfully generate autologous skin grafts by introducing mutations into mouse embryos, which then form sheets of epidermis containing hair follicles. These grafted skin patches survive up to 3 months and mimic mature epidermis structure.
Researchers have discovered that PR55α, a regulatory subunit of PP2A phosphatase, inhibits p16 expression and blocks cellular senescence induction by γ-irradiation. This finding provides a new insight into the regulation of the p16/RB pathway in response to stressors.
Research from UCSF found COVID antigens lingering in blood up to 14 months and tissue samples for over two years after infection. The persistence of these fragments may drive long COVID symptoms and associated risks.
Researchers found that e-liquids containing propylene glycol and vegetable glycerin enhance COVID-19 infection, while those with benzoic acid prevent it. Vapers are advised to quit or switch to e-liquids with acidic pH for better protection.
A team of researchers from Texas Heart Institute and Baylor College of Medicine have made a significant discovery about the underlying molecular cell states within transplanted pediatric hearts. They found that donor-derived tissue-resident macrophages are crucial for graft acceptance, but their loss leads to allograft failure.
University of Melbourne researchers have received a $35 million grant to develop a world-first tissue engineered cornea to treat corneal blindness. The technology has the potential to provide corneal tissue to surgeons worldwide, including countries with limited eye banks.
A new 3D bioprinted liver tissue model has been developed to study nonalcoholic steatohepatitis (NASH), a serious complication of nonalcoholic fatty liver disease (NAFLD). The model, created using liver cells from healthy or NASH-diseased donors, displays all characteristics of the disease, including fibrosis.
Researchers analyzed over 314,000 cells from rheumatoid arthritis tissue to define six types of inflammation involving diverse cell types and disease pathways. The findings shed new light on the cellular causes of RA, potentially informing targeted and effective therapeutic approaches.
Researchers found that a small fraction of eligible patients are being approached to consider eye donation, despite both healthcare professionals and patients having favorable views towards it. The study highlights the need for practice change to offer patients who wish to donate as part of routine end-of-life care.
Researchers at UMass Amherst are investigating the connection between PFAS chemicals and breast cancer. They will examine data from postmenopausal women to determine if PFAS concentrations are associated with less breast tissue involution, which may increase breast cancer risk.
Researchers assembled the largest atlas of post-zygotic genome mutations in healthy human tissue, providing insight into genetic underpinnings of disease. The study found that most detectable mutations occurred later in life, but some arose systematically and predictably as people age.
The funding will support preclinical research using genetically modified pigs, aiming to improve compatibility and reduce immune rejection in xenotransplantation. The goal is to enable human clinical trials and address the organ shortage crisis.
A new UC Davis study has identified 194 significantly different genes in the brains of people with autism, with many linked to brain connectivity, immune response, and inflammation. The research also found age-dependent differences in genes related to synaptic function and cell loss.
Researchers compared two methods of corneal transplant tissue preparation, finding the new DMEK EndoGlide technique to be safe and effective while providing a faster process. The study suggests this method may lead to better long-term outcomes for patients with Fuchs' dystrophy.
The Tabula Sapiens Consortium has unveiled a massive digital atlas that maps gene expression in nearly 500,000 cells from 24 human tissues and organs. The atlas provides unprecedented insights into human health and disease, offering new avenues for therapies and treatments.
Researchers revived photoreceptor cells in human macula, responding to bright and dim lights. The study restores communication between retinal cells, transforming brain and vision research.
A study found that informational content in videos, rather than emotional connectivity, encourages family members to donate tissues. The intervention increased willingness among next-of-kin to provide consent for tissue donation in Nevada, where the vast majority do not give consent after death.
A new global study found a significant decline in solid organ transplants performed during the first wave of Covid-19 in 2020, with over 48,000 years of patient life lost. Kidney transplantation showed the largest reduction across nearly all countries.
A study of 20,304 kidney transplants found that black recipients and patients receiving kidneys from Asian donors had a higher risk of graft failure within seven years. The study suggests that improved access to organ donation among ethnic minority groups can improve long-term outcomes for all recipients.
A new rapid 3D printing method developed by University at Buffalo engineers has the potential to create life-sized human tissue and organs in just minutes, rather than hours. The technique uses hydrogels and stereolithography to print cells with embedded blood vessel networks, a key step towards producing functional 3D-printed organs.
UTEP researchers will use 3D bioprinting to study the progression of diabetes and its effects on the heart, aiming to develop targeted treatments for cardiomyopathy. The project also aims to screen cardiac toxicity in common drugs used by patients with type 2 diabetes.
The Duodenum Intestine-Chip, a living product from Emulate, Inc., was shown to accurately recreate key functions of the human duodenum. The chip demonstrated superior functionality compared to organoids alone in terms of global transcriptomic profile and physiological function.
Researchers develop new method to preserve human livers for transplantation, extending viability from 9 hours to up to 27 hours. The new protocol uses a combination of technologies to prevent ice nucleation and deliver protective solution uniformly throughout the organ.
The Physicians Committee for Responsible Medicine has launched a new effort to encourage people to become organ and tissue donors, helping scientists save human lives and reduce animal experiments. Human tissue is used in various scientific advancements, including disease progression, drug development, and medical procedures.
Researchers developed bioengineered blood vessels that appear safe and functional after implantation in dialysis patients. The vessels showed no signs of rejection and maintained their mechanical integrity, with a 90% durability rate compared to traditional synthetic grafts.
University of Wisconsin-Madison scientists successfully grew functional vocal cord tissue in the laboratory using bioengineering techniques. The tissue was able to transmit sound and showed similar characteristics to native tissue, paving the way for potential clinical applications.
Scientists have developed a method for isolating primary human hepatocytes and different non-parenchymal cell fractions from the same donor tissue. The isolation process involves a two-step EDTA/collagenase perfusion technique followed by Percoll density gradient centrifugation, adherence separation, and magnetic activated cell sorting.
A new national transplant policy has sliced in half the racial disparities that have long characterized the allocation of lifesaving organs. The researchers attribute the drop to a 2003 decision by the United Network for Organ Sharing (UNOS) to change the relative priority given to tissue matching.
A 2-year clinical study demonstrated that biosynthetic corneas formulated with recombinant human type III collagen restored vision and promoted nerve regeneration in patients with corneal damage. The results provide proof-of-concept for a viable replacement for human donor tissue or animal-sourced collagens.
A new generation of biological scaffolds enables the development of off-the-shelf tissue transplants that can be repaired and renewed like normal tissue. The technique removes cells from natural tissues to leave a biocompatible scaffold made of collagen, allowing patients' own cells to populate and bind to it.
Scientists have successfully transplanted human and porcine 'kidney precursor cells' into mice, resulting in functional kidneys that produce urine. The optimal time for transplantation is between 7-8 weeks (human) and 4 weeks (porcine), reducing the risk of immune rejection.
Jan Lohmann and Thomas Bosch report a discovery of the novel peptide HEADY, which acts as a potent inducer of head formation in lower metazoans. Grafting experiments show that HEADY induces a secondary head in Hydra tissue, revealing its role as a developmental switch for axis specification.
Researchers identified a novel subset of T-cells called CD4-CD8- double negative regulatory T cells that can regulate killer T-cells and prevent rejection of donor tissue. These cells act as a kind of decoy, binding to the same antigen as killer T-cells and being destroyed, thereby inhibiting the immune response.
Researchers at Fred Hutchinson Cancer Center found that genetic techniques for matching patients with marrow donors can eliminate guesswork and improve survival rates. The study of 300 patients with chronic myeloid leukemia showed that even single mismatches in key genes don't affect long-term survival.
A study found that nearly one in five organ donor families would reconsider donating organs if given the chance. Factors such as prior discussion with family members, education level, and religion influenced satisfaction with donation decisions.