Articles tagged with Bipolar Disorder
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A study published in The Journal of Pediatrics found that delayed treatment of childhood-onset bipolar disorder results in longer periods of depression, more episodes, and increased substance abuse risk. Adults with untreated childhood-onset bipolar disorder experienced poorer quality of life and were less responsive to treatment.
A University of Colorado study found that intensive psychotherapy added to medication significantly improved bipolar disorder symptoms, with patients experiencing better mental health faster. The research also highlighted the importance of family-focused therapy in stabilizing daily routines and coping strategies.
Researchers studied 366 participants with bipolar disorder, finding that adding antidepressants to mood stabilizers did not improve outcomes or trigger manic episodes. The study suggests careful management of mood stabilizer medications may be a reasonable alternative to adding antidepressants.
Researchers at UT Southwestern Medical Center found that the Clock gene, regulating biological clocks, is involved in developing bipolar disorder in mice. The study reveals behaviors similar to humans with bipolar disorder, including hyperactivity and euphoria, which are restored by lithium treatment.
Recent advances in bipolar II disorder and related disorders highlight the need for further research due to changes in diagnostic criteria and mixed profiles. Treatment options, such as mood stabilisers, are recommended for mixed depression, but controlled pharmacological studies are lacking.
A new test, Hypomanic symptom check list (HCL-32), has been validated to identify type II bipolar disorder patients. The test, which consists of 32 questions, is more precise than the Mood disorder questionnaire in identifying this underdiagnosed disease.
Researchers at UIC aim to develop a compound blocking mania associated with bipolar disorder, improving on dated 'mood stabilizers' like lithium and valproic acid. The goal is to create safer, more effective treatments for the mental illness affecting over 2 million Americans.
Researchers aim to identify genetic underpinnings of early-onset bipolar disorder, a mental illness affecting millions of Americans. The two-year study will analyze DNA from participants and their parents to develop more rational treatments.
Scientists have identified a crucial role of TPH2 protein in regulating serotonin levels, which may be linked to the development of depression and manic depression. The study suggests that variations in the TPH2 gene are associated with an increased risk of developing these psychiatric disorders.
A new gene, Slynar, has been linked to both depression and bipolar disorder, affecting around 10% of cases. Researchers hope the discovery will lead to new treatments for these conditions.
A study of 438 children and adolescents with bipolar spectrum disorders found that those with short episodes of mania were similar to those meeting full diagnostic criteria, suggesting a need for revised diagnostic criteria. The study's results will inform changes to the Diagnostic and Statistical Manual of Mental Disorders-IV.
The survey reveals that caregivers experience devastating consequences, including relapse, hospitalization, and financial strain. Caregivers also emphasize the importance of effective medication and long-term care to maintain their loved ones' overall well-being.
A recent study by the National Institute of Mental Health found that bipolar disorder exacts twice as much toll on workplace productivity as major depression, costing nearly half as much in lost wages. The researchers attribute this disparity to bipolar disorder's more severe depressive episodes rather than its manic periods.
A Wake Forest University research team is analyzing brain changes in individuals with schizophrenia and bipolar disorder to better understand the diseases. They are comparing post-mortem brain tissue with normal tissue, focusing on the temporal lobe's structures involved in learning and memory.
A new care model for bipolar disorder, developed by Brown University researchers, has shown promise in reducing manic episodes and improving quality of life. The team-based approach involves psychiatrists and nurses working together to manage symptoms, resulting in a significant reduction in symptoms and improved function.
Youth with bipolar disorder show increased brain activity when rating hostile faces, indicating difficulty processing emotional cues. This finding may help refine diagnosis and understanding of the underlying brain mechanisms.
Researchers found five predictors associated with bipolar disorder risk: people were unfriendly, co-morbid anxiety, depression diagnosis within five years, family history of bipolar disorder, and legal problems. These findings may help physicians better assess a patient's risk for bipolar disorder.
A special issue of PLoS Medicine explores how corporate sponsorships are creating new diseases, medicalizing everyday life, and promoting unnecessary treatments. The articles highlight examples of disease mongering, including the marketing of Viagra for 'normal' men and the over-diagnosis of bipolar disorder in children.
The landmark COBY study found bipolar disorder in children and teens progresses differently than in adults, with more frequent mood swings and longer symptom duration. Children and teens often switch between different illness sub-types during the course of follow-up.
Researchers assessed 263 children and adolescents with bipolar spectrum disorders, finding that symptoms were longer-lasting and more variable in youth than adults. The study also revealed faster cycling between symptomatic periods and a higher likelihood of diagnosis changes over time.
Researchers at Yale discovered that brain changes associated with bipolar disorder are diminished in patients taking mood-stabilizing medications, holding promise for halting the progression of the disorder. The study's findings highlight the importance of research on bipolar disorder in youths, who are at high risk for suicide.
A team of scientists from the University of New South Wales has identified a gene called FAT that is associated with an increased risk of bipolar disorder. The discovery was made using a multi-faceted approach that included studying families, patients, and therapeutic drug mouse models.
A recent study by Bradley Hospital found that up to twenty percent of adolescents on psychiatric units may be manic-depressive. The study used a mania rating scale and found that these patients were more suicidal and aggressive than those admitted for depression alone.
Patients with bipolar disorder experience worsening psychosocial disability as depressive symptom severity increases, and vice versa. Psychosocial functioning normalizes when patients are asymptomatic, but remains poor compared to well controls.
Researchers found that CBZ-ERC significantly reduced manic and mixed symptoms for patients with Bipolar I Disorder. The study also showed that the medication was generally well-tolerated, with only 14.3% of patients experiencing a relapse.
A new study published in the Journal of Psychiatric Research found that children of bipolar parents scored higher than healthy controls on a creativity test. The research suggests a possible link between creativity and bipolar disorder, with some experts attributing creative activity to mobilizing energy from negative emotions.
Researchers found that children with bipolar disorder exhibit over-reactive amygdala responses to negative stimuli, leading to under-reactive cognitive behavior. This study highlights the need for targeted treatments and interventions for pediatric bipolar disorder.
A study combining genome scan data from 11 independent linkage studies found strong genetic signals on chromosomes 6 and 8 associated with bipolar disorder. The analysis involved over 1,000 families and 5,179 individuals from North America, Italy, Germany, Portugal, the UK, Ireland, and Israel.
A study has found a significant connection between the CAPON gene and schizophrenia, with brain samples from patients showing higher levels of the short form of the protein. This increase was predominantly seen in individuals with variants of the CAPON gene previously linked to schizophrenia.
Interpersonal and Social Rhythm Therapy (IPSRT) has been found to be an effective treatment for bipolar disorder, helping patients manage daily routines and relationships to prevent mania and depression. The study suggests that IPSRT is particularly beneficial for individuals with more regular social routines and better physical health.
A four-year multicenter study will examine why minorities face dangerous misdiagnoses for mood disorders, leading to excessive antipsychotic drug use among African-Americans. The research aims to identify underlying reasons and develop new education techniques to improve diagnosis and treatment plans.
Researchers found a disrupted brain wave pattern in patients with schizophrenia, which may help understand attention deficits. The study aims to develop a biological test to distinguish patients with schizophrenia from those with bipolar disorder.
A new survey suggests that Seroquel provides significant quality of life improvements for bipolar patients, with 79% believing a successful treatment would lead to increased functionality and improved lifestyle. The medication has been shown to effectively manage symptoms of depression and anxiety in rapid-cycling patients.
The global survey found that 26% of respondents never disclose their bipolar disorder due to social stigma, while 71% believe the public does not understand their illness. The survey also revealed that successful treatment would lead to significant quality of life changes.
New study finds bipolar disorder prevalence higher than previously thought, with a significant economic burden and high risk of suicide; Lithium treatment may help reduce these risks.
Researchers have found that bipolar disorder is associated with difficulties modulating brain regions that detect error and promote accurate responses. Additionally, a two-pronged pharmacologic approach of both a mood stabilizer and an antipsychotic may be necessary to treat both the depressive and manic phases of bipolar disorder.
Research identifies genetic linkages associated with bipolar disorder, including a possible connection to autoimmune thyroiditis. The findings suggest that identifying these genetic markers could help develop more effective treatments or prevent the disorder in at-risk individuals.
EQUETRO demonstrates significant reduction in manic symptoms for patients previously taking valproate or lithium, with average YMRS scores decreasing by 10.8 and 11.6 points, respectively. The medication is an effective treatment option for acute manic and mixed episodes associated with Bipolar I Disorder.
Studies show SEROQUEL reduces suicidal thinking in bipolar depression, improves quality of life, and enhances treatment adherence. Improved compliance with medication is also a significant benefit.
Scientists have identified several genes that appear to be switched on by lithium, which may lead to the development of more effective treatments for bipolar disorder. The study found that one gene, GPR88, is associated with a rat model of mania and codes for an orphan receptor that could potentially target dopamine signaling.
Researchers found decreased calcium responses in olfactory receptor cells from patients with bipolar disorder. These findings may provide new targets for drug development and improve treatment predictions.
The new guidelines, developed by a team of leading experts in child psychiatry, provide evidence-based recommendations for treating children and adolescents with bipolar disorder. The guidelines emphasize the importance of using multiple medications to stabilize moods and promote recovery.
A study found that bipolar disorder is prevalent among patients in an urban primary care clinic, with 9.8% screening positive for the condition. Patients who screened positive reported worse health-related quality of life and social impairment compared to those who did not screen positive.
Researchers have identified significant differences in brain chemistry between people with and without bipolar disorder using MR spectroscopy. The study's findings suggest that this imaging tool may help distinguish bipolar disorder from major depression, improving treatment outcomes.
Researchers found that extended-release carbamazepine capsules improved symptoms in patients with bipolar disorder, including those experiencing mania and mixed episodes. The treatment was generally well-tolerated, with few adverse events reported.
A new study reveals that stress activates the mania-linked enzyme PKC, leading to impaired cognitive functions in the prefrontal cortex and reduced memory-related cell firing. Inhibiting PKC may offer a fast-acting treatment for mania, with potential benefits for patients seeking emergency room care.
PKC enzyme's excessive activity is associated with symptoms of bipolar disorder and schizophrenia. Increasing PKC activity in the prefrontal cortex impairs cognitive function, while inhibition may offer therapeutic benefits.
A new study found Seroquel to be effective in rapidly relieving core symptoms of depression, such as sadness and suicidal thoughts, in patients with rapid-cycling bipolar disorder. The treatment was also well-tolerated, with a low risk of mania compared to other treatments.
The BOLDER trial found SEROQUEL significantly reduces anxiety symptoms in bipolar depression patients within the first week of treatment. It also improves depressive symptoms and is well-tolerated with a favorable side effect profile.
A new study shows that Seroquel achieves remission in bipolar mania, with a significant increase in remission rates over time. The medication has been shown to be effective in reducing symptoms of racing thoughts, reckless behavior, and decreased sleep.
The BOLDER study found SEROQUEL to be superior to placebo in reducing depressive symptoms and anxiety in patients with bipolar disorder. Approximately 50% of patients achieved remission from their bipolar depression symptoms.
A Stanford study examined 42 college-age bipolar patients, finding significant improvement in symptoms and function with treatment. The research suggests that early and accurate diagnosis is crucial for preventing disease progression and that these young adults can function well if properly diagnosed and treated.
A new treatment approach combines a tailored medication regimen with the RAINBOW psychotherapy program to alleviate symptoms of bipolar disorder in children. The program has shown promising results, with 94% of children improving after treatment.
A double-blind study found that Risperdal significantly reduced 'manic' symptoms in patients with bipolar disorder, with treatment response achieved by 48% of patients taking Risperdal. The medication was also shown to improve depressive symptoms and was better tolerated than haloperidol.
Studies suggest schizophrenia and bipolar disorder have reduced expression of genes responsible for myelin development in brain cells, potentially linked to environmental issues or infections. This discovery may enable early treatment before symptoms emerge in late adolescence or early adulthood.
Research suggests that schizophrenia and bipolar disorder share similar genetic causes, with key oligodendrocyte-related and myelin-related genes showing reduced expression in patients. This finding has implications for understanding the underlying mechanisms of these complex mental health conditions.
A study published in the Journal of Clinical Psychiatry found that divalproex improved mood and behavioral disorders in over 78% of at-risk children. The medication may delay or prevent the onset of bipolar disorder, offering an alternative treatment option.
A mutation in the GRK3 gene, specifically in the promoter region, is linked to bipolar disorder in up to 10% of cases. The study suggests that this mutation causes individuals to become hypersensitive to dopamine, leading to mood extremes characteristic of the disease.
Seroquel was shown to significantly reduce mean Young Mania Rating Scale (YMRS) total scores in patients with bipolar disorder, with a faster reduction in symptoms compared to placebo. The medication was well-tolerated and had fewer side effects than other treatments like haloperidol.
Quetiapine has been shown to be statistically more effective at treating manic symptoms of bipolar disorder than placebo. The results of the clinical trials indicate rapid symptom improvement from day four and a favorable side effect profile, making it an exciting development in psychiatry.