A new review describes the development and impact of a Latin American mentorship program for Fracture Liaison Services (FLS), resulting in 64 FLSs getting started and providing coverage for over 17,200 patients. The program also supports the establishment of active communities of mentors across Mexico, Brazil, Colombia, and Argentina.
Researchers developed a 'Skeletal Age' metric to assess impact of fractures on mortality, revealing a loss of one to seven years of life depending on gender, age, and bone site. The online calculator measures bone fragility to help doctors and patients understand fracture risks.
Researchers developed a novel approach that promotes bone regeneration in mice without implantation of bone tissue or biomaterials. By carefully stretching the skull along its sutures, they activated skeletal stem cells that reside in these wiggly seams, repairing damage to the skull that would not have healed on its own.
A large study found that air pollution accelerates bone loss from osteoporosis in postmenopausal women, particularly on the lumbar spine. Nitrogen oxides were identified as a major contributor to this damage.
A new economic model estimates the health benefits and budget impact of Fracture Liaison Services, showing significant reductions in fragility fractures, hospital bed days, and social care costs. The model suggests that FLS implementation would lead to improved patient outcomes and cost-effectiveness.
Patients with high fracture risk and complex medical conditions are less likely to receive osteoporosis treatment and have poorer health outcomes. The study highlights the need for a comprehensive treatment approach that considers the patient as a whole, rather than just focusing on individual diseases and treatments.
A long-term study found that eating more than 100 micrograms of vitamin K1 daily reduced the risk of fractures and hospitalizations by 31-49%. Dark leafy vegetables and one-to-two serves of vegetables are recommended for optimal benefits. Vitamin K1 has been shown to enhance cardiovascular health and promote bone health.
A study of over 300,000 Danish adults found that fractures closer to the centre of the body were associated with higher mortality rates. The presence of certain clusters of health conditions compounded this risk, suggesting a new way of identifying patients at high risk of poor outcomes.
A Texas A&M study sheds light on a major health concern for people with Down syndrome, who may not heal from bone fractures. The researchers found that the glue-like cartilage that helps bones heal doesn't form properly in individuals with DS, leading to devastating health impacts.
The Patient-Centered Outcomes Research Institute (PCORI) has approved funding awards totaling $258 million to support 26 new research studies. These studies aim to fill evidence gaps and improve healthcare decision making for a range of high-burden conditions, including mental health, heart conditions, asthma, bone fractures, and sinus...
Researchers at Saarland University are developing orthopaedic implants that can actively stimulate bone healing by undergoing controlled micromotions. These innovative implants, which use shape-memory wires, can provide real-time information on fracture progression and identify potential complications.
A UNLV study analyzed nearly 30,000 broken bone cases and found that smoking increases the risk of breaking a bone by as much as 37%. The study also found that men are more likely to experience fractures, particularly in the wrists, spine, and shoulders, due to nicotine's negative impact on bone cells and calcium absorption.
Scientists at Tokyo Medical and Dental University discover that smaller alkyl groups in ceramic materials facilitate faster chemical reactions, speeding up hydroxyapatite formation. This breakthrough could lead to improved patient outcomes and reduced need for further repairs after bone surgery.
Women with obesity and high waist circumference are more susceptible to fractures than those with normal weight. The study found a linear relationship between waist circumference and the incidence of fracture at any site and at the distal lower limb, particularly at the ankle.
A new study uses artificial intelligence to predict bone fractures in cancer patients by creating a digital twin of the vertebra. The AI-assisted framework, ReconGAN, simulates how tumors affect the spine and predicts fracture risks, offering medical experts better treatment strategies and patient decisions.
Researchers at Lehigh University developed a new method to accurately gauge healing progress of bone fractures using 3D models. The model identifies the cutoff point between soft tissue and bone, allowing for more precise predictions of bone behavior during the healing process.
A study found that AI's sensitivity for detecting fractures was 91-92%, comparable to clinician performance. The technology has potential as an educational tool and 'second reader' to reduce misdiagnosis rates in challenging circumstances.
A new Irish survey found that no trauma sites capture all fracture patients, with only 50% receiving osteoporosis medication within four months of a fracture. Implementing a national Fracture Liaison Service (FLS) would bring services in line with international standards and reduce hospital admissions.
Researchers have developed a combination of materials that can morph into various shapes before hardening, similar to the natural process of bone development in the human skeleton. The soft material can be used to create microrobots that can inject themselves into complicated bone fractures and expand to form new bone.
A randomized controlled trial of 1,600 patients found that rates of survival, functional recovery, and post-operative delirium are similar for both general and spinal anesthesia. This challenges common thinking about spinal anesthesia being safer.
A subpopulation of mesenchymal stem cells expressing CD73 has been identified as crucial for bone regeneration, displaying enhanced proliferation and differentiation capabilities. This subgroup promotes fracture healing by forming new cartilage and bone cells, contributing to the remodeling process.
The study found that cycling accidents account for 81% of sports-related traumatic spine injuries, followed by skiing and snowboarding accidents. The research highlights the importance of implementing safety measures to prevent these types of injuries.
A new study followed 30,446 middle-aged individuals and found that older age, female sex, and low leisure-time physical activity are associated with a higher likelihood of experiencing a fracture. The study highlights the importance of these factors in public health initiatives for fracture prevention.
Researchers developed a computational model to calculate 'skeletal age', a personalised estimate of an individual's risk of bone fracture and premature death. The skeletal age calculator aims to better identify those at risk of a first bone fracture and subsequent fractures, as well as estimates how fractures impact life expectancy.
Excess weight in pre-schoolers is linked to a higher risk of lower limb fractures (42% increase) and upper limb fractures (19% increase) compared to normal-weight children. Overweight and obesity are associated with significantly higher fracture risks.
Researchers at UTSA are reexamining bone mineral density and proteoglycans to improve fracture risk assessments. Studies show that BMD captures only 50-60% of actual bone fragility fractures, highlighting the need for a more comprehensive approach.
A study published in JNCI Cancer Spectrum found that diets high in soy foods are associated with a decreased risk of osteoporotic bone fractures in pre-menopausal breast cancer survivors. Soy intake was linked to a 77% reduced risk of fractures, particularly among younger women.
Researchers at Purdue University have developed an injectable-targeted drug that demonstrates accelerated and improved bone fracture healing. The grant will support human trials for this novel treatment, which could also be used for other conditions such as dental implants and spinal fractures.
A new study found that exposure to air pollution is associated with osteoporosis-related bone fractures, particularly in low-income communities. The researchers suggest that reducing air pollution could help prevent these fractures and improve bone health.
A recent study found that young people taking anti-epileptic drugs experience elevated rates of bone fractures and reduced bone mineral density. The study highlights the need to further investigate bone health issues in pediatric patients on these medications.
Researchers found a combination of adult stem cells and parathyroid hormone significantly increased new bone formation in laboratory animals. The therapy also showed enhanced stem cell migration to the area of bone fractures, leading to improved bone density.
Research suggests that SSRIs taken for menopausal symptoms may increase bone fracture risk in middle-aged women, with significant increases observed after several years of treatment. Shorter treatment lengths may be preferable to mitigate this risk.
A new study from Forsyth Institute reveals that proton pump inhibitor-based antacids reduce stomach acidity, disrupting calcium absorption and increasing the risk of bone fractures. The research provides a best explanation for the side effect of these medications, which are used by 100 million Americans.
A new hand-held instrument called OsteoProbe measures the bone material strength index (BMSi), which predicts bone fracture risk. The device is more sensitive than standard measurement techniques and can detect changes in cortical bone indentation following treatment with osteoporosis therapies.
A study found that cinacalcet reduced the rate of bone fracture in patients on dialysis by 16-29%, after adjusting for patient characteristics. The drug may provide a protective effect against fractures in these patients, who are at increased risk due to kidney failure.
A study of 51,785 individuals with kidney stones found a significant link between the condition and an increased risk of bone fractures. The excess risk was greatest in males during adolescence and women during middle age.
A new study found that US osteoporosis screening guidelines failed to identify the majority of younger post-menopausal women who experienced major fractures. The guidelines recommended testing and treatment for women aged 65+, but only predicted fractures in around 25% of those aged 50-64.
Researchers at Penn State College of Medicine identified common gene variants associated with delayed fracture healing, potentially leading to improved treatment for patients. The study's findings suggest that specific genetic polymorphisms may impair or fail to support fracture healing.
Researchers have made a breakthrough in evaluating long bone fractures using ultrasound, providing a new method for monitoring healing. The study found that the amplitude of ultrasonic guided waves can quantify fracture degree and depth, offering a non-invasive diagnostic tool.
Researchers at Cornell University have developed a new X-ray imaging technique that visualizes damage in bone at the cellular level. The technique uses high-energy hard X-rays to produce images of microdamage in sheep bone with unprecedented resolution.
Researchers at Henry Ford Health found a significant link between steroid injections and increased risk of bone fractures in the spine. The study revealed a 29% higher fracture rate with each injection, highlighting patient safety concerns.
Researchers at Yale University found that skin wrinkles and quality can reflect bone mineral density in early menopausal women. The severity of wrinkles was related to lower bone density, while higher skin rigidity was associated with better bone health.
A recent study published in Clinical Infectious Diseases found that HIV-infected patients have a higher risk of bone fractures compared to the general US population. The study analyzed data from over 5,800 HIV-infected patients and observed annual fracture rates 1.98-3.69 times greater than the general population.
A $1.76 million study at Rensselaer Polytechnic Institute investigates the role of two proteins, osteocalcin and osteopontin, in bone fractures over time. The research aims to develop new methods of diagnosing osteoporosis and treating related bone diseases.
Researchers developed models to investigate non-healing bone fractures, suggesting cell transplantation as a potential treatment. The study used an animal model and mathematical modeling to demonstrate the effectiveness of this approach.
A recent study published in The Journal of Clinical Endocrinology & Metabolism found that women with type 2 diabetes who take thiazolidinediones are at a higher risk for developing bone fractures. Women over 65 years old were shown to be particularly susceptible, with a 50% increased risk after one year of treatment.
A new study found that HIV-infected postmenopausal women have a high prevalence of low bone mineral density and high bone turnover, increasing their risk for future bone fractures. The study suggests that estrogen deficiency may play a role in the accelerated bone loss in these women.
A recent study published in PLOS Medicine suggests that individuals prescribed thiazolidinediones for type 2 diabetes are at increased risk of bone fractures. The self-controlled case-series study analyzed data from over 6 million patients and found a nearly one-and-a-half times higher fracture rate among those taking the medication.
A four-year study found that adults who took a daily calcium supplement experienced significantly fewer bone fractures than those who received a placebo. Maintaining calcium intake is crucial to sustain benefits, but the effects disappeared after four years.
The study found an annual bone fracture rate of 3.6% in the UK population, with men having a higher rate than women, and manual workers more prone to fractures. The lifetime fracture rate among white people was almost double that of black and minority ethnic people.
A new study from the University of Missouri-Columbia found that men engaging in predominantly low-impact forms of exercise have an increased incidence of osteopenia, a condition resulting in two times the risk of bone fracture. Regular weight-bearing activities can mitigate this risk and maintain healthy bones.
Researchers have discovered that transforming growth factor beta (TGF-ß) regulates bone matrix properties, which affect bone elasticity, toughness, and resistance to fracture. The study suggests that targeting TGF-ß signaling could improve bone quality, potentially preventing osteoporosis and improving bone repair.
A large prospective cohort study of 24,403 postmenopausal women found that higher soy intake was associated with a significantly lower risk of fracture. Soy protein and isoflavone intakes were inversely related to fracture risk, with a notable reduction among those in the highest intake groups.
Scientists at UC Santa Barbara have made a groundbreaking discovery about the molecular mechanisms that hold human bone together, revealing a 'glue' that absorbs shock and helps prevent fractures. The findings may lead to new therapies for bone fracture treatment and prevention.
A large case-control analysis found that use of beta-blockers, alone or combined with thiazide diuretics, is associated with a significantly decreased fracture risk. Long-term users showed a 29% lower risk of fractures, particularly in men, while women exhibited a weaker association.
A study found that vibrating insoles can significantly improve balance and reduce sway among elderly participants. Younger individuals also showed reduced sway with stimulation, suggesting the potential of noise-based devices to enhance motor control performance.