Articles tagged with Brain Injuries
A study examining the use of Actual Reality in traumatic brain injury (TBI) found that individuals with TBI had difficulty performing internet-based tasks. The results suggest that Actual Reality is a potential tool for capturing the status of everyday functional activity in this population, supporting its use in clinical assessments.
Researchers at McGill University have developed a new diagnostic tool for concussions in children, utilizing brain activation study findings. The spatial memory task has the potential to aid in assessing recovery and determining safe return to activities.
Research by Columbia University finds that glucocorticoid treatment restores BBB function within a day of primary blast injury, potentially reducing mandatory rest periods for military personnel. The study's positive results could lead to the development of targeted therapies using steroids to restore BBB integrity after blast injury.
Researchers found that early post-traumatic stress symptoms are the strongest predictors of later disability in military personnel with mild brain injuries. A study evaluated 38 patients with mild blast-related brain injury and 34 controls, showing that mental health assessments soon after injury were more predictive of long-term disab...
A recent Connecticut study found a marked increase in the number of teenagers receiving medical treatment for sports-related concussions after laws were passed in 2010. The study suggests that extending concussion laws to include summer camps, travel teams, and all-star teams could improve safety and education for all young athletes.
A new pharmacological agent, Thymosin beta-4, has shown promise in treating neurological diseases by increasing protective myelin around nerve fibers. Current standard drug therapy, like tPA, is limited and often ineffective, prompting a shift towards restorative therapies.
Researchers are advancing blood biomarker capabilities using the Simoa technology, which offers unprecedented improvement in sensitivity proteins for detecting traumatic brain injury. The technology allows for more effective measurement of low concentrations of proteins such as tau, enabling more accurate diagnosis and treatment.
A study published in Critical Care Medicine defines the prevalence, associated factors, and time course of vasospasm in children with moderate to severe traumatic brain injury. The study found that children with higher Injury Severity Scores, fever at admission, and lower Glasgow Coma scores were at increased risk of developing vasospasm.
Scientists at Monash University have made a major breakthrough in understanding how the brain adapts to vision loss by discovering a second pathway for visual information. This new pathway, through the pulvinar area of the brain, plays a crucial role in rerouting visual information following injury or trauma.
Researchers at Ben Gurion University of the Negev have discovered a promising peptide called humanin that can counteract cell death caused by hypoxia. The peptide's derivatives were tested on neuronal cells and showed successful results, potentially leading to new treatments for necrosis-related diseases.
A groundbreaking study published in The Journal of Pediatrics suggests a relationship between concussions sustained by young ice hockey players and subtle changes in the cortex, indicating an early marker for brain damage. Researchers hope to further investigate the long-term effects of repeated blows to the head on young athletes.
Researchers at UVA School of Medicine have identified interleukin-33 as the biological trigger for a protective immune response to spinal cord injury. This discovery holds promise for improved treatments and diagnostic tests for conditions such as Alzheimer's disease and brain trauma.
The University of Michigan has launched a major initiative to find new ways to treat Traumatic Brain Injury (TBI) thanks to a $10M gift from the Joyce and Don Massey Family Foundation. The new Emergency Critical Care Center will provide advanced care to patients with TBI, stroke, or other critical illnesses.
Researchers at NYU Langone Medical Center developed a novel eye-tracking device to diagnose concussion severity, tracking pupils for over 200 seconds while watching a music video. The study found that trauma patients with normal CT scans were slightly worse at 1-2 weeks after injury and recovered about one month later.
Research finds accumulated brain damage linked to memory deficits and mood regulation in former NFL players, supporting calls for improved athlete protection from concussion. PET scans show concentrated zones of high translocator protein levels, indicating brain injury and potential long-term neurological risk.
A Northwestern University study found that family members sharing familiar stories with coma patients who wore headphones recovered consciousness faster and had improved outcomes. This 'familiar auditory sensory training' stimulated the brain's memory circuits, helping patients wake up more easily and respond to their environment.
A new study suggests that traumatic brain injury triggers long-term inflammation in the brain, causing chronic degenerative problems. The research proposes that this inflammation is a major treatable cause of brain damage after trauma.
A study by Johns Hopkins pathologists identified a unique pattern of injuries in the brains of combat veterans who survived IED blasts and later died. The honeycomb pattern of damaged nerve fibers is distinct from other types of brain injury, suggesting a possible signature of 'shell shock' or blast neurotrauma.
A new study in mice suggests that a blood-based biomarker for traumatic brain injury (TBI) may not be effective due to the complex glymphatic system. The researchers found that treatments and clinical approaches can disrupt waste removal, leading to unreliable protein levels in the blood.
The new guidance provides a six-step process for progressive activity after mild traumatic brain injury (mTBI), with specific recommendations for rest and activity. Patients can only progress to the next stage if they are symptom-free, with worsening symptoms requiring return to previous stages.
The article highlights the lack of injury data in youth rugby, putting junior players at risk. Creative match scheduling and preseason training can help improve safety, but a comprehensive dataset is needed to set rational policies.
A new study of over 40,000 cases of brain trauma in children reveals that falling from bikes or scooters is the leading cause of injury in kids under 12. The findings emphasize the importance of safety helmets and seatbelts to reduce severity.
A University of Michigan study found a 92% increase in children seeking medical assistance for concussions in states with concussion laws. The legislation, combined with heightened public awareness, has led to significant increases in concussion treatment rates among school-age athletes.
A study published in JAMA Pediatrics found that state concussion legislation is associated with a significant increase in healthcare utilization for children with concussions. Between 2008-2009 and 2011-2012, states with legislation saw a 92% rise in concussion-related healthcare usage, compared to a 75% increase in states without laws.
Researchers at NYU Langone Medical Center developed new technology that tracks eye movements to assess brain injuries, offering a potential biological marker for brain function and recovery. The study found abnormal eye movement ratios in patients with nerve damage or swelling in the brain, which were restored after surgery.
A patient who suffered a traumatic brain injury unexpectedly recovered full consciousness after receiving midazolam, a mild depressant drug. The administration of this medication resulted in the first reported case of an 'awakening' from a minimally-conscious state using this therapy.
A new study suggests that measuring glial fibrillary acidic protein (GFAP) in the blood can predict the presence of intracranial lesions following mild traumatic brain injury. The study found GFAP to be a more reliable biomarker than S100β, which was not as effective in distinguishing between intracranial and extracranial lesions.
A study of Ontario adults found that nearly 17% reported a history of traumatic brain injury (TBI), with those who had TBI more likely to engage in harmful behaviors such as opioid use and smoking. The study suggests a link between TBI and substance abuse, highlighting the need for preventive action against TBI.
A phase III clinical trial found that treatment with progesterone after traumatic brain injury provided no significant benefits compared to placebo. The study involved 49 trauma centers and 882 patients, but was stopped early due to safety concerns.
A study of US Marines who suffered concussions found persistent post-concussive symptoms and lingering cognitive effects are due to concussion-related brain trauma. Multiple concussions were associated with worse emotional and post-concussive symptoms, an important finding for military and civilian settings.
A new study reveals that traumatic brain injury can accelerate dementia by disrupting the brain's waste removal system, specifically the glymphatic system. This impaired system allows toxic proteins to accumulate in the brain, setting the stage for neurodegenerative diseases.
Researchers measured head blows in girls' lacrosse players, finding accelerations of up to 60g and reducing effects with protective headgear. The study's results suggest that while headgear can reduce accelerations, it may also increase aggression in the game.
Research found teens with traumatic brain injury (TBI) are two to four times more likely to drink alcohol, use cannabis, or abuse other drugs compared to peers without a history of TBI. Specifically, teens with TBI reported higher rates of using crystal meth.
Researchers at Penn Medicine identified a protein that predicts post-concussion severity in professional athletes. Elevated levels of calpain-cleaved αII-spectrin N-terminal fragment (SNTF) shortly after sports-related concussion can predict the severity of post-concussion symptoms.
A new MRI diagnostic approach has identified significant damage to the blood-brain barrier of professional football players following unreported trauma or mild concussions. The study showed that 40% of examined football players with unreported concussions had evidence of 'leaky BBB' compared to 8.3% of control athletes.
A new study suggests that repeated head injuries can disrupt the brain's energy use, leading to inflammation, degeneration of brain cell segments, and problems with learning and memory. The discovery could help explain the development of chronic traumatic encephalopathy, a brain disease seen in professional athletes.
A nationwide study of over 43,000 children with head trauma provides valuable data on epidemiology, mechanisms, diagnoses, and treatments. The study found that falls were the leading cause of injury in young children, while older kids more often suffered head injuries due to assaults or motor-vehicle crashes.
A study of over 43,000 children with head trauma found that falls were the most common cause of head injuries in children under 12, while assaults, sports, and car crashes were more prevalent in teenagers. The findings suggest that CT scans may be overused during diagnosis, and could help policy makers develop injury-prevention measures.
The Brain 101 website, developed by Oregon researchers, increased knowledge and attitudes about concussions among students and parents in a study of 12 high schools. The tool, accessible online for free, includes educational resources for coaches, educators, teens, and parents.
A recent study published in Neural Computation found that CoQ10 supplements improved physical function in 80% of treated veterans with Gulf War illness. The study suggests that CoQ10 may be beneficial for those suffering from this chronic condition, which is linked to chemical exposures and mitochondrial damage.
A recent traumatic brain injury (TBI) is associated with an increased risk of developing dementia in middle-aged and older adults. The study found that moderate to severe TBI was linked to higher dementia rates at age 55, while mild TBI at age 65 increased the risk.
A new study published in Journal of Neurotrauma found that existing models for predicting outcomes after mild traumatic brain injury perform poorly. The study identified older age, pre-existing psychiatric conditions, and less education as the strongest predictors of poor outcomes after mTBI.
Two studies presented at a pediatric sports medicine symposium found that many parents lack knowledge about concussions, leading to delayed diagnosis and inadequate treatment. The studies reveal common misconceptions about concussion symptoms and diagnosis, emphasizing the need for education and proper evaluation.
Researchers found that the brain's limited ability to repair itself after trauma can be enhanced when treated with tPA, a clot-buster commonly used for acute ischemic stroke. The study suggests that tPA administered through a nasal spray may have potential as a noninvasive treatment for subacute traumatic brain injury.
A study published by LA BioMed researchers found that patients who tested positive for THC in their system had a lower mortality rate than those who didn't, with only 2.4% of THC-positive patients dying compared to 11.5% of THC-negative patients. The researchers suggest that THC may help protect the brain after traumatic injury.
A public-private partnership aims to develop better-run clinical trials and identify effective measures of brain injury and recovery. The collaboration will analyze data from thousands of patients using biomarkers, imaging equipment, and software.
A study of 9,288 Ontario students found that teenagers with traumatic brain injuries, especially girls, reported significantly higher rates of harmful behaviors. The research highlights the importance of monitoring adolescents with TBI and providing support to prevent mental health issues and addiction.
MIT researchers develop a scaling law to estimate the risk of brain injury for humans and animals, revealing that humans are more vulnerable due to thinner skulls. The method may aid in diagnosing traumatic brain injury and developing protective helmets.
The university will focus on athletes participating in various sports, including football, soccer, and lacrosse, and receive comprehensive preseason evaluations for concussion. The study aims to inform a comprehensive understanding of sport-related concussion and traumatic brain injury.
The journal tackles past, current and future concepts of sports concussion through advocacy, education, prevention, treatment and groundbreaking research. Recent studies show that persistent post-concussion symptoms may arise from structural or metabolic alterations in the brain.
A comprehensive review of sports concussions highlights the evolution of concussion treatment and research, from helmets to rule changes. Neurosurgeons emphasize the importance of helmet safety and cultural changes in reducing head injuries.
A GW researcher is investigating the phenomenon of global brain injury in patients with intracerebral hemorrhage (ICH). The study aims to understand the impact of ICH on clinical outcomes and develop more effective treatment strategies. With a grant of $154K, Dr. Shahram Majidi will analyze CT scans and clinical data from 354 patients.
A new MRI technique using Diffusion Tensor Imaging (DTI) can help clinicians predict the likelihood of poor clinical outcomes following mild traumatic brain injury. This technique shows significant differences in white matter between mTBI patients with positive versus negative findings on CT and MRI evaluation.
A new class of compounds has been shown to protect brain cells from damage caused by blast-mediated TBI. The compounds, called P7C3 series, block axon damage and preserve normal brain function, even when treatment is delayed until 24-36 hours after injury.
A study by Imperial College London found that xenon gas limits brain damage and improves neurological outcomes in mice, both short-term and long-term. The findings suggest that xenon could be a potential treatment for head injuries in humans.
Researchers at Yale School of Medicine have found a synthetic molecule called PreImplantation Factor (sPIF) that protects against neuronal death and brain injury. The study suggests that sPIF mitigates brain damage through a novel pathway, potentially treating perinatal brain injuries and neurodegenerative disorders.
Researchers at Indiana University have isolated a process that damages the lungs of donors who suffered from traumatic brain injury, which may lead to improved lung transplant outcomes. The study found that fluid accumulation in the lungs occurs within hours after head trauma, limiting oxygenation and reducing lung function by nearly 80%.
Researchers studied white matter damage and cognitive impairments in patients with traumatic axonal injuries. The study found that diffusion tensor imaging (DTI) can detect early white matter compromise and associate it with functional outcomes.
Researchers suggest that an injury to the cerebellum during early life may disrupt brain development, leading to cognitive and behavioral symptoms associated with autism. The theory proposes that the cerebellum plays a crucial role in processing sensory information and organizing internal processes.
Researchers emphasize the need for cultural competence in brain injury research and rehabilitation to address growing minority populations and their higher risk of poorer outcomes. Studies highlight persistent health disparities among minorities with acquired brain injury, underscoring the importance of patient-centered interventions.