Articles tagged with Brain Injuries
Pretreatment with SSTF reduces infarct volume and apoptosis in hippocampal neurons, restoring neurological deficits and improving the integrity of the blood-brain barrier. SSTF increases Bcl-2 expression and decreases Bax expression, suggesting multiple pathways for neuroprotection.
Researchers found blocking an inflammatory protein in mice prevents brain injury, but not premature birth. The anti-inflammatory drug halted brain damage without affecting birth timing.
Veterans exposed to explosions may have brain damage despite lacking symptoms of traumatic brain injury (TBI), according to researchers at Duke Medicine. The study found comparable white matter damage in both groups, with no clear link between brain injury and cognitive problems such as reaction time or decision-making.
Researchers found that higher educational attainment attenuates the negative impact of TBI on cognitive status. The study suggests that intellectually enriching activities may protect against further cognitive decline.
A study by University of Illinois researchers found that a single polymorphism in the BDNF gene affects intelligence after traumatic brain injury. Individuals with a specific genetic variation showed improved cognitive function, while those without it experienced impaired recovery.
A simple vision test, the King-Devick test, can be used to increase the accuracy of concussion diagnosis in athletes. The study found that 100% of concussions were identified when combining the test results with other concussion assessments.
Researchers studied 30 adults with TBI to understand the relationship between self-awareness, depression, and self-reported quality of life. They found that higher levels of self-awareness were associated with poorer quality of life and lower satisfaction, while depressive symptoms significantly impacted self-reports.
A review of UK troop mental health finds most regulars resilient, but certain groups more vulnerable; depression and anxiety prevalent, while harmful drinking remains a concern. The evidence suggests that social support during childhood and after leaving the Army has a greater impact on suicide rates than deployment.
A new study published in Journal of Neurotrauma found that retired professional football players who suffered repeated concussions had reduced levels of growth hormone, gonadotropin, and testosterone, leading to disorders such as metabolic syndrome and impaired quality of life. The study suggests that repeat concussion may elicit pitui...
A new study by the American Academy of Neurology found that football helmets on average reduce the risk of traumatic brain injury by only 20 percent compared to not wearing a helmet. The study also showed that some helmet brands, such as the Adams a2000, provide better protection against concussion and closed head injury than others.
Researchers have identified the 'scaffold' of human brain networks, detailing connections that have the greatest influence over all other connections. The study found not all brain connections are equally important and some may be more vulnerable to damage, with implications for understanding brain injury and disease.
Researchers at Medical College of Georgia are investigating the potential of brilliant blue G to treat traumatic brain injuries. The dye may temporarily block an immune response that leads to swelling, which can cause damage to brain tissue.
Researchers warn that soccer's unique aspect – the purposeful use of the head to control the ball – may contribute to long-term cognitive consequences. Studies found concussions accounted for 5.8% to 8.6% of injuries in soccer games, with players who executed more headers experiencing memory and planning deficits.
A study found that susceptibility-weighted imaging can detect small clusters of hypointensity in the brain, indicating acute and chronic injuries from concussion or subconcussive events. The research also identified sex differences in the extent of these changes.
Researchers explore different models of recovery after brain injury, highlighting the importance of combining clinical intuition with CRT theory. Studies also investigate the impact of pediatric CRT on intellectual functioning and nonverbal communication processing after TBI.
A new study confirms a variant in the SERPINE1 gene is linked to cerebral palsy and death in very preterm babies. The findings add to evidence that genes may play a role in brain injury and death risk in preterm infants.
Researchers found that retrieval practice (RP) significantly improved memory in individuals with severe traumatic brain injury (TBI), particularly after short delays. RP was more effective than massed restudy (MR) or spaced restudy (SR) strategies, indicating its potential to improve real-life performance.
A Johns Hopkins study finds that newborn brain injury causes different responses in male and female brains, with females showing milder cell death and better response to certain therapies. Researchers highlight the need for gender-specific research to develop precisely targeted treatments.
Researchers Sarj Patel and Tom Rau aim to identify biomarkers of TBI through blood samples, improving diagnosis and treatment. The goal is to understand how localized injuries affect the entire brain.
Researchers at IU School of Medicine will use advanced neuroimaging techniques to study high school athletes and understand the impact of concussions on brain blood flow. The study aims to improve understanding of concussion symptoms, cognitive functioning, and detection methods.
A new study found that an estimated 530,494 children were injured in US emergency departments from 1990 to 2011 due to shopping cart-related incidents. The majority of injuries were head trauma cases, with a significant increase in concussions and closed-head injuries over the study period.
A new study found that NHL teams pay out $218 million annually for lost time due to injuries. Concussions were the most expensive type of injury, accounting for $42.8 million per year. The research highlights the need for better protection for athletes in hockey.
Concussions are common among middle-school girls who play soccer, with cumulative concussion incidence of 13 percent per season. Most players (58.6%) continue to play with symptoms, while almost half (44.1%) seek medical attention.
Researchers found that traumatic brain injury (TBI) survivors are three times more likely to die prematurely from suicide or fatal injuries. The study also showed that TBI survivors who have a history of substance abuse or psychiatric disorders are at highest risk of premature death.
Researchers discovered that brain regions synchronize their activity to make it possible for people to pay attention, with the process likened to tuning multiple walkie-talkies to the same frequency. The findings have implications for understanding attention deficits in brain injuries or strokes.
Researchers have discovered a novel method of treating traumatic brain injury by stimulating 'caretaker cells' to reduce swelling. The treatment, using compounds like 2-methylthio-ADP and MRS2365, has shown promise in reducing edema and prolonging the life of neurons.
The US Army's new strategic research plan aims to improve treatment outcomes for traumatic brain injury by identifying critical research priority areas. The report highlights six main target areas, including pharmacological interventions and preclinical drug assessment.
Researchers used mass spectrometry to identify 10 differentially expressed proteins in the brain after acute high-altitude hypoxia. These proteins are involved in the electron transport chain and ATP synthase function, providing potential targets for treating hypobaric hypoxia-related brain injury.
Researchers found that fetal umbilical veins exhibit stress relaxation and creep properties similar to those of middle cerebral arteries, making them a suitable alternative for reconstruction. These findings indicate that the fetal umbilical vein can be transplanted to repair middle cerebral artery injury with favorable outcomes.
A new review published in the journal Neuropsychology Review finds that computerized neurocognitive testing for concussions lacks consistent evidence on reliability and validity. The study suggests caution when using these tests due to their marketing prevalence over scientific proof, emphasizing the need for a multi-dimensional approa...
Scientists use reactive glial cells to regenerate healthy neurons in a breakthrough technology for treating brain injuries and Alzheimer's disease. In mouse models and human cell cultures, the method successfully converts glial cells into functional neurons.
The NIH has selected eight projects to study the long-term effects of repeated head injuries and develop more accurate concussion diagnoses. The partnership between the NIH and the NFL aims to reduce the risk of chronic traumatic encephalopathy (CTE) in athletes and military personnel.
The grant aims to build a more precise understanding of chronic traumatic encephalopathy and traumatic brain injury in civilians over age 45. Investigators will use extensive resources from an ongoing study of brain aging and conduct analyses of neuropsychology, neuroradiology, neurological, geriatric, and epidemiological aspects.
Researchers found that feeding mice with branched chain amino acids improved sleep disturbances and restored orexin neurons to normal activity levels, suggesting a dietary treatment for TBI patients. The study provides a proof-of-principle for investigating this intervention as a potential public health benefit.
A study of U.S. Marines found that traumatic brain injury (TBI) during deployment was a significant predictor of post-traumatic stress disorder (PTSD) over time. Pre-deployment PTSD symptoms and combat intensity also played a role in the development of PTSD.
Researchers at Stanford University have observed a cellular response to concussions in mice, revealing how individual cells react to the injury. The study suggests a possible therapeutic approach by using natural antioxidant molecules like glutathione to prevent brain damage.
A study by Nationwide Children's Hospital found nearly all high chair-related injuries involve a fall, with 93% of cases reporting a child climbing or standing in the chair. The annual number of injured children increased by almost 90%, with closed head injuries and facial injuries being most common.
Scientists have successfully restored behavior in rats using a neural prosthesis after brain injury. The device, a closed-loop microelectronic system, recorded signals from one part of the brain and stimulated another to facilitate repair. Two weeks after implantation, rat models recovered nearly all function lost due to injury.
A new study suggests that a head injury can lead to depressive complications years later due to an overactive immune response and inflammation. The research found that brain cells went on 'high alert' after the injury, affecting behavior and leading to symptoms that were linked to inflammation.
A newly developed mouse trauma model reveals that the brain's protective coverings feel the brunt of even mild traumatic brain injuries. Researchers discovered a similar immune response in patients with mild head injury, suggesting a new potential treatment approach.
A study using MRI technology found that veterans with mild traumatic brain injury (MTBI) caused by blasts have long-term brain differences, including changes in white matter structure. This suggests a potential link between blast exposure and ongoing cognitive symptoms in veterans.
A study published in Neural Regeneration Research found that dl-3n-butylphthalide improved motor and sensory functions after diffuse brain injury. The compound also increased vascular density and cerebral blood flow, suggesting potential therapeutic benefits for microcirculation disorders.
Mayo Clinic researchers found that improved mood is associated with increased participation in daily activities and independent living after brain injury rehabilitation. The study suggests a holistic approach to care can address both physical and personal problems, leading to better outcomes for patients.
The UTMB project aims to develop new treatments for TBI by understanding its progressive effects and using adult circulating mesenchymal cells. Researchers hope to learn how these cells can be programmed to protect brain cells, counter inflammation or replace damaged ones.
Studies show that concussions can lead to brain abnormalities four months after symptoms have resolved, with memory and behavioral issues improving more quickly than physical injuries. These findings suggest that healing from concussions may be similar to recovering from burns, with tissue scabs forming before the body is fully healed.
Researchers found that a virtual sailing simulator improved quality of life, self-confidence, and overall well-being for participants with chronic spinal cord injuries. The study showed rapid improvement in sailing skills and successful completion of sailing lessons on the water.
Researchers have discovered a blood biomarker that accurately diagnoses concussions and predicts long-term cognitive disability. The protein SNTF levels were found to correlate with brain tissue damage, making it a potential tool for identifying patients at risk of persistent cognitive deficits.
Researchers at MU School of Medicine found a new protocol using preventive blood thinners reduces life-threatening blood clots in brain-injured patients. The study compared outcomes between 107 and 129 patients treated with or without the medication, showing zero instances of deep-venous clotting among those who received it.
Researchers at Tel Aviv University demonstrate hyperbaric oxygen therapy can revive brain functions and improve life quality for mild TBI patients. The treatment improved cognitive function, memory restoration, and language use, offering a new hope for millions of victims.
Researchers found that women injured during the premenstrual phase had slower recovery and poorer health one month after injury compared to those injured during other phases. The study suggests that sex hormones like estrogen and progesterone may play a role in concussion outcomes.
A study published in Neurosurgery found significant variations in hospitals' management of children with traumatic brain injury, particularly in ICP monitoring and craniectomy. The study analyzed data from over 7,000 children treated at 156 US hospitals and found that rates of these interventions varied significantly between hospitals.
A new biosensor developed by Johns Hopkins University researchers can detect a protein associated with brain injuries, alerting doctors to devise new treatments or begin treatment more quickly. The device could help minimize brain damage and improve long-term outcomes for patients who undergo heart surgery.
A preclinical study led by UTHealth researchers found that stem cell therapy promotes lasting cognitive improvement after brain injury. The treatment, known as MAPC therapy, was shown to reduce inflammation and improve brain function in mice.
Researchers found that amyloid beta-peptide worsened cognitive impairment following cerebral ischemia-reperfusion injury by inducing glycogen synthase kinase 3β and protein phosphatase 2A activity, resulting in tau protein phosphorylation. This study suggests a potential link between Alzheimer's disease and cerebral ischemia.
A new study published in CMAJ found that the odds of patients with brain injury deteriorating to neurologic death decreased over a 10-year period, likely due to improved care and prevention measures such as road safety initiatives and enhanced clinical care.
A study presented by Loyola University Medical Center sports medicine physician Neeru Jayanthi found that lower back injuries are the third most common injury suffered by young athletes under age 18. The study included over 1,200 athletes who suffered 843 injuries, with serious cases putting them at risk for long-term back problems.
The American Academy of Pediatrics recommends a collaborative team approach to help students recover from concussions. A gradual return to academics, with individualized adjustments as needed, is suggested to minimize disruptions and promote optimal learning and recovery.
Researchers found that Danhong injection enhances the expression of transforming growth factor-beta 1 and GM130, maintaining neuronal Golgi morphology and structure after cerebral ischemia-reperfusion injury. This study suggests a potential neuroprotective effect of Danhong injection in treating cerebral ischemia-reperfusion injury.
A recent study published by the American Academy of Pediatrics reveals that children with brain injuries are at a higher risk of developing depression. The research, which analyzed data from over 2,000 children with brain injuries, found a 4.9-fold increase in the odds of diagnosed depression compared to other children.
A study published in Journal of Neurotrauma found that genetic differences can affect an individual's recovery from traumatic brain injury. Genetic variations in cytokine genes impact the magnitude and duration of neuroinflammation, affecting long-term repair processes.