Articles tagged with Brain Injuries
Researchers found that apolipoprotein E-derived therapeutic peptide improved synaptic stability and learning and memory performance after diffuse brain injury. The peptide also protected against brain injury by reducing oxidative stress, suppressing the ERK1/2-Bax mitochondrial apoptotic pathway, and decreasing neuronal death.
A University of Oregon study found that high school athletes who return to activity within 60 days experience a significant regression in their balance and walking speed, affecting their ability to perform simple mental tasks. This regression was seen in 12 of 19 athletes, with 10 returning within less than a month.
The iTAKL study aims to increase understanding of pediatric mild traumatic brain injury by employing imaging, cognitive testing and biomechanical data. The research team hopes to provide objective data that will help prevent, mitigate, identify and treat head injuries.
Researchers have successfully created functional 3D brain-like tissue that exhibits grey-white matter compartmentalization and can survive in the lab for over two months. The tissue displays physical properties similar to rodent brain tissue, enabling scientists to study traumatic brain injury in real-time.
Cognitive research by Kessler Foundation scientists reveals that unexpected task constraint following self-generated task choice impairs task-switching performance. The study shows that individuals struggle to undo preparation for a task, leading to negative effects on multitasking ability.
Research published in Neural Regeneration Research found that atorvastatin, a commonly used lipid-lowering drug, protects against cerebral ischemia/reperfusion injury. The study discovered that atorvastatin's anti-inflammatory and antioxidant effects contribute to its protective benefits.
Researchers tested mechanical tissue resuscitation by applying negative pressure to induce localized TBI in swine, showing a significantly smaller area of brain contusion and reduced bleeding. The procedure appeared safe without seizures or brain deformation, with all animals surviving after five days of vacuum application.
A new study published by University at Buffalo medical faculty finds that many of the same symptoms are common to concussions and to injuries to the neck and/or balance system, known collectively as cervical/vestibular injuries. Determining which condition a patient has experienced is critical, as courses of treatment are very different.
The NIH Stroke Trials Network brings together teams of researchers to identify priorities and provide training opportunities. Kessler Foundation & Kessler Institute participate in the network, focusing on rehabilitation and neuroimaging research.
Cerebral microbleeds have been shown to be a significant marker for diffuse axonal injury, which can lead to severe neurological disorders. The study highlights the importance of using susceptibility-weighted imaging to detect these tiny changes and evaluate traumatic cerebral microbleeds with high sensitivity.
The study found that melatonin treatment reduced decreased levels of antioxidant vitamins and enzymes in rats with traumatic brain injury, indicating a protective effect on cerebral cortex and blood toxicity. Melatonin also inhibited free radical formation and supported the antioxidant vitamin redox system.
A 3D image of a Paleolithic child's skull shows compound fractures indicating blunt force trauma, likely caused by interpersonal violence. The child is believed to have suffered from severe traumatic brain injury, which may have impacted their social communication and behavior.
Researchers found that high school lacrosse players experienced over 1,400 injuries between 2008 and 2012, with concussions making up 22% of the total. The study suggests that girls' lacrosse players are particularly at risk due to a lack of helmet requirements.
Researchers found that Ginkgo biloba treatment improved recovery and reduced brain damage after inducing experimental stroke in mice. The treatment also enhanced neurogenesis due to increased protein expression of hemeoxygenase 1, an antioxidant gene involved in neurogenesis.
A study published in Neurology found that even mild traumatic brain injury can cause brain damage and disrupt nerve axons in white matter. Cognitive tests showed a 25% decline in verbal letter fluency task scores for patients with injuries, strongly related to imaging measures of white matter damage.
A recent study suggests that persistent symptoms following concussion may be posttraumatic stress disorder (PTSD), rather than postconcussion syndrome (PCS). The study found that 8.8% of patients with head injuries met the criteria for PTSD, compared to 2.2% of those without head injuries.
Researchers found that ADC values accurately reflect changes on the injured side but not on the uninjured side, indicating a delay in pathological changes. This study suggests that ADC measurements may not be reliable for detecting cytotoxic edema on the unaffected brain tissue after traumatic brain injury.
The Lancet Neurology calls for sports authorities to consider long-term neurological problems caused by repeated concussions in footballers. Many sporting organisations have drawn up new protocols to protect athletes who sustain a head injury, but the decision on return-to-play should be made solely by healthcare professionals.
A research review identified four clinical indicators most strongly associated with concussion, including disorientation, impaired balance, and verbal learning difficulties. The analysis provides an evidence-based foundation for developing guidelines for concussion diagnosis, prognosis, and treatment.
The study found that electrical stimulation of the fastigial nucleus can increase Ku70 expression, leading to decreased Bax protein and reduced mitochondrial apoptosis. Injured brain tissue showed co-localization of Ku70 with Bax.
A VLSM study found that neuronal injury in the corona radiate, caudate nucleus and putamen of patients with chronic stroke can predict walking speed. The study suggests that VLSM may provide a more accurate prognosis of motor recovery from chronic stroke according to neuronal injury in cerebral motor cortex.
Researchers found that non-invasive brain stimulations, including rTMS and tDCS, can regulate the activities of cerebral motor cortex neurons. These findings suggest potential therapeutic benefits for individuals with central nervous system injuries or damage.
A chronic subdural haematoma was reported after a Motörhead concert, highlighting the potential dangers of headbanging. The case study suggests that heavy metal music's fast tempo may contribute to such injuries.
A randomized clinical trial of 200 patients with traumatic brain injury found that administering erythropoietin or maintaining a higher hemoglobin concentration did not improve neurological outcomes at 6 months. Transfusion thresholds also had no significant impact on recovery rates.
Researchers recommend moving emphasis from dysfunction to competence, and propose embodiment theory as a viable solution. The latest edition of the DSM-5 also focuses on improving evaluations of persons with TBI by mental health professionals.
A recent study published in Neurology suggests that veterans with a history of traumatic brain injury (TBI) are 60% more likely to develop dementia than those without TBI. The study found that veterans with TBI developed dementia about two years earlier, highlighting the potential long-term consequences of TBI on cognitive health.
A new study found that blast traumatic brain injury may be linked to pituitary dysfunction, particularly in overweight patients. The study suggests that treating hormone deficiencies may help alleviate symptoms in veterans with this condition.
A pioneering study aims to quantify eye movements and brain responses in adults with convergence insufficiency (CI) to understand the underlying mechanisms of vision therapy. The research hopes to lead to new therapies improving daily activities, such as reading comfortably for longer periods.
A new study by researchers at the University of Chicago suggests that examining children's gestures at an early age can help identify those at risk for language and cognitive delays. The study found that early gesture can be used to diagnose language delays before they appear in speech, allowing for earlier interventions.
A study of 255 patients found that military personnel with concussive TBI caused by a blast or nonblast event had similar outcomes, including headache severity and depression. The study also found higher rates of moderate to severe disability in both TBI groups compared to control patients.
A new study published in JAMA Neurology found no significant difference in overall disability between military personnel with mild traumatic brain injury (TBI) from blast and non-blast causes. Both groups suffered moderate to severe disabilities, as well as similar rates of depression, PTSD, and cognitive impairment.
A new study published in Frontiers in Neurology found that eight-session gist-reasoning training can significantly improve higher-order thinking and other key frontal lobe functions in chronic recovery stages. Participants showed improved abstraction of meanings, executive functions, and memory for facts.
The TGen Concussion Research Fund will support a collaboration between TGen, Riddell, Barrow Neurological Institute, and Arizona State University's Sun Devil football team to find a better way to diagnose concussions on the field. This research could enable physicians to identify when a player is concussed and when they might recover.
Researchers found that apolipoprotein E-derived therapeutic peptide improves synaptic stability and learning memory performance after diffuse brain injury. Apolipoprotein E mimetic peptide also reduces neuronal apoptosis by suppressing the ERK1/2-Bax mitochondrial apoptotic pathway.
A new study suggests that genes play a key role in the risk of brain injury for premature babies. Variation in genes associated with schizophrenia and fat metabolism has been linked to increased risk of brain injury on MRI scans.
A new study suggests that older individuals with a history of migraines are more likely to experience ischemic silent brain infarction, which can increase the risk of future strokes. Researchers found a doubling of these injuries in people with migraine compared to those without, highlighting the importance of lifestyle changes and pre...
Traumatic brain injury (TBI) saw a significant increase in emergency department visits, with rates rising by 29% between 2006 and 2010. The majority of visits were for minor injuries, and most patients were discharged from the ED.
A University of Washington researcher found that a 20-minute conversation with a social worker can significantly reduce functional decline in patients with mild traumatic brain injuries. Social workers can provide education, coping strategies, resources, and follow-up care to help patients recover from these types of injuries.
A study published in Radiology found that males with concussions took an average of 66.9 days to recover, compared to 26.3 days for females. DTI scans revealed abnormalities in the white matter tract UF, which correlated with recovery time and was a stronger predictor than initial symptom severity.
A study of Utah youth with suspected sports-related head injuries found that emergency room visits and head CT scans have increased since the state's concussion law was passed in 2011, potentially leading to unnecessary radiation exposure. Researchers are calling for legislators to consider the effects of the law on treatment protocols.
Researchers developed a new mouse model to study the behavioral damage caused by repeated blows to the head. The study shows that mice with mild TBI develop similar behavioral problems as humans with chronic traumatic encephalopathy (CTE), including difficulty sleeping, memory issues, depression, and poor judgment.
A study by St. Michael's Hospital found that nearly half of homeless men suffered a traumatic brain injury in their life, with most occurring before they lost their homes. The study highlights the links between TBI and mental health issues, substance abuse, seizures, and poorer physical health.
Nancy Chiaravalloti, PhD, was named the 63rd Mendel Lecturer by Saint Peter's University for her research on treating cognitive deficits following neurological illness and injury. Her work focuses on improving cognition in individuals with multiple sclerosis, TBI, stroke, and dementia.
Research suggests that cognitive reserve, the brain's ability to adapt and compensate for injury, plays a role in recovery from traumatic brain injury. Those with higher educational attainment are more likely to achieve full recovery, with nearly 40% of patients with 16 or more years of education fully recovering.
A study published in the American Academy of Neurology found that individuals with higher levels of education tend to recover better from traumatic brain injuries. This is attributed to the cognitive reserve theory, which suggests that educated individuals have a greater ability to maintain brain function despite damage.
A recent study published in Neural Regeneration Research found that atorvastatin, a commonly used lipid-lowering drug, protects against cerebral ischemia/reperfusion injury through anti-inflammatory and antioxidant effects. The study, led by Dr. Qiuyun Tu and colleagues, showed that atorvastatin reduces inflammation and oxidative stres...
A study of US military personnel with blast plus impact concussive TBI found that those with the injury experienced high levels of overall disability and a significantly increased risk of post-traumatic stress disorders. The study also highlights the importance of considering the long-term effects of such injuries in military populations.
A recent study found that football players' brains do not fully recover from head hits, even after six months of rest. The study suggests that inflammation may be a key factor in whether players recovered within six months.
Researchers used MRI to identify regional white matter damage in brain regions associated with chronic dizziness and vestibulopathy after concussion. The study suggests that MRI can speed the onset of effective treatments for concussion patients.
A new study by Brigham Young University researchers has linked lingering brain injury from head trauma to social difficulties in children. The study found that the thickness of a specific brain region was associated with a child's social life and thinking skills.
Polysaccharides from Angelica sinensis have been shown to protect PC12 neuronal cells from H2O2-induced cytotoxicity, reduce apoptosis and intracellular reactive oxygen species levels, and increase mitochondrial membrane potential. In a rat model of local cerebral ischemia, Angelica sinensis polysaccharides enhanced antioxidant activit...
Research published in PNAS identifies the insula as a key brain region disrupted in individuals with gambling addiction. The study reveals that problems gamblers are more susceptible to cognitive distortions, such as the gambler's fallacy, due to insula hyperactivity.
Researchers at the University of Western Ontario found that rural youth are more prone to concussions caused by motorized vehicle accidents, while urban youth tend to suffer from sports-related injuries. The study highlights the need for targeted injury prevention programs and education on concussion protocols in various settings.
Researchers found that Dab2 overexpression significantly increased TβRII and p-SMAD2/3 levels, reducing amyloid-beta deposition, microglia activation, and neuronal loss in APP/PS1 mouse brain tissue. This suggests a neuroprotective role of Dab2 in Alzheimer's disease.
A study of homeless and vulnerably housed individuals with traumatic brain injury (TBI) found they are more likely to visit emergency departments, be arrested or assaulted. The research highlights the importance of screening for TBI and providing support to manage behaviors after brain injuries.
A study published in Neurosurgery found that rats with diffuse axonal injury showed no significant abnormalities despite visible evidence of brain damage. This suggests that even subconcussive injury may lead to neuropathological changes, supporting concerns about long-term effects in humans.
Researchers at USF Health have found that a combination of human umbilical cord blood cells and granulocyte colony stimulating factor significantly reduced TBI-induced loss of neuronal cells in the hippocampus. The therapy also showed beneficial results in animals with experimental TBI, with G-CSF alone producing short-lived benefits.
A new study found that extreme sports like skateboarding and snowboarding have the highest risk of severe head and neck injuries. Concussions were the most common injury, with a higher risk in snowboarding and skateboarding. The Academy recommends helmet use for safer participation.
A new cell type has been identified as a contributing factor to post-traumatic epilepsy caused by traumatic brain injury. The study found that damage to interneurons disrupts neurotransmitter levels, leading to increased epileptic activity.
A team of researchers at the University of Pennsylvania has used mathematical modeling to better understand the mechanisms involved in traumatic brain injuries. Their findings reveal that rapid impacts can cause permanent damage due to the rate of stretching, not just the force applied.