Articles tagged with Coronary Artery Disease
A global analysis of Kawasaki disease cases found a seasonal occurrence shared by regions across the Northern hemisphere, with peak cases in winter months. The study suggests that large-scale wind currents may play a role in transmitting the suspected infectious agent.
A study published in JAMA Network found that aliskiren, a renin inhibitor, did not slow the progression of coronary artery disease in patients with prehypertension. The treatment had no significant impact on atheroma burden or regression of fatty deposits.
A retrospective study from Cleveland Clinic found that patients who underwent stenting of the carotid artery followed by open heart surgery had the best outcomes. The researchers compared three common treatment approaches and found that this combination had significantly lower risks of serious events after one year.
Coronary artery disease (CAD) disproportionately affects women, with unique risk factors including pregnancy and autoimmune diseases. Women are more likely to die from CAD than men in similar circumstances, especially at younger ages.
Researchers found a significant difference in cardiac catheterization rates between New York State and Ontario, with New York performing fewer procedures due to lower obstructive coronary artery disease (CAD) burdens. This selective approach improved diagnostic efficiency while reducing costs.
A new study found that DNA particles in the blood can serve as markers of disease and may help identify patients with severely narrowed coronary arteries. Higher levels of these particles were linked to high levels of coronary artery calcium deposits.
Researchers found that men with haplogroup I have lower numbers of copies of two important genes in macrophages, which may contribute to increased risk of coronary artery disease. The study used a sample of around 2,000 men from four European populations and aimed to decipher the genetic background behind the association.
Patients with low baseline diastolic blood pressure (DBP) had more subcortical brain atrophy progression. Those with declining DBP levels over time showed less brain atrophy progression compared to those with rising BP levels.
Researchers found that metabolic PET imaging detected coronary disease at an early stage, with a sensitivity of 96%, compared to 56% for MPI. This technique could potentially be used for initial CAD screening to help doctors better determine a patient's cardiac risk and manage care.
A recent study published in the Canadian Medical Association Journal found that people with job stress and an unhealthy lifestyle are at a higher risk of coronary artery disease. The study analyzed data from 7 cohort studies involving 102,128 participants and found that those with job strain had a 10-year incidence rate of 18.4 per 100...
A new study links type 1 diabetes to an increased risk of heart disease through the production of the inflammatory protein calprotectin, which fuels the buildup of artery-clogging plaque.
A large study found that high serum C-peptide levels are linked to an increased risk of death from all causes and cardiovascular disease. People with high C-peptide levels had a 1.8- to 3.2-fold increased risk compared to those with low levels.
A meta-analysis of published evidence found a link between male pattern baldness and an increased risk of coronary heart disease, especially on the crown of the head. Men with extensive vertex baldness were 44% more likely to develop coronary artery disease than those with a full head of hair.
A study led by the University of Leicester found a link between faster telomere shortening and increased risk of age-related diseases, including coronary artery disease and certain cancers. The research suggests that biological aging plays a key role in causing these diseases.
The study found that hybrid revascularization had a similar rate of major adverse events in the first year compared to percutaneous intervention. Hybrid revascularization combines coronary bypass surgery and stenting, offering a minimally invasive approach for treating multi-vessel coronary artery disease.
A 12-week cardiac rehabilitation program reduced mortality in women with coronary artery disease by two-thirds, yet referrals and attendance among women fall short compared to men. Women who receive a referral but don't attend also have better outcomes, suggesting a referral bias towards healthier individuals.
A study found that limited scar burden was linked to improved heart contraction and reversal of wall thinning in patients with coronary artery disease. Regional myocardial wall thinning may represent viable myocardium with potential for recovery, challenging current views on the condition.
A new study found that CT angiography is an effective tool for determining the risk of heart attacks and other adverse cardiac events in patients with suspected coronary artery disease but no treatable risk factors. The test identified a high prevalence of coronary artery disease, even in patients without modifiable risk factors.
A new urine test using protein biomarkers may enable early diagnosis and treatment of Kawasaki disease, a rare but increasingly prevalent condition that can cause inflammation of blood vessels and lead to heart attacks. The test has shown promising results in distinguishing children with Kawasaki disease from those with other conditions.
A large-scale international study identified 15 new genetic regions associated with coronary artery disease, revealing a link between inflammation and plaque buildup in heart vessels. The research, which analyzed data from over 190,000 participants, provides insights into the molecular pathways causing the deadly disease.
A large-scale study has identified 15 new genetic regions associated with coronary artery disease risk, bringing the total to 46 regions. The research also found that lipid metabolism and inflammation play a significant role in CAD.
Researchers have identified a link between inflammation and heart disease through the largest genetic study of Coronary Artery Disease (CAD) to date. The study found that lipid metabolism and inflammation play a significant role in CAD, providing evidence for a novel pathway for prevention and treatment.
A new MRI technique has shown promise in identifying early-stage coronary disease, which can be treated with lifestyle changes and medications. The study used time-resolved multi-frame acquisition to measure coronary artery wall thickness with a high success rate and precise measurements.
Patients with stable coronary artery disease who have at least one narrowed blood vessel benefit from early stent placement, reducing hospitalization and urgent revascularization needs. The study used fractional flow reserve to identify eligible patients, which significantly reduces the risk of adverse events.
The CORE320 study demonstrated that combined non-invasive CT angiography and myocardial perfusion imaging has robust diagnostic accuracy for identifying patients with flow-limiting coronary artery disease. The addition of CTP increased diagnostic power, allowing clinicians to distinguish between anatomic and flow-limiting stenoses.
The FAME 2 trial found that FFR-guided PCI plus optimal medical therapy significantly reduced the need for urgent revascularisation and hospital readmission in patients with stable coronary artery disease. The study also showed a lower risk of primary endpoint events, including death and heart attack.
A country-wide German registry found that women received a lower percentage of drug eluting stents (DES) compared to men for the same condition. DES are known to decrease repeat target vessel revascularization procedures and provide favorable long-term results, especially in women with smaller epicardial vessels.
A study found that coronary artery calcium provides superior discrimination and risk reclassification compared to other risk markers for intermediate-risk individuals. The marker offers the highest improvement in discrimination over traditional risk scores, supporting its use in refining cardiovascular risk prediction.
Cardiologists at WashU Medicine have developed a noninvasive imaging technique to detect coronary artery disease in pediatric heart transplant patients, reducing the need for invasive tests. The technique uses contrast-enhanced cardiac MRI to assess coronary arteries and has shown promising results, although further study is needed.
A recent study found that Federally funded clinics for low-income patients demonstrated greater adherence to guidelines on six quality measures compared to private primary care practices. The clinics performed better in pharmacologic management of chronic diseases and appropriate use of screening tests, while performing similarly on ot...
The EVINCI study found that non-invasive imaging tests, such as multi-slice CT and radionuclide imaging, can accurately diagnose coronary artery disease in most patients. This approach could safely avoid invasive procedures in 75% of cases, reducing unnecessary treatments.
The exercise stress test remains an essential tool for diagnosing coronary artery disease, particularly in patients who can exercise. The test is non-invasive and can be administered in doctor's offices, offering a cost-effective and efficient solution.
University of Minnesota public health researchers found two high-signal genetic markers correlated with coronary artery disease, which may help define genetic fingerprints for increased risk. The study analyzed data from over 75,000 patients and offers biological and clinical data supporting future research into the genetic markers.
Researchers develop a molecular imaging tool to detect coronary artery disease, which is caused by atherosclerosis. The technique measures the coronary flow reserve, or CFR, and calculates precise dilation of blood vessels at rest and under stress.
Researchers developed a method to induce transient ischemia during non-surgical interventional cardiac procedures, boosting adenovector gene transfection by over 100 fold. Cardium Therapeutics' Generx product candidate is being tested in a 100-patient Phase 3 trial for patients with myocardial ischemia and stable angina.
Global gene expression analysis reveals distinct molecular differences between perivascular and subcutaneous fat tissues. Perivascular fat tissue is highly inflamed in humans with coronary artery diseases, suggesting it as a key player in disease formation.
A study found that patients who viewed images of their coronary artery calcium scores were more likely to take statins as directed and lose weight, with compliance increasing as disease severity increased. This suggests that visualizing the extent of cardiovascular disease can motivate patients to adhere to recommended therapies.
A new study reveals that South Asians living with coronary disease in Alberta experience a lower quality of life compared to Canadians of European descent. The study, published in American Heart Journal, found that they have more frequent and severe chest pains, and are less physically active.
Researchers found a significant correlation between coronary artery disease and prostate cancer in a large study, suggesting that heart disease may be a risk factor for the malignancy. Lifestyle changes such as weight loss, exercise, and a healthy diet may help combat both conditions.
Researchers at University of Leicester found a significant link between the Y chromosome and an increased risk of coronary artery disease in men. The study analyzed DNA from over 3,000 men and found that 90% of British Y chromosomes belong to two major groups that increase the risk by 50%.
A study published in The Lancet has found that a common variant on the Y chromosome increases the risk of coronary artery disease by 50 percent in men. Men carrying this variant have a higher risk of CAD, independent of traditional cardiovascular and socioeconomic risk factors.
The updated appropriate use criteria provide detailed guidance on when to use invasive procedures to improve blood flow to the heart. The new criteria affirm the role of revascularization for patients with acute coronary syndromes and significant symptoms, while emphasizing careful selection of high-risk surgery patients for PCI.
Researchers found that daily positive affect and self-affirmation strategies helped patients make better decisions about their health. The interventions increased physical activity for coronary artery disease patients and improved medication adherence for those with high blood pressure.
A new study published in The Lancet shows that multiparametric cardiovascular magnetic resonance (CMR) is superior to single-photon emission computed tomography (SPECT) for diagnosing coronary artery disease. CMR has a higher sensitivity and negative predictive value, making it a more accurate and reliable diagnostic tool.
A blood-based gene expression test was found to be more effective than myocardial perfusion imaging (MPI) in ruling out obstructive coronary artery disease in stable symptomatic patients. The test demonstrated high sensitivity and negative predictive value, enabling clinicians to rule out patients with high accuracy.
A new diagnostic test for coronary artery disease is associated with a higher rate of subsequent invasive cardiac procedures and higher health-care spending. The study found that patients who underwent coronary CT angiography were nearly twice as likely to have a subsequent cardiac catheterization as those who had a stress test.
A new technique measures myocardial perfusion reserve and volume reserve to predict severe stenosis in coronary arteries. This method detects 50% or greater narrowing with excellent sensitivity, enabling timely intervention for high-risk patients.
Researchers at Washington University School of Medicine have identified a genetic variant associated with the severity of coronary artery disease in patients with type 2 diabetes. The variant, located in the TLL1 gene, was found to correlate strongly with the extent of coronary disease, even better than traditional clinical factors.
Researchers at NYU Langone Health identified a hidden cause of heart attacks in women without significant coronary artery disease. Plaque disruption, a rupture or ulceration of cholesterol plaque in a coronary artery, was found to be the mechanism behind myocardial infarction in some women.
Results from CREDO-Kyoto registry show CABG associated with lower risk for serious adverse events in patients with triple vessel disease. Higher risk of MI and all-cause death found with PCI, particularly in those with high SYNTAX scores.
The new ESC guidelines on peripheral artery disease emphasize the need to assess patients with coronary artery disease for symptoms or asymptomatic atherosclerosis in other vascular areas. The guidelines also highlight the importance of considering multisite artery disease and the overall clinical status of patients.
Researchers developed a high-resolution imaging technology called microOCT that can reveal cellular and subcellular features of coronary artery disease. The study shows detailed images of endothelial cells, inflammatory cells, smooth muscle cells, fibrin proteins, and platelets involved in clot formation.
Researchers have found that HDL cholesterol from patients with coronary artery disease has impaired anti-inflammatory effects on blood vessel-lining cells and fails to stimulate repair of the blood vessel lining. This study highlights the importance of considering not just abundance but also biological functions of HDL in preventing CAD.
A small study found PCI to be safe in patients with significant CAD who were referred for liver transplantation. The procedure was successfully performed in 94% of patients, and all remained clinically stable at one month following the intervention.
Increased peripheral arterial disease (PAD) screening is correlated with substantial growth in PAD revascularization procedures, particularly vascular surgery. Non-invasive physiologic testing in cardiology has demonstrated a nearly twice the compounded annual growth rate of vascular surgery and radiology.
A large waist circumference or high waist-to-hip ratio significantly increases the risk of death in coronary artery disease patients, even among those with a normal Body Mass Index (BMI). The study refutes the obesity paradox, suggesting that central obesity is a more critical factor than overall weight.
A study of over 5 million Medicare beneficiaries found that hospital regions with a higher frequency of diagnoses have a lower case-fatality rate for chronic conditions. The analysis suggested that increased diagnosis frequency leads to better patient outcomes.
Researchers discovered 13 novel genetic variants linked to coronary artery disease, including seven related to LDL cholesterol and hypertension. The findings shed light on previously unknown mechanisms increasing heart disease risk.
Researchers found that automatic referrals and patient discussions significantly increased the rate of cardiac rehabilitation usage. A combined referral strategy showed an 8-fold increase in enrollment rates compared to usual care.
A new study from the University of Cincinnati found that patients with lower socioeconomic status have worse stroke severity at presentation. Researchers analyzed 1,933 cases of ischemic stroke and discovered that poorer patients had significantly increased initial stroke severity.