Articles tagged with Coronary Artery Disease
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The CORE320 study demonstrated that combined non-invasive CT angiography and myocardial perfusion imaging has robust diagnostic accuracy for identifying patients with flow-limiting coronary artery disease. The addition of CTP increased diagnostic power, allowing clinicians to distinguish between anatomic and flow-limiting stenoses.
The FAME 2 trial found that FFR-guided PCI plus optimal medical therapy significantly reduced the need for urgent revascularisation and hospital readmission in patients with stable coronary artery disease. The study also showed a lower risk of primary endpoint events, including death and heart attack.
Patients with stable coronary artery disease who have at least one narrowed blood vessel benefit from early stent placement, reducing hospitalization and urgent revascularization needs. The study used fractional flow reserve to identify eligible patients, which significantly reduces the risk of adverse events.
A country-wide German registry found that women received a lower percentage of drug eluting stents (DES) compared to men for the same condition. DES are known to decrease repeat target vessel revascularization procedures and provide favorable long-term results, especially in women with smaller epicardial vessels.
A study found that coronary artery calcium provides superior discrimination and risk reclassification compared to other risk markers for intermediate-risk individuals. The marker offers the highest improvement in discrimination over traditional risk scores, supporting its use in refining cardiovascular risk prediction.
Cardiologists at WashU Medicine have developed a noninvasive imaging technique to detect coronary artery disease in pediatric heart transplant patients, reducing the need for invasive tests. The technique uses contrast-enhanced cardiac MRI to assess coronary arteries and has shown promising results, although further study is needed.
A recent study found that Federally funded clinics for low-income patients demonstrated greater adherence to guidelines on six quality measures compared to private primary care practices. The clinics performed better in pharmacologic management of chronic diseases and appropriate use of screening tests, while performing similarly on ot...
The EVINCI study found that non-invasive imaging tests, such as multi-slice CT and radionuclide imaging, can accurately diagnose coronary artery disease in most patients. This approach could safely avoid invasive procedures in 75% of cases, reducing unnecessary treatments.
The exercise stress test remains an essential tool for diagnosing coronary artery disease, particularly in patients who can exercise. The test is non-invasive and can be administered in doctor's offices, offering a cost-effective and efficient solution.
University of Minnesota public health researchers found two high-signal genetic markers correlated with coronary artery disease, which may help define genetic fingerprints for increased risk. The study analyzed data from over 75,000 patients and offers biological and clinical data supporting future research into the genetic markers.
Researchers develop a molecular imaging tool to detect coronary artery disease, which is caused by atherosclerosis. The technique measures the coronary flow reserve, or CFR, and calculates precise dilation of blood vessels at rest and under stress.
Researchers developed a method to induce transient ischemia during non-surgical interventional cardiac procedures, boosting adenovector gene transfection by over 100 fold. Cardium Therapeutics' Generx product candidate is being tested in a 100-patient Phase 3 trial for patients with myocardial ischemia and stable angina.
Global gene expression analysis reveals distinct molecular differences between perivascular and subcutaneous fat tissues. Perivascular fat tissue is highly inflamed in humans with coronary artery diseases, suggesting it as a key player in disease formation.
A study found that patients who viewed images of their coronary artery calcium scores were more likely to take statins as directed and lose weight, with compliance increasing as disease severity increased. This suggests that visualizing the extent of cardiovascular disease can motivate patients to adhere to recommended therapies.
A new study reveals that South Asians living with coronary disease in Alberta experience a lower quality of life compared to Canadians of European descent. The study, published in American Heart Journal, found that they have more frequent and severe chest pains, and are less physically active.
Researchers found a significant correlation between coronary artery disease and prostate cancer in a large study, suggesting that heart disease may be a risk factor for the malignancy. Lifestyle changes such as weight loss, exercise, and a healthy diet may help combat both conditions.
Researchers at University of Leicester found a significant link between the Y chromosome and an increased risk of coronary artery disease in men. The study analyzed DNA from over 3,000 men and found that 90% of British Y chromosomes belong to two major groups that increase the risk by 50%.
A study published in The Lancet has found that a common variant on the Y chromosome increases the risk of coronary artery disease by 50 percent in men. Men carrying this variant have a higher risk of CAD, independent of traditional cardiovascular and socioeconomic risk factors.
The updated appropriate use criteria provide detailed guidance on when to use invasive procedures to improve blood flow to the heart. The new criteria affirm the role of revascularization for patients with acute coronary syndromes and significant symptoms, while emphasizing careful selection of high-risk surgery patients for PCI.
Researchers found that daily positive affect and self-affirmation strategies helped patients make better decisions about their health. The interventions increased physical activity for coronary artery disease patients and improved medication adherence for those with high blood pressure.
A new study published in The Lancet shows that multiparametric cardiovascular magnetic resonance (CMR) is superior to single-photon emission computed tomography (SPECT) for diagnosing coronary artery disease. CMR has a higher sensitivity and negative predictive value, making it a more accurate and reliable diagnostic tool.
A blood-based gene expression test was found to be more effective than myocardial perfusion imaging (MPI) in ruling out obstructive coronary artery disease in stable symptomatic patients. The test demonstrated high sensitivity and negative predictive value, enabling clinicians to rule out patients with high accuracy.
A new diagnostic test for coronary artery disease is associated with a higher rate of subsequent invasive cardiac procedures and higher health-care spending. The study found that patients who underwent coronary CT angiography were nearly twice as likely to have a subsequent cardiac catheterization as those who had a stress test.
A new technique measures myocardial perfusion reserve and volume reserve to predict severe stenosis in coronary arteries. This method detects 50% or greater narrowing with excellent sensitivity, enabling timely intervention for high-risk patients.
Researchers at Washington University School of Medicine have identified a genetic variant associated with the severity of coronary artery disease in patients with type 2 diabetes. The variant, located in the TLL1 gene, was found to correlate strongly with the extent of coronary disease, even better than traditional clinical factors.
Researchers at NYU Langone Health identified a hidden cause of heart attacks in women without significant coronary artery disease. Plaque disruption, a rupture or ulceration of cholesterol plaque in a coronary artery, was found to be the mechanism behind myocardial infarction in some women.
Results from CREDO-Kyoto registry show CABG associated with lower risk for serious adverse events in patients with triple vessel disease. Higher risk of MI and all-cause death found with PCI, particularly in those with high SYNTAX scores.
The new ESC guidelines on peripheral artery disease emphasize the need to assess patients with coronary artery disease for symptoms or asymptomatic atherosclerosis in other vascular areas. The guidelines also highlight the importance of considering multisite artery disease and the overall clinical status of patients.
Researchers developed a high-resolution imaging technology called microOCT that can reveal cellular and subcellular features of coronary artery disease. The study shows detailed images of endothelial cells, inflammatory cells, smooth muscle cells, fibrin proteins, and platelets involved in clot formation.
Researchers have found that HDL cholesterol from patients with coronary artery disease has impaired anti-inflammatory effects on blood vessel-lining cells and fails to stimulate repair of the blood vessel lining. This study highlights the importance of considering not just abundance but also biological functions of HDL in preventing CAD.
A small study found PCI to be safe in patients with significant CAD who were referred for liver transplantation. The procedure was successfully performed in 94% of patients, and all remained clinically stable at one month following the intervention.
Increased peripheral arterial disease (PAD) screening is correlated with substantial growth in PAD revascularization procedures, particularly vascular surgery. Non-invasive physiologic testing in cardiology has demonstrated a nearly twice the compounded annual growth rate of vascular surgery and radiology.
A large waist circumference or high waist-to-hip ratio significantly increases the risk of death in coronary artery disease patients, even among those with a normal Body Mass Index (BMI). The study refutes the obesity paradox, suggesting that central obesity is a more critical factor than overall weight.
A study of over 5 million Medicare beneficiaries found that hospital regions with a higher frequency of diagnoses have a lower case-fatality rate for chronic conditions. The analysis suggested that increased diagnosis frequency leads to better patient outcomes.
Researchers discovered 13 novel genetic variants linked to coronary artery disease, including seven related to LDL cholesterol and hypertension. The findings shed light on previously unknown mechanisms increasing heart disease risk.
Researchers found that automatic referrals and patient discussions significantly increased the rate of cardiac rehabilitation usage. A combined referral strategy showed an 8-fold increase in enrollment rates compared to usual care.
A new study from the University of Cincinnati found that patients with lower socioeconomic status have worse stroke severity at presentation. Researchers analyzed 1,933 cases of ischemic stroke and discovered that poorer patients had significantly increased initial stroke severity.
Researchers found that a single DNA variation helps protect African-Americans from coronary artery disease, with those having the alternative genetic code having a fivefold reduction in artery narrowing or clogging. The protective effect is even more pronounced when individuals inherit two copies of the guanine gene variant.
A six-year follow-up study found that shouldering family demands and worries increases the risk of angina in middle-aged Danish women and men. The study tracked over 4,500 participants and found that worrisome/demanding relationships with a partner or child posed the greatest risks, with a nearly four-fold increase in angina symptoms.
New study shows combo CT scans of heart and arteries are comparable to traditional SPECT nuclear imaging tests in detecting coronary artery disease. The combination CT scans identified 71% of patients with reduced blood flow, while correctly identifying those without slowing down 90% of the time.
A massive international study found no association between a genetic marker and the risk of coronary artery disease. The study analyzed data from over 17,000 patients with cardiovascular disease and 40,000 others, concluding that carrying a particular variant of the KIF6 gene does not indicate a greater risk for the disease.
Researchers found that a low-carb diet based on animal protein may increase death risk compared to a vegetable-based diet. Additionally, patients often overestimate the benefits of percutaneous coronary intervention (PCI) and radiation-free magnetic resonance angiography (MRA) offers an accurate diagnosis for peripheral arterial disease.
Patients with hypertension, diabetes, and coronary artery disease who maintained systolic blood pressure at less than 130 mm Hg did not have improved cardiovascular outcomes compared to usual blood pressure control. Tight blood pressure control was actually associated with increased risk of all-cause mortality.
A systematic review of C-reactive protein studies found publication bias and low study quality, casting doubt on the marker's reliability. The authors propose improved research protocols to address these issues.
Researchers found significant cost increases in Medicare claims between 2003 and 2006, with DES contributing $3.32 billion to growth and ICDs contributing $774 million. Average costs for coronary artery disease and chronic heart failure patients increased substantially, driven by the use of these devices.
A study by UC Davis researchers has identified a blood component, lipoprotein-associated phospholipase A2 (Lp-PLA2), as a predictor of coronary artery disease in African-Americans. The finding highlights the role of inflammation in vascular disease among this ethnic group and may lead to more targeted treatment approaches.
Men experiencing impotence should undergo thorough medical assessments due to significant proportion exhibiting early signs of coronary artery disease. The authors suggest that the link between the two conditions could be due to atherosclerosis, leading to restricted blood flow.
Researchers have developed a non-invasive Respiratory Stress Response (RSR) test that can accurately measure the presence of significant coronary artery disease, with a sensitivity and specificity of 83% and 70%, respectively. The test uses a Pulse Oximeter to measure blood flow in response to paced breathing.
A study found that a 35 percent decrease in CHD mortality was largely attributed to reductions in traditional risk factors. The decline in deaths was associated with significant declines in the use of treatments for conditions such as heart failure, coronary artery disease, and high blood pressure.
A meta-analysis of fibrate drugs found significant reductions in major cardiovascular events and coronary events. Fibrates also showed a modest risk reduction for albuminuria progression, an early marker of kidney disease.
A retrospective study found that complete revascularization significantly improved outcomes for patients with coronary artery disease (CAD), with a 3-year mortality rate of 6.6% compared to 14.8% in those with incomplete revascularization. The study also revealed that advanced medical therapy may contribute to improved mortality rates.
A recent study published in the American Journal of Roentgenology found that the Framingham risk assessment tool has limited sensitivity in detecting coronary artery disease. In fact, simple observation of coronary calcium presence using CT scans was more effective in identifying patients with substantial atherosclerosis.
A new pilot study led by UC and VA researchers is evaluating the functional significance of blockages in cardiac blood vessels. Using a formula derived from fluid mechanics principles, they aim to provide more accurate assessments of vessel blockages.
A new study from Henry Ford Health finds that patients with high levels of abdominal aortic calcium (plaque) are nearly 60% at risk of coronary artery disease and dying. Conversely, those with low AAC scores have a lower risk of heart disease.
Researchers found that lowering systolic blood pressure below 115 can increase cardiovascular risk for patients with diabetes and coronary artery disease. This new data challenges traditional guidelines recommending lower blood pressure levels as better.
Researchers found that a family history of early coronary artery disease increases the risk of developing obstructive CAD and plaque buildup in arteries. The study analyzed over 8,200 patients who underwent cardiac computed tomography angiography, revealing a 28% higher chance of disease development among those with a family history.
A new study finds that nearly 60% of chest pain patients without prior heart disease have no significant coronary artery disease, highlighting the need for improved identification methods. The study suggests re-evaluating patient selection processes, including history taking and risk factor assessment.
Researchers have developed a novel, non-invasive measure called Respiratory Modulation Response (RMR) to quickly and accurately detect the presence of significant coronary artery disease. Patients with sCAD had a lower RMR compared to patients without, regardless of their risk factors or clinical history.
Research reveals that a DNA interval in chromosome 9p21 increases the risk for coronary artery disease by regulating cell division genes, which can lead to vascular cell proliferation and narrowed coronary arteries. The study's findings suggest potential therapies targeting these genes could combat the disease.
Researchers at Duke University Medical Center identified specific metabolic profiles associated with coronary artery disease, heart attacks, and death. The study analyzed metabolites in nearly 10,000 patients and found two sets of metabolites that differentiated between those with and without cardiovascular disease.