Articles tagged with Coronary Artery Disease
Researchers used coronary computed tomography angiography (CCTA) to detect high-risk coronary artery plaque and non-alcoholic fatty liver disease (NAFLD), a condition characterized by abnormal liver function. The study found that NAFLD is associated with high-risk plaque, even after adjusting for traditional risk factors.
A study of nearly 38,000 patients found that those diagnosed with nonobstructive coronary artery disease (CAD) had a significantly increased risk of heart attack or death one year after diagnosis. Patients with nonobstructive CAD had an associated risk of MI that was 2-to 4.5-fold greater than among those with no apparent CAD.
Despite no detectable coronary artery disease, nearly three-quarters of patients experience severe or moderate symptoms before and after angiography. Symptoms persist in over seven out of ten cases. Validated questionnaires reveal higher anxiety levels, increased somatoform disorders, and hypochondria in these patients.
A new study by researchers at Intermountain Medical Center Heart Institute suggests that lifestyle choices, not just genetics, may contribute to the risk of heart attack. The study found that severe coronary artery disease can be inherited, but the presence of heart attacks in people with less severe disease was not clustered in families.
Researchers developed new methods to reduce imaging time in myocardial perfusion imaging (MPI) by up to 50%, making scans easier for patients. The methods also correct errors caused by patient movement, resulting in error-free MPI images.
A new study reveals that PET/MR imaging is highly effective in detecting coronary artery disease, outperforming traditional SPECT methods. The hybrid technique provides a comprehensive view of the heart, combining anatomical and functional information for more accurate diagnoses.
Researchers identified a gene expression profile associated with an increased risk of cardiovascular death in patients with coronary artery disease. The profile, based on a simple blood test, may help identify patients who could benefit from personalized treatment and counseling.
Researchers found an estimated 9 million people with diabetes and 5.6 million people with coronary artery disease are not receiving statins, highlighting a concerning trend driven by high cholesterol. Statin use is often associated with reduced cardiovascular risk, regardless of cholesterol levels.
A study published in Annals of Internal Medicine found that men with HIV have a greater risk and extent of coronary artery disease compared to uninfected men. Meanwhile, nearly one-third of patients fail to fill their first-time prescriptions, which may impact clinical outcomes.
A Johns Hopkins study reveals that long-term HIV infections increase the risk of plaque buildup in coronary arteries, regardless of other risk factors. The researchers found noncalcified and partly calcified plaques more prevalent in HIV-infected men, suggesting a higher risk of heart attacks.
People with celiac disease may have a near two-fold increased risk of coronary artery disease compared to the general population. Researchers found that systemic inflammation and autoimmune processes might influence cardiovascular disease development.
People who are married have lower rates of several cardiovascular diseases compared to those who are single, divorced, or widowed. Married individuals were found to be 5% less likely to have any vascular disease and had lower odds of other vascular conditions.
A large-scale survey of 3.5 million Americans found that married people have a significantly lower risk of heart disease than singles, divorced, or widowed individuals. The study also revealed age-related differences in cardiovascular disease risk among married couples.
Research shows that vitamin D deficiency is associated with higher prevalence and severity of coronary artery disease. Patients with low vitamin D levels are at a higher risk of developing severe heart disease, and the study suggests that vitamin D may be beneficial in preventing heart disease.
A new blood test detects specific genes activated in individuals with obstructive coronary artery disease (CAD), excluding diagnosis without imaging studies. This approach reduces healthcare costs and may improve patient outcomes by minimizing invasive tests.
A study evaluated the role of infliximab in treating Kawasaki disease, a condition that can lead to irreversible heart damage if not diagnosed or treated promptly. Infliximab treatment was found to be safe and effective in preventing coronary artery damage in children with Kawasaki disease.
Sanford-Burnham researchers identify THRIL molecule that regulates immune response and associates with Kawasaki disease severity. THRIL may also contribute to other inflammatory diseases like rheumatoid arthritis and inflammatory bowel disease.
Patients undergoing cardiac surgery have a substantially higher risk of depression if they are physically inactive, with 58% of those at-risk progressing to clinical depression. Inactive patients also experience double the risk of depressive symptoms before surgery and postoperatively.
Cardiovascular complications and hypoglycemia are common nonfatal complications in older adults with diabetes. The study found that patients with diabetes for a longer duration had higher rates of all outcomes, including mortality.
An international multicenter study found that men and women with mild coronary artery disease and similar cardiovascular risk profiles share similar prognoses. The study analyzed data from 27,725 individuals in six countries and revealed that nonobstructive coronary artery disease conferred a similar adverse risk of death or heart atta...
A new study by Johns Hopkins Medicine found that higher levels of physical fitness lower the risk of having heart attacks and increase survival in those with coronary artery disease. The study included over 9,800 adults with coronary artery disease and showed a 75% lower risk of dying from any cause among the fittest patients.
A new study by Johns Hopkins Medicine found that young and middle-aged women with type 2 diabetes are at a significantly increased risk of coronary artery disease, comparable to men's risk. The study analyzed data from over 10,000 participants and suggests distinct genetic and hormonal factors may contribute to the higher risk.
The ADVISE II trial found that iFR accurately classified 94.2% of coronary stenoses, with high positive and negative predictive values for hemodynamically severe stenosis detection. The study supports the use of iFR to simplify physiological guidance of percutaneous coronary intervention without adenosine administration.
A study published in JAMA found that coronary artery bypass graft (CABG) surgery provides slightly better health status and quality of life than procedures using drug-eluting stents for patients with diabetes and multiple arteries affected, but this difference disappears beyond 2 years.
A global analysis of Kawasaki disease cases found a seasonal occurrence shared by regions across the Northern hemisphere, with peak cases in winter months. The study suggests that large-scale wind currents may play a role in transmitting the suspected infectious agent.
A study published in JAMA Network found that aliskiren, a renin inhibitor, did not slow the progression of coronary artery disease in patients with prehypertension. The treatment had no significant impact on atheroma burden or regression of fatty deposits.
A retrospective study from Cleveland Clinic found that patients who underwent stenting of the carotid artery followed by open heart surgery had the best outcomes. The researchers compared three common treatment approaches and found that this combination had significantly lower risks of serious events after one year.
Coronary artery disease (CAD) disproportionately affects women, with unique risk factors including pregnancy and autoimmune diseases. Women are more likely to die from CAD than men in similar circumstances, especially at younger ages.
Researchers found a significant difference in cardiac catheterization rates between New York State and Ontario, with New York performing fewer procedures due to lower obstructive coronary artery disease (CAD) burdens. This selective approach improved diagnostic efficiency while reducing costs.
A new study found that DNA particles in the blood can serve as markers of disease and may help identify patients with severely narrowed coronary arteries. Higher levels of these particles were linked to high levels of coronary artery calcium deposits.
Researchers found that men with haplogroup I have lower numbers of copies of two important genes in macrophages, which may contribute to increased risk of coronary artery disease. The study used a sample of around 2,000 men from four European populations and aimed to decipher the genetic background behind the association.
Patients with low baseline diastolic blood pressure (DBP) had more subcortical brain atrophy progression. Those with declining DBP levels over time showed less brain atrophy progression compared to those with rising BP levels.
Researchers found that metabolic PET imaging detected coronary disease at an early stage, with a sensitivity of 96%, compared to 56% for MPI. This technique could potentially be used for initial CAD screening to help doctors better determine a patient's cardiac risk and manage care.
A recent study published in the Canadian Medical Association Journal found that people with job stress and an unhealthy lifestyle are at a higher risk of coronary artery disease. The study analyzed data from 7 cohort studies involving 102,128 participants and found that those with job strain had a 10-year incidence rate of 18.4 per 100...
A new study links type 1 diabetes to an increased risk of heart disease through the production of the inflammatory protein calprotectin, which fuels the buildup of artery-clogging plaque.
A large study found that high serum C-peptide levels are linked to an increased risk of death from all causes and cardiovascular disease. People with high C-peptide levels had a 1.8- to 3.2-fold increased risk compared to those with low levels.
A meta-analysis of published evidence found a link between male pattern baldness and an increased risk of coronary heart disease, especially on the crown of the head. Men with extensive vertex baldness were 44% more likely to develop coronary artery disease than those with a full head of hair.
A study led by the University of Leicester found a link between faster telomere shortening and increased risk of age-related diseases, including coronary artery disease and certain cancers. The research suggests that biological aging plays a key role in causing these diseases.
The study found that hybrid revascularization had a similar rate of major adverse events in the first year compared to percutaneous intervention. Hybrid revascularization combines coronary bypass surgery and stenting, offering a minimally invasive approach for treating multi-vessel coronary artery disease.
A 12-week cardiac rehabilitation program reduced mortality in women with coronary artery disease by two-thirds, yet referrals and attendance among women fall short compared to men. Women who receive a referral but don't attend also have better outcomes, suggesting a referral bias towards healthier individuals.
A study found that limited scar burden was linked to improved heart contraction and reversal of wall thinning in patients with coronary artery disease. Regional myocardial wall thinning may represent viable myocardium with potential for recovery, challenging current views on the condition.
A new study found that CT angiography is an effective tool for determining the risk of heart attacks and other adverse cardiac events in patients with suspected coronary artery disease but no treatable risk factors. The test identified a high prevalence of coronary artery disease, even in patients without modifiable risk factors.
A new urine test using protein biomarkers may enable early diagnosis and treatment of Kawasaki disease, a rare but increasingly prevalent condition that can cause inflammation of blood vessels and lead to heart attacks. The test has shown promising results in distinguishing children with Kawasaki disease from those with other conditions.
A large-scale study has identified 15 new genetic regions associated with coronary artery disease risk, bringing the total to 46 regions. The research also found that lipid metabolism and inflammation play a significant role in CAD.
Researchers have identified a link between inflammation and heart disease through the largest genetic study of Coronary Artery Disease (CAD) to date. The study found that lipid metabolism and inflammation play a significant role in CAD, providing evidence for a novel pathway for prevention and treatment.
A large-scale international study identified 15 new genetic regions associated with coronary artery disease, revealing a link between inflammation and plaque buildup in heart vessels. The research, which analyzed data from over 190,000 participants, provides insights into the molecular pathways causing the deadly disease.
A new MRI technique has shown promise in identifying early-stage coronary disease, which can be treated with lifestyle changes and medications. The study used time-resolved multi-frame acquisition to measure coronary artery wall thickness with a high success rate and precise measurements.
The CORE320 study demonstrated that combined non-invasive CT angiography and myocardial perfusion imaging has robust diagnostic accuracy for identifying patients with flow-limiting coronary artery disease. The addition of CTP increased diagnostic power, allowing clinicians to distinguish between anatomic and flow-limiting stenoses.
The FAME 2 trial found that FFR-guided PCI plus optimal medical therapy significantly reduced the need for urgent revascularisation and hospital readmission in patients with stable coronary artery disease. The study also showed a lower risk of primary endpoint events, including death and heart attack.
Patients with stable coronary artery disease who have at least one narrowed blood vessel benefit from early stent placement, reducing hospitalization and urgent revascularization needs. The study used fractional flow reserve to identify eligible patients, which significantly reduces the risk of adverse events.
A country-wide German registry found that women received a lower percentage of drug eluting stents (DES) compared to men for the same condition. DES are known to decrease repeat target vessel revascularization procedures and provide favorable long-term results, especially in women with smaller epicardial vessels.
A study found that coronary artery calcium provides superior discrimination and risk reclassification compared to other risk markers for intermediate-risk individuals. The marker offers the highest improvement in discrimination over traditional risk scores, supporting its use in refining cardiovascular risk prediction.
Cardiologists at WashU Medicine have developed a noninvasive imaging technique to detect coronary artery disease in pediatric heart transplant patients, reducing the need for invasive tests. The technique uses contrast-enhanced cardiac MRI to assess coronary arteries and has shown promising results, although further study is needed.
A recent study found that Federally funded clinics for low-income patients demonstrated greater adherence to guidelines on six quality measures compared to private primary care practices. The clinics performed better in pharmacologic management of chronic diseases and appropriate use of screening tests, while performing similarly on ot...
The EVINCI study found that non-invasive imaging tests, such as multi-slice CT and radionuclide imaging, can accurately diagnose coronary artery disease in most patients. This approach could safely avoid invasive procedures in 75% of cases, reducing unnecessary treatments.
University of Minnesota public health researchers found two high-signal genetic markers correlated with coronary artery disease, which may help define genetic fingerprints for increased risk. The study analyzed data from over 75,000 patients and offers biological and clinical data supporting future research into the genetic markers.
The exercise stress test remains an essential tool for diagnosing coronary artery disease, particularly in patients who can exercise. The test is non-invasive and can be administered in doctor's offices, offering a cost-effective and efficient solution.
Researchers develop a molecular imaging tool to detect coronary artery disease, which is caused by atherosclerosis. The technique measures the coronary flow reserve, or CFR, and calculates precise dilation of blood vessels at rest and under stress.
Researchers developed a method to induce transient ischemia during non-surgical interventional cardiac procedures, boosting adenovector gene transfection by over 100 fold. Cardium Therapeutics' Generx product candidate is being tested in a 100-patient Phase 3 trial for patients with myocardial ischemia and stable angina.
Global gene expression analysis reveals distinct molecular differences between perivascular and subcutaneous fat tissues. Perivascular fat tissue is highly inflamed in humans with coronary artery diseases, suggesting it as a key player in disease formation.