Articles tagged with Coronary Artery Disease
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A new AI model has been developed that can predict the risk of death in patients with heart disease more accurately than medical experts. The model was trained on electronic health data from over 80,000 patients and identified new variables that doctors hadn't considered.
A study found that febuxostat significantly reduced the rate of primary endpoint events, including cerebral and cardiovascular disease. Lowering serum uric acid levels also decreased renal impairment and related complications.
A new study found that combining oral anticoagulants with antiplatelets worsened outcomes in patients with newly diagnosed atrial fibrillation, especially those without coronary artery disease or peripheral artery disease. This challenges the use of combined therapy in these patients.
A recent study published by the European Society of Cardiology found that sleeping six to eight hours a night is most beneficial for heart health. The research, which analyzed data from over one million adults, suggests that both short and long sleepers have an increased risk of developing coronary artery disease or stroke.
The new guidelines recommend open heart surgery for patients with complex coronary artery disease, as it provides better long-term survival and outcomes compared to stent placement. In contrast, patients with simpler disease can benefit from both surgical bypass and PCI, with complete revascularization being the preferred option.
A new genome analysis method predicts risk for coronary artery disease, breast cancer, and type 2 diabetes based on genetic variants. Up to 25 million people in the US may be at triple the normal risk for coronary artery disease, highlighting the potential for early interventions.
A study published in Radiology found that cardiac hybrid imaging, combining CT and nuclear stress testing, is an excellent long-term predictor of adverse cardiac events. The imaging approach helps identify stenosis and perfusion, providing critical information for treatment decisions.
Researchers at Florida State University emphasize the importance of early depression diagnosis in patients with coronary artery disease. Studies have shown that individuals with both CAD and depression experience significantly poorer health outcomes, including a two-fold higher risk of mortality. The article provides criteria for major...
The study reveals a tendency for duplication in the 9p21.3 sequence associated with coronary artery disease, which may affect predisposition to CAD. Sequence analysis shows varied repeats with 10-15 SNPs between each other and 82 SNPs between the human genome sequence.
Researchers found that hospitalized patients with coronary artery disease who developed low blood glucose levels during their stay had higher mortality rates, longer hospital stays, and increased healthcare costs. Frequent glucose monitoring could potentially save lives and decrease hospital length of stay and healthcare expenses.
Researchers found that imaging technologies more precisely predict who's at risk for heart attacks, allowing for timely prevention. The study used PET/CT imaging to measure coronary artery calcium, revealing existing disease and identifying patients at high risk.
A review published in the Journal of the American College of Cardiology suggests that environmental noise, including traffic noise, may contribute to the development of heart disease. The study proposes that noise induces a stress response, leading to vascular damage and increased risk of hypertension and diabetes.
A new multi-gene test predicts a high risk for early-onset heart disease in 1 out of 53 individuals, surpassing the prevalence of a rare genetic defect. The study suggests that combining polygenic screening with current testing could identify five-fold more cases with a genetic explanation.
A Mayo Clinic study reveals that hysterectomy alone is associated with a significantly increased risk of cardiovascular diseases and metabolic conditions. Women under 35 had a high risk of congestive heart failure and coronary artery disease.
A study of 6,051 patients with coronary artery disease found that being unmarried was associated with a 24% higher risk of death from any cause. Unmarried individuals were also at a higher risk of cardiovascular death/heart attack, with a 52% increased risk compared to married patients.
A meta-analysis of trials involving nearly 5,000 patients found no differences in mortality between percutaneous coronary intervention and coronary artery bypass grafting. Percutaneous coronary intervention is less burdensome on patients, enabling rapid return to work without long-term hospitalization.
A blood-based precision medicine test incorporating age, sex, and gene expression score (ASGES) helped evaluate older outpatients with symptoms of obstructive coronary artery disease. The study found higher incidence of major adverse cardiovascular events in those with high ASGES scores compared to low ASGES scores
A study published by the European Society of Cardiology found that male-pattern baldness and premature greying are associated with a higher risk of coronary artery disease in young men. Obesity was also linked to an increased risk, but not to the same extent as these two factors.
A study published in the American Journal of Pathology found that higher levels of the protein CXCL5 are associated with clearer heart arteries and lower risk of coronary artery disease. Researchers believe that mimicking or increasing CXCL5 production could lead to new prevention and treatment strategies for CAD.
Researchers found that individuals with A, B, and AB blood types have an elevated risk of heart attacks during times of significant air pollution compared to those with O blood type. The study links increased risk of heart attack associated with small particulate pollution to increased risk for people with coronary artery disease.
A study of over 60,000 patients with known heart disease found that follow-up LDL cholesterol tests significantly reduce the risk of reoccurring heart attacks and strokes. Patients who didn't receive these tests were more likely to experience major adverse outcomes.
Research suggests anabolic androgenic steroid use may be associated with early coronary artery disease in healthy young individuals. The study found that steroid users had atherosclerosis, reduced HDL levels, and impaired HDL function.
Patients with left main coronary artery disease (LMCAD) who underwent percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG) showed similar quality of life improvements at three years. PCI demonstrated a greater early benefit, with improved health status measures that were sustained over time.
The ESC Guidelines provide comprehensive recommendations for the diagnosis and treatment of peripheral arterial diseases, affecting over 40 million Europeans. Key findings include revised guidelines for revascularization of asymptomatic carotid stenosis and a strong recommendation against systematic revascularisation of renal stenosis.
The ESC Focused Update provides recommendations for dual antiplatelet therapy (DAPT) in patients with coronary artery disease. DAPT reduces the risk of acute to very late stent thrombosis, but the optimal duration is uncertain. The Task Force recommends a personalized approach based on ischaemic versus bleeding risks.
A multicenter study found a significant association between higher income and increased risk of coronary artery disease and multivessel disease among patients undergoing coronary angiography. Poor lifestyle practices, including physical inactivity, unhealthy diet, and tobacco use, contribute to this finding.
A new study finds that depression in heart patients significantly increases the risk of death, with depressed heart patients having twice the risk as non-depressed heart patients. The study emphasizes the importance of continued screening for depression in all heart disease patients.
A genetic variant at chromosome 6p24 is associated with five vascular diseases, including coronary artery disease and hypertension. The variant enhances the activity of endothelin-1 gene, promoting vasoconstriction and hardening of arteries.
A genetic predisposition to higher blood calcium levels is associated with an increased risk of coronary artery disease and heart attack. The study used mendelian randomization to examine the association between serum calcium levels and CAD, finding a link between the two.
A study published in The Open Cardiovascular Medicine Journal found that higher income is associated with a higher risk of significant coronary artery disease and multivessel disease in patients undergoing coronary angiography. Poor lifestyle practices and high stress levels are thought to contribute to this association.
Researchers at Linkoping University discovered that lutein can suppress long-term inflammation in patients with coronary artery disease. The study found that higher levels of lutein were associated with lower levels of inflammatory markers and reduced inflammatory activity in immune cells.
Researchers found that new opioid use among older adults with COPD is associated with a higher risk of coronary artery disease-related death. The study suggests that opioids may have negative effects on the heart, including lower blood oxygen levels and increased inflammatory factors.
A genetic study suggests that human genes for coronary artery disease contribute to greater numbers of children, providing an evolutionary trade-off between early-life reproductive benefits and later-life disease costs. The study uses genome-wide scans and lifetime reproductive data to identify genetic variation linked to the disease.
Researchers have found that genes for coronary heart disease (CAD) also influence reproduction, suggesting a trade-off between heart disease and fertility. The study, published in PLOS Genetics, reveals CAD genes have been positively selected for through evolution, improving human reproduction.
Research reveals a defective immune cell's sweet tooth predisposes people to shingles, exacerbating heart disease. The connection shows how the same mechanism disabling immune response to viral infections also affects heart conditions.
Researchers have discovered 15 new genetic risk factors for coronary artery disease, linking them to blood vessel cell functions. The findings aim to improve understanding of the disease and inform the development of new therapies.
Chronic anabolic steroid use can lead to reduced heart function, including impaired pumping capacity and increased blood pressure. The study found strong associations between lifetime duration of illicit anabolic steroid use and plaque build-up in coronary arteries, highlighting the critical need for clinicians to monitor this population.
Research found that Hodgkin lymphoma survivors who received chest irradiation had significantly more multi-vessel coronary artery disease and higher segment involvement scores compared to controls. The study suggests that patients should be screened for coronary artery disease at regular intervals after irradiation.
Peripheral artery disease affects 200 million people worldwide, but less than half receive appropriate medication and lifestyle counseling. This study highlights the need to improve quality of care for high-risk individuals, who are at risk of adverse outcomes such as coronary heart disease, heart attacks, and strokes.
A prospective observational study found a high association between grey hair and coronary artery disease in adult men. Researchers discovered that as age increases, so does the incidence of both atherosclerosis and hair greying due to similar biological pathways.
A new study has developed a score called the Intermountain Chronic Disease Risk Score (ICHRON) that uses routine blood tests and age to measure future risk of chronic disease. ICHRON predictions are 77-78% accurate in identifying patients who'll be diagnosed with a chronic disease within three years.
Researchers found that non-toxic amounts of ammonia increase the production of heme oxygenase-1 (HO-1), which protects endothelial cells and prevents plaque buildup. Glutamine, an amino acid supplement, triggers this natural response.
Dual-energy computed tomography angiography (DECT) shows moderate diagnostic accuracy and improves image quality compared to conventional CT angiography. DECT also significantly reduces contrast medium dose without compromising image quality.
A study published in Journal of Addiction Medicine found that decreasing cocaine use leads to regression of unstable coronary plaques, a type of plaque most likely to cause a heart attack. Reducing cocaine use also decreases inflammation markers and improves cardiovascular health.
A study from Lund University found that consuming high amounts of added sucrose increases the risk of myocardial infarction by about a third. The researchers analyzed data from over 26,000 participants and found no correlation between sugar intake and cardiovascular disease for those following general dietary recommendations.
The EXCEL trial found that drug-eluting stents are a viable alternative to CABG for patients with LMCAD, with fewer MIs and less bleeding within 30 days. However, more repeat revascularization procedures were required at three years.
A major international study found that drug-eluting stents are equally effective as bypass surgery for patients with left main coronary artery disease, with fewer complications. The EXCEL trial followed 1,905 patients and showed stents to be safer in the first 30 days after treatment.
Researchers found that CTA tests led to higher adoption of preventive measures and healthier lifestyle practices compared to exercise electrocardiography and stress tests. After 60 days, more people who underwent CTA tests started taking aspirin, statins, and beta-blockers, and eating healthier, with lower rates of obesity.
The Canadian Cardiovascular Society has released updated guidelines for managing atrial fibrillation, prioritizing the use of non-vitamin K antagonist oral anticoagulants (NOACs) over warfarin. The new recommendations aim to improve patient outcomes and reduce stroke risk.
A study published in JAMA Cardiology found that prolonged dual antiplatelet therapy reduces the risk of death, heart attack, or stroke in patients with peripheral arterial disease undergoing percutaneous coronary intervention. Concomitant PAD is associated with a 2-fold increased risk of ischemic events, but not bleeding.
A large study of over 22,000 patients with coronary artery disease found that too low blood pressure was associated with worse outcomes. The optimal blood pressure target continues to be debated, and caution is urged when using blood pressure lowering treatment in these patients.
A new study published by the European Society of Cardiology found that an active strategy of detecting and treating asymptomatic multisite artery disease did not improve 2-year outcomes compared to a traditional approach. The study enrolled 521 CAD patients and found no significant difference in all-cause mortality, rehospitalization f...
Researchers from Mount Sinai and international partners have identified specific genes that contribute to cardiometabolic diseases, such as heart attack and stroke. The study analyzed gene-expression data from patients with coronary artery disease and found genes that regulate blood lipid levels in abdominal fat.
The study highlights the importance of managing pericardial effusions, myocardial disease, pulmonary arterial hypertension, and other cardiac complications in HIV-infected patients. Clinicians must be aware of these manifestations, diagnosis, and treatment options to improve patient outcomes.
A Finnish study found that nearly 60% of patients with coronary artery disease also had dental root tip infections. The researchers discovered a strong link between the two conditions, suggesting that oral infections may contribute to heart disease risk. Root canal treatment may help reduce this risk.
A study of over 23,000 patients found that women had a lower risk of comorbidities and experienced fewer vascular complications in-hospital after TAVR. Despite this, women's one-year survival rate was still higher than men's.
A study by Brigham and Women's Hospital identifies four factors contributing to sex disparities in statin therapy among patients with coronary artery disease. Women were less likely to start or continue statin therapy due to lower cardiologist evaluations and higher rates of adverse reaction reports.
A study found that familial hypercholesterolemia mutations account for less than 2% of cases with severely elevated LDL levels, but significantly increase the risk of coronary artery disease. Gene sequencing identified individuals at high risk who may benefit from additional preventive therapies.
Women experiencing suspected heart disease exhibit similar classic symptoms to men, including chest pain and shortness of breath, but differ in diagnosis and risk assessment. The study found that women have more risk factors for heart disease than men, yet are often assessed as lower risk.
A study of over 287,000 patients found that African-American patients with connective tissue diseases like lupus and rheumatoid arthritis were twice as likely to develop narrowed or atherosclerotic blood vessels. Young African-Americans with CTD also had a higher risk of cardiovascular disease, including heart attacks and strokes.