Articles tagged with Coronary Artery Disease
A new study published in Radiology: Cardiothoracic Imaging found that aspirin therapy did not reduce major cardiovascular events in patients with non-obstructive coronary artery disease. Statin use, however, was associated with a significant reduction in cardiovascular events.
Researchers found smokers have significantly lower A1AT levels, which may reduce cardiac tissue protection during a heart attack. No difference was detected in hypertensive and non-hypertensive individuals.
A prospective study found that the 3-T Dixon gradient-recalled echo (GRE) sequence performed better than the current standard of 1.5-T SSFP for unenhanced coronary MRA, particularly in distal and branch segments. The technique demonstrated higher image quality, visible segments, sensitivity, and specificity for significant stenoses.
A new smartphone app developed by Scripps Research calculates genetic risk for coronary artery disease and finds that users at high risk are more likely to start using statins or other cholesterol-lowering therapies. The app, called MyGeneRank, uses genetic data from 23andMe and outputs a CAD risk score.
Researchers at the University of Virginia Health System have identified a potential way to treat obesity and type 2 diabetes in women by targeting a specific gene called KLF14. Increasing KLF14 abundance in fat cells may help alleviate metabolic abnormalities, including slower metabolic rates and less efficient triglyceride management.
A comprehensive analysis suggests that cardiac computed tomography (CT) provides a safe alternative to cardiac catheterization for patients with stable chest pain and suspected CAD. The trial confirms CT's diagnostic accuracy, while also showing lower procedure-related complications.
The American Roentgen Ray Society recognizes Drs. Nguyen, Beheshtian, Harfouch, and Hashiba for their outstanding research and education contributions to the field of radiology. The awards honor the candidates' scientific merit and potential impact on imaging and allied sciences research.
A new study has identified the critical genes most likely to cause coronary heart disease and trigger heart attacks. The research provides a prioritized list of 162 genes, which will enable more accurate genetic testing and targeted therapies for patients at risk of coronary heart disease.
A small study found statistically significant improvements in various symptoms, including fatigue and chest discomfort, after EECP therapy in long COVID patients. Researchers believe this is the most plausible explanation for the benefits derived from EECP and its link to long COVID.
The annual conference will cover important themes such as decision-making in coronary revascularization, specific treatment of complex lesion subsets, and the use of adjunctive tools. CTO Plus 2022 will feature 12 live case transmissions performed by world-class faculty members.
A new study from USF Health reveals that activated protein C may help improve aging patients' tolerance to reperfusion injury, a potentially adverse effect of treatment for ischemic heart disease. The researchers suggest that drugs derived from APC may limit ischemia and reperfusion-induced heart damage.
A new study published in Clinical Nutrition found that drinking less than the UK's recommended 14 units of alcohol per week increases the risk of cardiovascular events. Moderate alcohol consumption is associated with a 23% increased risk of suffering a cardiovascular event for every additional 1.5 pints of beer consumed.
A study suggests that nearly 60 percent of the risk associated with coronary artery disease may be explained by changes in hundreds of genes working together in networks across several organs. Fat processing hormones may play a central role in coordinating this activity.
A new PET/CT artificial intelligence model has been developed to predict the risk of future heart attacks with improved accuracy. By combining information from PET and CT angiography, the model provides a more robust prediction of heart attack risk than clinical data alone.
A new issue of the CVIA journal has been published, featuring research on the clinical significance of angiographically detectable neovascularity in patients with cardiac myxoma. Studies found that ADN was present in 42.4% of patients and was associated with higher levels of eosinophils and low-density lipoprotein cholesterol.
A Mayo Clinic study reveals that cardiovascular risks, including coronary artery disease and diabetes, have a stronger association with memory and thinking skills decline in middle-aged women. The research found that women with these conditions experience an annual decline in global cognition more than two times greater than men.
The new guideline recommends a patient-centric approach to managing patients with coronary artery disease, incorporating clinical indications and multidisciplinary team decision-making. The guideline aims to improve quality of care and reduce disparities in treatment, particularly among women and underrepresented racial or ethnic groups.
Women with breast implants after mastectomy are at high risk of developing cardiovascular disease due to chemotherapy and radiation. Inaccuracies in cardiac imaging studies, such as echocardiography and nuclear tests, have been reported in some cases.
A new study from the University of Eastern Finland found that patients with type 2 diabetes often do not receive adequate cholesterol-lowering treatment, despite guidelines recommending statin prescriptions for elevated LDL-C levels. Women tend to have higher average LDL-C levels and receive less statin treatment than men.
The global red and processed meat trade has risen exponentially, leading to a sharp increase in diet-related illnesses, particularly bowel cancer, diabetes, and coronary artery heart disease. Health policies should be integrated with agricultural and trade policies to address this issue.
A new risk score developed by Mount Sinai researchers can help predict possible contrast-associated acute kidney injury among patients undergoing PCI. The 'Mehran-2 CA-AKI Risk Score' enhances management of high-risk patients before, during, and after the procedure.
A new trial shows that the novel surgical device venous external support (VEST) may improve outcomes of coronary bypass grafting using leg veins by preventing intimal hyperplasia, a key factor in vein graft failure.
A new study published in The New England Journal of Medicine found that percutaneous coronary intervention (PCI) guided by fractional flow reserve (FFR) did not meet noninferiority for one-year outcomes compared to bypass surgery. However, FFR-guided PCI performed favorably in patients with low SYNTAX scores and less complex disease.
A new study found that QFR-guided PCI resulted in lower one-year rates of heart attack and a lesser chance of needing additional PCI, with a 35% reduction in mortality. The technology helped eliminate unnecessary stents and identified more obstructive lesions.
A new canine mutant model mimics human cerebrovascular disease by exhibiting severe arteriosclerosis, thrombosis, and stroke. The ApoE knockout dogs show extensive and severe arteriosclerosis plaques and arterial stenosis, consistent with human cerebral arteries and coronary arteries.
The ACC Middle East 2021 conference will showcase the latest evidence-based strategies for improving heart health in the Middle East. The event features presentations from renowned experts on the most impactful clinical trials and contemporary best practices in treating cardiovascular disease.
Research suggests that people sensitive to stress hormones are at greater risk of developing cardiovascular disease, with markers indicating increased risk of stroke and heart attack. A novel proteomic signature may help identify these individuals and inform stress management strategies.
A new study finds that left-sided breast cancer radiation therapy increases the risk of coronary artery disease in younger survivors, with a significant increase in risk seen at 10.5% for those who received left-sided radiation therapy compared to 5.8% for right-sided.
Researchers develop novel models to investigate the impact of drug-eluting stents on arterial tissue permeability and blood flow. The study identifies key factors contributing to restenosis near stent edges, highlighting potential avenues for design improvements.
The MASTER DAPT trial found that one month of dual antiplatelet therapy preserves ischemic benefits and reduces bleeding risk in high bleeding risk patients. Abbreviated DAPT was noninferior to standard DAPT in terms of net adverse clinical events, but superior in reducing major or clinically relevant nonmajor bleeding.
A new study found that 44% of micro-arteries from patients had abnormal myogenic tone, associated with excessive caldesmon presence and poor cell alignment. This abnormality affects blood supply within the heart and other organs, impacting quality of life and life expectancy.
Researchers developed a new imaging technique that uses light and sound to detect plaques in arteries, potentially preventing strokes and heart attacks. The technique uses nanoparticles that absorb light and emit sound waves, allowing doctors to visualize the plaques in a non-invasive way.
A study found a strong association between pre- and post-transplant cardio-cerebrovascular diseases, with an estimated hazard ratio of 12.50. Pre-transplant CCVD was independently associated with high non-relapse mortality and inferior survival in patients undergoing hematopoietic cell transplant.
The study used single cell technology to map epigenetic changes in different cells involved in coronary artery disease, revealing that genetic risk variants are particularly enriched in endothelial and smooth muscle cells. This research provides a new understanding of the role of these cells in transmitting susceptibility to the disease.
A study of 805,992 Japanese individuals found that systolic blood pressure (SBP) above 120 mmHg increases the rate of cardiovascular disease. SBP levels were also associated with an increased risk of coronary artery disease and cerebrovascular disease, even in individuals with normal glucose status.
A global health problem has been identified as microvascular angina, a disease affecting the smallest heart blood vessels. The study found that patients with MVA experience chest pains similar to those of a heart attack, yet are often misdiagnosed due to the lack of definitive diagnostic criteria.
A meta-analysis found that adding revascularization to medical therapy reduces cardiovascular death by 21% in patients with stable ischemic heart disease. The benefit increases over time, with a greater impact on survival for those with extensive disease.
A study found that people living with HIV have a two to three times higher noncalcified coronary plaque burden than non-HIV healthy volunteers. Researchers emphasize the importance of adopting a heart-healthy lifestyle for those with HIV.
Developed and validated clinical prediction models estimate the probability of patients having coronary artery disease (CAD) using a nomogram. The nomogram improves accuracy in Chinese populations by identifying individualized risk factors.
Men with stable coronary artery disease who take Viagra live longer and have lower risk of new heart attack compared to those treated with alprostadil. The study's findings suggest a dose-dependent reduction in cardiovascular events.
A new study reveals that over one third of genetic variants associated with coronary artery disease regulate liver-specific genes involved in cholesterol metabolism. Researchers pinpoint the causal single nucleotide polymorphisms and target genes mediating the risk, expanding our understanding of the disease's mechanisms.
A study published in Radiology found that cocaine use significantly affects the progression of coronary artery disease, while HIV infection has a more profound effect on younger individuals. Radiomics analysis revealed distinctive contributions of different risk factors to changes in plaque over time.
Researchers at UVA Health System identified a gene variant MIA3 that produces a protein promoting smooth muscle cell proliferation, leading to thicker, stable protective caps on blood vessel plaques. This discovery could help prevent heart attacks by stabilizing plaque lesions and reducing the risk of coronary artery disease.
A new screening questionnaire can predict individuals at high risk of coronary artery disease, according to a Swedish study. The questionnaire uses data easily measured at home and is successfully imaged using CCTA images to examine patients' arteries for the presence of plaque.
Women with premature menopause are at higher risk of developing coronary artery disease due to the presence of clonal hematopoiesis in their blood cells. The study found a 36% increased likelihood of clonal hematopoiesis and a 48% higher risk of coronary artery disease among women with premature menopause.
A study published in Nature Genetics developed a more accurate predictor of coronary artery disease based on genetic factors by comparing genome-wide association analysis across different ancestries. The researchers identified 48 genetic loci associated with the disease, including eight previously unknown variants.
Cases and deaths among younger cohorts are more prevalent in India than in high-income countries. The study found that cases and deaths were concentrated in children ages 0-14 years, adults older than 65 years, and had higher comorbidity rates than US cases.
The LoDoCo2 trial found that low-dose colchicine significantly reduced the risk of major cardiovascular events by almost one-third in patients with chronic coronary disease. The study also showed that colchicine was well-tolerated over the long-term, with no significant adverse effects.
Researchers used facial photos to detect coronary artery disease using a deep learning algorithm, achieving high sensitivity and specificity rates. The study shows promise for developing a self-reported application to assess heart disease risk in advance of visiting a clinic.
Among patients with peripheral artery disease (PAD) and coronary artery disease, limited use of recommended medications was observed. Despite similar treatment needs, Hispanics of Mexican background reported the lowest usage of cardiovascular medications, highlighting the need for targeted interventions.
Hospitalized patients with heart failure experience increasing comorbidity burden over time, particularly women with HFpEF. The study suggests a shift towards multi-morbidity heart failure, emphasizing the importance of managing multiple conditions in guiding patient care.
A combined analysis of six studies found that consuming chocolate more than once a week was associated with an 8% decreased risk of coronary artery disease. The researchers attributed the potential benefit to flavonoids and other heart-healthy nutrients in chocolate.
A large-scale survey found that meditation was associated with reduced rates of high cholesterol, high blood pressure, diabetes, stroke, and coronary artery disease. The study controlled for other factors connected to cardiovascular risk and still showed a significant effect of meditation on cardiovascular health.
Researchers at Massachusetts General Hospital developed an algorithm to track patients' medical records over time in EHRs to predict disease likelihood. The strategy connects information on medications and diagnoses, revealing accurate disease markers that can be interpreted by clinicians.
Researchers found that genetic risk scores can identify at-risk patients who are not presently identified through standard clinical evaluations. The study, published in the Journal of the American College of Cardiology, found that individuals with high PRS were more likely to develop coronary artery disease and should be recommended fo...
Researchers found that patients with peripheral artery disease or stroke were less likely than those with coronary artery disease to receive recommended treatments to prevent heart attack. Lifestyle changes and medication, including statins and aspirin, are crucial for all three types of atherosclerotic cardiovascular disease.
The Society for Cardiovascular Angiography and Interventions (SCAI) has released a position statement on optimal percutaneous interventional therapy for complex coronary artery disease. The guidelines address the challenges of treating patients with advanced age, frailty, comorbidities, and compromised hemodynamic status.
A new study has shown that patients with intermediate left main coronary artery disease are at a higher risk of cardiovascular events compared to those without the condition. The ISCHEMIA trial sub study found no significant difference in outcomes between invasive and conservative strategies for these patients.
A study published by The BMJ found that childhood body size is associated with an increased risk of coronary artery disease and type 2 diabetes in later life. However, a larger early life body size may help protect women against breast cancer. The study suggests that maintaining a normal body mass index (BMI) in adulthood can reduce th...
Researchers found a significant increase in premature coronary artery disease deaths among rural women under 65, while also noting that people living in rural areas have lower survival rates for heart failure. This disparity highlights the need for targeted public health efforts to improve cardiovascular health in rural communities.