Articles tagged with Coronary Artery Disease
Research highlights treating anxiety and depression in people with heart disease can significantly reduce emergency room visits, hospitalizations, and even death. The study found that talk therapy and antidepressant medications improved heart outcomes among those with blocked arteries or heart failure.
Bruno Scheller developed a procedure using drug-coated balloons to treat coronary and peripheral artery disease, improving patients' quality of life. The technique has been widely recognized and effective, with countless patients spared further pain and surgery.
A multicenter randomized trial showed a paclitaxel-coated balloon to be superior to an uncoated balloon in preventing target lesion failure in patients with coronary in-stent restenosis. The study included 600 patients and demonstrated the effectiveness of paclitaxel-coated balloons as a treatment option.
A new study published in Radiology found that coronary artery calcium scoring can identify patients with a low risk of heart attacks or strokes. Patients with a zero coronary artery calcium score showed very low risk of major adverse cardiovascular events, suggesting they may not require invasive coronary angiography.
A new study published in Radiology found that ultrahigh-spatial-resolution photon-counting detector CT improved the assessment of coronary artery disease, allowing for reclassification to a lower disease category in 54% of patients. This technology has the potential to improve patient management and reduce unnecessary interventions.
A study has identified 1,289 genetic markers associated with Type 2 diabetes, including 145 newly discovered markers. The research provides risk scores for diabetes complications and suggests potential genetic targets for new treatments.
A new study found that women with migraines and long-term hot flashes or night sweats are at increased risk of heart disease and stroke. However, the research suggests that focusing on prevention and correcting unhealthy habits can help most women mitigate this risk. Women who have experienced both migraines and vasomotor symptoms for ...
Researchers have developed a new gene mapping technique that reveals how genetic alterations in cells lining blood vessels contribute to coronary artery disease. The technique, called Variant-to-Gene-to-Program (V2G2P), identifies biological mechanisms driving CAD risk by linking genetic variants to gene expression and function.
A recent survey found that 51% of Americans are unaware that heart disease is the leading cause of death in the US. This lack of knowledge can be deadly, with nearly half of adults having some form of cardiovascular disease.
The study found that APOE4 carriers have elevated LDL cholesterol levels, increasing their risk of developing subclinical atherosclerosis. In contrast, APOE2 carriers have lower cholesterol and reduced atherosclerosis prevalence.
Experts recommend increasing the use of intravascular ultrasound (IVUS) in lower extremity revascularization procedures to optimize outcomes and reduce complications. The technique provides detailed information about vessel walls, plaque composition, and blood flow characteristics, enabling more accurate diagnosis and treatment planning.
The Canadian Cardiovascular Society has updated its guidelines to no longer recommend routine daily aspirin use for primary prevention of heart attacks or death. However, daily aspirin may be considered for people with high risk factors for heart attack, such as diabetes, high cholesterol, and smoking. The new guidelines emphasize the ...
Black patients in integrated communities experience greatest benefits from PCI-CF openings, including a five times greater likelihood of receiving same-day PCI. Segregation is associated with poorer outcomes for racial minority groups.
Researchers at UVA Health System created an 'atlas of atherosclerosis' revealing critical processes that form harmful plaque buildup. The study provides unprecedented insights into atherosclerosis and its impact on coronary artery disease, heart attacks, and strokes.
Research found a significant linear relationship between age of coronary heart disease onset and dementia, highlighting the detrimental influence of premature cardiovascular events on brain health. Adults diagnosed with coronary heart disease at a young age may be at increased risk of developing dementia, Alzheimer's disease, and vascu...
Biomedical engineers at Duke University created a new 'digital twins' framework using smartwatch data to capture personalized arterial forces over 700,000 heartbeats. This approach reduces the computational load by simulating tasks in parallel, enabling real-time tracking of cardiovascular disease progression and risk assessment.
Thirty-two institutions earned the SET-10 distinction, with top ten recognized globally for their dedication to advancing scientific knowledge in interventional cardiovascular medicine. The rankings span six categories and acknowledge excellence within and outside the United States.
A new resorbable scaffold has been shown to be more effective than traditional angioplasty in treating severe artery blockages in the lower leg. In a large clinical trial, patients who received the scaffold had a 74% chance of avoiding adverse events, compared to 44% for those who underwent angioplasty.
The ORBITA-2 trial found that stenting improves symptoms compared to a placebo procedure, providing evidence-based treatment for stable chest pain. The study suggests updating guidelines for stable coronary artery disease and offers patients and medical teams two treatment strategies with similar benefits.
A single infusion of CRISPR-based gene-editing therapy significantly reduced LDL cholesterol levels in people with heterozygous familial hypercholesterolemia, a condition that increases heart attack risk. The treatment has shown potential as a long-term or permanent option for high LDL-C control.
A recent study published in Circulation found that non-ischemic or dual cardiomyopathy occurs in 1 out of every 6 patients with coronary artery disease. These conditions are characterized by heart muscle damage and can lead to worse long-term outcomes. The researchers used cardiac MRI to determine the cause of cardiomyopathy, which has...
Researchers have developed AI tools that can effectively detect heart valve disease and predict cardiovascular risk using digital stethoscopes. A study found that AI-powered digital stethoscopes predicted nearly 90% of valve disease diagnoses, offering a promising tool for transforming CVD care.
The American Heart Association has selected five finalists in its 6th annual Health Tech Competition to present their innovative technologies. The competition aims to drive technology innovation and transform the landscape of heart and brain health.
A secondary analysis of the Women's Ischemia Syndrome Evaluation (WISE) cohort study found that black and non-black women with obstructive coronary artery disease had similar long-term cardiovascular outcomes. The study suggests that guideline-based treatment, including statins and ACE inhibitors, may reduce racial disparities in cardi...
A new study published in eClinicalMedicine suggests that ECG-AI can flag some risks years sooner than current risk calculator equations by identifying signs of coronary artery disease, such as calcification and blockages. The technology has the potential to save more lives by identifying people who do not know they have coronary disease.
Researchers found that polygenic risk scores identify only 11% of individuals who develop disease and generate 5% false positives. The scores contribute little health benefit while adding cost and complexity to healthcare systems.
Researchers analyzed UK data to identify patterns of illnesses in individuals leading up to a type 2 diabetes diagnosis. High blood pressure, respiratory tract infections, heart conditions, and asthma were commonly observed, suggesting earlier diagnosis may be possible.
A new study from Tulane University found that walking more than five flights of stairs daily can cut the risk of heart disease by 20%. The study, published in Atherosclerosis, used UK Biobank data from 450,000 adults and found that stair climbing reduced cardiovascular disease risk in those with multiple risk factors.
A large study published in Journal of Investigative Dermatology found that patients with severe psoriasis have a high prevalence of coronary microvascular dysfunction, which is associated with increased cardiovascular risk. Psoriasis severity and duration, as well as the presence of psoriatic arthritis, are independently linked to redu...
A new CT test can identify individuals with stable angina at a reduced risk of three-year adverse outcomes despite having high coronary artery calcium scores. The test uses AI algorithms and computational fluid dynamics to simulate blood flow through the coronary arteries.
Researchers found that people with high blood pressure while lying flat on their backs had a higher risk of heart attack, stroke, and premature death. The study suggests that measuring blood pressure in different body positions may help identify cardiovascular disease risk.
A recent study from Mayo Clinic found that exercise test abnormalities, such as low functional aerobic capacity, predicted non-cardiovascular causes of death like cancer, alongside cardiovascular-related deaths. The study's findings suggest that clinicians should focus on data beyond ECG results to identify patients at risk.
Researchers found that optimized statin therapy can significantly reduce mortality and cardiovascular events in US military veterans with coronary artery disease. Widespread use of ezetimibe alongside statins may lead to additional reductions in cardiovascular risk.
Public health experts recommend continuing routine mask-wearing in healthcare settings to protect vulnerable patients and staff from COVID-19. The authors argue that while severe cases have decreased, asymptomatic spread remains a threat, particularly among high-risk patients and healthcare workers who may not be aware they are infected.
Octapharma's Balfaxar, a prothrombin complex concentrate, has received FDA approval for the urgent reversal of acquired coagulation factor deficiency induced by vitamin K antagonist therapy. The product demonstrated effective hemostasis in 94.6% of patients and was non-inferior to comparator Kcentra.
A novel molecular pathway has been identified, explaining how a mutation in the ACTA2 gene can cause individuals in their 30s with normal cholesterol levels to develop coronary artery disease. The mutation leads to stress in smooth muscle cells, triggering the production of excess cholesterol and driving atherosclerotic plaque formation.
The American College of Chest Physicians (CHEST) has released a new clinical guideline for managing antithrombotic therapy in patients with COVID-19-related arterial thrombosis and thromboembolism. The guideline provides evidence-based recommendations to improve risk-evaluation and treatment course.
A novel PET perfusion radiotracer, 18F-flurpiridaz, demonstrates high diagnostic efficacy for obese patients with coronary artery disease, outperforming traditional imaging methods. The study showed improved sensitivity and specificity in diagnosing significant CAD, even at lower radiation doses.
A new ultra-high-resolution CT technology has been developed to detect coronary artery disease in high-risk patients, providing a potentially significant benefit for people previously ineligible for noninvasive screening. The technology delivers excellent image quality and accurate diagnosis with high sensitivity and specificity.
Chronic exposure to low levels of contaminant metals through household items, air, water, soil, and food increases the risk of cardiovascular disease. Monitoring environmental metal levels and testing for exposure are key steps to implement public health initiatives.
The American Heart Association invites researchers to compete in a data challenge to better understand how lipoprotein(a) levels impact cardiovascular disease and stroke risk. The winning project can receive a $40,000 cash prize.
A supervised hospital walking program has been shown to reduce nursing facility admissions for older adults by lowering the proportion of patients discharged to skilled nursing facilities from 13% to 8%. However, low participation rates and limited impact on length of stay or inpatient falls were noted.
Researchers at UCSF tested a nitroglycerin patch for treating menopausal women experiencing severe hot flashes. The study found short-term improvements, but benefits did not last past 12 weeks, with some side effects reported.
A new study published in JAMA finds that adding a coronary artery calcium score to traditional risk factor models improves CHD risk discrimination for middle-aged adults. The researchers suggest this non-invasive imaging technique could be a reliable predictor of heart disease, particularly in older adults.
Researchers have identified 16 genes associated with an increased risk of Spontaneous Coronary Artery Dissection (SCAD), a type of heart attack primarily affecting young to middle-aged women. The study also found that patients with SCAD have some genetic protection from the risk of conventional coronary artery disease.
A global clinical trial found that bioresorbable vascular scaffolds (BVS) are nearly as safe and effective as conventional metal stents in treating coronary artery disease. The study, led by a researcher from the Mount Sinai Hospital, showed improved outcomes for patients when properly implanted.
Research highlights unique effects of Asian American subgroups on heart disease and Type 2 diabetes risk. Variations in cardiovascular risk among Asian Americans indicate the need for individual subgroup data to better understand health risks.
A new study reveals delayed diagnosis of HoFH leads to premature cardiovascular disease, highlighting the need for increased lipid screening and aggressive treatment. Despite available therapies, most patients require further lipid-lowering treatments.
A study found that young women are more likely to experience adverse outcomes and rehospitalization after a heart attack, with non-cardiac hospitalizations showing the most significant disparity. Researchers highlight the need for public awareness and sex-specific post-heart attack care.
Researchers have developed a non-invasive technique using laser speckle imaging to visualize microvasculature in donor hearts and detect abnormal blood flow. The method enables precise visualization of blood circulation, potentially identifying hearts suitable for transplantation.
A study published in Circulation Research identifies the FHL5 gene as a key regulator of vascular disease, including heart attacks and aneurysms. The discovery advances our understanding of the underlying causes of vascular disease and provides new insights into genetic risk factors.
A new study from the University of Eastern Finland identified 12 cell types involved in CAD pathogenesis. The genetic risk factors for CAD take effect via smooth vascular muscle cells, which change their phenotype as the disease progresses.
A machine learning model has been developed to predict a patient's risk for a sleep disorder using demographic, lifestyle, physical exam results, and laboratory values. The model identified depression, weight, age, and waist circumference as the greatest predictors of a sleep disorder diagnosis.
A cohort study of over 9,000 persons found that asymptomatic middle-aged individuals with subclinical coronary atherosclerosis are at an 8-fold increased risk for myocardial infarction. The study highlights the importance of identifying and addressing obstructive coronary artery disease in patients without known cardiovascular disease.
The Lp(a) Discovery Project will develop clinical standards for optimal patient care through a new screening measure and quality improvement interventions. The three-year project aims to fill knowledge gaps around Lp(a) and encourage better treatments to reduce cardiovascular risk.
Researchers from Kyushu University found that the single mechanosensitive protein VGLL3 induces fibrosis, thickening and scarring tissue. The study suggests targeting this protein could lead to new treatments against fibrosis.
A real-world analysis found that high-risk Americans who fail to reach guideline-recommended LDL-C levels experience a 44% higher rate of cardiovascular events. The study, presented at the AMCP Conference, used data from over 300 million Americans and compared those who met and maintained recommended targets with those who did not.
The VALOR-QI program will provide a blueprint for quality care improvement, focusing on high-risk patients and addressing health equity gaps. It will offer education, staff training, monitoring, and other steps to achieve better compliance with cholesterol management.
Women have a roughly 30-40% higher risk of dying following coronary artery bypass surgery, with female patients having a 2.8% rate of death during or soon after surgery compared to 1.7% for male patients.
A study of over 1.2 million patients found women remain at higher risk for adverse outcomes after coronary artery bypass grafting. No significant improvement in outcomes has been observed over the past decade.